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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
55473

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:55473

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:55473
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003779actin bindingNos2IDARatRGD:7777144|PMID:15858215
Molecular FunctionGO:0034618arginine bindingNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Molecular FunctionGO:0008013beta-catenin bindingNos2IPIRGD:70487RatRGD:7777144|PMID:15858215
Molecular FunctionGO:0045296cadherin bindingNos2IPIRGD:69280RatRGD:7777144|PMID:15858215
Molecular FunctionGO:0008603cAMP-dependent protein kinase regulator activityNos2IDARatRGD:625635|PMID:12107056
Molecular FunctionGO:0050660flavin adenine dinucleotide bindingNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Molecular FunctionGO:0010181FMN bindingNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Molecular FunctionGO:0020037heme bindingNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Molecular FunctionGO:0020037heme bindingNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Molecular FunctionGO:0051879Hsp90 protein bindingNos2IDARatRGD:5132625|PMID:15475520
Molecular FunctionGO:0004517nitric-oxide synthase activityNOS2IDAHumanPMID:7504305
Molecular FunctionGO:0004517nitric-oxide synthase activityNOS2IDAHumanPMID:7682706
Molecular FunctionGO:0004517nitric-oxide synthase activityNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Molecular FunctionGO:0004517nitric-oxide synthase activityNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Molecular FunctionGO:0004517nitric-oxide synthase activityNos2IDARatRGD:1580262|PMID:16172396
Molecular FunctionGO:0004517nitric-oxide synthase activityNos2IDARatRGD:70247|PMID:11788371
Molecular FunctionGO:0050998nitric-oxide synthase bindingNos2IPIRGD:3186RatRGD:7777144|PMID:15858215
Molecular FunctionGO:0005515protein bindingNOS2IPIUniProtKB:P07901HumanPMID:12855682
Molecular FunctionGO:0005515protein bindingNOS2IPIUniProtKB:P04406HumanPMID:25417112
Molecular FunctionGO:0005515protein bindingNos2IPIUniProtKB:P35354MouseMGI:MGI:4887336|PMID:16373578
Molecular FunctionGO:0005515protein bindingNos2IPIUniProtKB:Q76LV2MouseMGI:MGI:3687888|PMID:12855682
Molecular FunctionGO:0005515protein bindingNos2IPIUniProtKB:P07900MouseMGI:MGI:3687888|PMID:12855682
Molecular FunctionGO:0005515protein bindingNos2IPIUniProtKB:P57780MouseMGI:MGI:2674212|PMID:12960352
Molecular FunctionGO:0005515protein bindingNos2IPIUniProtKB:P04441MouseMGI:MGI:4943392|PMID:18003616
Molecular FunctionGO:0042803protein homodimerization activityNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Molecular FunctionGO:0042803protein homodimerization activityNos2IDARatRGD:1580262|PMID:16172396
Molecular FunctionGO:0019901protein kinase bindingNos2IPIRGD:2263RatRGD:7240712|PMID:17293490
Molecular FunctionGO:0005102receptor bindingNOS2IPIUniProtKB:P50542HumanPMID:20178365
Molecular FunctionGO:0034617tetrahydrobiopterin bindingNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Cellular ComponentGO:0030863cortical cytoskeletonNos2IDAMouseMGI:MGI:2674212|PMID:12960352
Cellular ComponentGO:0005737cytoplasmNOS2IDAHumanPMID:12085352
Cellular ComponentGO:0005737cytoplasmNOS2IDAHumanPMID:9916929
Cellular ComponentGO:0005737cytoplasmNos2IDAMouseMGI:MGI:2674212|PMID:12960352
Cellular ComponentGO:0005737cytoplasmNos2IDAMouseMGI:MGI:2157736|PMID:11732991
Cellular ComponentGO:0005737cytoplasmNos2IDARatRGD:1580263|PMID:16387842
Cellular ComponentGO:0005737cytoplasmNos2IDARatRGD:8554470|PMID:11943139
Cellular ComponentGO:0005737cytoplasmNos2IDARatRGD:8656007|PMID:12085352
Cellular ComponentGO:0005829cytosolNOS2IMPHumanPMID:7504305
Cellular ComponentGO:0005829cytosolNos2IDARatRGD:8656007|PMID:12085352
Cellular ComponentGO:0005615extracellular spaceNos2IDARatRGD:5509038|PMID:22019508
Cellular ComponentGO:0005622intracellularNOS2IDAHumanPMID:7544003
Cellular ComponentGO:0005634nucleusNos2IDARatRGD:1580263|PMID:16387842
Cellular ComponentGO:0005634nucleusNos2IDARatRGD:8554470|PMID:11943139
Cellular ComponentGO:0048471perinuclear region of cytoplasmNos2IDAMouseMGI:MGI:2674212|PMID:12960352
Cellular ComponentGO:0048471perinuclear region of cytoplasmNos2IDARatRGD:7240712|PMID:17293490
Cellular ComponentGO:0005777peroxisomeNOS2IDAHumanPMID:12085352
Cellular ComponentGO:0005777peroxisomeNos2IDARatRGD:1580262|PMID:16172396
Cellular ComponentGO:0005777peroxisomeNos2IDARatRGD:8656007|PMID:12085352
Cellular ComponentGO:0012506vesicle membraneNos2IDARatRGD:5131895|PMID:21448354
Biological ProcessGO:0006527arginine catabolic processNOS2IDAHumanPMID:7504305
Biological ProcessGO:0006527arginine catabolic processNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Biological ProcessGO:0001974blood vessel remodelingNos2IMPRatRGD:1580261|PMID:15800493
Biological ProcessGO:0071345cellular response to cytokine stimulusNos2IDARatRGD:10402041|PMID:19414010
Biological ProcessGO:0035690cellular response to drugNos2IDAMouseMGI:MGI:5619708|PMID:24486487
Biological ProcessGO:0071346cellular response to interferon-gammaNos2IDAMouseMGI:MGI:4412460|PMID:18025219
Biological ProcessGO:0071222cellular response to lipopolysaccharideNos2IDAMouseMGI:MGI:3821815|PMID:18791161
Biological ProcessGO:0071222cellular response to lipopolysaccharideNos2IDAMouseMGI:MGI:4412460|PMID:18025219
Biological ProcessGO:0071407cellular response to organic cyclic compoundNos2IDARatRGD:10402041|PMID:19414010
Biological ProcessGO:0019934cGMP-mediated signalingNos2IDARatRGD:625635|PMID:12107056
Biological ProcessGO:0042742defense response to bacteriumNOS2IMPHumanPMID:9284131
Biological ProcessGO:0042742defense response to bacteriumNos2IMPMGI:MGI:1857228MouseMGI:MGI:2673089|PMID:12933833
Biological ProcessGO:0007199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messengerNos2IDARatRGD:625635|PMID:12107056
Biological ProcessGO:0072604interleukin-6 secretionNOS2IDAHumanPMID:19688109
Biological ProcessGO:0072606interleukin-8 secretionNOS2IDAHumanPMID:19688109
Biological ProcessGO:0035556intracellular signal transductionNos2IMPRatRGD:1580266|PMID:15001568
Biological ProcessGO:0010629negative regulation of gene expressionNOS2IGIUniProtKB:P29477HumanPMID:12085352
Biological ProcessGO:0010629negative regulation of gene expressionNos2IGIUniProtKB:P35228MouseMGI:MGI:5319619|PMID:12085352
Biological ProcessGO:0042177negative regulation of protein catabolic processNos2IDAMouseMGI:MGI:4943392|PMID:18003616
Biological ProcessGO:0006809nitric oxide biosynthetic processNOS2IDAHumanPMID:7504305
Biological ProcessGO:0006809nitric oxide biosynthetic processNOS2IDAHumanPMID:7682706
Biological ProcessGO:0006809nitric oxide biosynthetic processNos2IDAMouseMGI:MGI:3807772|PMID:1383204
Biological ProcessGO:0006809nitric oxide biosynthetic processNos2IDAMouseMGI:MGI:3807769|PMID:9271491
Biological ProcessGO:0006809nitric oxide biosynthetic processNos2IDARatRGD:1358527|PMID:12826065
Biological ProcessGO:0006809nitric oxide biosynthetic processNos2IDARatRGD:1580262|PMID:16172396
Biological ProcessGO:0018119peptidyl-cysteine S-nitrosylationNos2IDAMouseMGI:MGI:4887336|PMID:16373578
Biological ProcessGO:0043065positive regulation of apoptotic processNos2IMPRatRGD:4891948|PMID:12208351
Biological ProcessGO:0051712positive regulation of killing of cells of other organismNOS2IMPHumanPMID:7544003
Biological ProcessGO:0032310prostaglandin secretionNOS2IDAHumanPMID:19688109
Biological ProcessGO:0008217regulation of blood pressureNos2IMPRatRGD:1580267|PMID:12959638
Biological ProcessGO:0008217regulation of blood pressureNos2IMPRatRGD:1582114|PMID:16650388
Biological ProcessGO:0042127regulation of cell proliferationNos2IGIMGI:MGI:88039MouseMGI:MGI:2151649|PMID:11606502
Biological ProcessGO:0042127regulation of cell proliferationNos2IGIMGI:MGI:88039MouseMGI:MGI:2154629|PMID:11731407
Biological ProcessGO:1900015regulation of cytokine production involved in inflammatory responseNOS2IDAHumanPMID:19688109
Biological ProcessGO:0008016regulation of heart contractionNos2IMPRatRGD:1582114|PMID:16650388
Biological ProcessGO:0050796regulation of insulin secretionNOS2IMPHumanPMID:8383325
Biological ProcessGO:0001666response to hypoxiaNos2IDAMouseMGI:MGI:2674212|PMID:12960352
Biological ProcessGO:0032496response to lipopolysaccharideNos2IDAMouseMGI:MGI:5308514|PMID:22073225
Biological ProcessGO:0034612response to tumor necrosis factorNos2IMPRatRGD:4891376|PMID:19802525
Biological ProcessGO:0007165signal transductionNos2IDARatRGD:625635|PMID:12107056
Biological ProcessGO:0006801superoxide metabolic processNos2IMPMGI:MGI:1857228MouseMGI:MGI:2673089|PMID:12933833

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory