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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
47944

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:47944

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:47944
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0004935adrenergic receptor activityAdra2aIMPMouseMGI:MGI:3616148|PMID:15218143
Molecular FunctionGO:0031696alpha-2C adrenergic receptor bindingADRA2AIPIUniProtKB:P18825HumanPMID:16605244
Molecular FunctionGO:0004938alpha2-adrenergic receptor activityADRA2AIDAHumanPMID:10948191
Molecular FunctionGO:0004938alpha2-adrenergic receptor activityAdra2aIDARatRGD:1304193|PMID:1645350
Molecular FunctionGO:0051379epinephrine bindingADRA2AIDAHumanPMID:10948191
Molecular FunctionGO:0051379epinephrine bindingADRA2AIDAHumanPMID:2823383
Molecular FunctionGO:0032795heterotrimeric G-protein bindingADRA2AIDAHumanPMID:10948191
Molecular FunctionGO:0051380norepinephrine bindingADRA2AIDAHumanPMID:2823383
Molecular FunctionGO:0005515protein bindingADRA2AIPIUniProtKB:P51693HumanPMID:16531006
Molecular FunctionGO:0046982protein heterodimerization activityADRA2AIPIUniProtKB:P18825HumanPMID:16605244
Molecular FunctionGO:0042803protein homodimerization activityADRA2AIDAHumanPMID:16605244
Molecular FunctionGO:0019901protein kinase bindingADRA2AIPIUniProtKB:P21146HumanPMID:15653687
Molecular FunctionGO:0031996thioesterase bindingADRA2AIPIUniProtKB:P09936HumanPMID:19477270
Cellular ComponentGO:0005737cytoplasmADRA2AIDAHumanPMID:19477270
Cellular ComponentGO:0005737cytoplasmAdra2aIDARatRGD:1625184|PMID:15475682
Cellular ComponentGO:0005887integral component of plasma membraneADRA2AIDAHumanPMID:10948191
Cellular ComponentGO:0005887integral component of plasma membraneADRA2AIDAHumanPMID:10948198
Cellular ComponentGO:0005887integral component of plasma membraneADRA2AIDAHumanPMID:2823383
Cellular ComponentGO:0005886plasma membraneAdra2aIDARatRGD:1625184|PMID:15475682
Cellular ComponentGO:0005886plasma membraneAdra2aIDARatRGD:631753|PMID:12398941
Cellular ComponentGO:0005886plasma membraneAdra2aIDARatRGD:631769|PMID:12373741
Cellular ComponentGO:0043235receptor complexADRA2AIDAHumanPMID:10948191
Cellular ComponentGO:0045202synapseAdra2aIDARatRGD:1625184|PMID:15475682
Biological ProcessGO:0071883activation of MAPK activity by adrenergic receptor signaling pathwayADRA2AIDAHumanPMID:10948191
Biological ProcessGO:0032147activation of protein kinase activityADRA2AIDAHumanPMID:15653687
Biological ProcessGO:0032148activation of protein kinase B activityADRA2AIDAHumanPMID:17215105
Biological ProcessGO:0002526acute inflammatory responseAdra2aIMPRatRGD:6480483|PMID:19894027
Biological ProcessGO:0071881adenylate cyclase-inhibiting adrenergic receptor signaling pathwayADRA2AIDAHumanPMID:10948191
Biological ProcessGO:0071875adrenergic receptor signaling pathwayAdra2aIMPMouseMGI:MGI:3616148|PMID:15218143
Biological ProcessGO:0032870cellular response to hormone stimulusADRA2AIGIUniProtKB:P25962HumanPMID:10948198
Biological ProcessGO:0006260DNA replicationAdra2aIMPRatRGD:1625185|PMID:15351511
Biological ProcessGO:0035625epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayADRA2AIDAHumanPMID:17215105
Biological ProcessGO:0035625epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayADRA2AIDAHumanPMID:17655843
Biological ProcessGO:0042596fear responseAdra2aIMPMouseMGI:MGI:3039992|PMID:15105370
Biological ProcessGO:0007565female pregnancyAdra2aIMPRatRGD:6893569|PMID:19450576
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayAdra2aIDAMouseMGI:MGI:3616148|PMID:15218143
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayAdra2aIMPRatRGD:2316628|PMID:19965390
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayAdra2aIMPRatPMID:19965390
Biological ProcessGO:0042593glucose homeostasisADRA2AIMPHumanPMID:10952463
Biological ProcessGO:0042593glucose homeostasisAdra2aIMPRatRGD:2316628|PMID:19965390
Biological ProcessGO:0042593glucose homeostasisAdra2aIMPRatPMID:19965390
Biological ProcessGO:0045955negative regulation of calcium ion-dependent exocytosisAdra2aIMPRatRGD:2316628|PMID:19965390
Biological ProcessGO:0045955negative regulation of calcium ion-dependent exocytosisAdra2aIMPRatPMID:19965390
Biological ProcessGO:0030818negative regulation of cAMP biosynthetic processADRA2AIDAHumanPMID:16531006
Biological ProcessGO:0046676negative regulation of insulin secretionADRA2AIMPHumanPMID:10952463
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusADRA2AIMPHumanPMID:19965390
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusAdra2aIMPRatRGD:2316628|PMID:19965390
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusAdra2aIMPRatPMID:19965390
Biological ProcessGO:0050995negative regulation of lipid catabolic processADRA2AIGIUniProtKB:P25962HumanPMID:10948198
Biological ProcessGO:0070473negative regulation of uterine smooth muscle contractionAdra2aIMPRatRGD:6893570|PMID:17664026
Biological ProcessGO:0071882phospholipase C-activating adrenergic receptor signaling pathwayADRA2AIDAHumanPMID:10948191
Biological ProcessGO:0030335positive regulation of cell migrationADRA2AIMPHumanPMID:17655843
Biological ProcessGO:0001819positive regulation of cytokine productionADRA2AIDAHumanPMID:17655843
Biological ProcessGO:0045741positive regulation of epidermal growth factor-activated receptor activityADRA2AIDAHumanPMID:17655843
Biological ProcessGO:0043406positive regulation of MAP kinase activityADRA2AIDAHumanPMID:19477270
Biological ProcessGO:0051044positive regulation of membrane protein ectodomain proteolysisADRA2AIDAHumanPMID:17655843
Biological ProcessGO:0045909positive regulation of vasodilationAdra2aIMPRatRGD:6480489|PMID:20837990
Biological ProcessGO:0090303positive regulation of wound healingADRA2AIMPHumanPMID:17655843
Biological ProcessGO:0050955thermoceptionAdra2aIDARatRGD:6480493|PMID:20110357

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory