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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
4494

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:4494

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:4494
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0004882androgen receptor activityNKX3-1IDAHumanPMID:19886863
Molecular FunctionGO:0001047core promoter bindingNKX3-1IDAHumanPMID:18974119
Molecular FunctionGO:0008656cysteine-type endopeptidase activator activity involved in apoptotic processNKX3-1IDAHumanPMID:19266349
Molecular FunctionGO:0003677DNA bindingNkx3-1IDAMouseMGI:MGI:1928182|PMID:10993896
Molecular FunctionGO:0030284estrogen receptor activityNKX3-1IDAHumanPMID:18794125
Molecular FunctionGO:0030331estrogen receptor bindingNKX3-1IDAHumanPMID:18794125
Molecular FunctionGO:0042826histone deacetylase bindingNKX3-1IPIUniProtKB:Q13547HumanPMID:18974119
Molecular FunctionGO:0097162MADS box domain bindingNkx3-1IDAMouseMGI:MGI:5294290|PMID:18296735
Molecular FunctionGO:0005515protein bindingNKX3-1IPIUniProtKB:P11387HumanPMID:17234752
Molecular FunctionGO:0005515protein bindingNKX3-1IPIUniProtKB:Q9NS56HumanPMID:18077445
Molecular FunctionGO:0005515protein bindingNKX3-1IPIUniProtKB:P11831HumanPMID:18296735
Molecular FunctionGO:0005515protein bindingNKX3-1IPIUniProtKB:Q8IZQ8HumanPMID:19797053
Molecular FunctionGO:0005515protein bindingNkx3-1IPIUniProtKB:Q9Z2G0MouseMGI:MGI:3809320|PMID:18816836
Molecular FunctionGO:0030295protein kinase activator activityNKX3-1IDAHumanPMID:20395202
Molecular FunctionGO:0043621protein self-associationNKX3-1IDAHumanPMID:19780584
Molecular FunctionGO:0043565sequence-specific DNA bindingNKX3-1IDAHumanPMID:19780584
Molecular FunctionGO:0043565sequence-specific DNA bindingNkx3-1IDAMouseMGI:MGI:87385|PMID:9142502
Molecular FunctionGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specificNkx3-1IMPMouseMGI:MGI:5294290|PMID:18296735
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingNKX3-1IDAHumanPMID:20855495
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingNkx3-1IDAMouseMGI:MGI:1928182|PMID:10993896
Molecular FunctionGO:0008134transcription factor bindingNKX3-1IPIUniProtKB:P08047HumanPMID:20716579
Molecular FunctionGO:0008134transcription factor bindingNkx3-1IDAMouseMGI:MGI:1928182|PMID:10993896
Molecular FunctionGO:0008134transcription factor bindingNkx3-1IPIUniProtKB:P11831MouseMGI:MGI:5294290|PMID:18296735
Molecular FunctionGO:0044212transcription regulatory region DNA bindingNKX3-1IDAHumanPMID:19263243
Molecular FunctionGO:0000976transcription regulatory region sequence-specific DNA bindingNKX3-1IDAHumanPMID:20855495
Cellular ComponentGO:0005622intracellularNKX3-1IDAHumanPMID:19597465
Cellular ComponentGO:0005622intracellularNkx3-1IDAMouseMGI:MGI:4366606|PMID:19597465
Cellular ComponentGO:0005634nucleusNKX3-1IDAHumanPMID:18757402
Cellular ComponentGO:0005634nucleusNKX3-1IDAHumanPMID:19263243
Cellular ComponentGO:0005634nucleusNkx3-1IDAMouseMGI:MGI:3603077|PMID:15987773
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processNKX3-1IDAHumanPMID:17486276
Biological ProcessGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic processNKX3-1IDAHumanPMID:19266349
Biological ProcessGO:0030521androgen receptor signaling pathwayNKX3-1IDAHumanPMID:19886863
Biological ProcessGO:0060442branching involved in prostate gland morphogenesisNkx3-1IMPMGI:MGI:1926960MouseMGI:MGI:1335939|PMID:10215624
Biological ProcessGO:0060442branching involved in prostate gland morphogenesisNkx3-1IMPMGI:MGI:1928655MouseMGI:MGI:1891543|PMID:11002344
Biological ProcessGO:0060442branching involved in prostate gland morphogenesisNkx3-1IMPMGI:MGI:1928654MouseMGI:MGI:1861552|PMID:10906459
Biological ProcessGO:0048754branching morphogenesis of an epithelial tubeNkx3-1IMPMGI:MGI:1928655MouseMGI:MGI:1891543|PMID:11002344
Biological ProcessGO:0071456cellular response to hypoxiaNKX3-1IDAHumanPMID:21056661
Biological ProcessGO:0071383cellular response to steroid hormone stimulusNKX3-1IDAHumanPMID:19886863
Biological ProcessGO:0060664epithelial cell proliferation involved in salivary gland morphogenesisNkx3-1IMPMGI:MGI:1928654MouseMGI:MGI:1861552|PMID:10906459
Biological ProcessGO:0071850mitotic cell cycle arrestNKX3-1IDAHumanPMID:19266349
Biological ProcessGO:0008285negative regulation of cell proliferationNKX3-1IDAHumanPMID:17486276
Biological ProcessGO:0008285negative regulation of cell proliferationNKX3-1IDAHumanPMID:19266349
Biological ProcessGO:0008285negative regulation of cell proliferationNkx3-1IGIUniProtKB:P17936MouseMGI:MGI:3839214|PMID:19258508
Biological ProcessGO:0050680negative regulation of epithelial cell proliferationNkx3-1IMPMGI:MGI:1928655MouseMGI:MGI:1891543|PMID:11002344
Biological ProcessGO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentNkx3-1IMPMGI:MGI:1928655MouseMGI:MGI:1891543|PMID:11002344
Biological ProcessGO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentNkx3-1IMPMGI:MGI:3045877MouseMGI:MGI:2158150|PMID:11839815
Biological ProcessGO:0071899negative regulation of estrogen receptor bindingNKX3-1IDAHumanPMID:18794125
Biological ProcessGO:0010629negative regulation of gene expressionNKX3-1IDAHumanPMID:17486276
Biological ProcessGO:0043569negative regulation of insulin-like growth factor receptor signaling pathwayNkx3-1IDAMouseMGI:MGI:3839214|PMID:19258508
Biological ProcessGO:0045930negative regulation of mitotic cell cycleNKX3-1IDAHumanPMID:19266349
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedNKX3-1IMPHumanPMID:18360715
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedNKX3-1IDAHumanPMID:18794125
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedNKX3-1IMPHumanPMID:18974119
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedNKX3-1IDAHumanPMID:19597465
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedNkx3-1IMPMouseMGI:MGI:4366606|PMID:19597465
Biological ProcessGO:2000836positive regulation of androgen secretionNKX3-1IDAHumanPMID:19886863
Biological ProcessGO:2001235positive regulation of apoptotic signaling pathwayNKX3-1IDAHumanPMID:20599703
Biological ProcessGO:0010942positive regulation of cell deathNKX3-1IDAHumanPMID:19266349
Biological ProcessGO:0051781positive regulation of cell divisionNKX3-1IMPHumanPMID:20855495
Biological ProcessGO:0008284positive regulation of cell proliferationNKX3-1IMPHumanPMID:18360715
Biological ProcessGO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic processNKX3-1IDAHumanPMID:20599703
Biological ProcessGO:0010628positive regulation of gene expressionNKX3-1IDAHumanPMID:17486276
Biological ProcessGO:0010628positive regulation of gene expressionNKX3-1IDAHumanPMID:20599703
Biological ProcessGO:0010628positive regulation of gene expressionNKX3-1IMPHumanPMID:20716579
Biological ProcessGO:2001244positive regulation of intrinsic apoptotic signaling pathwayNKX3-1IDAHumanPMID:17486276
Biological ProcessGO:0045931positive regulation of mitotic cell cycleNKX3-1IMPHumanPMID:20855495
Biological ProcessGO:0014068positive regulation of phosphatidylinositol 3-kinase signalingNKX3-1IDAHumanPMID:20395202
Biological ProcessGO:0001934positive regulation of protein phosphorylationNKX3-1IDAHumanPMID:20395202
Biological ProcessGO:2001022positive regulation of response to DNA damage stimulusNKX3-1IDAHumanPMID:20395202
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterNKX3-1IDAHumanPMID:19797053
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterNKX3-1IDAHumanPMID:20855495
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedNKX3-1IMPHumanPMID:18360715
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedNkx3-1IDAMouseMGI:MGI:1928182|PMID:10993896
Biological ProcessGO:0043491protein kinase B signalingNKX3-1IMPHumanPMID:19597465
Biological ProcessGO:0043491protein kinase B signalingNkx3-1IMPMouseMGI:MGI:4366606|PMID:19597465
Biological ProcessGO:0033574response to testosteroneNkx3-1IMPMouseMGI:MGI:87385|PMID:9142502
Biological ProcessGO:0007431salivary gland developmentNkx3-1IMPMGI:MGI:1928654MouseMGI:MGI:1861552|PMID:10906459

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory