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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
4314

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:4314

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:4314
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0048185activin bindingSMAD7IPIUniProtKB:P36896HumanPMID:16720724
Molecular FunctionGO:0008013beta-catenin bindingSMAD7IPIUniProtKB:P35222HumanPMID:18593713
Molecular FunctionGO:0005518collagen bindingSmad7IPIUniProtKB:Q01149|UniProtKB:Q3U962|UniProtKB:P08121MouseMGI:MGI:2679769|PMID:14559231
Molecular FunctionGO:0070411I-SMAD bindingSMAD7IPIUniProtKB:O43541HumanPMID:9256479
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:Q92905HumanPMID:14993265
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:O15169HumanPMID:16601693
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:Q99ML9HumanPMID:16601693
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:P36896HumanPMID:16720724
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:P62942HumanPMID:16720724
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:O15169HumanPMID:18593713
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:O43294HumanPMID:18762808
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:O00308HumanPMID:21258410
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:Q9Y4E8HumanPMID:22344298
Molecular FunctionGO:0005515protein bindingSMAD7IPIUniProtKB:P46937HumanPMID:25283809
Molecular FunctionGO:0005515protein bindingSmad7IPIUniProtKB:Q923E4MouseMGI:MGI:5306300|PMID:17098745
Molecular FunctionGO:0005515protein bindingSmad7IPIUniProtKB:O88566MouseMGI:MGI:3628833|PMID:16601693
Molecular FunctionGO:0005515protein bindingSmad7IPIUniProtKB:O35625MouseMGI:MGI:3628833|PMID:16601693
Molecular FunctionGO:0005515protein bindingSmad7IPIUniProtKB:Q9C0C9MouseMGI:MGI:5508676|PMID:23455153
Molecular FunctionGO:0005515protein bindingSmad7IPIUniProtKB:Q99PD6RatRGD:8553475|PMID:18762808
Molecular FunctionGO:0044212transcription regulatory region DNA bindingSMAD7IDAHumanPMID:17438144
Molecular FunctionGO:0030617transforming growth factor beta receptor, inhibitory cytoplasmic mediator activitySMAD7IDAHumanPMID:9256479
Molecular FunctionGO:0034713type I transforming growth factor beta receptor bindingSMAD7IPIUniProtKB:P36897HumanPMID:11278251
Molecular FunctionGO:0031625ubiquitin protein ligase bindingSMAD7IPIUniProtKB:Q9HCE7HumanPMID:12151385
Molecular FunctionGO:0031625ubiquitin protein ligase bindingSmad7IPIRGD:1310067|RGD:1310097RatRGD:2302562|PMID:17347560
Cellular ComponentGO:0016342catenin complexSMAD7IDAHumanPMID:18593713
Cellular ComponentGO:0005913cell-cell adherens junctionSMAD7IDAHumanPMID:18593713
Cellular ComponentGO:0005813centrosomeSMAD7IDAHumanGO_REF:0000052
Cellular ComponentGO:0005737cytoplasmSMAD7IDAHumanPMID:11278251
Cellular ComponentGO:0005737cytoplasmSMAD7IDAHumanPMID:17438144
Cellular ComponentGO:0005829cytosolSMAD7IDAHumanGO_REF:0000052
Cellular ComponentGO:0001650fibrillar centerSMAD7IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmSMAD7IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusSMAD7IDAHumanPMID:11278251
Cellular ComponentGO:0005634nucleusSMAD7IDAHumanPMID:12151385
Cellular ComponentGO:0005634nucleusSMAD7IDAHumanPMID:17438144
Cellular ComponentGO:0005634nucleusSmad7IDAMouseMGI:MGI:4367296|PMID:19796622
Cellular ComponentGO:0005634nucleusSmad7IDAMouseMGI:MGI:3628833|PMID:16601693
Cellular ComponentGO:0005886plasma membraneSMAD7IDAHumanPMID:12151385
Cellular ComponentGO:0043234protein complexSMAD7IDAHumanPMID:23610558
Cellular ComponentGO:0043234protein complexSmad7IDAMouseMGI:MGI:3628833|PMID:16601693
Biological ProcessGO:0034333adherens junction assemblySMAD7IMPHumanPMID:18593713
Biological ProcessGO:0048844artery morphogenesisSmad7IMPMouseMGI:MGI:3836072|PMID:18952608
Biological ProcessGO:0034629cellular protein complex localizationSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusSMAD7IMPHumanPMID:18593713
Biological ProcessGO:0071560cellular response to transforming growth factor beta stimulusSmad7IMPMouseMGI:MGI:5532916|PMID:18593713
Biological ProcessGO:0035556intracellular signal transductionSmad7IDARatRGD:625758|PMID:11959632
Biological ProcessGO:0030514negative regulation of BMP signaling pathwaySMAD7IDAHumanPMID:17438144
Biological ProcessGO:0030514negative regulation of BMP signaling pathwaySmad7IDAMouseMGI:MGI:4429763|PMID:19850029
Biological ProcessGO:0060394negative regulation of pathway-restricted SMAD protein phosphorylationSMAD7IDAHumanPMID:17438144
Biological ProcessGO:0033137negative regulation of peptidyl-serine phosphorylationSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0033137negative regulation of peptidyl-serine phosphorylationSmad7IMPMouseMGI:MGI:5532916|PMID:18593713
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0010801negative regulation of peptidyl-threonine phosphorylationSmad7IMPMouseMGI:MGI:5532916|PMID:18593713
Biological ProcessGO:0031397negative regulation of protein ubiquitinationSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0043433negative regulation of sequence-specific DNA binding transcription factor activitySMAD7IDAHumanPMID:17438144
Biological ProcessGO:0002725negative regulation of T cell cytokine productionSmad7IMPMouseMGI:MGI:5634593|PMID:25642768
Biological ProcessGO:2000320negative regulation of T-helper 17 cell differentiationSmad7IMPMouseMGI:MGI:5634593|PMID:25642768
Biological ProcessGO:2000317negative regulation of T-helper 17 type immune responseSmad7IMPMouseMGI:MGI:5634593|PMID:25642768
Biological ProcessGO:0010944negative regulation of transcription by competitive promoter bindingSMAD7IDAHumanPMID:17438144
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterSMAD7IDAHumanPMID:17438144
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwaySMAD7IDAHumanPMID:12151385
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwaySMAD7IDAHumanPMID:17438144
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwaySMAD7IDAHumanPMID:18762808
Biological ProcessGO:0051444negative regulation of ubiquitin-protein transferase activitySMAD7IDAHumanPMID:18593713
Biological ProcessGO:0060389pathway-restricted SMAD protein phosphorylationSmad7IMPMouseMGI:MGI:3836072|PMID:18952608
Biological ProcessGO:0022409positive regulation of cell-cell adhesionSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0022409positive regulation of cell-cell adhesionSmad7IMPMouseMGI:MGI:5532916|PMID:18593713
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processSMAD7IDAHumanPMID:11278251
Biological ProcessGO:0031398positive regulation of protein ubiquitinationSMAD7IDAHumanPMID:16720724
Biological ProcessGO:0050821protein stabilizationSMAD7IDAHumanPMID:18593713
Biological ProcessGO:0032925regulation of activin receptor signaling pathwaySMAD7IDAHumanPMID:16720724
Biological ProcessGO:0055117regulation of cardiac muscle contractionSmad7IMPMouseMGI:MGI:3836072|PMID:18952608
Biological ProcessGO:0010717regulation of epithelial to mesenchymal transitionSMAD7IMPHumanPMID:24887517
Biological ProcessGO:0017015regulation of transforming growth factor beta receptor signaling pathwaySmad7IDARatRGD:625758|PMID:11959632
Biological ProcessGO:0007179transforming growth factor beta receptor signaling pathwaySmad7IDAMouseMGI:MGI:2153598|PMID:11557747
Biological ProcessGO:0055010ventricular cardiac muscle tissue morphogenesisSmad7IMPMouseMGI:MGI:3836072|PMID:18952608
Biological ProcessGO:0060412ventricular septum morphogenesisSmad7IMPMouseMGI:MGI:3836072|PMID:18952608

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory