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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
37643

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:37643

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:37643
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:00046763-phosphoinositide-dependent protein kinase activityPDPK1IDAHumanPMID:9368760
Molecular FunctionGO:00046763-phosphoinositide-dependent protein kinase activityPdpk1IDAMouseMGI:MGI:1332935|PMID:10075713
Molecular FunctionGO:00046763-phosphoinositide-dependent protein kinase activityPdpk1IDARatRGD:1581774|PMID:16314505
Molecular FunctionGO:00046763-phosphoinositide-dependent protein kinase activityPdpk1IDARatRGD:1581775|PMID:14585963
Molecular FunctionGO:0005158insulin receptor bindingPdpk1IDARatRGD:1581774|PMID:16314505
Molecular FunctionGO:0016301kinase activityPDPK1EXPHumanReactome:REACT_908
Molecular FunctionGO:0016004phospholipase activator activityPDPK1IMPHumanPMID:22454520
Molecular FunctionGO:0043274phospholipase bindingPDPK1IPIUniProtKB:P19174HumanPMID:22454520
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:P31749HumanPMID:11438723
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:Q8WTW4HumanPMID:18616680
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:Q00005HumanPMID:21075311
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:P31749HumanPMID:21775285
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:P31749HumanPMID:23397142
Molecular FunctionGO:0005515protein bindingPDPK1IPIUniProtKB:Q8IUH5HumanPMID:24705354
Molecular FunctionGO:0019901protein kinase bindingPdpk1IDARatRGD:1581775|PMID:14585963
Molecular FunctionGO:0004674protein serine/threonine kinase activityPDPK1IDAHumanPMID:9368760
Cellular ComponentGO:0042995cell projectionPDPK1IDAHumanPMID:22454520
Cellular ComponentGO:0005737cytoplasmPDPK1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005737cytoplasmPDPK1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005737cytoplasmPDPK1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005737cytoplasmPDPK1IDAHumanPMID:9637919
Cellular ComponentGO:0005737cytoplasmPdpk1IDAMouseMGI:MGI:2673048|PMID:12783890
Cellular ComponentGO:0016023cytoplasmic membrane-bounded vesiclePdpk1IDAMouseMGI:MGI:2673048|PMID:12783890
Cellular ComponentGO:0005829cytosolPdpk1IDARatRGD:1581774|PMID:16314505
Cellular ComponentGO:0005886plasma membranePDPK1IDAHumanPMID:14749367
Cellular ComponentGO:0005886plasma membranePDPK1IDAHumanPMID:22454520
Cellular ComponentGO:0005886plasma membranePDPK1IDAHumanPMID:9637919
Cellular ComponentGO:0005886plasma membranePdpk1IDARatRGD:1581774|PMID:16314505
Biological ProcessGO:0032148activation of protein kinase B activityPDPK1IDAHumanPMID:9368760
Biological ProcessGO:0019722calcium-mediated signalingPDPK1IMPHumanPMID:22454520
Biological ProcessGO:0016477cell migrationPDPK1IMPHumanPMID:22454520
Biological ProcessGO:0071364cellular response to epidermal growth factor stimulusPDPK1IMPHumanPMID:22454520
Biological ProcessGO:0032869cellular response to insulin stimulusPDPK1IMPHumanPMID:10567711
Biological ProcessGO:0007173epidermal growth factor receptor signaling pathwayPDPK1IMPHumanPMID:22454520
Biological ProcessGO:0097191extrinsic apoptotic signaling pathwayPDPK1IMPHumanPMID:16207722
Biological ProcessGO:0048041focal adhesion assemblyPdpk1IMPRatRGD:1581775|PMID:14585963
Biological ProcessGO:0006972hyperosmotic responsePdpk1IDAMouseMGI:MGI:2673048|PMID:12783890
Biological ProcessGO:0035556intracellular signal transductionPDPK1IDAHumanPMID:14749367
Biological ProcessGO:0010667negative regulation of cardiac muscle cell apoptotic processPdpk1IMPMouseMGI:MGI:3849539|PMID:19429709
Biological ProcessGO:0006469negative regulation of protein kinase activityPDPK1IDAHumanPMID:9373175
Biological ProcessGO:0034122negative regulation of toll-like receptor signaling pathwayPdpk1IMPMouseMGI:MGI:4821539|PMID:20584979
Biological ProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayPDPK1IDAHumanPMID:17327236
Biological ProcessGO:0018107peptidyl-threonine phosphorylationPDPK1IDAHumanPMID:9368760
Biological ProcessGO:0090004positive regulation of establishment of protein localization to plasma membranePDPK1IMPHumanPMID:10567711
Biological ProcessGO:0010518positive regulation of phospholipase activityPDPK1IMPHumanPMID:22454520
Biological ProcessGO:0051281positive regulation of release of sequestered calcium ion into cytosolPDPK1IDAHumanPMID:22454520
Biological ProcessGO:0006468protein phosphorylationPDPK1IDAHumanPMID:14585963
Biological ProcessGO:0006468protein phosphorylationPdpk1IDAMouseMGI:MGI:1332935|PMID:10075713
Biological ProcessGO:0010594regulation of endothelial cell migrationPdpk1IMPMouseMGI:MGI:3789556|PMID:17371830
Biological ProcessGO:0043122regulation of I-kappaB kinase/NF-kappaB signalingPDPK1IMPHumanPMID:16207722
Biological ProcessGO:0043304regulation of mast cell degranulationPdpk1IMPMouseMGI:MGI:5298334|PMID:21063107
Biological ProcessGO:0003323type B pancreatic cell developmentPdpk1IMPMouseMGI:MGI:4365695|PMID:19635472

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory