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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
36215

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:36215

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Aug 5 20:57:06 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:36215
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005524ATP bindingIRAK3IDAHumanPMID:10383454
Molecular FunctionGO:0005524ATP bindingIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Molecular FunctionGO:0000287magnesium ion bindingIRAK3IDAHumanPMID:10383454
Molecular FunctionGO:0000287magnesium ion bindingIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Molecular FunctionGO:0005515protein bindingIrak3IPIUniProtKB:P70196MouseMGI:MGI:3688344|PMID:15102471
Molecular FunctionGO:0005515protein bindingIrak3IPIUniProtKB:P70196|UniProtKB:Q8R4K2|UniProtKB:Q9NWZ3MouseMGI:MGI:5553230|PMID:23376919
Molecular FunctionGO:0046982protein heterodimerization activityIRAK3IPIUniProtKB:O43187HumanPMID:10383454
Molecular FunctionGO:0046982protein heterodimerization activityIRAK3IPIUniProtKB:P51617HumanPMID:10383454
Molecular FunctionGO:0042803protein homodimerization activityIRAK3IPIUniProtKB:Q9Y616HumanPMID:10383454
Molecular FunctionGO:0004672protein kinase activityIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Molecular FunctionGO:0004674protein serine/threonine kinase activityIRAK3IDAHumanPMID:10383454
Molecular FunctionGO:0004674protein serine/threonine kinase activityIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Cellular ComponentGO:0005737cytoplasmIRAK3IDAHumanPMID:17379480
Cellular ComponentGO:0005737cytoplasmIrak3IDAMouseMGI:MGI:3843426|PMID:17379480
Cellular ComponentGO:0005634nucleusIRAK3IDAHumanPMID:17379480
Cellular ComponentGO:0005634nucleusIrak3IDAMouseMGI:MGI:3843426|PMID:17379480
Biological ProcessGO:0019221cytokine-mediated signaling pathwayIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0070498interleukin-1-mediated signaling pathwayIRAK3IMPHumanPMID:10383454
Biological ProcessGO:0070498interleukin-1-mediated signaling pathwayIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0045824negative regulation of innate immune responseIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIRAK3IMPHumanPMID:18156187
Biological ProcessGO:0032695negative regulation of interleukin-12 productionIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0032715negative regulation of interleukin-6 productionIRAK3IMPHumanPMID:18156187
Biological ProcessGO:0032715negative regulation of interleukin-6 productionIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0010936negative regulation of macrophage cytokine productionIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0043407negative regulation of MAP kinase activityIRAK3IMPHumanPMID:17379480
Biological ProcessGO:0043407negative regulation of MAP kinase activityIrak3IMPMouseMGI:MGI:3843426|PMID:17379480
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityIRAK3IMPHumanPMID:10383454
Biological ProcessGO:0032088negative regulation of NF-kappaB transcription factor activityIRAK3IMPHumanPMID:18156187
Biological ProcessGO:0042177negative regulation of protein catabolic processIRAK3IMPHumanPMID:17379480
Biological ProcessGO:0042177negative regulation of protein catabolic processIRAK3IMPHumanPMID:18156187
Biological ProcessGO:0042177negative regulation of protein catabolic processIrak3IMPMouseMGI:MGI:3843426|PMID:17379480
Biological ProcessGO:0043242negative regulation of protein complex disassemblyIRAK3IMPHumanPMID:12150927
Biological ProcessGO:0034122negative regulation of toll-like receptor signaling pathwayIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionIRAK3IMPHumanPMID:15728517
Biological ProcessGO:0032720negative regulation of tumor necrosis factor productionIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0010933positive regulation of macrophage tolerance inductionIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIRAK3IMPHumanPMID:10383454
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0046777protein autophosphorylationIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0006468protein phosphorylationIRAK3IDAHumanPMID:10383454
Biological ProcessGO:0006468protein phosphorylationIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0043244regulation of protein complex disassemblyIrak3IDAMouseMGI:MGI:2181508|PMID:12054681
Biological ProcessGO:0043330response to exogenous dsRNAIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0070555response to interleukin-1IRAK3IMPHumanPMID:10383454
Biological ProcessGO:0032496response to lipopolysaccharideIrak3IMPMouseMGI:MGI:2183694|PMID:12150927
Biological ProcessGO:0032494response to peptidoglycanIrak3IMPMouseMGI:MGI:2183694|PMID:12150927

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory