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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
30994

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:30994

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:30994
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0050662coenzyme bindingHMGCRIDAHumanPMID:10698924
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:2180727|PMID:8647961
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:2386518|PMID:12114517
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:2157179|PMID:11792727
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:70238|PMID:7798939
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:49557|PMID:1352323
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:2679748|PMID:12920113
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:3603108|PMID:16100574
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:892202|PMID:9186920
Molecular FunctionGO:0004420hydroxymethylglutaryl-CoA reductase (NADPH) activityHmgcrIDAMouseMGI:MGI:3603484|PMID:15845870
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityHMGCRIDAHumanPMID:2991281
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityHmgcrIDARatRGD:1300058|PMID:12841361
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityHmgcrIDARatRGD:2316848|PMID:16140414
Molecular FunctionGO:0042282hydroxymethylglutaryl-CoA reductase activityHmgcrIDARatRGD:2316922|PMID:10484604
Molecular FunctionGO:0070402NADPH bindingHMGCRIDAHumanPMID:10698924
Molecular FunctionGO:0005515protein bindingHMGCRIPIUniProtKB:Q9Y5Z9HumanPMID:23169578
Molecular FunctionGO:0005515protein bindingHMGCRIPIUniProtKB:Q9Y5Z9-1HumanPMID:23169578
Molecular FunctionGO:0042803protein homodimerization activityHmgcrIDARatRGD:1625194|PMID:4019513
Molecular FunctionGO:0051721protein phosphatase 2A bindingHmgcrIPIRGD:3380RatRGD:8693702|PMID:18031790
Cellular ComponentGO:0005783endoplasmic reticulumHMGCRIDAHumanPMID:17180682
Cellular ComponentGO:0043231intracellular membrane-bounded organelleHmgcrIDARatRGD:1300058|PMID:12841361
Cellular ComponentGO:0043231intracellular membrane-bounded organelleHmgcrIDARatRGD:2316848|PMID:16140414
Cellular ComponentGO:0005778peroxisomal membraneHMGCRIDAHumanPMID:17180682
Biological ProcessGO:0006695cholesterol biosynthetic processHMGCRIDAHumanPMID:23063590
Biological ProcessGO:0006695cholesterol biosynthetic processHmgcrIDAMouseMGI:MGI:3603484|PMID:15845870
Biological ProcessGO:0006695cholesterol biosynthetic processHmgcrIDAMouseMGI:MGI:70238|PMID:7798939
Biological ProcessGO:0006695cholesterol biosynthetic processHmgcrIDAMouseMGI:MGI:2180727|PMID:8647961
Biological ProcessGO:0006695cholesterol biosynthetic processHmgcrIDARatRGD:1300058|PMID:12841361
Biological ProcessGO:0009790embryo developmentHmgcrIMPMGI:MGI:2682329MouseMGI:MGI:2679748|PMID:12920113
Biological ProcessGO:0008299isoprenoid biosynthetic processHmgcrIDARatRGD:2316848|PMID:16140414
Biological ProcessGO:0008299isoprenoid biosynthetic processHmgcrIDARatRGD:2316922|PMID:10484604
Biological ProcessGO:0043066negative regulation of apoptotic processHmgcrIMPRatRGD:5508700|PMID:15385411
Biological ProcessGO:0097756negative regulation of blood vessel diameterHmgcrIMPRatRGD:2316498|PMID:19221211
Biological ProcessGO:0061179negative regulation of insulin secretion involved in cellular response to glucose stimulusHmgcrIMPRatRGD:5508687|PMID:20610886
Biological ProcessGO:0043407negative regulation of MAP kinase activityHmgcrIGIMGI:MGI:97306MouseMGI:MGI:3610917|PMID:12409258
Biological ProcessGO:0010664negative regulation of striated muscle cell apoptotic processHmgcrIMPRatRGD:5508691|PMID:19505369
Biological ProcessGO:0061045negative regulation of wound healingHmgcrIMPRatRGD:5508683|PMID:19578821
Biological ProcessGO:0010666positive regulation of cardiac muscle cell apoptotic processHmgcrIMPRatRGD:5508693|PMID:19298698
Biological ProcessGO:0008284positive regulation of cell proliferationHmgcrIMPRatRGD:5508684|PMID:21907337
Biological ProcessGO:0008284positive regulation of cell proliferationHmgcrIMPRatRGD:5508702|PMID:12713866
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeHmgcrIMPRatRGD:5508698|PMID:17161379
Biological ProcessGO:0048643positive regulation of skeletal muscle tissue developmentHmgcrIMPRatRGD:2317940|PMID:19388010
Biological ProcessGO:0048661positive regulation of smooth muscle cell proliferationHmgcrIMPRatRGD:5508694|PMID:18413661
Biological ProcessGO:0032874positive regulation of stress-activated MAPK cascadeHmgcrIMPRatRGD:5508698|PMID:17161379
Biological ProcessGO:0051262protein tetramerizationHMGCRIDAHumanPMID:10698924
Biological ProcessGO:0006743ubiquinone metabolic processHmgcrIMPRatRGD:5508697|PMID:17192694
Biological ProcessGO:0008542visual learningHmgcrIGIMGI:MGI:97306MouseMGI:MGI:3610917|PMID:12409258

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory