About   Help   FAQ
Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 67, Dec 12, 2012)
20695

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:20695

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Jan 27 18:25:03 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:20695
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0042498diacyl lipopeptide bindingTlr2IDAMouseMGI:MGI:4419037|PMID:19931471
Molecular FunctionGO:0042498diacyl lipopeptide bindingTlr2IDAMouseMGI:MGI:4437881|PMID:17889651
Molecular FunctionGO:0071723lipopeptide bindingTlr2IMPRatRGD:5684896|PMID:18353287
Molecular FunctionGO:0070891lipoteichoic acid bindingTlr2IDAMouseMGI:MGI:4419037|PMID:19931471
Molecular FunctionGO:0042834peptidoglycan bindingTLR2IDAHumanPMID:11986301
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q9H0E2HumanPMID:10854325
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q9H0E2HumanPMID:11441107
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:P0A5J0HumanPMID:12594264
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q15654HumanPMID:15657077
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:P15712HumanPMID:16622205
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q50615HumanPMID:17095513
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:P58753HumanPMID:19509286
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q7D8M9HumanPMID:19880448
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:C3PTT6HumanPMID:20802527
Molecular FunctionGO:0005515protein bindingTLR2IPIUniProtKB:Q676U5HumanPMID:23376921
Molecular FunctionGO:0005515protein bindingTlr2IPIUniProtKB:Q99JY1MouseMGI:MGI:4943396|PMID:17322885
Molecular FunctionGO:0005515protein bindingTlr2IPIRGD:735043RatRGD:2312510|PMID:19144836
Molecular FunctionGO:0046982protein heterodimerization activityTLR2IDAHumanPMID:17889651
Molecular FunctionGO:0046982protein heterodimerization activityTlr2IPIUniProtKB:Q9EPW9MouseMGI:MGI:4419037|PMID:19931471
Molecular FunctionGO:0004872receptor activityTLR2IDAHumanPMID:11672593
Molecular FunctionGO:0008329signaling pattern recognition receptor activityTLR2IDAHumanPMID:10384090
Molecular FunctionGO:0042497triacyl lipopeptide bindingTLR2IDAHumanPMID:17889651
Molecular FunctionGO:0042497triacyl lipopeptide bindingTlr2IDAMouseMGI:MGI:4437881|PMID:17889651
Cellular ComponentGO:0044297cell bodyTlr2IDARatRGD:7241097|PMID:21971760
Cellular ComponentGO:0042995cell projectionTlr2IDARatRGD:7241097|PMID:21971760
Cellular ComponentGO:0009986cell surfaceTLR2IDAHumanPMID:12443841
Cellular ComponentGO:0009986cell surfaceTlr2IDARatRGD:7241098|PMID:21765618
Cellular ComponentGO:0005737cytoplasmTLR2IDAHumanPMID:19740627
Cellular ComponentGO:0009897external side of plasma membraneTlr2IDAMouseMGI:MGI:3050756|PMID:15220916
Cellular ComponentGO:0005886plasma membraneTLR2IDAHumanPMID:19740627
Cellular ComponentGO:0005886plasma membraneTlr2IDAMouseMGI:MGI:3042099|PMID:12719478
Cellular ComponentGO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complexTLR2IDAHumanPMID:17889651
Cellular ComponentGO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complexTlr2IPIUniProtKB:Q9EPW9MouseMGI:MGI:4419037|PMID:19931471
Biological ProcessGO:0002752cell surface pattern recognition receptor signaling pathwayTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3042099|PMID:12719478
Biological ProcessGO:0071221cellular response to bacterial lipopeptideTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3528769|PMID:15690042
Biological ProcessGO:0071726cellular response to diacyl bacterial lipopeptideTLR2IDAHumanPMID:19931471
Biological ProcessGO:0071223cellular response to lipoteichoic acidTLR2IDAHumanPMID:12594207
Biological ProcessGO:0071223cellular response to lipoteichoic acidTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3528769|PMID:15690042
Biological ProcessGO:0071224cellular response to peptidoglycanTlr2IMPMouseMGI:MGI:3686795|PMID:16949315
Biological ProcessGO:0071727cellular response to triacyl bacterial lipopeptideTLR2IDAHumanPMID:19931471
Biological ProcessGO:0032289central nervous system myelin formationTlr2IDARatRGD:7241097|PMID:21971760
Biological ProcessGO:0042892chloramphenicol transportTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3526877|PMID:12091878
Biological ProcessGO:0050830defense response to Gram-positive bacteriumTLR2IDAHumanPMID:11521063
Biological ProcessGO:0050830defense response to Gram-positive bacteriumTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3528769|PMID:15690042
Biological ProcessGO:0050830defense response to Gram-positive bacteriumTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3619313|PMID:11067888
Biological ProcessGO:0050830defense response to Gram-positive bacteriumTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3839525|PMID:19139201
Biological ProcessGO:0042496detection of diacyl bacterial lipopeptideTLR2IDAHumanPMID:19931471
Biological ProcessGO:0042495detection of triacyl bacterial lipopeptideTLR2IDAHumanPMID:19931471
Biological ProcessGO:0007252I-kappaB phosphorylationTLR2IDAHumanPMID:19740627
Biological ProcessGO:0052063induction by symbiont of defense-related host nitric oxide productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0006954inflammatory responseTlr2IDARatRGD:4889539|PMID:16154916
Biological ProcessGO:0006691leukotriene metabolic processTlr2IDARatRGD:7241098|PMID:21765618
Biological ProcessGO:0001774microglial cell activationTlr2IDARatRGD:1643119|PMID:16973131
Biological ProcessGO:0002755MyD88-dependent toll-like receptor signaling pathwayTlr2IGIMGI:MGI:108005MouseMGI:MGI:3042099|PMID:12719478
Biological ProcessGO:0008285negative regulation of cell proliferationTlr2IDARatRGD:7241097|PMID:21971760
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3528769|PMID:15690042
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3619313|PMID:11067888
Biological ProcessGO:0032695negative regulation of interleukin-12 productionTlr2IMPMouseMGI:MGI:3686795|PMID:16949315
Biological ProcessGO:0032700negative regulation of interleukin-17 productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0046209nitric oxide metabolic processTlr2IDARatRGD:1643119|PMID:16973131
Biological ProcessGO:0032722positive regulation of chemokine productionTLR2IDAHumanPMID:19740627
Biological ProcessGO:0032722positive regulation of chemokine productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0050715positive regulation of cytokine secretionTlr2IGIMGI:MGI:2157947MouseMGI:MGI:4365650|PMID:19770268
Biological ProcessGO:0032728positive regulation of interferon-beta productionTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0032733positive regulation of interleukin-10 productionTlr2IDARatRGD:7241093|PMID:22653369
Biological ProcessGO:0032735positive regulation of interleukin-12 productionTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0032741positive regulation of interleukin-18 productionTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0032755positive regulation of interleukin-6 productionTLR2IDAHumanPMID:19740627
Biological ProcessGO:0032755positive regulation of interleukin-6 productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:2178646|PMID:10549626
Biological ProcessGO:0032755positive regulation of interleukin-6 productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3619313|PMID:11067888
Biological ProcessGO:0032755positive regulation of interleukin-6 productionTlr2IDAMouseMGI:MGI:3775161|PMID:18261938
Biological ProcessGO:0032755positive regulation of interleukin-6 productionTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0032757positive regulation of interleukin-8 productionTLR2IDAHumanPMID:17128265
Biological ProcessGO:0032757positive regulation of interleukin-8 productionTLR2IDAHumanPMID:19740627
Biological ProcessGO:0002687positive regulation of leukocyte migrationTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3814295|PMID:17114491
Biological ProcessGO:0060907positive regulation of macrophage cytokine productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:2178646|PMID:10549626
Biological ProcessGO:0042346positive regulation of NF-kappaB import into nucleusTLR2IDAHumanPMID:19740627
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityTLR2IDAHumanPMID:12594207
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processTlr2IMPMGI:MGI:2178675MouseMGI:MGI:2178646|PMID:10549626
Biological ProcessGO:0045429positive regulation of nitric oxide biosynthetic processTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0051770positive regulation of nitric-oxide synthase biosynthetic processTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0048714positive regulation of oligodendrocyte differentiationTlr2IDARatRGD:7241097|PMID:21971760
Biological ProcessGO:0034123positive regulation of toll-like receptor signaling pathwayTLR2IDAHumanPMID:17128265
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0042535positive regulation of tumor necrosis factor biosynthetic processTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:2178646|PMID:10549626
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3042099|PMID:12719478
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3528769|PMID:15690042
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3611539|PMID:16239543
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3619313|PMID:11067888
Biological ProcessGO:0032760positive regulation of tumor necrosis factor productionTlr2IDAMouseMGI:MGI:4456948|PMID:15356140
Biological ProcessGO:0030177positive regulation of Wnt signaling pathwayTLR2IMPHumanPMID:16601243
Biological ProcessGO:0032493response to bacterial lipoproteinTlr2IDARatRGD:1643119|PMID:16973131
Biological ProcessGO:0009617response to bacteriumTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3814295|PMID:17114491
Biological ProcessGO:0070542response to fatty acidTlr2IDARatRGD:2312510|PMID:19144836
Biological ProcessGO:0002238response to molecule of fungal originTlr2IMPMGI:MGI:2178675MouseMGI:MGI:3042099|PMID:12719478
Biological ProcessGO:0032494response to peptidoglycanTlr2IMPMGI:MGI:2178675MouseMGI:MGI:2178646|PMID:10549626
Biological ProcessGO:0032494response to peptidoglycanTlr2IMPMGI:MGI:2674036MouseMGI:MGI:3814295|PMID:17114491
Biological ProcessGO:0002224toll-like receptor signaling pathwayTlr2IDARatRGD:1643119|PMID:16973131
Biological ProcessGO:0002224toll-like receptor signaling pathwayTlr2IMPRatRGD:5684896|PMID:18353287

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory