Comparative GO Graph (mouse, human, rat)

Source
Class ID

HomoloGene (Release 68, May 6, 2014)
20171

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:20171

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

This class contains
- Human genes ADRB1
- Mouse genes Adrb1
- Rat genes Adrb1
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD.
Only experimental annotations are displayed: EXP, IDA, IGI, IMP, IPI. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:20171

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031694	alpha-2A adrenergic receptor binding	ADRB1	IPI	UniProtKB:P18871	Human	PMID:12529373
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Mouse	MGI:MGI:72815\|PMID:7738011
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:82113\|PMID:8693001
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Mouse	MGI:MGI:1097308\|PMID:9305915
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Rat	RGD:2301946\|PMID:6381693
Molecular Function	GO:0004940	beta1-adrenergic receptor activity	Adrb1	IDA		Rat	RGD:632158\|PMID:12514203
Molecular Function	GO:0035240	dopamine binding	Adrb1	IDA		Rat	RGD:2301946\|PMID:6381693
Molecular Function	GO:0008144	drug binding	Adrb1	IDA		Rat	RGD:2301944\|PMID:6289140
Molecular Function	GO:0051379	epinephrine binding	Adrb1	IDA		Rat	RGD:2301946\|PMID:6381693
Molecular Function	GO:0051380	norepinephrine binding	Adrb1	IDA		Rat	RGD:2301946\|PMID:6381693
Molecular Function	GO:0030165	PDZ domain binding	ADRB1	IPI	UniProtKB:P31016	Human	PMID:11526121
Molecular Function	GO:0030165	PDZ domain binding	ADRB1	IPI	UniProtKB:Q86UL8	Human	PMID:11526121
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q9Y4G8	Human	PMID:12391161
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q5TCQ9	Human	PMID:16316992
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:Q86UL8	Human	PMID:16316992
Molecular Function	GO:0005515	protein binding	ADRB1	IPI	UniProtKB:P14270	Human	PMID:23381222
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	UniProtKB:Q01063	Mouse	MGI:MGI:3773471\|PMID:18188154
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	RGD:620829	Rat	RGD:2313215\|PMID:16940053
Molecular Function	GO:0005515	protein binding	Adrb1	IPI	UniProtKB:Q9JK71	Rat	RGD:8553792\|PMID:16316992
Molecular Function	GO:0046982	protein heterodimerization activity	ADRB1	IPI	UniProtKB:P18871	Human	PMID:12529373
Molecular Function	GO:0005088	Ras guanyl-nucleotide exchange factor activity	ADRB1	IDA		Human	PMID:12391161
Molecular Function	GO:0005057	signal transducer activity, downstream of receptor	ADRB1	IDA		Human	PMID:12391161
Cellular Component	GO:0005737	cytoplasm	Adrb1	IDA		Rat	RGD:5129148\|PMID:17337326
Cellular Component	GO:0005769	early endosome	ADRB1	IDA		Human	PMID:21540189
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Adrb1	IDA		Rat	RGD:2301949\|PMID:2858976
Cellular Component	GO:0016020	membrane	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:82113\|PMID:8693001
Cellular Component	GO:0016020	membrane	Adrb1	IDA		Rat	RGD:2301954\|PMID:1686765
Cellular Component	GO:0005634	nucleus	Adrb1	IDA		Rat	RGD:5129153\|PMID:16631628
Cellular Component	GO:0005886	plasma membrane	ADRB1	IDA		Human	PMID:11526121
Cellular Component	GO:0005886	plasma membrane	ADRB1	IDA		Human	PMID:21540189
Cellular Component	GO:0005886	plasma membrane	Adrb1	IDA		Rat	RGD:8554163\|PMID:12391161
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:82113\|PMID:8693001
Biological Process	GO:0006915	apoptotic process	Adrb1	IDA		Rat	RGD:5129152\|PMID:16820859
Biological Process	GO:0050873	brown fat cell differentiation	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2388907\|PMID:12387862
Biological Process	GO:0002024	diet induced thermogenesis	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2387786\|PMID:12161655
Biological Process	GO:0042596	fear response	Adrb1	IMP		Mouse	MGI:MGI:3040004\|PMID:15066288
Biological Process	GO:0007186	G-protein coupled receptor signaling pathway	Adrb1	IDA		Rat	RGD:632158\|PMID:12514203
Biological Process	GO:0005980	glycogen catabolic process	Adrb1	IDA		Rat	RGD:5129142\|PMID:17911346
Biological Process	GO:0031649	heat generation	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2387786\|PMID:12161655
Biological Process	GO:0060080	inhibitory postsynaptic potential	Adrb1	IMP		Rat	RGD:5129137\|PMID:18262504
Biological Process	GO:0055088	lipid homeostasis	Adrb1	IMP		Rat	RGD:6893582\|PMID:22457517
Biological Process	GO:0007613	memory	Adrb1	IMP		Rat	RGD:5129141\|PMID:17961922
Biological Process	GO:0040015	negative regulation of multicellular organism growth	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2388907\|PMID:12387862
Biological Process	GO:0045986	negative regulation of smooth muscle contraction	Adrb1	IMP		Rat	RGD:5129131\|PMID:18306009
Biological Process	GO:0035811	negative regulation of urine volume	Adrb1	IDA		Rat	RGD:5129105\|PMID:7912752
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IGI	MGI:MGI:87938	Mouse	MGI:MGI:1338641\|PMID:10358009
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IGI	MGI:MGI:87938	Mouse	MGI:MGI:3608195\|PMID:11641423
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:1338641\|PMID:10358009
Biological Process	GO:0002025	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:3608195\|PMID:11641423
Biological Process	GO:0045762	positive regulation of adenylate cyclase activity	Adrb1	IMP		Rat	RGD:8693686\|PMID:21143600
Biological Process	GO:0043065	positive regulation of apoptotic process	Adrb1	IMP		Rat	RGD:7241557\|PMID:17143192
Biological Process	GO:0030819	positive regulation of cAMP biosynthetic process	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:0030819	positive regulation of cAMP biosynthetic process	ADRB1	IDA		Human	PMID:12529373
Biological Process	GO:0030819	positive regulation of cAMP biosynthetic process	Adrb1	IMP		Rat	RGD:5129138\|PMID:18202135
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:2001259	positive regulation of cation channel activity	Adrb1	IDA		Rat	RGD:6893581\|PMID:22505670
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	Adrb1	IMP		Rat	RGD:5129139\|PMID:18194989
Biological Process	GO:0043547	positive regulation of GTPase activity	ADRB1	IDA		Human	PMID:12391161
Biological Process	GO:0010460	positive regulation of heart rate	Adrb1	IMP		Rat	RGD:5129112\|PMID:9089896
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:82113\|PMID:8693001
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:1338641\|PMID:10358009
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Adrb1	IDA		Rat	RGD:8693685\|PMID:21848869
Biological Process	GO:1900135	positive regulation of renin secretion into blood stream	Adrb1	IMP		Rat	RGD:7241562\|PMID:15810988
Biological Process	GO:0046878	positive regulation of saliva secretion	Adrb1	IMP		Rat	RGD:5129135\|PMID:18275933
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	Adrb1	IMP		Rat	RGD:5129129\|PMID:18931026
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adrb1	IDA		Mouse	MGI:MGI:84440\|PMID:7761854
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	Adrb1	IMP	MGI:MGI:1857120	Mouse	MGI:MGI:82113\|PMID:8693001
Biological Process	GO:0003061	positive regulation of the force of heart contraction by norepinephrine	Adrb1	IDA		Rat	RGD:5129126\|PMID:19133992
Biological Process	GO:0033365	protein localization to organelle	Adrb1	IDA		Rat	RGD:6893637\|PMID:22105697
Biological Process	GO:0051924	regulation of calcium ion transport	Adrb1	IDA		Rat	RGD:5129126\|PMID:19133992
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	Adrb1	IMP		Rat	RGD:6893639\|PMID:22216755
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2387786\|PMID:12161655
Biological Process	GO:0009409	response to cold	Adrb1	IGI	MGI:MGI:87938\|MGI:MGI:87939	Mouse	MGI:MGI:2388907\|PMID:12387862
Biological Process	GO:0007266	Rho protein signal transduction	Adrb1	IMP		Rat	RGD:5129131\|PMID:18306009
Biological Process	GO:0019233	sensory perception of pain	Adrb1	IMP		Rat	RGD:5129125\|PMID:19283893
Biological Process	GO:0042060	wound healing	Adrb1	IMP		Rat	RGD:5129124\|PMID:19320892

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 12/03/2019 MGI 6.14

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.