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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
20171

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:20171

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:20171
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0031694alpha-2A adrenergic receptor bindingADRB1IPIUniProtKB:P18871HumanPMID:12529373
Molecular FunctionGO:0004940beta1-adrenergic receptor activityAdrb1IDAMouseMGI:MGI:72815|PMID:7738011
Molecular FunctionGO:0004940beta1-adrenergic receptor activityAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:82113|PMID:8693001
Molecular FunctionGO:0004940beta1-adrenergic receptor activityAdrb1IDAMouseMGI:MGI:1097308|PMID:9305915
Molecular FunctionGO:0004940beta1-adrenergic receptor activityAdrb1IDARatRGD:2301946|PMID:6381693
Molecular FunctionGO:0004940beta1-adrenergic receptor activityAdrb1IDARatRGD:632158|PMID:12514203
Molecular FunctionGO:0035240dopamine bindingAdrb1IDARatRGD:2301946|PMID:6381693
Molecular FunctionGO:0008144drug bindingAdrb1IDARatRGD:2301944|PMID:6289140
Molecular FunctionGO:0051379epinephrine bindingAdrb1IDARatRGD:2301946|PMID:6381693
Molecular FunctionGO:0051380norepinephrine bindingAdrb1IDARatRGD:2301946|PMID:6381693
Molecular FunctionGO:0030165PDZ domain bindingADRB1IPIUniProtKB:P31016HumanPMID:11526121
Molecular FunctionGO:0030165PDZ domain bindingADRB1IPIUniProtKB:Q86UL8HumanPMID:11526121
Molecular FunctionGO:0005515protein bindingADRB1IPIUniProtKB:Q9Y4G8HumanPMID:12391161
Molecular FunctionGO:0005515protein bindingADRB1IPIUniProtKB:Q5TCQ9HumanPMID:16316992
Molecular FunctionGO:0005515protein bindingADRB1IPIUniProtKB:Q86UL8HumanPMID:16316992
Molecular FunctionGO:0005515protein bindingADRB1IPIUniProtKB:P14270HumanPMID:23381222
Molecular FunctionGO:0005515protein bindingAdrb1IPIUniProtKB:Q01063MouseMGI:MGI:3773471|PMID:18188154
Molecular FunctionGO:0005515protein bindingAdrb1IPIRGD:620829RatRGD:2313215|PMID:16940053
Molecular FunctionGO:0005515protein bindingAdrb1IPIUniProtKB:Q9JK71RatRGD:8553792|PMID:16316992
Molecular FunctionGO:0046982protein heterodimerization activityADRB1IPIUniProtKB:P18871HumanPMID:12529373
Molecular FunctionGO:0005088Ras guanyl-nucleotide exchange factor activityADRB1IDAHumanPMID:12391161
Molecular FunctionGO:0005057signal transducer activity, downstream of receptorADRB1IDAHumanPMID:12391161
Cellular ComponentGO:0005737cytoplasmAdrb1IDARatRGD:5129148|PMID:17337326
Cellular ComponentGO:0005769early endosomeADRB1IDAHumanPMID:21540189
Cellular ComponentGO:0043231intracellular membrane-bounded organelleAdrb1IDARatRGD:2301949|PMID:2858976
Cellular ComponentGO:0016020membraneAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:82113|PMID:8693001
Cellular ComponentGO:0016020membraneAdrb1IDARatRGD:2301954|PMID:1686765
Cellular ComponentGO:0005634nucleusAdrb1IDARatRGD:5129153|PMID:16631628
Cellular ComponentGO:0005886plasma membraneADRB1IDAHumanPMID:11526121
Cellular ComponentGO:0005886plasma membraneADRB1IDAHumanPMID:21540189
Cellular ComponentGO:0005886plasma membraneAdrb1IDARatRGD:8554163|PMID:12391161
Biological ProcessGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathwayADRB1IDAHumanPMID:12391161
Biological ProcessGO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathwayAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:82113|PMID:8693001
Biological ProcessGO:0006915apoptotic processAdrb1IDARatRGD:5129152|PMID:16820859
Biological ProcessGO:0050873brown fat cell differentiationAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2388907|PMID:12387862
Biological ProcessGO:0002024diet induced thermogenesisAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2387786|PMID:12161655
Biological ProcessGO:0042596fear responseAdrb1IMPMouseMGI:MGI:3040004|PMID:15066288
Biological ProcessGO:0007186G-protein coupled receptor signaling pathwayAdrb1IDARatRGD:632158|PMID:12514203
Biological ProcessGO:0005980glycogen catabolic processAdrb1IDARatRGD:5129142|PMID:17911346
Biological ProcessGO:0031649heat generationAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2387786|PMID:12161655
Biological ProcessGO:0060080inhibitory postsynaptic potentialAdrb1IMPRatRGD:5129137|PMID:18262504
Biological ProcessGO:0055088lipid homeostasisAdrb1IMPRatRGD:6893582|PMID:22457517
Biological ProcessGO:0007613memoryAdrb1IMPRatRGD:5129141|PMID:17961922
Biological ProcessGO:0040015negative regulation of multicellular organism growthAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2388907|PMID:12387862
Biological ProcessGO:0045986negative regulation of smooth muscle contractionAdrb1IMPRatRGD:5129131|PMID:18306009
Biological ProcessGO:0035811negative regulation of urine volumeAdrb1IDARatRGD:5129105|PMID:7912752
Biological ProcessGO:0002025norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressureAdrb1IGIMGI:MGI:87938MouseMGI:MGI:1338641|PMID:10358009
Biological ProcessGO:0002025norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressureAdrb1IGIMGI:MGI:87938MouseMGI:MGI:3608195|PMID:11641423
Biological ProcessGO:0002025norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressureAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:1338641|PMID:10358009
Biological ProcessGO:0002025norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressureAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:3608195|PMID:11641423
Biological ProcessGO:0045762positive regulation of adenylate cyclase activityAdrb1IMPRatRGD:8693686|PMID:21143600
Biological ProcessGO:0043065positive regulation of apoptotic processAdrb1IMPRatRGD:7241557|PMID:17143192
Biological ProcessGO:0030819positive regulation of cAMP biosynthetic processADRB1IDAHumanPMID:12391161
Biological ProcessGO:0030819positive regulation of cAMP biosynthetic processADRB1IDAHumanPMID:12529373
Biological ProcessGO:0030819positive regulation of cAMP biosynthetic processAdrb1IMPRatRGD:5129138|PMID:18202135
Biological ProcessGO:0043950positive regulation of cAMP-mediated signalingADRB1IDAHumanPMID:12391161
Biological ProcessGO:2001259positive regulation of cation channel activityAdrb1IDARatRGD:6893581|PMID:22505670
Biological ProcessGO:0061051positive regulation of cell growth involved in cardiac muscle cell developmentAdrb1IMPRatRGD:5129139|PMID:18194989
Biological ProcessGO:0043547positive regulation of GTPase activityADRB1IDAHumanPMID:12391161
Biological ProcessGO:0010460positive regulation of heart rateAdrb1IMPRatRGD:5129112|PMID:9089896
Biological ProcessGO:0001996positive regulation of heart rate by epinephrine-norepinephrineAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:82113|PMID:8693001
Biological ProcessGO:0001996positive regulation of heart rate by epinephrine-norepinephrineAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:1338641|PMID:10358009
Biological ProcessGO:1900273positive regulation of long-term synaptic potentiationAdrb1IDARatRGD:8693685|PMID:21848869
Biological ProcessGO:1900135positive regulation of renin secretion into blood streamAdrb1IMPRatRGD:7241562|PMID:15810988
Biological ProcessGO:0046878positive regulation of saliva secretionAdrb1IMPRatRGD:5129135|PMID:18275933
Biological ProcessGO:0003084positive regulation of systemic arterial blood pressureAdrb1IMPRatRGD:5129129|PMID:18931026
Biological ProcessGO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineAdrb1IDAMouseMGI:MGI:84440|PMID:7761854
Biological ProcessGO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineAdrb1IMPMGI:MGI:1857120MouseMGI:MGI:82113|PMID:8693001
Biological ProcessGO:0003061positive regulation of the force of heart contraction by norepinephrineAdrb1IDARatRGD:5129126|PMID:19133992
Biological ProcessGO:0033365protein localization to organelleAdrb1IDARatRGD:6893637|PMID:22105697
Biological ProcessGO:0051924regulation of calcium ion transportAdrb1IDARatRGD:5129126|PMID:19133992
Biological ProcessGO:0086004regulation of cardiac muscle cell contractionAdrb1IMPRatRGD:6893639|PMID:22216755
Biological ProcessGO:0009409response to coldAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2387786|PMID:12161655
Biological ProcessGO:0009409response to coldAdrb1IGIMGI:MGI:87938|MGI:MGI:87939MouseMGI:MGI:2388907|PMID:12387862
Biological ProcessGO:0007266Rho protein signal transductionAdrb1IMPRatRGD:5129131|PMID:18306009
Biological ProcessGO:0019233sensory perception of painAdrb1IMPRatRGD:5129125|PMID:19283893
Biological ProcessGO:0042060wound healingAdrb1IMPRatRGD:5129124|PMID:19320892

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory