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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
18982

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:18982

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Jan 27 18:25:03 2014.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:18982
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0005525GTP bindingLRRK2IDAHumanPMID:16980962
Molecular FunctionGO:0005525GTP bindingLRRK2IDAHumanPMID:17260967
Molecular FunctionGO:0005525GTP bindingLRRK2IDAHumanPMID:17442267
Molecular FunctionGO:0034211GTP-dependent protein kinase activityLRRK2IMPHumanPMID:17200152
Molecular FunctionGO:0034211GTP-dependent protein kinase activityLRRK2IDAHumanPMID:17260967
Molecular FunctionGO:0005096GTPase activator activityLRRK2IDAHumanPMID:17442267
Molecular FunctionGO:0003924GTPase activityLRRK2IDAHumanPMID:21048939
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:16321986
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:18397888
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:19712061
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:19733152
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:20515039
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:21073465
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:22363216
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:22952686
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:23220480
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:23241358
Molecular FunctionGO:0042802identical protein bindingLRRK2IPIUniProtKB:Q5S007HumanPMID:24275654
Molecular FunctionGO:0042802identical protein bindingLrrk2IPIUniProtKB:Q5S006MouseMGI:MGI:5487494|PMID:22952686
Molecular FunctionGO:0042802identical protein bindingLrrk2IPIUniProtKB:Q5S006MouseMGI:MGI:5487519|PMID:21390248
Molecular FunctionGO:0044325ion channel bindingLRRK2IPIUniProtKB:Q8NHX9HumanPMID:22012985
Molecular FunctionGO:0004708MAP kinase kinase activityLRRK2IDAHumanPMID:19302196
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q16543HumanPMID:16321986
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O60260HumanPMID:16352719
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P11142HumanPMID:17400507
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q9UKV8HumanPMID:17400507
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P61020HumanPMID:18445495
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P61021HumanPMID:18445495
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q13158HumanPMID:19176810
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O14640-2HumanPMID:19625296
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O14641HumanPMID:19625296
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q92997HumanPMID:19625296
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P53355HumanPMID:19712061
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q38SD2HumanPMID:19712061
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O14733HumanPMID:20067578
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P46734HumanPMID:20067578
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P52564HumanPMID:20067578
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q38SD2HumanPMID:20144646
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P46734HumanPMID:20173330
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q58A65HumanPMID:20173330
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P26038HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P27348HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P31946HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P61981HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P62258HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P63104HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q04917HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q16543HumanPMID:20642453
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q9UKV8HumanPMID:20671708
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P60953HumanPMID:21048939
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q14155HumanPMID:21048939
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q9W596HumanPMID:21159966
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P39053HumanPMID:21307259
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P30275HumanPMID:21370995
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P60953HumanPMID:21454543
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P63000HumanPMID:21454543
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P02687HumanPMID:21658387
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P31749HumanPMID:21658387
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P30048HumanPMID:21850687
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q13469HumanPMID:21983832
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O00429HumanPMID:22228096
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P02687HumanPMID:22303461
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P10636-8HumanPMID:22303461
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P26038HumanPMID:22363216
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q62848HumanPMID:22363216
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q8N6T3-2HumanPMID:22363216
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q16543HumanPMID:22612223
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O00429HumanPMID:22639965
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O75581HumanPMID:22899650
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P26038HumanPMID:22952686
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q99962HumanPMID:22998870
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P27348HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P61981HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P62258HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P63104HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q04917HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q16543HumanPMID:23075850
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P37840HumanPMID:23183827
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P26038HumanPMID:23241358
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q63481HumanPMID:23395371
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P11142HumanPMID:23455607
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O00429HumanPMID:23813973
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O00429-3HumanPMID:23813973
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O95295HumanPMID:23949442
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P10636-2HumanPMID:24113872
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P10636-8HumanPMID:24113872
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P49841HumanPMID:24165324
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P04350HumanPMID:24275654
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P07437HumanPMID:24275654
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O00429HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O60313HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:O95140HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:P39053HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q05193HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLRRK2IPIUniProtKB:Q811U4HumanPMID:24282027
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:P46460MouseMGI:MGI:4941068|PMID:21307259
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:Q9ES28MouseMGI:MGI:5318010|PMID:21048939
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:Q9EPJ9MouseMGI:MGI:5318121|PMID:22423108
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:Q9EPJ9MouseMGI:MGI:5318636|PMID:22363216
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:Q8K1M6MouseMGI:MGI:5431272|PMID:22639965
Molecular FunctionGO:0005515protein bindingLrrk2IPIUniProtKB:P61982|UniProtKB:P62259|UniProtKB:P63101|UniProtKB:P68254|UniProtKB:P68510|UniProtKB:Q9CQV8MouseMGI:MGI:5487519|PMID:21390248
Molecular FunctionGO:0042803protein homodimerization activityLRRK2IPIUniProtKB:Q5S007HumanPMID:16321986
Molecular FunctionGO:0004672protein kinase activityLRRK2IDAHumanPMID:16269541
Molecular FunctionGO:0004672protein kinase activityLRRK2IDAHumanPMID:16321986
Molecular FunctionGO:0004672protein kinase activityLRRK2IDAHumanPMID:17442267
Molecular FunctionGO:0004672protein kinase activityLRRK2IDAHumanPMID:21850687
Molecular FunctionGO:0004674protein serine/threonine kinase activityLRRK2IDAHumanPMID:17200152
Molecular FunctionGO:0004674protein serine/threonine kinase activityLRRK2IDAHumanPMID:19576176
Molecular FunctionGO:0004674protein serine/threonine kinase activityLRRK2IDAHumanPMID:21048939
Molecular FunctionGO:0004674protein serine/threonine kinase activityLRRK2IDAHumanPMID:22423108
Molecular FunctionGO:0017048Rho GTPase bindingLRRK2IPIUniProtKB:P60953HumanPMID:21048939
Molecular FunctionGO:0017048Rho GTPase bindingLrrk2IPIUniProtKB:P60766MouseMGI:MGI:5318010|PMID:21048939
Molecular FunctionGO:0015631tubulin bindingLRRK2IDAHumanPMID:21159966
Cellular ComponentGO:0030424axonLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0005737cytoplasmLRRK2IDAHumanPMID:16321986
Cellular ComponentGO:0005737cytoplasmLRRK2IDAHumanPMID:16352719
Cellular ComponentGO:0005737cytoplasmLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0032473cytoplasmic side of mitochondrial outer membraneLRRK2IDAHumanPMID:16269541
Cellular ComponentGO:0030425dendriteLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0032839dendrite cytoplasmLRRK2IDAHumanPMID:21696411
Cellular ComponentGO:0043231intracellular membrane-bounded organelleLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0016020membraneLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0045121membrane raftLrrk2IDAMouseMGI:MGI:3711602|PMID:17341485
Cellular ComponentGO:0005739mitochondrionLRRK2IDAHumanPMID:21850687
Cellular ComponentGO:0043005neuron projectionLRRK2IDAHumanPMID:21048939
Cellular ComponentGO:0043005neuron projectionLrrk2IDARatRGD:2289047|PMID:17120249
Cellular ComponentGO:0043025neuronal cell bodyLRRK2IDAHumanPMID:21048939
Cellular ComponentGO:0043025neuronal cell bodyLRRK2IDAHumanPMID:21696411
Cellular ComponentGO:0005886plasma membraneLrrk2IDAMouseMGI:MGI:3711602|PMID:17341485
Cellular ComponentGO:0045202synapseLrrk2IDAMouseMGI:MGI:5318121|PMID:22423108
Cellular ComponentGO:0008021synaptic vesicleLrrk2IDAMouseMGI:MGI:3711602|PMID:17341485
Cellular ComponentGO:0005802trans-Golgi networkLrrk2IDAMouseMGI:MGI:3711602|PMID:17341485
Biological ProcessGO:0000187activation of MAPK activityLRRK2IDAHumanPMID:19302196
Biological ProcessGO:0000186activation of MAPKK activityLRRK2IDAHumanPMID:19302196
Biological ProcessGO:0008340determination of adult lifespanLRRK2IMPHumanPMID:19692353
Biological ProcessGO:0035640exploration behaviorLRRK2IMPHumanPMID:20659558
Biological ProcessGO:0006184GTP catabolic processLRRK2IDAHumanPMID:21048939
Biological ProcessGO:0048312intracellular distribution of mitochondriaLRRK2IMPHumanPMID:21159966
Biological ProcessGO:0000165MAPK cascadeLRRK2IDAHumanPMID:17200152
Biological ProcessGO:2000173negative regulation of branching morphogenesis of a nerveLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0061002negative regulation of dendritic spine morphogenesisLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0034260negative regulation of GTPase activityLRRK2IDAHumanPMID:22423108
Biological ProcessGO:0007406negative regulation of neuroblast proliferationLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0014043negative regulation of neuron maturationLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0007528neuromuscular junction developmentLRRK2IMPHumanPMID:21159966
Biological ProcessGO:0070997neuron deathLRRK2IMPHumanPMID:19692353
Biological ProcessGO:0021772olfactory bulb developmentLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0018105peptidyl-serine phosphorylationLRRK2IDAHumanPMID:19576176
Biological ProcessGO:0018107peptidyl-threonine phosphorylationLRRK2IDAHumanPMID:21048939
Biological ProcessGO:0010508positive regulation of autophagyLRRK2IMPHumanPMID:22012985
Biological ProcessGO:0010508positive regulation of autophagyLrrk2IMPMouseMGI:MGI:4454597|PMID:20457918
Biological ProcessGO:0010942positive regulation of cell deathLRRK2IMPHumanPMID:21168496
Biological ProcessGO:0060161positive regulation of dopamine receptor signaling pathwayLRRK2IMPHumanPMID:20659558
Biological ProcessGO:0043547positive regulation of GTPase activityLRRK2IDAHumanPMID:17442267
Biological ProcessGO:0043068positive regulation of programmed cell deathLRRK2IDAHumanPMID:17200152
Biological ProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processLrrk2IMPMouseMGI:MGI:4454597|PMID:20457918
Biological ProcessGO:0001934positive regulation of protein phosphorylationLRRK2IMPHumanPMID:20659558
Biological ProcessGO:0031398positive regulation of protein ubiquitinationLRRK2IDAHumanPMID:16352719
Biological ProcessGO:0046777protein autophosphorylationLRRK2IDAHumanPMID:16269541
Biological ProcessGO:0046777protein autophosphorylationLRRK2IDAHumanPMID:16321986
Biological ProcessGO:0046777protein autophosphorylationLRRK2IMPHumanPMID:16980962
Biological ProcessGO:0046777protein autophosphorylationLRRK2IDAHumanPMID:17200152
Biological ProcessGO:0046777protein autophosphorylationLRRK2IDAHumanPMID:17442267
Biological ProcessGO:0035564regulation of kidney sizeLrrk2IMPMouseMGI:MGI:4454597|PMID:20457918
Biological ProcessGO:0040012regulation of locomotionLRRK2IMPHumanPMID:19692353
Biological ProcessGO:0042391regulation of membrane potentialLRRK2IMPHumanPMID:21159966
Biological ProcessGO:0006979response to oxidative stressLRRK2IMPHumanPMID:19692353
Biological ProcessGO:0022028tangential migration from the subventricular zone to the olfactory bulbLRRK2IMPHumanPMID:21168496

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory