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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1658

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:1658

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:1658
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003677DNA bindingIrf1IDAMouseMGI:MGI:2679145|PMID:14568984
Molecular FunctionGO:0005515protein bindingIRF1IPIUniProtKB:P03129HumanPMID:10702232
Molecular FunctionGO:0005515protein bindingIRF1IPIUniProtKB:Q09472HumanPMID:15509808
Molecular FunctionGO:0005515protein bindingIrf1IPIUniProtKB:P22366MouseMGI:MGI:3691368|PMID:17018642
Molecular FunctionGO:0005515protein bindingIrf1IPIUniProtKB:Q13114|UniProtKB:Q14145MouseMGI:MGI:5292417|PMID:21903422
Molecular FunctionGO:0005515protein bindingIrf1IPIUniProtKB:Q15327MouseMGI:MGI:5294529|PMID:20599664
Molecular FunctionGO:0005515protein bindingIrf1IPIUniProtKB:Q99J95|UniProtKB:Q9ESU6MouseMGI:MGI:5461251|PMID:23154982
Molecular FunctionGO:0005515protein bindingIrf1IPIRGD:1309799RatRGD:5128776|PMID:19843519
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIRF1IMPHumanPMID:15509808
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIRF1IDAHumanPMID:18035482
Molecular FunctionGO:0043565sequence-specific DNA bindingIrf1IDAMouseMGI:MGI:3709230|PMID:17159910
Molecular FunctionGO:0043565sequence-specific DNA bindingIrf1IDARatRGD:5128716|PMID:11880315
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIrf1IDAMouseMGI:MGI:3709230|PMID:17159910
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIrf1IDAMouseMGI:MGI:2679145|PMID:14568984
Molecular FunctionGO:0003700transcription factor activity, sequence-specific DNA bindingIrf1IMPRatRGD:619663|PMID:11742807
Molecular FunctionGO:0001077transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingIRF1IMPHumanPMID:15509808
Cellular ComponentGO:0005737cytoplasmIrf1IDAMouseMGI:MGI:3691368|PMID:17018642
Cellular ComponentGO:0000790nuclear chromatinIRF1IDAHumanPMID:18035482
Cellular ComponentGO:0005634nucleusIrf1IDAMouseMGI:MGI:3691368|PMID:17018642
Cellular ComponentGO:0005634nucleusIrf1IDARatRGD:5128716|PMID:11880315
Biological ProcessGO:0006915apoptotic processIRF1IDAHumanPMID:19851330
Biological ProcessGO:0043374CD8-positive, alpha-beta T cell differentiationIrf1IMPMGI:MGI:1857205MouseMGI:MGI:1934722|PMID:11359801
Biological ProcessGO:0007050cell cycle arrestIRF1IDAHumanPMID:22200613
Biological ProcessGO:0035458cellular response to interferon-betaIRF1IDAHumanPMID:18035482
Biological ProcessGO:0071347cellular response to interleukin-1Irf1IDARatRGD:5128776|PMID:19843519
Biological ProcessGO:0071375cellular response to peptide hormone stimulusIrf1IDARatRGD:5128791|PMID:11022129
Biological ProcessGO:0071356cellular response to tumor necrosis factorIrf1IDARatRGD:5128784|PMID:16978650
Biological ProcessGO:0051607defense response to virusIRF1IDAHumanPMID:21389130
Biological ProcessGO:0051607defense response to virusIrf1IMPMouseMGI:MGI:4881394|PMID:20451243
Biological ProcessGO:0007249I-kappaB kinase/NF-kappaB signalingIrf1IMPRatRGD:5128786|PMID:15141302
Biological ProcessGO:0060333interferon-gamma-mediated signaling pathwayIrf1IMPMouseMGI:MGI:5317515|PMID:21909274
Biological ProcessGO:0045590negative regulation of regulatory T cell differentiationIrf1IMPMouseMGI:MGI:3803082|PMID:18641303
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIRF1IMPHumanPMID:18084608
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIRF1IMPHumanPMID:22200613
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedIrf1IDAMouseMGI:MGI:3803082|PMID:18641303
Biological ProcessGO:0010942positive regulation of cell deathIrf1IMPRatRGD:5128727|PMID:21261980
Biological ProcessGO:0032728positive regulation of interferon-beta productionIRF1IMPHumanPMID:21389130
Biological ProcessGO:0045084positive regulation of interleukin-12 biosynthetic processIrf1IMPMGI:MGI:1857205MouseMGI:MGI:2679145|PMID:14568984
Biological ProcessGO:0045084positive regulation of interleukin-12 biosynthetic processIrf1IDAMouseMGI:MGI:2679145|PMID:14568984
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIRF1IMPHumanPMID:15509808
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIrf1IDAMouseMGI:MGI:3709230|PMID:17159910
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIrf1IMPRatRGD:619663|PMID:11742807
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIRF1IMPHumanPMID:15509808
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIRF1IMPHumanPMID:17516545
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIRF1IMPHumanPMID:19851330
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIRF1IDAHumanPMID:22200613
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIRF1IMPHumanPMID:22367195
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIrf1IMPMouseMGI:MGI:4454517|PMID:20308629
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIrf1IDAMouseMGI:MGI:2679145|PMID:14568984
Biological ProcessGO:0032481positive regulation of type I interferon productionIrf1IMPMouseMGI:MGI:3691368|PMID:17018642
Biological ProcessGO:2000564regulation of CD8-positive, alpha-beta T cell proliferationIrf1IMPMouseMGI:MGI:5317515|PMID:21909274
Biological ProcessGO:0010468regulation of gene expressionIrf1IMPMGI:MGI:1857205MouseMGI:MGI:1934722|PMID:11359801
Biological ProcessGO:0034124regulation of MyD88-dependent toll-like receptor signaling pathwayIrf1IMPMouseMGI:MGI:3691368|PMID:17018642
Biological ProcessGO:0060416response to growth hormoneIrf1IDARatRGD:5128792|PMID:9492014

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory