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Comparative GO Graph (mouse, human, rat)
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1629

Compare experimental GO annotations for Human-Mouse-Rat HomoloGene:1629

Graphs for Molecular Function, Cellular Component, Biological Process generated Tue Apr 25 11:11:33 2017.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human and rat homologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Mouse-Rat genes in HomoloGene:1629
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003677DNA bindingIrf8IDAMouseMGI:MGI:3773503|PMID:18045875
Molecular FunctionGO:0005515protein bindingIRF8IPIUniProtKB:O14896HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingIrf8IPIUniProtKB:O35284MouseMGI:MGI:5441724|PMID:22992524
Molecular FunctionGO:0005515protein bindingIrf8IPIUniProtKB:P59110MouseMGI:MGI:5448615|PMID:22942423
Molecular FunctionGO:0005515protein bindingIrf8IPIUniProtKB:Q60821MouseMGI:MGI:3773503|PMID:18045875
Molecular FunctionGO:0005515protein bindingIrf8IPIUniProtKB:P41183|UniProtKB:Q8CGN4|UniProtKB:P17433|UniProtKB:Q8BG73|UniProtKB:P07141|UniProtKB:P37242|UniProtKB:Q9QUG2|UniProtKB:E9PYR1|UniProtKB:Q63943|UniProtKB:O70237|UniProtKB:Q60674|UniProtKB:Q9QUN3|UniProtKB:P25322|UniProtKB:Q99P68|UniProtKB:Q9EQH4|UniProtKB:Q61096MouseMGI:MGI:5618398|PMID:25331958
Molecular FunctionGO:0005515protein bindingIrf8IPIRGD:1359607RatRGD:9586722|PMID:15688197
Molecular FunctionGO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIRF8IDAHumanPMID:1460054
Molecular FunctionGO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIrf8IDAMouseMGI:MGI:5618398|PMID:25331958
Molecular FunctionGO:0001078transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingIRF8IDAHumanPMID:1460054
Cellular ComponentGO:0005737cytoplasmIRF8IDAHumanPMID:25122610
Cellular ComponentGO:0005654nucleoplasmIRF8IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusIRF8IDAHumanPMID:25122610
Cellular ComponentGO:0005634nucleusIrf8IDAMouseMGI:MGI:5618398|PMID:25331958
Cellular ComponentGO:0005634nucleusIrf8IDAMouseMGI:MGI:5448615|PMID:22942423
Cellular ComponentGO:0005634nucleusIrf8IDAMouseMGI:MGI:3773503|PMID:18045875
Biological ProcessGO:0071346cellular response to interferon-gammaIRF8IDAHumanPMID:25122610
Biological ProcessGO:0071222cellular response to lipopolysaccharideIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310
Biological ProcessGO:0042742defense response to bacteriumIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3773503|PMID:18045875
Biological ProcessGO:0042832defense response to protozoanIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310
Biological ProcessGO:0006955immune responseIrf8IMPMGI:MGI:1926332MouseMGI:MGI:2448104|PMID:12393690
Biological ProcessGO:0030099myeloid cell differentiationIrf8IMPMGI:MGI:1926332MouseMGI:MGI:2448104|PMID:12393690
Biological ProcessGO:0044130negative regulation of growth of symbiont in hostIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIRF8IDAHumanPMID:1460054
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIRF8IDAHumanPMID:25122610
Biological ProcessGO:0000122negative regulation of transcription from RNA polymerase II promoterIrf8IGIMGI:MGI:1918708MouseMGI:MGI:5618398|PMID:25331958
Biological ProcessGO:0006909phagocytosisIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3773503|PMID:18045875
Biological ProcessGO:0032729positive regulation of interferon-gamma productionIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310
Biological ProcessGO:0032735positive regulation of interleukin-12 productionIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310
Biological ProcessGO:0045944positive regulation of transcription from RNA polymerase II promoterIRF8IDAHumanPMID:25122610
Biological ProcessGO:0060261positive regulation of transcription initiation from RNA polymerase II promoterIrf8IDAMouseMGI:MGI:5448615|PMID:22942423
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedIrf8IPIUniProtKB:Q60821MouseMGI:MGI:3773503|PMID:18045875
Biological ProcessGO:0009617response to bacteriumIrf8IMPMGI:MGI:1926332MouseMGI:MGI:3653161|PMID:9348310

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory