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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LARGE1 HGNC:6511 (HGNC)
9215 (Entrez Gene)
603590 (OMIM)
LARGE (MyGene.info)
HGNC homology
Chr22 q12.3 Chr22:33162237-33922841 (-)
muscular dystrophy-dystroglycanopathy
muscular dystrophy-dystroglycanopathy type B6
Walker-Warburg syndrome
O95461 (UniProt | EBI)
NM_004737 (RefSeq)
mouse Large1 MGI:1342270 (MGI)
16795 (Entrez Gene)
Gene Tree
HGNC homology
Chr8 35.08 cM Chr8:72814599-73353540 (-)
facioscapulohumeral muscular dystrophy
muscular dystrophy-dystroglycanopathy
muscular dystrophy-dystroglycanopathy type B6
OTTMUSG00000030306 (VEGA)
OTTMUSP00000039267 (VEGA)
OTTMUST00000075036 (VEGA)
chimpanzee LARGE1 470192 (Entrez Gene)
Chr22 XP_001154669 (RefSeq)
cattle LARGE1 506466 (Entrez Gene)
Chr5 NP_001192517 (RefSeq)
NM_001205588 (RefSeq)
dog LARGE1 474521 (Entrez Gene)
Chr10 XP_005625982 (RefSeq)
chicken LARGE1 418062 (Entrez Gene)
Chr1 Q66PG3 (UniProt | EBI)
NM_001004383 (RefSeq)
zebrafish large1 446213 (Entrez Gene)
Chr4 Q66PG2 (UniProt | EBI)
NM_001004537 (RefSeq)
frog, western clawed large1 100498555 (Entrez Gene)
ChrUN XP_002943094 (RefSeq)
macaque, rhesus LARGE1 717403 (Entrez Gene)
Chr10 NP_001247834 (RefSeq)
NM_001260905 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory