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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human NCSTN HGNC:17091 (HGNC)
23385 (Entrez Gene)
605254 (OMIM)
Nicastrin (MyGene.info)
HGNC homology
Chr1 q23.2 Chr1:160343056-160358952 (+)
hidradenitis suppurativa
Q92542 (UniProt | EBI)
NM_001290184 (RefSeq)
mouse Ncstn MGI:1891700 (MGI)
59287 (Entrez Gene)
Gene Tree
HGNC homology
Chr1 79.54 cM Chr1:172066013-172082795 (-)
chronic myeloid leukemia
urinary bladder cancer
OTTMUSG00000021508 (VEGA)
OTTMUSP00000023933 (VEGA)
OTTMUST00000050982 (VEGA)
rat Ncstn 289231 (Entrez Gene)
Chr13 q24 Q8CGU6 (UniProt | EBI)
NM_174864 (RefSeq)
chimpanzee NCSTN 457435 (Entrez Gene)
Chr1 XP_513923 (RefSeq)
cattle NCSTN 514929 (Entrez Gene)
Chr3 NP_001029647 (RefSeq)
NM_001034475 (RefSeq)
dog NCSTN 488638 (Entrez Gene)
Chr38 NP_001300769 (RefSeq)
NM_001313840 (RefSeq)
chicken NCSTN 426905 (Entrez Gene)
Chr25 NP_001004413 (RefSeq)
NM_001004413 (RefSeq)
zebrafish ncstn 494449 (Entrez Gene)
Chr2 NP_001009556 (RefSeq)
NM_001009556 (RefSeq)
frog, western clawed ncstn 100170459 (Entrez Gene)
Chr8 NP_001123711 (RefSeq)
NM_001130239 (RefSeq)
macaque, rhesus NCSTN 719696 (Entrez Gene)
Chr1 NP_001247709 (RefSeq)
NM_001260780 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory