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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
265

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PTEN HGNC:9588 (HGNC)
5728 (Entrez Gene)
601728 (OMIM)
Chr10 q23.3 Chr10:87863438-87970345 (+)
GRCh38
Bannayan-Riley-Ruvalcaba Syndrome; BRRS
Cowden Syndrome 1; CWS1
Endometrial Cancer
Glioma Susceptibility 2; GLM2
Macrocephaly/Autism Syndrome
Melanoma, Cutaneous Malignant, Susceptibility to, 1; CMM1
Meningioma, Familial, Susceptibility to
Phosphatase and Tensin Homolog; PTEN
Prostate Cancer
Squamous Cell Carcinoma, Head and Neck; HNSCC
Thyroid Carcinoma, Follicular; FTC
Vacterl Association with Hydrocephalus
P60484 (UniProt | EBI)
NM_000314 (RefSeq)
mouse Pten MGI:109583 (MGI)
19211 (Entrez Gene)
Gene Tree
VISTA-Point
Chr19 28.14 cM Chr19:32757497-32826160 (+)
GRCm38
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins;
Anal Canal Carcinoma
Autism
Bannayan-Riley-Ruvalcaba Syndrome; BRRS
Bladder Cancer
Breast Cancer
Cowden Syndrome 1; CWS1
Endometrial Cancer
Glioma Susceptibility 2; GLM2
Hepatocellular Carcinoma
Leukemia, Acute Lymphoblastic; ALL
Melanoma, Cutaneous Malignant, Susceptibility to, 1; CMM1
Neurofibromatosis, Type I; NF1
Ovarian Cancer
Pancreatic Cancer
Phosphatase and Tensin Homolog; PTEN
Prostate Cancer
Squamous Cell Carcinoma, Head and Neck; HNSCC
Thyroid Carcinoma, Follicular; FTC
Von Hippel-Lindau Syndrome; VHL
OTTMUSG00000021203 (VEGA)
OTTMUSP00000023423 (VEGA)
OTTMUST00000050229 (VEGA)
rat Pten 50557 (Entrez Gene)
Chr1 q41-q43 NP_113794 (RefSeq)
NM_031606 (RefSeq)
chimpanzee PTEN 466142 (Entrez Gene)
Chr10 XP_521544 (RefSeq)
rhesus macaque PTEN 705121 (Entrez Gene)
Chr9 NP_001247894 (RefSeq)
NM_001260965 (RefSeq)
cattle PTEN 540786 (Entrez Gene)
Chr26 XP_613125 (RefSeq)
dog PTEN 403832 (Entrez Gene)
Chr26 P60483 (UniProt | EBI)
NM_001003192 (RefSeq)
chicken PTEN 423675 (Entrez Gene)
Chr6 XP_421555 (RefSeq)
western clawed frog pten 100144716 (Entrez Gene)
ChrUN NP_001116943 (RefSeq)
NM_001123471 (RefSeq)
zebrafish ptenb 368415 (Entrez Gene)
Chr12 NP_001001822 (RefSeq)
NM_001001822 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory