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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human PTEN HGNC:9588 (HGNC)
5728 (Entrez Gene)
601728 (OMIM)
HGNC homology
Chr10 q23.31 Chr10:87863438-87971930 (+)
Bannayan-Riley-Ruvalcaba Syndrome; BRRS
Cowden Syndrome 1; CWS1
Endometrial Cancer
Glioma Susceptibility 2; GLM2
Macrocephaly/Autism Syndrome
Melanoma, Cutaneous Malignant, Susceptibility to, 1; CMM1
Meningioma, Familial, Susceptibility to
Phosphatase and Tensin Homolog; PTEN
Prostate Cancer
Squamous Cell Carcinoma, Head and Neck; HNSCC
Thyroid Cancer, Nonmedullary, 2; NMTC2
Vacterl Association with Hydrocephalus
P60484 (UniProt | EBI)
NM_000314 (RefSeq)
mouse Pten MGI:109583 (MGI)
19211 (Entrez Gene)
Gene Tree
HGNC homology
Chr19 28.14 cM Chr19:32757497-32826160 (+)
Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins;
Bannayan-Riley-Ruvalcaba Syndrome; BRRS
Bladder Cancer
Cowden Syndrome 1; CWS1
Endometrial Cancer
Fatty Liver Disease, Nonalcoholic, Susceptibility to, 1; NAFLD1
Hepatocellular Carcinoma
Leukemia, Acute Lymphoblastic; ALL
Macrocephaly/Autism Syndrome
Phosphatase and Tensin Homolog; PTEN
Prostate Cancer
OTTMUSG00000021203 (VEGA)
OTTMUSP00000023423 (VEGA)
OTTMUST00000050229 (VEGA)
rat Pten 50557 (Entrez Gene)
Chr1 q52 NP_113794 (RefSeq)
NM_031606 (RefSeq)
chimpanzee PTEN 466142 (Entrez Gene)
Chr10 XP_016774311 (RefSeq)
cattle PTEN 540786 (Entrez Gene)
Chr26 NP_001306827 (RefSeq)
NM_001319898 (RefSeq)
dog PTEN 403832 (Entrez Gene)
Chr26 P60483 (UniProt | EBI)
NM_001003192 (RefSeq)
chicken PTEN 423675 (Entrez Gene)
Chr6 XP_015134187 (RefSeq)
zebrafish ptenb 368415 (Entrez Gene)
Chr12 NP_001001822 (RefSeq)
NM_001001822 (RefSeq)
frog, western clawed pten 100144716 (Entrez Gene)
Chr7 NP_001116943 (RefSeq)
NM_001123471 (RefSeq)
macaque, rhesus PTEN 705121 (Entrez Gene)
Chr9 NP_001247894 (RefSeq)
NM_001260965 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory