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Vertebrate Homology Class
Source
Class ID
HomoloGene (Release 68, May 6, 2014)
1747

Comparative GO Graph (mouse, human, rat)  
MGI Homology Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LRP6 HGNC:6698 (HGNC)
4040 (Entrez Gene)
603507 (OMIM)
Chr12 p13.2 Chr12:12116025-12266877 (-)
GRCh38
Coronary Artery Disease, Autosomal Dominant 2; ADCAD2
O75581 (UniProt | EBI)
NM_002336 (RefSeq)
mouse Lrp6 MGI:1298218 (MGI)
16974 (Entrez Gene)
Gene Tree
VISTA-Point
Chr6 65.37 cM Chr6:134446476-134566965 (-)
GRCm38
Neural Tube Defects, Folate-Sensitive
OTTMUSG00000021240 (VEGA)
OTTMUSP00000023469 (VEGA)
OTTMUST00000050309 (VEGA)
rat Lrp6 312781 (Entrez Gene)
Chr4 q43 NP_001101362 (RefSeq)
NM_001107892 (RefSeq)
chimpanzee LRP6 465295 (Entrez Gene)
Chr12 XP_001152103 (RefSeq)
rhesus macaque LOC695843 695843 (Entrez Gene)
Chr11 NP_001244648 (RefSeq)
NM_001257719 (RefSeq)
cattle LRP6 536328 (Entrez Gene)
Chr5 XP_607058 (RefSeq)
dog LRP6 477692 (Entrez Gene)
Chr27 XP_534886 (RefSeq)
chicken LRP6 419097 (Entrez Gene)
Chr1 XP_417286 (RefSeq)
western clawed frog lrp6 100489328 (Entrez Gene)
ChrUN XP_002942697 (RefSeq)
zebrafish lrp6 100003877 (Entrez Gene)
Chr19 NP_001128156 (RefSeq)
NM_001134684 (RefSeq)
MGI Homology Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory