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HomoloGene Vertebrate Homology
Class ID
HomoloGene (Release 68, May 6, 2014)

Comparative GO Graph (mouse, human, rat)  
MGI HomoloGene Information
Species Symbol Gene Links Genetic Location Genome Coordinates
(mouse and human only)
Associated Human Diseases Sequences
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human LRP6 HGNC:6698 (HGNC)
4040 (Entrez Gene)
603507 (OMIM)
LRP6 (MyGene.info)
HGNC homology
Chr12 p13.2 Chr12:12116025-12267021 (-)
coronary artery disease
O75581 (UniProt | EBI)
NM_002336 (RefSeq)
mouse Lrp6 MGI:1298218 (MGI)
16974 (Entrez Gene)
Gene Tree
HGNC homology
Chr6 65.37 cM Chr6:134446476-134566965 (-)
fatty liver disease
neural tube defect
OTTMUSG00000021240 (VEGA)
OTTMUSP00000023469 (VEGA)
OTTMUST00000050309 (VEGA)
rat Lrp6 312781 (Entrez Gene)
Chr4 q43 NP_001101362 (RefSeq)
NM_001107892 (RefSeq)
chimpanzee LRP6 465295 (Entrez Gene)
Chr12 XP_001152103 (RefSeq)
cattle LRP6 536328 (Entrez Gene)
Chr5 XP_005207086 (RefSeq)
dog LRP6 477692 (Entrez Gene)
Chr27 XP_013964029 (RefSeq)
chicken LRP6 419097 (Entrez Gene)
Chr1 XP_015146392 (RefSeq)
zebrafish lrp6 100003877 (Entrez Gene)
Chr4 NP_001128156 (RefSeq)
NM_001134684 (RefSeq)
frog, western clawed lrp6 100489328 (Entrez Gene)
ChrUN XP_012814842 (RefSeq)
macaque, rhesus LRP6 695843 (Entrez Gene)
Chr11 NP_001244648 (RefSeq)
NM_001257719 (RefSeq)
MGI HomoloGene Information

MGI loads vertebrate homology data from NCBI HomoloGene, which programmatically detects homologs among the genome features of completely sequenced eukaryotic genomes (see: HomoloGene Build Procedure).

MGI includes homology for the following selected vertebrate species from HomoloGene:
 - human
 - mouse
 - rat
 - cattle
 - chicken
 - chimpanzee
 - dog
 - monkey, Rhesus
 - western clawed frog (Xenopus tropicalis)
 - zebrafish

These are a subset of the total species represented in HomoloGene Classes at NCBI.
Additional species may be present in an NCBI HomoloGene Class than appear in MGI.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory