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Gene Expression Literature Summary
Assay
Age
Western blot
Postnatal

17 matching records from 17 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Cdk5  cyclin-dependent kinase 5   (Synonyms: Crk6)
Results  Reference
1J:241332 Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ, Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302
1*J:167101 Frank CL, Ge X, Xie Z, Zhou Y, Tsai LH, Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis. J Biol Chem. 2010 Oct 22;285(43):33324-37
1*J:168656 Ikeda Y, Matsunaga Y, Takiguchi M, Ikeda MA, Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):64-71
1J:77532 Keshvara L, Magdaleno S, Benhayon D, Curran T, Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling. J Neurosci. 2002 Jun 15;22(12):4869-77
1*J:71181 Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH, p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci. 2001 Sep 1;21(17):6758-71
1J:161853 Mokalled MH, Johnson A, Kim Y, Oh J, Olson EN, Myocardin-related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development. Development. 2010 Jul;137(14):2365-74
1J:178882 Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P, Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell. 2011 Oct 18;21(4):655-68
1J:135129 Ohshima T, Hirasawa M, Tabata H, Mutoh T, Adachi T, Suzuki H, Saruta K, Iwasato T, Itohara S, Hashimoto M, Nakajima K, Ogawa M, Kulkarni AB, Mikoshiba K, Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development. 2007 Jun;134(12):2273-82
1J:205333 Otero JJ, Kalaszczynska I, Michowski W, Wong M, Gygli PE, Gokozan HN, Griveau A, Odajima J, Czeisler C, Catacutan FP, Murnen A, Schuller U, Sicinski P, Rowitch D, Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
1J:138266 Sato Y, Taoka M, Sugiyama N, Kubo K, Fuchigami T, Asada A, Saito T, Nakajima K, Isobe T, Hisanaga S, Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5. Genes Cells. 2007 Dec;12(12):1315-27
1J:67058 Tanaka T, Veeranna, Ohshima T, Rajan P, Amin N, Cho A, Sreenath T, Pant H, Brady R, Kulkarni A, Neuronal cyclin-dependent kinase 5 activity is critical for survival. J Neurosci. 2001 Jan 15;21(2):550-8
1J:16556 Tsai LH, Takahashi T, Caviness VS Jr, Harlow E, Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development. 1993 Dec;119(4):1029-40
1J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
1J:159853 Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K, Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci. 2010 Apr 14;30(15):5219-28
1J:40391 Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ, Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Dev Biol. 1997 Mar 15;183(2):222-33
1*J:254508 Zheng YL, Zhang X, Fu HX, Guo M, Shukla V, Amin ND, E J, Bao L, Luo HY, Li B, Lu XH, Gao YC, Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. PLoS One. 2016;11(8):e0160252
1*J:85489 Zhong JL, Banerjee MD, Nikolic M, Pak1 and its T212 phosphorylated form accumulate in neurones and epithelial cells of the developing rodent. Dev Dyn. 2003 Sep;228(1):121-7

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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory