Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kcnq1  potassium voltage-gated channel, subfamily Q, member 1   (Synonyms: Kcna9, KVLQT1)
Results	Reference
1	J:10529 Bastian H, Gruss P, A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
1*	J:47668 Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM, Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol Cell Biol. 1998 Jun;18(6):3466-74
1*	J:96366 Cerrato F, Sparago A, Di Matteo I, Zou X, Dean W, Sasaki H, Smith P, Genesio R, Bruggemann M, Reik W, Riccio A, The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster. Hum Mol Genet. 2005 Feb 15;14(4):503-11
1	J:143477 Chotalia M, Smallwood SA, Ruf N, Dawson C, Lucifero D, Frontera M, James K, Dean W, Kelsey G, Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev. 2009 Jan 1;23(1):105-17
1	J:68046 Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D, Pereon Y, Jarry A, Moorman AF, Escande D, Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol. 2001 Feb;280(2):C359-72
1*	J:46363 Gould TD, Pfeifer K, Imprinting of mouse Kvlqt1 is developmentally regulated. Hum Mol Genet. 1998 Mar;7(3):483-7
1*	J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
1*	J:50953 Jiang S, Hemann MA, Lee MP, Feinberg AP, Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1. Genomics. 1998 Nov 1;53(3):395-9
1	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
1	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1	J:108906 Koay G, Heffner R, Heffner H, Behavioral audiograms of homozygous med(J) mutant mice with sodium channel deficiency and unaffected controls. Hear Res. 2002 Sep;171(1-2):111-118
1	J:190449 Korostowski L, Sedlak N, Engel N, The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart. PLoS Genet. 2012 Sep;8(9):e1002956
1	J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
1	J:114401 Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W, Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov;133(21):4203-10
1	J:200823 Li X, Zhou F, Marcus DC, Wangemann P, Endolymphatic Na(+) and K(+) concentrations during cochlear growth and enlargement in mice lacking Slc26a4/pendrin. PLoS One. 2013;8(5):e65977
1*	J:91511 Mai W, Janier MF, Allioli N, Quignodon L, Chuzel T, Flamant F, Samarut J, Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10332-7
1	J:108700 Mancini-Dinardo D, Steele SJ, Levorse JM, Ingram RS, Tilghman SM, Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes. Genes Dev. 2006 May 15;20(10):1268-82
1	J:163857 Mohammad F, Mondal T, Guseva N, Pandey GK, Kanduri C, Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Development. 2010 Aug 1;137(15):2493-9
1	J:108905 Nicolas M, Dememes D, Martin A, Kupershmidt S, Barhanin J, KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells. Hear Res. 2001 Mar;153(1-2):132-45
1	J:161410 Oh-McGinnis R, Bogutz AB, Lee KY, Higgins MJ, Lefebvre L, Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50
1*	J:48435 Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J, Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Hum Mol Genet. 1998 Jul;7(7):1149-59
1	J:239349 Rannals MD, Hamersky GR, Page SC, Campbell MN, Briley A, Gallo RA, Phan BN, Hyde TM, Kleinman JE, Shin JH, Jaffe AE, Weinberger DR, Maher BJ, Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1. Neuron. 2016 Apr 06;90(1):43-55
1	J:223238 Schultz BM, Gallicio GA, Cesaroni M, Lupey LN, Engel N, Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain. Nucleic Acids Res. 2015 Jan;43(2):745-59
1	J:130529 Shin JY, Fitzpatrick GV, Higgins MJ, Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J. 2008 Jan 9;27(1):168-78
1	J:274138 Singh VB, Sribenja S, Wilson KE, Attwood KM, Hillman JC, Pathak S, Higgins MJ, Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Development. 2017 May 15;144(10):1820-1830
1	J:189624 Son EJ, Wu L, Yoon H, Kim S, Choi JY, Bok J, Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
1*	J:94241 Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R, Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
1*	J:160540 Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF, Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9753-8