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Gene Expression Literature Summary
Assay
Age
In situ RNA (section)
Adult

55 matching records from 55 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ihh  Indian hedgehog  
Results  Reference
1J:153618 Ahrens MJ, Li Y, Jiang H, Dudley AT, Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Development. 2009 Oct;136(20):3463-74
1*J:75699 Albrecht AN, Schwabe GC, Stricker S, Boddrich A, Wanker EE, Mundlos S, The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67
1J:119152 Arnold MA, Kim Y, Czubryt MP, Phan D, McAnally J, Qi X, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN, MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007 Mar;12(3):377-89
1J:96524 Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fassler R, Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. J Cell Sci. 2005 Mar 1;118(Pt 5):929-36
1J:90403 Boulet AM, Capecchi MR, Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod. Development. 2004 Jan;131(2):299-309
1J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
1J:166058 Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R, Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19;19(4):533-46
1J:79920 Dabovic B, Chen Y, Colarossi C, Zambuto L, Obata H, Rifkin DB, Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. J Endocrinol. 2002 Oct;175(1):129-41
1J:178944 Daikoku T, Cha J, Sun X, Tranguch S, Xie H, Fujita T, Hirota Y, Lydon J, Demayo F, Maxson R, Dey SK, Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity. Dev Cell. 2011 Dec 13;21(6):1014-25
1J:103007 DiPaola CP, Farmer JC, Manova K, Niswander LA, Molecular signaling in intervertebral disk development. J Orthop Res. 2005 Sep;23(5):1112-9
1J:181901 Eitzinger N, Surmann-Schmitt C, Bosl M, Schett G, Engelke K, Hess A, von der Mark K, Stock M, Ucma is not necessary for normal development of the mouse skeleton. Bone. 2012 Mar;50(3):670-80
1J:202337 Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM, Smad7 regulates terminal maturation of chondrocytes in the growth plate. Dev Biol. 2013 Oct 15;382(2):375-84
1*J:77698 Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P, The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002 Aug 15;129(16):3783-93
1*J:57820 Ferguson C, Alpern E, Miclau T, Helms JA, Does adult fracture repair recapitulate embryonic skeletal formation?. Mech Dev. 1999 Sep;87(1-2):57-66
1J:151466 Gamer LW, Cox K, Carlo JM, Rosen V, Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Dev Dyn. 2009 Aug 3;238(9):2374-2381
1J:107239 Govindarajan V, Overbeek PA, FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev Biol. 2006;6:7
1J:110783 Grashoff C, Aszodi A, Sakai T, Hunziker EB, Fassler R, Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 2003 Apr;4(4):432-8
1J:117334 Gritli-Linde A, Hallberg K, Harfe BD, Reyahi A, Kannius-Janson M, Nilsson J, Cobourne MT, Sharpe PT, McMahon AP, Linde A, Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell. 2007 Jan;12(1):99-112
1J:86043 Han M, Yang X, Farrington JE, Muneoka K, Digit regeneration is regulated by Msx1 and BMP4 in fetal mice. Development. 2003 Nov;130(21):5123-32
1J:171670 Hojyo S, Fukada T, Shimoda S, Ohashi W, Bin BH, Koseki H, Hirano T, The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth. PLoS One. 2011;6(3):e18059
1*J:45684 Iwasaki M, Le AX, Helms JA, Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis. Mech Dev. 1997 Dec;69(1-2):197-202
1J:63198 Iwata T, Chen L, Li Cl, Ovchinnikov DA, Behringer RR, Francomano CA, Deng CX, A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum Mol Genet. 2000 Jul 1;9(11):1603-13
1J:38389 Jensen AM, Wallace VA, Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development. 1997 Jan;124(2):363-71
1J:114852 Jiang F, Herman GE, Analysis of Nsdhl-deficient embryos reveals a role for Hedgehog signaling in early placental development. Hum Mol Genet. 2006 Nov 15;15(22):3293-305
1J:87676 Ko Y, Kobbe B, Nicolae C, Miosge N, Paulsson M, Wagener R, Aszodi A, Matrilin-3 is dispensable for mouse skeletal growth and development. Mol Cell Biol. 2004 Feb;24(4):1691-9
1J:121700 Kolanczyk M, Kossler N, Kuhnisch J, Lavitas L, Stricker S, Wilkening U, Manjubala I, Fratzl P, Sporle R, Herrmann BG, Parada LF, Kornak U, Mundlos S, Multiple roles for neurofibromin in skeletal development and growth. Hum Mol Genet. 2007 Apr 15;16(8):874-86
1J:42408 Lewis MT, Ross S, Strickland PA, Sugnet CW, Jimenez E, Scott MP, Daniel CW, Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1. Development. 1999 Nov;126(22):5181-93
1J:88635 Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP, Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar;131(6):1309-18
1J:161784 Lyashenko N, Weissenbock M, Sharir A, Erben RG, Minami Y, Hartmann C, Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn. 2010 Jun 30;
1J:87618 Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, Bouillon R, Carmeliet G, Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest. 2004 Jan;113(2):188-99
1J:152912 Matsumoto K, Li Y, Jakuba C, Sugiyama Y, Sayo T, Okuno M, Dealy CN, Toole BP, Takeda J, Yamaguchi Y, Kosher RA, Conditional inactivation of Has2 reveals a crucial role for hyaluronan in skeletal growth, patterning, chondrocyte maturation and joint formation in the developing limb. Development. 2009 Aug;136(16):2825-35
1J:186306 Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B, Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
1J:170582 Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011 Mar 1;351(1):70-81
1*J:80052 Nakashima M, Tanese N, Ito M, Auerbach W, Bai C, Furukawa T, Toyono T, Akamine A, Joyner AL, A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. Mech Dev. 2002 Nov;119(1):21
1J:50292 Naski MC, Colvin JS, Coffin JD, Ornitz DM, Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development. 1998 Dec;125(24):4977-88
1J:99177 Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG, Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol Cell Biol. 2005 Jun;25(12):5073-83
1J:128917 Provot S, Nachtrab G, Paruch J, Chen AP, Silva A, Kronenberg HM, A-raf and B-raf are dispensable for normal endochondral bone development, and parathyroid hormone-related peptide suppresses extracellular signal-regulated kinase activation in hypertrophic chondrocytes. Mol Cell Biol. 2008 Jan;28(1):344-57
1J:134727 Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson RS, Longaker MT, Giaccia AJ, Schipani E, Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol. 2007 May 7;177(3):451-64
1J:167067 Seidel K, Ahn CP, Lyons D, Nee A, Ting K, Brownell I, Cao T, Carano RA, Curran T, Schober M, Fuchs E, Joyner A, Martin GR, de Sauvage FJ, Klein OD, Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development. 2010 Nov;137(22):3753-61
1J:143455 Settembre C, Arteaga-Solis E, McKee MD, de Pablo R, Al Awqati Q, Ballabio A, Karsenty G, Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. Genes Dev. 2008 Oct 1;22(19):2645-50
1J:150837 Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH, TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009 Jul 22;28(14):2028-41
1J:88817 Smits P, Dy P, Mitra S, Lefebvre V, Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58
1J:121342 Song B, Haycraft CJ, Seo HS, Yoder BK, Serra R, Development of the post-natal growth plate requires intraflagellar transport proteins. Dev Biol. 2007 May 1;305(1):202-16
1J:134924 Spagnoli A, O'Rear L, Chandler RL, Granero-Molto F, Mortlock DP, Gorska AE, Weis JA, Longobardi L, Chytil A, Shimer K, Moses HL, TGF-beta signaling is essential for joint morphogenesis. J Cell Biol. 2007 Jun 18;177(6):1105-17
1*J:121115 Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz UH, Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo. Dev Dyn. 2007 May;236(5):1313-8
1J:171003 Sugito H, Shibukawa Y, Kinumatsu T, Yasuda T, Nagayama M, Yamada S, Minugh-Purvis N, Pacifici M, Koyama E, Ihh signaling regulates mandibular symphysis development and growth. J Dent Res. 2011 May;90(5):625-31
1J:53310 Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG, Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94
1*J:67784 Takeda S, Bonnamy JP, Owen MJ, Ducy P, Karsenty G, Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 2001 Feb 15;15(4):467-81
1J:101405 Tranguch S, Cheung-Flynn J, Daikoku T, Prapapanich V, Cox MB, Xie H, Wang H, Das SK, Smith DF, Dey SK, Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14326-31
1J:154906 Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X, Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development. 2009 Dec;136(24):4143-53
1J:179733 Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X, Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Development. 2012 Feb;139(3):601-11
1J:163721 Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B, E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul 1;120(7):2474-85
1J:68792 Yang X, Chen L, Xu X, Li C, Huang C, Deng CX, TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol. 2001 Apr 2;153(1):35-46
1J:89327 Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T, Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15;18(8):952-63
1J:79481 Yu J, Carroll TJ, McMahon AP, Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002 Nov;129(22):5301-12

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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory