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Gene Expression Literature Summary
Assay
Age
In situ RNA (whole mount)
9.5 DPC

57 matching records from 57 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results  Reference
1J:143626 Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF, Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9319-24
1J:81795 Barrow JR, Thomas KR, Boussadia-Zahui O, Moore R, Kemler R, Capecchi MR, McMahon AP, Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 1;17(3):394-409
1J:120113 Behesti H, Holt JK, Sowden JC, The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup. BMC Dev Biol. 2006;6:62
1J:144933 Benazet JD, Bischofberger M, Tiecke E, Goncalves A, Martin JF, Zuniga A, Naef F, Zeller R, A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning. Science. 2009 Feb 20;323(5917):1050-3
1J:83660 Bobola N, Carapuco M, Ohnemus S, Kanzler B, Leibbrandt A, Neubuser A, Drouin J, Mallo M, Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development. 2003 Aug;130(15):3403-14
1J:178530 Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL, Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2. Dev Biol. 2011 Dec 15;360(2):381-90
1J:198628 Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL, Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87
1J:142648 Castranio T, Mishina Y, Bmp2 is required for cephalic neural tube closure in the mouse. Dev Dyn. 2008 Dec 18;238(1):110-122
1J:181474 Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A, LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
1J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1*J:148775 Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O, BMP and BMP receptor expression during murine organogenesis. Gene Expr Patterns. 2009 Apr 22;
1J:162165 Dudley B, Palumbo C, Nalepka J, Molyneaux K, BMP signaling controls formation of a primordial germ cell niche within the early genital ridges. Dev Biol. 2010 Jul 1;343(1-2):84-93
1J:165424 Fuchs A, Inthal A, Herrmann D, Cheng S, Nakatomi M, Peters H, Neubuser A, Regulation of Tbx22 during facial and palatal development. Dev Dyn. 2010 Nov;239(11):2860-74
1J:166947 Fujimori S, Novak H, Weissenbock M, Jussila M, Goncalves A, Zeller R, Galloway J, Thesleff I, Hartmann C, Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol. 2010 Dec 1;348(1):97-106
1J:191791 Garrido-Allepuz C, Gonzalez-Lamuno D, Ros MA, Sirenomelia phenotype in bmp7;shh compound mutants: a novel experimental model for studies of caudal body malformations. PLoS One. 2012;7(9):e44962
1J:140315 Geng X, Speirs C, Lagutin O, Inbal A, Liu W, Solnica-Krezel L, Jeong Y, Epstein DJ, Oliver G, Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
1J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
1*J:22842 Hogan BL, Blessing M, Winnier GE, Suzuki N, Jones CM, Growth factors in development: the role of TGF-Beta related polypeptide signalling molecules in embryogenesis. Development. 1994;Suppl:53-60
1*J:54908 Houzelstein D, Auda-Boucher G, Cheraud Y, Rouaud T, Blanc I , Tajbakhsh S , Buckingham ME , Fontaine-Perus J , Robert B, The homeobox gene Msx1 is expressed in a subset of somites, and in muscle progenitor cells migrating into the forelimb. Development. 1999 Jun;126(12):2689-701
1J:102844 Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr, Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov;132(22):4937-50
1J:187010 Jiang X, Zhou Y, Xian L, Chen W, Wu H, Gao X, The mutation in chd7 causes misexpression of bmp4 and developmental defects in telencephalic midline. Am J Pathol. 2012 Aug;181(2):626-41
1J:186421 Klaus A, Muller M, Schulz H, Saga Y, Martin JF, Birchmeier W, Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6
1J:128941 Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y, Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47
1J:66020 LaMantia A, Bhasin N, Rhodes K, Heemskerk J, Mesenchymal/Epithelial induction mediates olfactory pathway formation. Neuron. 2000 Nov;28(2):411-25
1J:130851 Lavado A, Lagutin OV, Oliver G, Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development. 2008 Feb;135(3):441-50
1J:69771 Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP, Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell. 2001 Jun 1;105(5):599-612
1J:81581 Liu C, Nakamura E, Knezevic V, Hunter S, Thompson K, Mackem S, A role for the mesenchymal T-box gene Brachyury in AER formation during limb development. Development. 2003 Apr;130(7):1327-37
1J:99697 Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF, Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15;283(2):282-93
1J:149571 MacKenzie B, Wolff R, Lowe N, Billington CJ Jr, Peterson A, Schmidt B, Graf D, Mina M, Gopalakrishnan R, Petryk A, Twisted gastrulation limits apoptosis in the distal region of the mandibular arch in mice. Dev Biol. 2009 Apr 1;328(1):13-23
1J:155154 Mesbah K, Harrelson Z, Theveniau-Ruissy M, Papaioannou VE, Kelly RG, Tbx3 is required for outflow tract development. Circ Res. 2008 Sep 26;103(7):743-50
1J:200776 Mittal A, Pulina M, Hou SY, Astrof S, Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis. Dev Biol. 2013 Sep 1;381(1):73-82
1*J:47261 Morsli H, Choo D, Ryan A, Johnson R, Wu DK, Development of the mouse inner ear and origin of its sensory organs. J Neurosci. 1998 May 1;18(9):3327-35
1J:172819 Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H, Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field. J Mol Cell Cardiol. 2011 Jul;51(1):58-66
1J:100384 Okano J, Takigawa T, Seki K, Suzuki S, Shiota K, Ishibashi M, Transforming growth factor beta2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol. 2005;49(1):23-31
1J:164383 Pan W, Jin Y, Stanger B, Kiernan AE, Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15798-803
1J:143444 Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM, An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 2008 Nov;135(21):3599-610
1J:127039 Rash BG, Grove EA, Patterning the dorsal telencephalon: a role for sonic hedgehog?. J Neurosci. 2007 Oct 24;27(43):11595-603
1J:67731 Revest JM, Spencer-Dene B, Kerr K, De Moerlooze L, Rosewell I, Dickson C, Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol. 2001 Mar 1;231(1):47-62
1J:128002 Rizzoti K, Lovell-Badge R, SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007 Oct;134(19):3437-48
1J:100426 Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL, Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development. 2005 Aug;132(15):3405-17
1J:118343 Schulte I, Schlueter J, Abu-Issa R, Brand T, Manner J, Morphological and molecular left-right asymmetries in the development of the proepicardium: A comparative analysis on mouse and chick embryos. Dev Dyn. 2007 Mar;236(3):684-95
1J:197026 Sheth R, Gregoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M, Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth. Development. 2013 May;140(10):2130-8
1J:169971 Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A, Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal. Circ Res. 2009 Aug 28;105(5):442-52
1J:95319 Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE, LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005 Jan;132(2):405-14
1*J:59920 St Amand TR, Zhang Y, Semina EV, Zhao X, Hu Y, Nguyen L, Murray JC, Chen Y, Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth-forming anlage. Dev Biol. 2000 Jan 15;217(2):323-32
1J:192045 Suzuki K, Adachi Y, Numata T, Nakada S, Yanagita M, Nakagata N, Evans SM, Graf D, Economides A, Haraguchi R, Moon AM, Yamada G, Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia. PLoS One. 2012;7(9):e43453
1*J:53903 Theil T, Alvarez-Bolado G, Walter A, Ruther U, Gli3 is required for Emx gene expression during dorsal telencephalon development. Development. 1999 Aug;126(16):3561-71
1*J:73777 Trainor PA, Sobieszczuk D, Wilkinson D, Krumlauf R, Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways. Development. 2002 Jan;129(2):433-42
1J:175465 Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL, Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Dev Biol. 2011 Aug 15;356(2):383-97
1J:169047 Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF, Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14;19(6):903-12
1J:166929 Wang Y, Martin JF, Bai CB, Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 2010 Dec 15;348(2):199-209
1J:152813 Wolf M, Lommes P, Sock E, Reiprich S, Friedrich RP, Kriesch J, Stolt CC, Bermingham JR Jr, Wegner M, Replacement of related POU transcription factors leads to severe defects in mouse forebrain development. Dev Biol. 2009 Aug 15;332(2):418-28
1J:83545 Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead M, Shuler C, Maxson RE Jr, Liu YH, Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2404-12
1J:106091 Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D, Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar;59(3):349-54
1J:154982 Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM, Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec;136(23):3895-906
1*J:98379 Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM, Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May;132(10):2489-99
1J:156737 Zhao L, Saitsu H, Sun X, Shiota K, Ishibashi M, Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mech Dev. 2010 January - February;127(1-2):62-72

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory