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Gene Expression Literature Summary
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Age
In situ RNA (whole mount)
8 DPC

37 matching records from 37 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pitx2  paired-like homeodomain transcription factor 2   (Synonyms: Brx1, Brx1a, Brx1b, Munc30, Otlx2, Pitx2a, Pitx2b, Pitx2c, Ptx2, Rieg, solurshin)
Results  Reference
1J:79098 Brennan J, Norris DP, Robertson EJ, Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002 Sep 15;16(18):2339-44
1*J:67751 Campione M, Ros MA, Icardo JM, Piedra E, Christoffels VM, Schweickert A, Blum M, Franco D, Moorman AF, Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice. Dev Biol. 2001 Mar 1;231(1):252-64
1*J:52601 Campione M, Steinbeisser H, Schweickert A, Deissler K, van Bebber F , Lowe LA , Nowotschin S , Viebahn C , Haffter P , Kuehn MR , Blum M, The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. Development. 1999 Mar;126(6):1225-34
1*J:60975 Chang H, Zwijsen A, Vogel H, Huylebroeck D, Matzuk MM, Smad5 is essential for left-right asymmetry in mice. Dev Biol. 2000 Mar 1;219(1):71-8
1*J:116645 Cota CD, Bagher P, Pelc P, Smith CO, Bodner CR, Gunn TM, Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis. Dev Dyn. 2006 Dec;235(12):3438-47
1*J:56091 Davidson BP, Kinder SJ, Steiner K, Schoenwolf GC, Tam PP, Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis. Dev Biol. 1999 Jul 1;211(1):11-26
1J:170490 Field S, Riley KL, Grimes DT, Hilton H, Simon M, Powles-Glover N, Siggers P, Bogani D, Greenfield A, Norris DP, Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2. Development. 2011 Mar;138(6):1131-42
1J:140928 Furtado MB, Solloway MJ, Jones VJ, Costa MW, Biben C, Wolstein O, Preis JI, Sparrow DB, Saga Y, Dunwoodie SL, Robertson EJ, Tam PP, Harvey RP, BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 2008 Nov 1;22(21):3037-49
1J:119664 Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW, Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol. 2006 Dec 15;300(2):523-33
1*J:142123 Ishimura A, Chida S, Osada S, Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Dev Dyn. 2008 Dec;237(12):3565-76
1*J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1J:142430 Kumar A, Lualdi M, Lewandoski M, Kuehn MR, Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn. 2008 Dec;237(12):3591-601
1J:199559 Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR, Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. J Am Soc Nephrol. 2013 Jan;24(1):100-12
1*J:54575 Marszalek JR, Ruiz-Lozano P, Roberts E, Chien KR, Goldstein LS, Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5043-8
1J:49052 Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S , Noji S , Kondoh H , Hamada H, lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 1998 Aug 7;94(3):287-97
1J:70483 Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T, Hamada H, Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell. 2001 Jul;1(1):127-138
1J:137629 Mine N, Anderson RM, Klingensmith J, BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. Development. 2008 Jul;135(14):2425-34
1J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
1J:104377 Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP, Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development. 2005 Dec;132(24):5425-36
1J:126337 Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H, Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 2007 Nov;134(21):3893-904
1J:49089 Piedra ME, Icardo JM, Albajar M, Rodriguez-Rey JC, Ros MA, Pitx2 participates in the late phase of the pathway controlling left-right asymmetry. Cell. 1998 Aug 7;94(3):319-24
1J:60755 Rankin CT, Bunton T, Lawler AM, Lee SJ, Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat Genet. 2000 Mar;24(3):262-5
1J:49337 Ryan AK, Blumberg B, Rodriguez-Esteban C, Yonei-Tamura S, Tamura K, Tsukui T, de la Pena J, Sabbagh W, Greenwald J, Choe S, Norris DP, Robertson EJ, Evans RM, Rosenfeld MG, Izpisua Belmonte JC, Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature. 1998 Aug 6;394(6693):545-51
1J:82703 Saijoh Y, Oki S, Ohishi S, Hamada H, Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
1J:185535 Saund RS, Kanai-Azuma M, Kanai Y, Kim I, Lucero MT, Saijoh Y, Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development. 2012 Jul;139(13):2426-35
1J:162640 Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y, Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning. Nature. 2010 Jul 15;466(7304):378-82
1J:128601 Tanaka C, Sakuma R, Nakamura T, Hamada H, Saijoh Y, Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007 Dec 15;21(24):3272-82
1J:155112 Tsiairis CD, McMahon AP, An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 1;19(22):1912-7
1J:57950 Tsukui T, Capdevila J, Tamura K, Ruiz-Lozano P, Rodriguez-Esteban C, Yonei-Tamura S, Magallon J, Chandraratna RA, Chien K, Blumberg B, Evans RM, Belmonte JC, Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11376-81
1J:122745 Vierkotten J, Dildrop R, Peters T, Wang B, Ruther U, Ftm is a novel basal body protein of cilia involved in Shh signalling. Development. 2007 Jul;134(14):2569-77
1*J:58413 Wasiak S, Lohnes D, Retinoic acid affects left-right patterning. Dev Biol. 1999 Nov 15;215(2):332-42
1J:82311 Yamamoto M, Mine N, Mochida K, Sakai Y, Saijoh Y, Meno C, Hamada H, Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development. 2003 May;130(9):1795-804
1J:58104 Yan YT, Gritsman K, Ding J, Burdine RD, Corrales JD, Price SM, Talbot WS, Schier AF, Shen MM, Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 1999 Oct 1;13(19):2527-37
1J:187958 Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H, Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science. 2012 Oct 12;338(6104):226-31
1J:49484 Yoshioka H, Meno C, Koshiba K, Sugihara M, Itoh H, Ishimaru Y, Inoue T, Ohuchi H, Semina EV, Murray JC, Hamada H, Noji S, Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell. 1998 Aug 7;94(3):299-305
1*J:113766 Zhang M, Bolfing MF, Knowles HJ, Karnes H, Hackett BP, Foxj1 regulates asymmetric gene expression during left-right axis patterning in mice. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1413-20
1J:175111 Zhang XM, Ramalho-Santos M, McMahon AP, Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001 Jul 27;106(2):781-92

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory