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Gene Expression Literature Summary
Assay
Age
In situ RNA (whole mount)
6.5 DPC

27 matching records from 27 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Dkk1  dickkopf WNT signaling pathway inhibitor 1   (Synonyms: mdkk-1)
Results  Reference
1*J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
1J:110605 Camus A, Perea-Gomez A, Moreau A, Collignon J, Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Dev Biol. 2006 Jul 15;295(2):743-55
1J:85554 del Barco Barrantes I, Davidson G, Grone HJ, Westphal H, Niehrs C, Dkk1 and noggin cooperate in mammalian head induction. Genes Dev. 2003 Sep 15;17(18):2239-44
1J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
1*J:85637 Finley KR, Tennessen J, Shawlot W, The mouse Secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development. Gene Expr Patterns. 2003 Oct;3(5):681-4
1*J:122557 Furushima K, Yamamoto A, Nagano T, Shibata M, Miyachi H, Abe T, Ohshima N, Kiyonari H, Aizawa S, Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Dev Biol. 2007 Jun 15;306(2):480-92
1J:254969 Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J, Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6
1J:70278 Kimura C, Shen MM, Takeda N, Aizawa S, Matsuo I, Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev Biol. 2001 Jul 1;235(1):12-32
1J:103272 Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I, Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell. 2005 Nov;9(5):639-50
1J:120359 Kimura-Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, Aizawa S, Matsuo I, Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5919-24
1J:221169 Kumar A, Lualdi M, Lyozin GT, Sharma P, Loncarek J, Fu XY, Kuehn MR, Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. Dev Biol. 2015 Apr 1;400(1):1-9
1J:134688 Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP, Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development. 2008 May;135(10):1791-801
1J:132584 Liguori GL, Borges AC, D'Andrea D, Liguoro A, Goncalves L, Salgueiro AM, Persico MG, Belo JA, Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol. 2008 Mar 15;315(2):280-9
1J:178623 Madabhushi M, Lacy E, Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression. Dev Cell. 2011 Nov 15;21(5):907-19
1J:236404 Minocha S, Bessonnard S, Sung TL, Moret C, Constam DB, Herr W, Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016 Oct 1;418(1):75-88
1J:159998 Miura S, Singh AP, Mishina Y, Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. Dev Biol. 2010 May 1;341(1):246-54
1*J:57798 Monaghan AP, Kioschis P, Wu W, Zuniga A, Bock D, Poustka A, Delius H, Niehrs C, Dickkopf genes are co-ordinately expressed in mesodermal lineages. Mech Dev. 1999 Sep;87(1-2):45-56
1J:198687 Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK, The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 1;27(9):997-1002
1*J:67152 Perea-Gomez A, Lawson KA, Rhinn M, Zakin L, Brulet P, Mazan S, Ang SL, Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. Development. 2001 Mar;128(5):753-65
1J:171680 Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA, Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One. 2011;6(3):e17620
1J:151993 Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N, Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14426-31
1*J:74631 Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I, Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
1J:192194 Tortelote GG, Hernandez-Hernandez JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Perez JA, Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 1;374(1):164-73
1J:150707 Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H, Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009 Jul 15;23(14):1689-98
1J:146156 Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H, Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. J Cell Biol. 2009 Jan 26;184(2):323-34
1J:119304 Yang YP, Klingensmith J, Roles of organizer factors and BMP antagonism in mammalian forebrain establishment. Dev Biol. 2006 Aug 15;296(2):458-75
1*J:66476 Zakin L, Reversade B, Virlon B, Rusniok C, Glaser P, Elalouf JM, Brulet P, Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14388-93

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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory