Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shh  sonic hedgehog   (Synonyms: Hhg1)
Results	Reference
1*	J:223384 Abdelhamed ZA, Natarajan S, Wheway G, Inglehearn CF, Toomes C, Johnson CA, Jagger DJ, The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Dis Model Mech. 2015 Jun;8(6):527-41
1	J:197340 Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS, Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7732-7
1	J:217500 Cui CY, Yin M, Sima J, Childress V, Michel M, Piao Y, Schlessinger D, Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014 Oct;141(19):3752-60
1*	J:73075 Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A, The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development. 2001 Dec;128(24):5201-12
1	J:87181 Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton BA, RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18;40(6):1119-31
1	J:298641 Hasan MR, Takatalo M, Ma H, Rice R, Mustonen T, Rice DP, RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1. Elife. 2020 Jul 14;9:e55829
1	J:65293 Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA, Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov;127(22):4905-13
1	J:241569 Higashiyama H, Ozawa A, Sumitomo H, Uemura M, Fujino K, Igarashi H, Imaimatsu K, Tsunekawa N, Hirate Y, Kurohmaru M, Saijoh Y, Kanai-Azuma M, Kanai Y, Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia. Development. 2017 May 15;144(10):1906-1917
1	J:309463 Hor CHH, Lo JCW, Cham ALS, Leong WY, Goh ELK, Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation. J Neurosci. 2021 Aug 11;41(32):6850-6863
1	J:160335 Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, Litingtung Y, Chiang C, Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8422-7
1	J:236026 Kinsella E, Dora N, Mellis D, Lettice L, Deveney P, Hill R, Ditzel M, Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS One. 2016;11(6):e0157079
1	J:78990 Lamm ML, Catbagan WS, Laciak RJ, Barnett DH, Hebner CM, Gaffield W, Walterhouse D, Iannaccone P, Bushman W, Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol. 2002 Sep 15;249(2):349-66
1	J:182649 Levi B, James AW, Nelson ER, Brugmann SA, Sorkin M, Manu A, Longaker MT, Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg. 2011 Mar;127(3):1182-90
1*	J:217750 Lim A, Shin K, Zhao C, Kawano S, Beachy PA, Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate. Nat Cell Biol. 2014 Dec;16(12):1135-45
1	J:334074 McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour N, Butcher LD, Fisch K, Prince LS, Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development. Development. 2023 Mar 1;150(5):dev200839
1	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
1*	J:257759 Mouri K, Sagai T, Maeno A, Amano T, Toyoda A, Shiroishi T, Enhancer adoption caused by genomic insertion elicits interdigital Shh expression and syndactyly in mouse. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1021-1026
1	J:254493 Munoz-Bravo JL, Flores-Martinez A, Herrero-Martin G, Puri S, Taketo MM, Rojas A, Hebrok M, Cano DA, Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity. PLoS One. 2016;11(10):e0164714
1*	J:179587 Nelson ER, Levi B, Sorkin M, James AW, Liu KJ, Quarto N, Longaker MT, Role of GSK-3beta in the osteogenic differentiation of palatal mesenchyme. PLoS One. 2011;6(10):e25847
1*	J:297164 Nie X, Zheng J, Cruciger M, Yang P, Mao JJ, mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
1*	J:123755 Osmundsen H, Landin MA, From SH, Kolltveit KM, Risnes S, Changes in gene-expression during development of the murine molar tooth germ. Arch Oral Biol. 2007 Sep;52(9):803-13
1	J:149518 Sakagami K, Gan L, Yang XJ, Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci. 2009 May 27;29(21):6932-44
1	J:128323 Shiroyanagi Y, Liu B, Cao M, Agras K, Li J, Hsieh MH, Willingham EJ, Baskin LS, Urothelial sonic hedgehog signaling plays an important role in bladder smooth muscle formation. Differentiation. 2007 Dec;75(10):968-77
1	J:237499 Sima J, Piao Y, Chen Y, Schlessinger D, Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development. 2016 Dec 15;143(24):4723-4735
1	J:98750 Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA, Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 2005 Apr 8;280(14):13809-16
1	J:235702 Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X, LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481
1	J:196290 Wheway G, Abdelhamed Z, Natarajan S, Toomes C, Inglehearn C, Johnson CA, Aberrant Wnt signalling and cellular over-proliferation in a novel mouse model of Meckel-Gruber syndrome. Dev Biol. 2013 May 1;377(1):55-66
1	J:234179 Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, Wong SY, Brownell I, A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet. 2016 Jul;12(7):e1006150
1*	J:146829 Yamada W, Nagao K, Horikoshi K, Fujikura A, Ikeda E, Inagaki Y, Kakitani M, Tomizuka K, Miyazaki H, Suda T, Takubo K, Craniofacial malformation in R-spondin2 knockout mice. Biochem Biophys Res Commun. 2009 Apr 10;381(3):453-8
1	J:116953 Yamago G, Takata Y, Furuta I, Urase K, Momoi T, Huh N, Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res. 2001 Sep;293(9):435-41
1	J:321577 Yin W, Liontos A, Koepke J, Ghoul M, Mazzocchi L, Liu X, Lu C, Wu H, Fysikopoulos A, Sountoulidis A, Seeger W, Ruppert C, Gunther A, Stainier DYR, Samakovlis C, An essential function for autocrine hedgehog signaling in epithelial proliferation and differentiation in the trachea. Development. 2022 Feb 1;149(3):dev199804
1	J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72