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Gene Expression Literature Summary
Assay
Age
In situ RNA (section)
13.5 DPC

65 matching records from 65 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results  Reference
1J:74162 Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E, Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res. 2001 Jul;305(1):67-78
1*J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
1J:44411 Aberg T, Wozney J, Thesleff I, Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn. 1997 Dec;210(4):383-96
1J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31
1J:173382 Basch ML, Ohyama T, Segil N, Groves AK, Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj{kappa}. J Neurosci. 2011 Jun 1;31(22):8046-58
1J:29484 Bennett JH, Hunt P, Thorogood P, Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995 Sep;40(9):847-54
1*J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1J:156015 Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R, Zelzer E, Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev Cell. 2009 Dec;17(6):861-73
1J:200262 Bobick BE, Cobb J, Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci. 2012 Dec 15;125(Pt 24):6071-83
1J:198655 Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X, Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development. 2013 Jul;140(13):2711-23
1*J:36231 Chen Y, Bei M, Woo I, Satokata I, Maas R, Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
1J:81798 Chuang PT, Kawcak T, McMahon AP, Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1;17(3):342-7
1J:152420 Denaxa M, Sharpe PT, Pachnis V, The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009 Sep 15;333(2):324-36
1J:39018 Dudley AT, Robertson EJ, Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 1997 Mar;208(3):349-62
1*J:41080 Furuta Y, Piston DW, Hogan BL, Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997 Jun;124(11):2203-12
1J:167212 Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ, Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23;468(7327):1095-9
1J:138379 Gu S, Wei N, Yu L, Fei J, Chen Y, Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42
1J:165723 He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y, Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21
1J:144627 He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y, Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development. 2008 Dec;135(23):3871-9
1J:139635 Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C, Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn. 2008 Sep 24;237(10):3079-3087
1J:125109 Huang X, Litingtung Y, Chiang C, Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly. Hum Mol Genet. 2007 Jun 15;16(12):1454-68
1J:191714 Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R, Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013 Jan 15;140(2):423-32
1J:137800 Jin JZ, Li Q, Higashi Y, Darling DS, Ding J, Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008 Jul;333(1):29-38
1*J:11435 Jones CM, Lyons KM, Hogan BL, Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development. 1991 Feb;111(2):531-42
1*J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1J:51084 Keranen SV, Aberg T, Kettunen P, Thesleff I, Jernvall J, Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Dev Genes Evol. 1998 Nov;208(9):477-86
1J:116785 Kettunen P, Nie X, Kvinnsland IH, Luukko K, Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1250-8
1J:86231 Kim JY, Mochizuki T, Akita K, Jung HS, Morphological evidence of the importance of epithelial tissue during mouse tongue development. Exp Cell Res. 2003 Nov 1;290(2):217-26
1J:147277 Lan Y, Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96
1J:94755 Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R, Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004 Jul;131(13):3207-16
1J:104286 Levi G, Mantero S, Barbieri O, Cantatore D, Paleari L, Beverdam A, Genova F, Robert B, Merlo GR, Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev. 2006 Jan;123(1):3-16
1J:168033 Li L, Lin M, Wang Y, Cserjesi P, Chen Z, Chen Y, BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol. 2011 Jan 15;349(2):451-61
1J:57673 Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisua-Belmonte JC, Rosenfeld MG, Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature. 1999 Sep 16;401(6750):279-82
1J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24
1J:63337 Lu H, Jin Y, Tipoe GL, Alteration in the expression of bone morphogenetic protein-2,3,4,5 mRNA during pathogenesis of cleft palate in BALB/c mice. Arch Oral Biol. 2000 Feb;45(2):133-40
1J:199588 Luo XJ, Deng M, Xie X, Huang L, Wang H, Jiang L, Liang G, Hu F, Tieu R, Chen R, Gan L, GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea. Hum Mol Genet. 2013 Sep 15;22(18):3609-23
1J:146434 Maatouk DM, Choi KS, Bouldin CM, Harfe BD, In the limb AER Bmp2 and Bmp4 are required for dorsal-ventral patterning and interdigital cell death but not limb outgrowth. Dev Biol. 2009 Mar 15;327(2):516-23
1J:114175 Mallo M, Schrewe H, Martin JF, Olson EN, Ohnemus S, Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium. Development. 2000 Oct;127(19):4127-36
1J:170543 Matsushima D, Heavner W, Pevny LH, Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development. 2011 Feb;138(3):443-54
1J:180393 Miletich I, Yu WY, Zhang R, Yang K, Caixeta de Andrade S, Pereira SF, Ohazama A, Mock OB, Buchner G, Sealby J, Webster Z, Zhao M, Bei M, Sharpe PT, Developmental stalling and organ-autonomous regulation of morphogenesis. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19270-5
1J:186306 Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B, Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
1J:160264 Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H, Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol. 2010 Apr 15;340(2):438-49
1J:166455 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK, BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10;30(45):15044-51
1J:153100 Pauws E, Hoshino A, Bentley L, Prajapati S, Keller C, Hammond P, Martinez-Barbera JP, Moore GE, Stanier P, Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
1*J:77812 Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ, Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol. 2002 Jul 1;247(1):26-46
1J:49857 Peters H, Neubuser A, Kratochwil K, Balling R, Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998 Sep 1;12(17):2735-47
1J:35807 Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC, Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996 Sep;122(9):2729-37
1J:162170 Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE, Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol. 2010 Jul 1;343(1-2):28-39
1J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
1J:198279 Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y, Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50
1J:194058 Sun J, Ishii M, Ting MC, Maxson R, Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44
1*J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
1J:48939 Tucker AS, Al Khamis A, Sharpe PT, Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. Dev Dyn. 1998 Aug;212(4):533-9
1J:28253 Tureckova J, Sahlberg C, Aberg T, Ruch JV, Thesleff I, Peterkova R, Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia. Int J Dev Biol. 1995 Jun;39(3):459-68
1J:31907 Vainio S, Karavanova I, Jowett A, Thesleff I, Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
1J:200760 Wang Y, Zheng Y, Chen D, Chen Y, Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Dev Biol. 2013 Sep 15;381(2):301-11
1J:58847 Wang YH, Rutherford B, Upholt WB, Mina M, Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme. Dev Dyn. 1999 Dec;216(4-5):320-35
1J:128008 Xu H, Chen L, Baldini A, In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol. 2007 Oct 15;310(2):329-40
1J:145904 Zhang Z, Lan Y, Chai Y, Jiang R, Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27;323(5918):1232-4
1*J:78220 Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y, Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002 Sep;129(17):4135-46
1*J:83306 Zhang Z, Zhang X, Avniel WA, Song Y, Jones SM, Jones TA, Fermin C, Chen Y, Malleal processus brevis is dispensable for normal hearing in mice. Dev Dyn. 2003 May;227(1):69-77
1J:205040 Zhou J, Gao Y, Lan Y, Jia S, Jiang R, Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013 Dec;140(23):4709-18
1J:173121 Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R, Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53
1J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55

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last database update
04/08/2014
MGI 5.17
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