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Gene Expression Literature Summary
Assay
Age
In situ RNA (section)
13.5 DPC

28 matching records from 28 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ihh  Indian hedgehog  
Results  Reference
1*J:75699 Albrecht AN, Schwabe GC, Stricker S, Boddrich A, Wanker EE, Mundlos S, The synpolydactyly homolog (spdh) mutation in the mouse -- a defect in patterning and growth of limb cartilage elements. Mech Dev. 2002 Mar;112(1-2):53-67
1*J:59288 Baur ST, Mai JJ, Dymecki SM, Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity. Development. 2000 Feb;127(3):605-19
1J:85724 Bendall AJ, Hu G, Levi G, Abate-Shen C, Dlx5 regulates chondrocyte differentiation at multiple stages. Int J Dev Biol. 2003 Jun;47(5):335-44
1*J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1J:200262 Bobick BE, Cobb J, Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci. 2012 Dec 15;125(Pt 24):6071-83
1J:92433 Eswarakumar VP, Horowitz MC, Locklin R, Morriss-Kay GM, Lonai P, A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12555-60
1J:138379 Gu S, Wei N, Yu L, Fei J, Chen Y, Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42
1J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
1*J:53540 Kim IS, Otto F, Zabel B, Mundlos S, Regulation of chondrocyte differentiation by Cbfa1. Mech Dev. 1999 Feb;80(2):159-70
1J:92212 Koziel L, Kunath M, Kelly OG, Vortkamp A, Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev Cell. 2004 Jun;6(6):801-13
1J:205338 Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo-Garcia P, Mundlos S, Stricker S, Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93
1J:71832 Lee CS, Buttitta L, Fan CM, Evidence that the WNT-inducible growth arrest-specific gene 1 encodes an antagonist of sonic hedgehog signaling in the somite. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11347-52
1J:205339 Mis EK, Liem KF Jr, Kong Y, Schwartz NB, Domowicz M, Weatherbee SD, Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 1;385(1):67-82
1J:186306 Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B, Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
1J:97323 Niedermaier M, Schwabe GC, Fees S, Helmrich A, Brieske N, Seemann P, Hecht J, Seitz V, Stricker S, Leschik G, Schrock E, Selby PB, Mundlos S, An inversion involving the mouse Shh locus results in brachydactyly through dysregulation of Shh expression. J Clin Invest. 2005 Apr 1;115(4):900-909
1J:160263 Nielsen CM, Dymecki SM, Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol. 2010 Apr 15;340(2):430-7
1*J:88955 Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S, Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn. 2004 Feb;229(2):400-10
1*J:71996 Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML, Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001 Sep;128(18):3543-57
1J:88817 Smits P, Dy P, Mitra S, Lefebvre V, Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58
1J:134924 Spagnoli A, O'Rear L, Chandler RL, Granero-Molto F, Mortlock DP, Gorska AE, Weis JA, Longobardi L, Chytil A, Shimer K, Moses HL, TGF-beta signaling is essential for joint morphogenesis. J Cell Biol. 2007 Jun 18;177(6):1105-17
1J:119030 Spater D, Hill TP, O'sullivan RJ, Gruber M, Conner DA, Hartmann C, Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development. 2006 Aug;133(15):3039-49
1*J:57297 St-Jacques B, Hammerschmidt M, McMahon AP, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]. Genes Dev. 1999 Aug 15;13(16):2072-86
1*J:54643 Storm EE, Kingsley DM, GDF5 coordinates bone and joint formation during digit development. Dev Biol. 1999 May 1;209(1):11-27
1J:182757 Wilson DG, Phamluong K, Lin WY, Barck K, Carano RA, Diehl L, Peterson AS, Martin F, Solloway MJ, Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning. Dev Biol. 2012 Mar 15;363(2):413-25
1J:175218 Xie X, Qin J, Lin SH, Tsai SY, Tsai MJ, Nuclear receptor chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) modulates mesenchymal cell commitment and differentiation. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14843-8
1*J:81355 Yang Y, Topol L, Lee H, Wu J, Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003 Mar;130(5):1003-15
1J:89327 Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K, Yamana K, Zanma A, Takada K, Ito Y, Komori T, Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev. 2004 Apr 15;18(8):952-63
1*J:171806 Young B, Minugh-Purvis N, Shimo T, St-Jacques B, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol. 2006 Nov 1;299(1):272-82

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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory