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Gene Expression Literature Summary
Assay
Age
In situ RNA (section)
12.5 DPC

72 matching records from 72 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results  Reference
1J:74162 Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E, Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res. 2001 Jul;305(1):67-78
1J:44411 Aberg T, Wozney J, Thesleff I, Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn. 1997 Dec;210(4):383-96
1J:106499 Airik R, Bussen M, Singh MK, Petry M, Kispert A, Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006 Mar;116(3):663-74
1J:166547 Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A, Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme. Hum Mol Genet. 2010 Dec 15;19(24):4918-29
1J:78219 Aubin J, Dery U, Lemieux M, Chailler P, Jeannotte L, Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling. Development. 2002 Sep;129(17):4075-87
1*J:33591 Bellusci S, Henderson R, Winnier G, Oikawa T, Hogan BL, Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development. 1996 Jun;122(6):1693-702
1J:183848 Benadiba C, Magnani D, Niquille M, Morle L, Valloton D, Nawabi H, Ait-Lounis A, Otsmane B, Reith W, Theil T, Hornung JP, Lebrand C, Durand B, The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development. PLoS Genet. 2012 Mar;8(3):e1002606
1J:171429 Besse L, Neti M, Anselme I, Gerhardt C, Ruther U, Laclef C, Schneider-Maunoury S, Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development. 2011 May;138(10):2079-88
1*J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1J:119113 Bleul CC, Boehm T, BMP signaling is required for normal thymus development. J Immunol. 2005 Oct 15;175(8):5213-21
1J:200262 Bobick BE, Cobb J, Shox2 regulates progression through chondrogenesis in the mouse proximal limb. J Cell Sci. 2012 Dec 15;125(Pt 24):6071-83
1*J:67304 Bulchand S, Grove EA, Porter FD, Tole S, LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev. 2001 Feb;100(2):165-75
1J:92326 Burton Q, Cole LK, Mulheisen M, Chang W, Wu DK, The role of Pax2 in mouse inner ear development. Dev Biol. 2004 Aug 1;272(1):161-75
1*J:36231 Chen Y, Bei M, Woo I, Satokata I, Maas R, Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
1J:141874 Cheng W, Yeung CK, Ng YK, Zhang JR, Hui CC, Kim PC, Sonic Hedgehog mediator Gli2 regulates bladder mesenchymal patterning. J Urol. 2008;180(4):1543-50
1J:34068 Constam DB, Calfon M, Robertson EJ, SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
1J:152420 Denaxa M, Sharpe PT, Pachnis V, The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009 Sep 15;333(2):324-36
1J:49552 Ferguson CA, Tucker AS, Christensen L, Lau AL, Matzuk MM, Sharpe PT, Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev. 1998 Aug 15;12(16):2636-49
1J:199602 Fotaki V, Smith R, Pratt T, Price DJ, Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/beta-catenin signalling in the developing nasal retina of the mouse. Dev Biol. 2013 Aug 15;380(2):299-313
1J:136720 Friedrichs M, Larralde O, Skutella T, Theil T, Lamination of the cerebral cortex is disturbed in Gli3 mutant mice. Dev Biol. 2008 Jun 1;318(1):203-14
1J:174118 Fuccillo M, Rutlin M, Fishell G, Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice. Cereb Cortex. 2006 Jul;16 Suppl 1:i96-102
1J:166947 Fujimori S, Novak H, Weissenbock M, Jussila M, Goncalves A, Zeller R, Galloway J, Thesleff I, Hartmann C, Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol. 2010 Dec 1;348(1):97-106
1*J:49252 Hardcastle Z, Mo R, Hui CC, Sharpe PT, The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development. 1998 Aug;125(15):2803-11
1J:83123 Hebert JM, Hayhurst M, Marks ME, Kulessa H, Hogan BL, McConnell SK, BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis. 2003 Apr;35(4):214-9
1J:79021 Hebert JM, Mishina Y, McConnell SK, BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron. 2002 Sep 12;35(6):1029-41
1J:160258 Holley M, Rhodes C, Kneebone A, Herde MK, Fleming M, Steel KP, Emx2 and early hair cell development in the mouse inner ear. Dev Biol. 2010 Apr 15;340(2):547-56
1J:188806 Hurd EA, Micucci JA, Reamer EN, Martin DM, Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
1J:132023 Hwang CH, Wu DK, Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hum Mol Genet. 2008 Mar 15;17(6):844-53
1J:139170 Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R, Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
1J:200638 Islam SS, Mokhtari RB, Kumar S, Maalouf J, Arab S, Yeger H, Farhat WA, Spatio-temporal distribution of Smads and role of Smads/TGF-beta/BMP-4 in the regulation of mouse bladder organogenesis. PLoS One. 2013;8(4):e61340
1J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1*J:54206 Jung HS, Oropeza V, Thesleff I, Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
1J:51084 Keranen SV, Aberg T, Kettunen P, Thesleff I, Jernvall J, Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Dev Genes Evol. 1998 Nov;208(9):477-86
1J:116785 Kettunen P, Nie X, Kvinnsland IH, Luukko K, Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1250-8
1J:187316 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M, BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012;7(5):e37670
1J:175841 Lana-Elola E, Tylzanowski P, Takatalo M, Alakurtti K, Veistinen L, Mitsiadis TA, Graf D, Rice R, Luyten FP, Rice DP, Noggin null allele mice exhibit a microform of holoprosencephaly. Hum Mol Genet. 2011 Oct 15;20(20):4005-15
1J:107400 Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I, p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development. 2006 Apr;133(8):1553-63
1*J:82457 Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH, Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May;130(10):2275-87
1J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24
1J:157251 Lokmane L, Heliot C, Garcia-Villalba P, Fabre M, Cereghini S, vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development. 2010 Jan;137(2):347-57
1J:61482 Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I, Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest. 2000 Apr;105(7):863-73
1J:160264 Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H, Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol. 2010 Apr 15;340(2):438-49
1J:188836 Norden J, Greulich F, Rudat C, Taketo MM, Kispert A, Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50
1J:171035 Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJ, Englert C, Petry M, Mommersteeg MT, Christoffels VM, Niederreither K, Kispert A, Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns. Circ Res. 2010 Apr 16;106(7):1212-20
1J:166455 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK, BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10;30(45):15044-51
1J:185279 Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S, Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. Hum Mol Genet. 2012 Jul 15;21(14):3143-55
1J:50051 Pepicelli CV, Lewis PM, McMahon AP, Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol. 1998 Sep 24;8(19):1083-6
1J:165575 Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G, Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Oct 6;
1J:162170 Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE, Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol. 2010 Jul 1;343(1-2):28-39
1*J:98374 Shan SW, Tang MK, Cai DQ, Chui YL, Chow PH, Grotewold L, Lee KK, Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death. Dev Dyn. 2005 Jun;233(2):266-81
1*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1J:166526 Shum AS, Tang LS, Copp AJ, Roelink H, Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube. Dev Dyn. 2010 Dec;239(12):3192-203
1J:194058 Sun J, Ishii M, Ting MC, Maxson R, Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44
1J:171106 Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T, Dynamic spatiotemporal gene expression in embryonic mouse thalamus. J Comp Neurol. 2011 Feb 15;519(3):528-43
1J:53310 Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG, Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94
1*J:60313 Tang MK, Leung AK, Kwong WH, Chow PH, Chan JY, Ngo-Muller V, Li M, Lee KK, Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues. Dev Biol. 2000 Feb 1;218(1):89-98
1J:147648 Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M, Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Circ Res. 2008 Apr 11;102(7):813-22
1J:44838 Thomas BL, Tucker AS, Qui M, Ferguson CA, Hardcastle Z, Rubenstein JL, Sharpe PT, Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development. 1997 Dec;124(23):4811-8
1*J:55583 Tribioli C, Lufkin T, The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 1999 Dec;126(24):5699-711
1J:28253 Tureckova J, Sahlberg C, Aberg T, Ruch JV, Thesleff I, Peterkova R, Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia. Int J Dev Biol. 1995 Jun;39(3):459-68
1J:31907 Vainio S, Karavanova I, Jowett A, Thesleff I, Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
1J:200760 Wang Y, Zheng Y, Chen D, Chen Y, Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Dev Biol. 2013 Sep 15;381(2):301-11
1J:196616 Willaredt MA, Gorgas K, Gardner HA, Tucker KL, Multiple essential roles for primary cilia in heart development. Cilia. 2012;1(1):23
1J:176365 Yallowitz AR, Hrycaj SM, Short KM, Smyth IM, Wellik DM, Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS One. 2011;6(8):e23410
1J:122558 Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, Chen Y, Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007 Jun 15;306(2):549-59
1J:165712 Zakin L, Chang EY, Plouhinec JL, De Robertis EM, Crossveinless-2 is required for the relocalization of Chordin protein within the vertebral field in mouse embryos. Dev Biol. 2010 Nov 1;347(1):204-15
1J:145904 Zhang Z, Lan Y, Chai Y, Jiang R, Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27;323(5918):1232-4
1*J:87163 Zhang Z, Song Y, Zhang X, Tang J, Chen J, Chen Y, Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech Dev. 2003 Dec;120(12):1469-79
1*J:78220 Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y, Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002 Sep;129(17):4135-46
1*J:83306 Zhang Z, Zhang X, Avniel WA, Song Y, Jones SM, Jones TA, Fermin C, Chen Y, Malleal processus brevis is dispensable for normal hearing in mice. Dev Dyn. 2003 May;227(1):69-77
1J:173121 Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R, Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53
1J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55

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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory