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Gene Expression Literature Summary
Assay
Age
In situ RNA (section)
11.5 DPC

73 matching records from 73 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Bmp4  bone morphogenetic protein 4   (Synonyms: Bmp2b, Bmp2b1, Bmp2b-1, Bmp-4)
Results  Reference
1J:74162 Abdelwahid E, Rice D, Pelliniemi LJ, Jokinen E, Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart. Cell Tissue Res. 2001 Jul;305(1):67-78
1J:44411 Aberg T, Wozney J, Thesleff I, Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn. 1997 Dec;210(4):383-96
1J:186055 Ashique AM, Choe Y, Karlen M, May SR, Phamluong K, Solloway MJ, Ericson J, Peterson AS, The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis. Sci Signal. 2009;2(95):ra70
1J:152830 Balic A, Adams D, Mina M, Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Sep 23;238(10):2599-2613
1*J:33591 Bellusci S, Henderson R, Winnier G, Oikawa T, Hogan BL, Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development. 1996 Jun;122(6):1693-702
1J:29484 Bennett JH, Hunt P, Thorogood P, Bone morphogenetic protein-2 and -4 expression during murine orofacial development. Arch Oral Biol. 1995 Sep;40(9):847-54
1J:169150 Bharti K, Gasper M, Bertuzzi S, Arnheiter H, Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development. 2011 Mar;138(5):873-8
1*J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1J:119113 Bleul CC, Boehm T, BMP signaling is required for normal thymus development. J Immunol. 2005 Oct 15;175(8):5213-21
1J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1J:209678 Chandramouli A, Hatsell SJ, Pinderhughes A, Koetz L, Cowin P, Gli activity is critical at multiple stages of embryonic mammary and nipple development. PLoS One. 2013;8(11):e79845
1*J:36231 Chen Y, Bei M, Woo I, Satokata I, Maas R, Msx1 controls inductive signaling in mammalian tooth morphogenesis. Development. 1996 Oct;122(10):3035-44
1J:117141 Cho KW, Kim JY, Song SJ, Farrell E, Eblaghie MC, Kim HJ, Tickle C, Jung HS, Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16788-93
1J:34068 Constam DB, Calfon M, Robertson EJ, SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
1J:152420 Denaxa M, Sharpe PT, Pachnis V, The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009 Sep 15;333(2):324-36
1J:156733 Deng M, Pan L, Xie X, Gan L, Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol. 2010 Feb 1;338(1):38-49
1J:59472 Dou CL, Li S, Lai E, Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres. Cereb Cortex. 1999 Sep;9(6):543-50
1J:39018 Dudley AT, Robertson EJ, Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 1997 Mar;208(3):349-62
1J:130860 Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E, Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20838-43
1*J:46975 Ericson J, Norlin S, Jessell TM, Edlund T, Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development. 1998 Mar;125(6):1005-15
1J:176438 Esteve P, Sandonis A, Ibanez C, Shimono A, Guerrero I, Bovolenta P, Secreted frizzled-related proteins are required for Wnt/{beta}-catenin signalling activation in the vertebrate optic cup. Development. 2011 Oct;138(19):4179-84
1J:204657 Forni PE, Bharti K, Flannery EM, Shimogori T, Wray S, The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems. J Neurosci. 2013 Dec 11;33(50):19620-34
1J:115961 Fu M, Vohra BP, Wind D, Heuckeroth RO, BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition. Dev Biol. 2006 Nov 1;299(1):137-50
1*J:41080 Furuta Y, Piston DW, Hogan BL, Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Development. 1997 Jun;124(11):2203-12
1J:142425 Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP, Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol. 2008 Dec 15;324(2):322-33
1J:167212 Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ, Subtypes of medulloblastoma have distinct developmental origins. Nature. 2010 Dec 23;468(7327):1095-9
1*J:152487 Gong SG, Mai S, Chung K, Wei K, Flrt2 and Flrt3 have overlapping and non-overlapping expression during craniofacial development. Gene Expr Patterns. 2009 Oct;9(7):497-502
1J:175454 Goss AM, Tian Y, Cheng L, Yang J, Zhou D, Cohen ED, Morrisey EE, Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol. 2011 Aug 15;356(2):541-52
1J:125119 Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y, Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct;124(9-10):729-45
1J:125693 Hanashima C, Fernandes M, Hebert JM, Fishell G, The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J Neurosci. 2007 Oct 10;27(41):11103-11
1J:79021 Hebert JM, Mishina Y, McConnell SK, BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron. 2002 Sep 12;35(6):1029-41
1J:152574 High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA, Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest. 2009 Jul;119(7):1986-96
1J:188806 Hurd EA, Micucci JA, Reamer EN, Martin DM, Delayed fusion and altered gene expression contribute to semicircular canal defects in Chd7 deficient mice. Mech Dev. 2012 Sep;129(9-12):308-23
1*J:153730 Hwang CH, Simeone A, Lai E, Wu DK, Foxg1 is required for proper separation and formation of sensory cristae during inner ear development. Dev Dyn. 2009 Nov;238(11):2725-34
1J:139170 Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R, Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development. 2008 Aug;135(15):2531-41
1J:187966 Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein JL, Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn. 2012 Nov;241(11):1757-69
1*J:11435 Jones CM, Lyons KM, Hogan BL, Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse. Development. 1991 Feb;111(2):531-42
1J:90988 Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu MM, Epstein JA, Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development. 2004 Jul;131(14):3481-90
1J:116785 Kettunen P, Nie X, Kvinnsland IH, Luukko K, Histological development and dynamic expression of Bmp2-6 mRNAs in the embryonic and postnatal mouse cranial base. Anat Rec A Discov Mol Cell Evol Biol. 2006 Dec;288(12):1250-8
1J:70365 Kim RY, Robertson EJ, Solloway MJ, Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart. Dev Biol. 2001 Jul 15;235(2):449-66
1J:152264 Koo SK, Hill JK, Hwang CH, Lin ZS, Millen KJ, Wu DK, Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear. Dev Biol. 2009 Sep 1;333(1):14-25
1J:187316 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M, BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012;7(5):e37670
1J:122519 Linton JM, Martin GR, Reichardt LF, The ECM protein nephronectin promotes kidney development via integrin {alpha}8{beta}1-mediated stimulation of Gdnf expression. Development. 2007 Jul;134(13):2501-9
1J:49604 Litingtung Y, Lei L, Westphal H, Chiang C, Sonic hedgehog is essential to foregut development [see comments]. Nat Genet. 1998 Sep;20(1):58-61
1J:89237 Liu W, Selever J, Wang D, Lu MF, Moses KA, Schwartz RJ, Martin JF, Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4489-94
1J:173525 Lopes M, Goupille O, Cloment CS, Lallemand Y, Cumano A, Robert B, Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development. 2011 Jul;138(14):3055-66
1*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1J:154979 Miyagawa S, Moon A, Haraguchi R, Inoue C, Harada M, Nakahara C, Suzuki K, Matsumaru D, Kaneko T, Matsuo I, Yang L, Taketo MM, Iguchi T, Evans SM, Yamada G, Dosage-dependent hedgehog signals integrated with Wnt/{beta}-catenin signaling regulate external genitalia formation as an appendicular program. Development. 2009 Dec;136(23):3969-78
1*J:47261 Morsli H, Choo D, Ryan A, Johnson R, Wu DK, Development of the mouse inner ear and origin of its sensory organs. J Neurosci. 1998 May 1;18(9):3327-35
1J:53713 Morsli H, Tuorto F, Choo D, Postiglione MP, Simeone A, Wu DK, Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development. 1999 Jun;126(11):2335-43
1J:171473 Nie X, Xu J, El-Hashash A, Xu PX, Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol. 2011 Apr 1;352(1):141-51
1J:166455 Ohyama T, Basch ML, Mishina Y, Lyons KM, Segil N, Groves AK, BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea. J Neurosci. 2010 Nov 10;30(45):15044-51
1J:50051 Pepicelli CV, Lewis PM, McMahon AP, Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol. 1998 Sep 24;8(19):1083-6
1J:73971 Ponnio T, Burton Q, Pereira FA, Wu DK, Conneely OM, The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear. Mol Cell Biol. 2002 Feb;22(3):935-45
1J:165575 Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G, Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart. Hum Mol Genet. 2010 Oct 6;
1J:88507 Rizzoti K, Brunelli S, Carmignac D, Thomas PQ, Robinson IC, Lovell-Badge R, SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat Genet. 2004 Mar;36(3):247-55
1*J:209710 Roberts KA, Abraira VE, Tucker AF, Goodrich LV, Andrews NC, Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice. PLoS One. 2012;7(1):e29495
1J:128571 Selever J, Liu W, Lu MF, Behringer RR, Martin JF, Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development. Dev Biol. 2004 Dec 15;276(2):268-79
1J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
1*J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1J:144194 Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Birchmeier W, Kato S, Yamada G, Embryonic hair follicle fate change by augmented {beta}-catenin through Shh and Bmp signaling. Development. 2009 Feb;136(3):367-72
1*J:60313 Tang MK, Leung AK, Kwong WH, Chow PH, Chan JY, Ngo-Muller V, Li M, Lee KK, Bmp-4 requires the presence of the digits to initiate programmed cell death in limb interdigital tissues. Dev Biol. 2000 Feb 1;218(1):89-98
1J:139045 Thomason HA, Dixon MJ, Dixon J, Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling. Dev Biol. 2008 Sep 1;321(1):273-82
1J:48939 Tucker AS, Al Khamis A, Sharpe PT, Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. Dev Dyn. 1998 Aug;212(4):533-9
1J:31907 Vainio S, Karavanova I, Jowett A, Thesleff I, Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
1J:90386 Wang CK, Omi M, Ferrari D, Cheng HC, Lizarraga G, Chin HJ, Upholt WB, Dealy CN, Kosher RA, Function of BMPs in the apical ectoderm of the developing mouse limb. Dev Biol. 2004 May 1;269(1):109-22
1*J:73069 Wang W, Chan EK, Baron S, Van de Water T, Lufkin T, Hmx2 homeobox gene control of murine vestibular morphogenesis. Development. 2001 Dec;128(24):5017-29
1J:92940 Wang W, Grimmer JF, Van De Water TR, Lufkin T, Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx. Dev Cell. 2004 Sep;7(3):439-53
1J:200760 Wang Y, Zheng Y, Chen D, Chen Y, Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Dev Biol. 2013 Sep 15;381(2):301-11
1J:58847 Wang YH, Rutherford B, Upholt WB, Mina M, Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme. Dev Dyn. 1999 Dec;216(4-5):320-35
1J:122558 Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, Chen Y, Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007 Jun 15;306(2):549-59
1J:145904 Zhang Z, Lan Y, Chai Y, Jiang R, Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27;323(5918):1232-4
1J:157264 Zhao Y, Mailloux CM, Hermesz E, Palkovits M, Westphal H, A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol. 2010 Jan 15;337(2):313-23

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last database update
12/16/2014
MGI 5.20
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