Gene Expression Literature Summary

• Symbol: Syk
• Name: spleen tyrosine kinase
• ID: MGI:99515

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	1		1	1						1			1
In situ RNA (section)		1					1	1
Northern blot													1	1
Western blot				1		2			1			1	1	3
RT-PCR			1				1	1		1			1	1
cDNA clones									2
RNase protection													1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Syk  spleen tyrosine kinase   (Synonyms: Sykb)
Results	Reference
2	J:249752 Benon A, Ya C, Martin L, Watrin C, Chounlamountri N, Jaaoini I, Honnorat J, Pellier-Monnin V, Noraz N, The Syk kinases orchestrate cerebellar granule cell tangential migration. Neuroscience. 2017 Sep 30;360:230-239
1	J:159112 Bohmer R, Neuhaus B, Buhren S, Zhang D, Stehling M, Bock B, Kiefer F, Regulation of developmental lymphangiogenesis by Syk(+) leukocytes. Dev Cell. 2010 Mar 16;18(3):437-49
3	J:314169 Carriba P, Davies AM, Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth. Cells. 2021 Apr 7;10(4)
1*	J:29797 Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T, Syk tyrosine kinase required for mouse viability and B-cell development. Nature. 1995 Nov 16;378(6554):303-6
1	J:181715 Finney BA, Schweighoffer E, Navarro-Nunez L, Benezech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP, CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 2012 Feb 16;119(7):1747-56
2	J:27983 Fluck M, Zurcher G, Andres AC, Ziemiecki A, Molecular characterization of the murine syk protein tyrosine kinase cDNA, transcripts and protein. Biochem Biophys Res Commun. 1995 Aug 4;213(1):273-81
2	J:121179 Furuhata S, Ando K, Oki M, Aoki K, Ohnishi S, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T, Ohnami S, Gene expression profiles of endothelial progenitor cells by oligonucleotide microarray analysis. Mol Cell Biochem. 2007 Apr;298(1-2):125-38
1	J:18500 Gauen LK, Zhu Y, Letourneur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS, Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol. 1994 Jun;14(6):3729-41
1	J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86
1	J:259186 Heng X, Guo Q, Leung AW, Li JY, Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6:e23253
1	J:307823 Hoover C, Kondo Y, Shao B, McDaniel MJ, Lee R, McGee S, Whiteheart S, Bergmeier W, McEver RP, Xia L, Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood. 2021 May 20;137(20):2756-2769
4	J:35411 Latour S, Chow LML, Veillette A, Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem. 1996 Sep 13;271(37):22782-90
4	J:235677 Noraz N, Jaaoini I, Charoy C, Watrin C, Chounlamountri N, Benon A, Malleval C, Boudin H, Honnorat J, Castellani V, Pellier-Monnin V, Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway. Development. 2016 Jun 15;143(12):2183-93
1*	J:29796 Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL, Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995 Nov 16;378(6554):298-302
3	J:91730 Verma-Kurvari S, Parada LF, Identification of tyrosine kinases expressed in the male mouse gubernaculum during development. Dev Dyn. 2004 Aug;230(4):660-5
2	J:331895 Zengeler KE, Shapiro DA, Bruch KR, Lammert CR, Ennerfelt H, Lukens JR, SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology. Brain Behav Immun. 2022 Nov 4;108:80-97