Gene Expression Literature Summary

• Symbol: Tmsb4x
• Name: thymosin, beta 4, X chromosome
• ID: MGI:99510

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)					1		1	3		1	1		3	2			1		1		1	6
In situ RNA (section)					4	1	2	2	1	4	2	1	7	1	3	3		1	1	1		2
Immunohistochemistry (whole mount)				1	1
In situ RNA (whole mount)		1	1	2	2	1	3
Western blot																						1
RT-PCR				2	1		5	1	2	2	1	1	1		2	1	1	3		1	1	8
RNase protection	1	1		1	1		1			1												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tmsb4x  thymosin, beta 4, X chromosome   (Synonyms: Ptmb4, Tb4, Tbeta4)
Results	Reference
1	J:137057 Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, Itohara S, Terasaki T, Oohira A, Mishina Y, Yamada M, BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 2008 Jul;38(3):417-30
1	J:213328 Banerjee I, Moore Morris T, Evans SM, Chen J, Thymosin beta4 is not required for embryonic viability or vascular development. Circ Res. 2013 Feb 1;112(3):e25-8
3	J:185264 Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J, Thymosin beta 4 is dispensable for murine cardiac development and function. Circ Res. 2012 Feb 3;110(3):456-64
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5*	J:94254 Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D, Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004 Nov 25;432(7016):466-72
1	J:239251 Brzoska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA, Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 Dec;90(6):1274-1284
8*	J:23235 Carpinterio P, Anadon R, del Amo FF, Gomez-Marquez J, The thymosin beta 4 gene is strongly activated in neural tissues during early postimplantation mouse development. Neurosci Lett. 1995 Jan 16;184(1):63-6
3*	J:184290 Choi BD, Yun SH, Jeong SJ, Wang G, Kim HJ, Lim DS, Jeong MJ, Expression of thymosin beta4 in odontoblasts during mouse tooth development. Int J Mol Med. 2012 May;29(5):841-7
12*	J:147939 Dhaese S, Vandepoele K, Waterschoot D, Vanloo B, Vandekerckhove J, Ampe C, Van Troys M, The mouse thymosin beta15 gene family displays unique complexity and encodes a functional thymosin repeat. J Mol Biol. 2009 Apr 10;387(4):809-25
1	J:164028 Firulli BA, McConville DP, Byers JS 3rd, Vincentz JW, Barnes RM, Firulli AB, Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010 Oct;239(10):2748-60
1*	J:136138 Ganguly K, Favor J, Neuhauser-Klaus A, Sandulache R, Puk O, Beckers J, Horsch M, Schadler S, Vogt Weisenhorn D, Wurst W, Graw J, Novel allele of crybb2 in the mouse and its expression in the brain. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1533-41
1	J:204566 Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM, Heard E, Brockdorff N, Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Mol Cell Biol. 2013 Aug;33(16):3150-65
5*	J:33143 Gomez-Marquez J, Franco del Amo F, Carpintero P, Anadon R, High levels of mouse thymosin beta4 mRNA in differentiating P19 embryonic cells and during development of cardiovascular tissues. Biochim Biophys Acta. 1996 May 2;1306(2-3):187-93
1	J:199408 Goudy S, Angel P, Jacobs B, Hill C, Mainini V, Smith AL, Kousa YA, Caprioli R, Prince LS, Baldwin S, Schutte BC, Cell-autonomous and non-cell-autonomous roles for IRF6 during development of the tongue. PLoS One. 2013;8(2):e56270
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
3*	J:79832 Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M, Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development. 2002 Dec;129(24):5767-78
1	J:210222 Hupe M, Li MX, Gertow Gillner K, Adams RH, Stenman JM, Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. 2014 Jan;42(2):e14
1*	J:116586 Li H, Bishop KM, O'Leary DD, Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Mol Cell Neurosci. 2006 Oct;33(2):136-49
4	J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
2	J:315498 Ookuma YF, Kiyoshima T, Kobayashi I, Nagata K, Wada H, Fujiwara H, Yamaza H, Nonaka K, Sakai H, Multiple functional involvement of thymosin beta-4 in tooth germ development. Histochem Cell Biol. 2013 Feb;139(2):355-70
7	J:195902 Rossdeutsch A, Smart N, Dube KN, Turner M, Riley PR, Essential role for thymosin beta4 in regulating vascular smooth muscle cell development and vessel wall stability. Circ Res. 2012 Aug 3;111(4):e89-102
1	J:81737 Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M, Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J Neurosci. 2003 Jan 15;23(2):550-60
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
11*	J:207642 Shiotsuka M, Wada H, Kiyoshima T, Nagata K, Fujiwara H, Kihara M, Hasegawa K, Someya H, Takahashi I, Sakai H, The expression and function of thymosin beta 10 in tooth germ development. Int J Dev Biol. 2013;57(11-12):873-83
6	J:186037 Smart N, Dube KN, Riley PR, Identification of Thymosin beta4 as an effector of Hand1-mediated vascular development. Nat Commun. 2010;1:46
3*	J:81324 Smart N, Hill AA, Cross JC, Riley PR, A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis. Mech Dev. 2002 Dec;119 Suppl 1:S65-71
2	J:118157 Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR, Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007 Jan 11;445(7124):177-82
1*	J:324832 Sun Y, Wang L, Zhu T, Wu B, Wang G, Luo Z, Li C, Wei W, Liu Z, Single-cell transcriptomic landscapes of the otic neuronal lineage at multiple early embryonic ages. Cell Rep. 2022 Mar 22;38(12):110542
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
6*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
4	J:309992 Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA, Loss of endogenous thymosin beta4 accelerates glomerular disease. Kidney Int. 2016 Nov;90(5):1056-1070
6	J:250600 Vieira JM, Howard S, Villa Del Campo C, Bollini S, Dube KN, Masters M, Barnette DN, Rohling M, Sun X, Hankins LE, Gavriouchkina D, Williams R, Metzger D, Chambon P, Sauka-Spengler T, Davies B, Riley PR, BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease. Nat Commun. 2017 Jul 24;8:16034
2*	J:74152 Yamaza H, Matsuo K, Kiyoshima T, Shigemura N, Kobayashi I, Wada H, Akamime A, Sakai H, Detection of differentially expressed genes in the early developmental stage of the mouse mandible. Int J Dev Biol. 2001 Jun;45(4):675-80
1	J:197419 Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T, Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8966-71