Gene Expression Literature Summary

• Symbol: Irs1
• Name: insulin receptor substrate 1
• ID: MGI:99454

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E7	E11	E11.5	E12.5	E13.5	E14	E14.5	E15	E16	E17	E18.5	P
Immunohistochemistry (section)							1
In situ RNA (section)								1
Northern blot		1	1						1		1		1
Western blot				1	1	1							2
RT-PCR	1				1			1	1	1		2	7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Irs1  insulin receptor substrate 1   (Synonyms: G972R, IRS-1)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:184234 Chirivella L, Cano-Jaimez M, Perez-Sanchez F, Herraez L, Carretero J, Farinas I, Burks DJ, Kirstein M, IRS2 signalling is required for the development of a subset of sensory spinal neurons. Eur J Neurosci. 2012 Feb;35(3):341-52
1	J:106827 Duvillie B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ, Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology. 2002 Apr;143(4):1530-7
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:170999 Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M, Post L, Duckers HJ, Nellist M, Elgersma Y, Rheb is essential for murine development. Mol Cell Biol. 2011 Apr;31(8):1672-8
1	J:124667 Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM, Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 1;309(1):137-49
3	J:333870 Jazwiec PA, Patterson VS, Ribeiro TA, Yeo E, Kennedy KM, Mathias PCF, Petrik JJ, Sloboda DM, Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism. Biol Reprod. 2022 Aug 9;107(2):574-589
1	J:326543 Jiang A, Guo H, Jiang X, Tao J, Wu W, Liu H, G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle. Int J Mol Sci. 2022 Jul 4;23(13)
1	J:94589 Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L, Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain. Transgenic Res. 2004 Oct;13(5):463-73
1	J:203690 Martinez-Lopez N, Athonvarangkul D, Sahu S, Coletto L, Zong H, Bastie CC, Pessin JE, Schwartz GJ, Singh R, Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development. EMBO Rep. 2013 Sep;14(9):795-803
1	J:149326 Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ, A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. Hum Mol Genet. 2009 Jul 1;18(13):2378-87
2*	J:46114 Puscheck EE, Pergament E, Patel Y, Dreschler J, Rappolee DA, Insulin receptor substrate-1 is expressed at high levels in all cells of the peri-implantation mouse embryo. Mol Reprod Dev. 1998 Apr;49(4):386-93
4*	J:43854 Sciacchitano S, Taylor SI, Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology. 1997 Nov;138(11):4931-40
2*	J:152946 Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA, Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice. Biol Reprod. 2009 Jul;81(1):207-21
1	J:86157 Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A, Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis. 2003 Sep;37(1):5-11
1	J:262992 Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A, Liu C, Gavrilova O, Ge K, Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796
1	J:168571 Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B, Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell. 2011 Jan 18;20(1):97-108