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Gene Expression Literature Summary
Symbol
Name
ID
Tshb
thyroid stimulating hormone, beta subunit
MGI:98848

80 matching records from 80 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E6.5 E7.5 E8.5 E9.5 E11.5 E12 E12.5 E13.5 E14 E14.5 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E A
In situ protein (section) 1 1 4 4 4 1 16 2 14 2 24
In situ RNA (section) 1 2 3 3 4 3 8 10 6 3 10
Northern blot 2
RT-PCR 1 1 1 1 1 1 2 1 1 1 8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Tshb  thyroid stimulating hormone, beta subunit   (Synonyms: thyrotropin)
Results  Reference
2J:165061 Akimoto M, Nishimaki T, Arai Y, Uchinuma E, Yamauchi H, Kameda Y, Hes1 regulates formations of the hypophyseal pars tuberalis and the hypothalamus. Cell Tissue Res. 2010 Jun;340(3):509-21
3J:30290 Andersen B, Pearse RV 2nd, Jenne K, Sornson M, Lin SC, Bartke A, Rosenfeld MG, The Ames dwarf gene is required for Pit-1 gene activation. Dev Biol. 1995 Dec;172(2):495-503
2J:56185 Bentley CA, Zidehsarai MP, Grindley JC, Parlow AF, Barth-Hall S, Roberts VJ, Pax6 is implicated in murine pituitary endocrine function. Endocrine. 1999 Apr;10(2):171-7
1J:169150 Bharti K, Gasper M, Bertuzzi S, Arnheiter H, Lack of the ventral anterior homeodomain transcription factor VAX1 leads to induction of a second pituitary. Development. 2011 Mar;138(5):873-8
1J:41856 Bosse R, Fumagalli F, Jaber M, Giros B, Gainetdinov RR, Wetsel WC , Missale C , Caron MG, Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. 1997 Jul;19(1):127-38
3J:193143 Bouchoucha YX, Charnay P, Gilardi-Hebenstreit P, Ablation of Egr2-positive cells in male mouse anterior pituitary leads to atypical isolated GH deficiency. Endocrinology. 2013 Jan;154(1):270-82
2J:86317 Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA, TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol. 2003 Nov;17(11):2152-61
2J:127546 Brinkmeier ML, Potok MA, Davis SW, Camper SA, TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol. 2007 Nov 15;311(2):396-407
1J:188254 Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honore A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J, The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
1J:36590 Burrows HL, Birkmeier TS, Seasholtz AF, Camper SA, Targeted ablation of cells in the pituitary primordia of transgenic mice. Mol Endocrinol. 1996 Nov;10(11):1467-77
1*J:90448 Cha KB, Douglas KR, Potok MA, Liang H, Jones SN, Camper SA, WNT5A signaling affects pituitary gland shape. Mech Dev. 2004 Feb;121(2):183-94
1J:99227 Charles MA, Suh H, Hjalt TA, Drouin J, Camper SA, Gage PJ, PITX genes are required for cell survival and Lhx3 activation. Mol Endocrinol. 2005 Jul;19(7):1893-903
1J:127370 Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR, Pubertal Impairment in Nhlh2 Null Mice Is Associated with Hypothalamic and Pituitary Deficiencies. Mol Endocrinol. 2007 Dec;21(12):3013-3027
1*J:73085 Dasen JS, Barbera JP, Herman TS, Connell SO, Olson L, Ju B, Tollkuhn J, Baek SH, Rose DW, Rosenfeld MG, Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. Genes Dev. 2001 Dec 1;15(23):3193-207
4J:70561 Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG, Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell. 1999 May 28;97(5):587-98
2J:121318 Davis SW, Camper SA, Noggin regulates Bmp4 activity during pituitary induction. Dev Biol. 2007 May 1;305(1):145-60
1J:171477 Davis SW, Mortensen AH, Camper SA, Birthdating studies reshape models for pituitary gland cell specification. Dev Biol. 2011 Apr 15;352(2):215-27
1J:190411 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY, Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem. 2012 Sep 14;287(38):32172-9
1J:114716 Ellsworth BS, Egashira N, Haller JL, Butts DL, Cocquet J, Clay CM, Osamura RY, Camper SA, FOXL2 in the pituitary: molecular, genetic, and developmental analysis. Mol Endocrinol. 2006 Nov;20(11):2796-805
1*J:46975 Ericson J, Norlin S, Jessell TM, Edlund T, Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary. Development. 1998 Mar;125(6):1005-15
2J:37083 Gage PJ, Brinkmeier ML, Scarlett LM, Knapp LT, Camper SA, Mahon KA, The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation. Mol Endocrinol. 1996 Dec;10(12):1570-81
2J:174144 Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP, From the Cover: Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7
2J:142425 Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP, Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol. 2008 Dec 15;324(2):322-33
2J:195620 Gumbel JH, Patterson EM, Owusu SA, Kabat BE, Jung DO, Simmons J, Hopkins T, Ellsworth BS, The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS One. 2012;7(12):e52156
1J:143548 Himes AD, Raetzman LT, Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1. Dev Biol. 2009 Jan 1;325(1):151-61
1J:53226 Hitzler JK, Soares HD, Drolet DW, Inaba T, O'Connel S, MG Rosenfeld , Morgan JI , Look AT, Expression patterns of the hepatic leukemia factor gene in the nervous system of developing and adult mice. Brain Res. 1999 Feb 27;820(1-2):1-11
4*J:76131 Holley SJ, Hall SB, Mellon PL, Complementary Expression of IGF-II and IGFBP-5 during Anterior Pituitary Development. Dev Biol. 2002 Apr 15;244(2):319-28
1J:61840 Ito M, Yuan CX, Okano HJ, Darnell RB, Roeder RG, Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell. 2000 Apr;5(4):683-93
9*J:19457 Japon MA, Rubinstein M, Low MJ, In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. J Histochem Cytochem. 1994 Aug;42(8):1117-25
2J:191667 Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP, SOX2 regulates the hypothalamic-pituitary axis at multiple levels. J Clin Invest. 2012 Oct 1;122(10):3635-46
1J:80691 Kioussi C, Briata P, Baek SH, Rose DW, Hamblet NS, Herman T, Ohgi KA, Lin C, Gleiberman A, Wang J, Brault V, Ruiz-Lozano P, Nguyen HD, Kemler R, Glass CK, Wynshaw-Boris A, Rosenfeld MG, Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 Pathway Mediating Cell-Type-Specific Proliferation during Development. Cell. 2002 Nov 27;111(5):673-85
2J:58952 Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG, Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82
1J:121843 Kita A, Imayoshi I, Hojo M, Kitagawa M, Kokubu H, Ohsawa R, Ohtsuka T, Kageyama R, Hashimoto N, Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol. 2007 Jun;21(6):1458-66
1J:104339 Li X, Perissi V, Liu F, Rose DW, Rosenfeld MG, Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science. 2002 Aug 16;297(5584):1180-3
1J:57673 Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisua-Belmonte JC, Rosenfeld MG, Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature. 1999 Sep 16;401(6750):279-82
8J:17223 Lin SC, Li S, Drolet DW, Rosenfeld MG, Pituitary ontogeny of the Snell dwarf mouse reveals Pit-1-independent and Pit-1-dependent origins of the thyrotrope. Development. 1994 Mar;120(3):515-22
2J:70462 Liu J, Lin C, Gleiberman A, Ohgi KA, Herman T, Huang HP, Tsai MJ, Rosenfeld MG, Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8674-9
2J:161784 Lyashenko N, Weissenbock M, Sharir A, Erben RG, Minami Y, Hartmann C, Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn. 2010 Jun 30;
1J:178252 McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT, Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction. J Clin Endocrinol Metab. 2011 Oct;96(10):E1709-18
4*J:125491 McKnight KD, Hou J, Hoodless PA, Dynamic expression of Thyrotropin-releasing hormone in the mouse definitive endoderm. Dev Dyn. 2007 Oct;236(10):2909-17
1J:168181 Metz H, Wray S, Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis. Endocrinology. 2010 Feb;151(2):766-73
1J:50772 Michaud JL, Rosenquist T, May NR, Fan CM, Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 1998 Oct 15;12(20):3264-75
1J:140899 Million Passe CM, White CR, King MW, Quirk PL, Iovanna JL, Quirk CC, Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice. Biol Reprod. 2008 Oct;79(4):598-607
1J:182904 Moran TB, Goldberg LB, Serviss SL, Raetzman LT, Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation. Mol Endocrinol. 2011 Jan;25(1):117-27
2J:94409 Nasonkin IO, Ward RD, Raetzman LT, Seasholtz AF, Saunders TL, Gillespie PJ, Camper SA, Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Hum Mol Genet. 2004 Nov 15;13(22):2727-35
2J:114817 Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG, Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell. 2006 May 5;125(3):593-605
2J:114149 Pope C, McNeilly JR, Coutts S, Millar M, Anderson RA, McNeilly AS, Gonadotrope and thyrotrope development in the human and mouse anterior pituitary gland. Dev Biol. 2006 Sep 1;297(1):172-81
2J:132979 Potok MA, Cha KB, Hunt A, Brinkmeier ML, Leitges M, Kispert A, Camper SA, WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn. 2008 Apr;237(4):1006-20
2J:194768 Prince KL, Colvin SC, Park S, Lai X, Witzmann FA, Rhodes SJ, Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease. Endocrinology. 2013 Feb;154(2):738-48
1J:82562 Pulichino AM, Vallette-Kasic S, Tsai JP, Couture C, Gauthier Y, Drouin J, Tpit determines alternate fates during pituitary cell differentiation. Genes Dev. 2003 Mar 15;17(6):738-47
1J:143958 Qi Y, Ranish JA, Zhu X, Krones A, Zhang J, Aebersold R, Rose DW, Rosenfeld MG, Carriere C, Atbf1 is required for the Pit1 gene early activation. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2481-6
1J:122509 Raetzman LT, Cai JX, Camper SA, Hes1 is required for pituitary growth and melanotrope specification. Dev Biol. 2007 Apr 15;304(2):455-66
1J:79850 Raetzman LT, Ward R, Camper SA, Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Development. 2002 Sep;129(18):4229-39
2J:114717 Raetzman LT, Wheeler BS, Ross SA, Thomas PQ, Camper SA, Persistent expression of Notch2 delays gonadotrope differentiation. Mol Endocrinol. 2006 Nov;20(11):2898-908
1J:188151 Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M, Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
1J:142649 Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP, Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech. 2008 Nov;1(4-5):241-54
1J:44644 Sheng HZ, Moriyama K, Yamashita T, Li H, Potter SS, Mahon KA, Westphal H, Multistep control of pituitary organogenesis. Science. 1997 Dec 5;278(5344):1809-12
1J:33050 Sheng HZ, Zhadanov AB, Mosinger B Jr, Fujii T, Bertuzzi S, Grinberg A, Lee EJ, Huang SP, Mahon KA, Westphal H, Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science. 1996 May 17;272(5264):1004-7
3J:59141 Shibusawa N, Yamada M, Hirato J, Monden T, Satoh T, Mori M, Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice. Mol Endocrinol. 2000 Jan;14(1):137-46
1J:36967 Sornson MW, Wu W, Dasen JS, Flynn SE, Norman DJ, O'Connell SM, Gukovsky I, Carriere C, Ryan AK, Miller AP, Zuo L, Gleiberman AS, Andersen B, Beamer WG, Rosenfeld MG, Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism. Nature. 1996 Nov 28;384(6607):327-33
2J:108805 Stefaneanu L, Powell-Braxton L, Won W, Chandrashekar V, Bartke A, Somatotroph and lactotroph changes in the adenohypophyses of mice with disrupted insulin-like growth factor I gene. Endocrinology. 1999 Sep;140(9):3881-9
1J:73774 Suh H, Gage PJ, Drouin J, Camper SA, Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification. Development. 2002 Jan;129(2):329-37
2J:190867 Sun Y, Bak B, Schoenmakers N, van Trotsenburg AS, Oostdijk W, Voshol P, Cambridge E, White JK, le Tissier P, Gharavy SN, Martinez-Barbera JP, Stokvis-Brantsma WH, Vulsma T, Kempers MJ, Persani L, Campi I, Bonomi M, Beck-Peccoz P, Zhu H, Davis TM, Hokken-Koelega AC, Del Blanco DG, Rangasami JJ, Ruivenkamp CA, Laros JF, Kriek M, Kant SG, Bosch CA, Biermasz NR, Appelman-Dijkstra NM, Corssmit EP, Hovens GC, Pereira AM, den Dunnen JT, Wade MG, Breuning MH, Hennekam RC, Chatterjee K, Dattani MT, Wit JM, Bernard, Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet. 2012 Dec;44(12):1375-81
2J:53310 Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG, Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94
3J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
1J:66789 Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG, Hedgehog signaling is required for pituitary gland development. Development. 2001 Feb;128(3):377-86
1J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
3J:108374 Vesper AH, Raetzman LT, Camper SA, Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology. 2006 Apr;147(4):1654-63
1J:166513 Wallis K, Dudazy S, van Hogerlinden M, Nordstrom K, Mittag J, Vennstrom B, The thyroid hormone receptor alpha1 protein is expressed in embryonic postmitotic neurons and persists in most adult neurons. Mol Endocrinol. 2010 Oct;24(10):1904-16
3*J:121427 Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG, Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19;446(7138):882-7
1J:166929 Wang Y, Martin JF, Bai CB, Direct and indirect requirements of Shh/Gli signaling in early pituitary development. Dev Biol. 2010 Dec 15;348(2):199-209
1J:108961 Ward RD, Stone BM, Raetzman LT, Camper SA, Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol. 2006 Jun;20(6):1378-90
1J:201463 Watson LA, Solomon LA, Li JR, Jiang Y, Edwards M, Shin-ya K, Beier F, Berube NG, Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
2J:164366 Wen S, Ai W, Alim Z, Boehm U, Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16372-7
2*J:13323 Wilson DB, Wyatt DP, Immunocytochemistry of ambiguous cells in adult and embryonic dwarf (dw) mouse pituitaries. Anat Rec. 1993 Aug;236(4):671-8
6*J:108438 Yanagi Y, Takezawa S, Kato S, Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3489-94
1J:166872 Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA, MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010 Nov 5;285(45):34718-28
1J:182725 Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ, Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell. 2012 Mar 13;22(3):585-96
1J:157264 Zhao Y, Mailloux CM, Hermesz E, Palkovits M, Westphal H, A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol. 2010 Jan 15;337(2):313-23
3J:112960 Zhu X, Zhang J, Tollkuhn J, Ohsawa R, Bresnick EH, Guillemot F, Kageyama R, Rosenfeld MG, Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev. 2006 Oct 1;20(19):2739-53

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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory