Gene Expression Literature Summary
|
Symbol Name ID |
Trp53
transformation related protein 53 MGI:98834 |
| Age | E0.5 | E1 | E1.5 | E2 | E2.5 | E3 | E3.5 | E4 | E4.5 | E5.5 | E6 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E20 | E | P |
| Immunohistochemistry (section) | 1 | 3 | 9 | 3 | 12 | 6 | 1 | 14 | 2 | 22 | 2 | 22 | 1 | 30 | 3 | 30 | 31 | 3 | 20 | 2 | 11 | 3 | 8 | 3 | 8 | 1 | 1 | 9 | 42 | ||||||||||||
| In situ RNA (section) | 1 | 2 | 3 | 5 | 1 | 3 | 1 | 6 | 4 | 1 | 6 | 2 | 2 | 3 | 9 | ||||||||||||||||||||||||||
| Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | |||||||||||||||||||||||||||||||||
| In situ RNA (whole mount) | 1 | 1 | 3 | 8 | 4 | 1 | 5 | 4 | 1 | ||||||||||||||||||||||||||||||||
| In situ reporter (knock in) | 1 | ||||||||||||||||||||||||||||||||||||||||
| Northern blot | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 4 | ||||||||||||||||||||
| Western blot | 1 | 4 | 1 | 3 | 15 | 1 | 5 | 1 | 7 | 2 | 18 | 1 | 14 | 1 | 13 | 4 | 1 | 5 | 4 | 7 | 1 | 1 | 1 | 8 | 45 | ||||||||||||||||
| RT-PCR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 7 | 3 | 9 | 2 | 5 | 1 | 5 | 1 | 7 | 1 | 9 | 6 | 2 | 7 | 1 | 7 | 1 | 5 | 2 | 4 | 2 | 5 | 31 | ||||||||
| cDNA clones | 1 | 1 |
| Trp53 transformation related protein 53 (Synonyms: p44, p53) | |
| Results | Reference |
| 3 | J:167536 Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G, Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010 Nov 5;7(5):606-17 |
| 1 | J:182789 Abe K, Naruse C, Kato T, Nishiuchi T, Saitou M, Asano M, Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice. Biol Reprod. 2011 Nov;85(5):1013-24 |
| 10 | J:183431 Aboudehen K, Hilliard S, Saifudeen Z, El-Dahr SS, Mechanisms of p53 activation and physiological relevance in the developing kidney. Am J Physiol Renal Physiol. 2012 Apr;302(8):F928-40 |
| 3* | J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175 |
| 3 | J:326544 Alam SS, Kumar S, Beauchamp MC, Bareke E, Boucher A, Nzirorera N, Dong Y, Padilla R, Zhang SJ, Majewski J, Jerome-Majewska LA, Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis. Dis Model Mech. 2022 Jun 1;15(6):dmm049544 |
| 3* | J:271028 Albers E, Sbroggio M, Pladevall-Morera D, Bizard AH, Avram A, Gonzalez P, Martin-Gonzalez J, Hickson ID, Lopez-Contreras AJ, Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep. 2018 Sep 18;24(12):3274-3284 |
| 1 | J:227638 Alvarez S, Diaz M, Flach J, Rodriguez-Acebes S, Lopez-Contreras AJ, Martinez D, Canamero M, Fernandez-Capetillo O, Isern J, Passegue E, Mendez J, Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548 |
| 1 | J:275626 Anamthathmakula P, Miryala CSJ, Moreci RS, Kyathanahalli C, Hassan SS, Condon JC, Jeyasuria P, Steroidogenic Factor 1 (Nr5a1) is Required for Sertoli Cell Survival Post Sex Determination. Sci Rep. 2019 Mar 14;9(1):4452 |
| 2* | J:290235 Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J, Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10 |
| 1 | J:299451 Atkins A, Xu MJ, Li M, Rogers NP, Pryzhkova MV, Jordan PW, SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. Elife. 2020 Nov 17;9:e61171 |
| 11* | J:148991 Barkic M, Crnomarkovic S, Grabusic K, Bogetic I, Panic L, Tamarut S, Cokaric M, Jeric I, Vidak S, Volarevic S, The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival. Mol Cell Biol. 2009 May;29(10):2489-504 |
| 3 | J:200017 Barritt LC, Miller JM, Scheetz LR, Gardner K, Pierce ML, Soukup GA, Rocha-Sanchez SM, Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development. Indian J Hum Genet. 2012 Sep;18(3):310-9 |
| 2* | J:266583 Baumgartner M, Olthof AM, Aquino GS, Hyatt KC, Lemoine C, Drake K, Sturrock N, Nguyen N, Al Seesi S, Kanadia RN, Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells. Development. 2018 Aug 28;145(17):dev166322 |
| 3 | J:208632 Bazzi H, Anderson KV, Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500 |
| 1* | J:327815 Beauchamp MC, Boucher A, Dong Y, Aber R, Jerome-Majewska LA, Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion. Int J Mol Sci. 2022 Aug 12;23(16) |
| 1* | J:278323 Beauchamp MC, Djedid A, Daupin K, Clokie K, Kumar S, Majewski J, Jerome-Majewska LA, Loss of function mutation of Eftud2, the gene responsible for mandibulofacial dysostosis with microcephaly (MFDM), leads to pre-implantation arrest in mouse. PLoS One. 2019;14(7):e0219280 |
| 1 | J:260599 Belanger C, Berube-Simard FA, Leduc E, Bernas G, Campeau PM, Lalani SR, Martin DM, Bielas S, Moccia A, Srivastava A, Silversides DW, Pilon N, Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E620-E629 |
| 2 | J:261973 Bellelli R, Borel V, Logan C, Svendsen J, Cox DE, Nye E, Metcalfe K, O'Connell SM, Stamp G, Flynn HR, Snijders AP, Lassailly F, Jackson A, Boulton SJ, Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018 May 17;70(4):707-721.e7 |
| 1 | J:201097 Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffe M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA, Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J. 2013 Sep;27(9):3594-607 |
| 1 | J:255747 Berenjeno IM, Pineiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B, Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun. 2017 Nov 24;8(1):1773 |
| 1 | J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322 |
| 1 | J:252554 Bianchi FT, Tocco C, Pallavicini G, Liu Y, Verni F, Merigliano C, Bonaccorsi S, El-Assawy N, Priano L, Gai M, Berto GE, Chiotto AM, Sgro F, Caramello A, Tasca L, Ala U, Neri F, Oliviero S, Mauro A, Geley S, Gatti M, Di Cunto F, Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly. Cell Rep. 2017 Feb 14;18(7):1674-1686 |
| 1 | J:173627 Billington CJ Jr, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A, The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice. Dev Biol. 2011 Jul 1;355(1):21-31 |
| 1 | J:220864 Billmyre KK, Klingensmith J, Sonic hedgehog from pharyngeal arch 1 epithelium is necessary for early mandibular arch cell survival and later cartilage condensation differentiation. Dev Dyn. 2015 Apr;244(4):564-76 |
| 3 | J:319558 Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H, Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022; |
| 1 | J:132251 Boesten LS, Zadelaar SM, De Clercq S, Francoz S, van Nieuwkoop A, Biessen EA, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJ, Marine JC, Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. Cell Death Differ. 2006 Dec;13(12):2089-98 |
| 6 | J:234991 Bonney EA, Krebs K, Saade G, Kechichian T, Trivedi J, Huaizhi Y, Menon R, Differential senescence in feto-maternal tissues during mouse pregnancy. Placenta. 2016 Jul;43:26-34 |
| 3 | J:284146 Bowen ME, McClendon J, Long HK, Sorayya A, Van Nostrand JL, Wysocka J, Attardi LD, The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes. Dev Cell. 2019 Jul 22;50(2):212-228.e6 |
| 1 | J:240157 Breuss M, Fritz T, Gstrein T, Chan K, Ushakova L, Yu N, Vonberg FW, Werner B, Elling U, Keays DA, Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 2016 Apr 01;143(7):1126-33 |
| 2 | J:334092 Broadway-Stringer S, Jiang H, Wadmore K, Hooper C, Douglas G, Steeples V, Azad AJ, Singer E, Reyat JS, Galatik F, Ehler E, Bennett P, Kalisch-Smith JI, Sparrow DB, Davies B, Djinovic-Carugo K, Gautel M, Watkins H, Gehmlich K, Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2. Cells. 2023 Feb 24;12(5) |
| 3 | J:257747 Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J, Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature. 2018 Feb 1;554(7690):112-117 |
| 3 | J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61 |
| 2 | J:289039 Candi E, Rufini A, Terrinoni A, Giamboi-Miraglia A, Lena AM, Mantovani R, Knight R, Melino G, DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11999-2004 |
| 1 | J:125911 Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP, DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2733-7 |
| 1 | J:56509 Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oostuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, HerbertJM, Collen D, Dejana E, Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57 |
| 1 | J:229460 Chaffee BR, Hoang TV, Leonard MR, Bruney DG, Wagner BD, Dowd JR, Leone G, Ostrowski MC, Robinson ML, FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol. 2016 Feb 15;410(2):150-63 |
| 1 | J:300487 Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG, Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 Jan 20;109(2):241-256.e9 |
| 3* | J:94934 Challen GA, Martinez G, Davis MJ, Taylor DF, Crowe M, Teasdale RD, Grimmond SM, Little MH, Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol. 2004 Sep;15(9):2344-57 |
| 2 | J:231798 Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR, Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922 |
| 1 | J:74730 Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA, Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 7;21(7):1028-37 |
| 1* | J:65993 Chen Q, Hung FC, Fromm L, Overbeek PA, Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2. Invest Ophthalmol Vis Sci. 2000 Dec;41(13):4223-31 |
| 1 | J:238877 Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El-Dahr SS, Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15;142(6):1180-92 |
| 1* | J:89992 Chen ST, Chuang JI, Wang JP, Tsai MS, Li H, Chang NS, Expression of WW domain-containing oxidoreductase WOX1 in the developing murine nervous system. Neuroscience. 2004;124(4):831-9 |
| 1* | J:211539 Chen Y, Gridley T, Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res. 2013 Jun;28(6):1412-21 |
| 2 | J:306148 Chen Y, Sun J, Ju Z, Wang ZQ, Li T, Nbs1-mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis. Cell Prolif. 2021 Mar;54(3):e12972 |
| 2 | J:342014 Chen Y, Zhou T, Liao Z, Gao W, Wu J, Zhang S, Li Y, Liu H, Zhou H, Xu C, Su P, Hnrnpk is essential for embryonic limb bud development as a transcription activator and a collaborator of insulator protein Ctcf. Cell Death Differ. 2023 Oct;30(10):2293-2308 |
| 2 | J:343798 Cheng T, Agwu C, Shim K, Wang B, Jain S, Mahjoub MR, Aberrant centrosome biogenesis disrupts nephron and collecting duct progenitor growth and fate resulting in fibrocystic kidney disease. Development. 2023 Dec 15;150(24) |
| 3 | J:119657 Cheng W, Jacobs WB, Zhang JJ, Moro A, Park JH, Kushida M, Qiu W, Mills AA, Kim PC, DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development. 2006 Dec;133(23):4783-92 |
| 2* | J:290315 Cheong A, Archambault D, Degani R, Iverson E, Tremblay KD, Mager J, Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 May 26;147(10):dev188714 |
| 7 | J:169705 Ching BJ, Wittler L, Proske J, Yagnik G, Qi L, Draaken M, Reutter H, Gearhart JP, Ludwig M, Boyadjiev SA, p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue. Int J Mol Med. 2010 Dec;26(6):861-7 |
| 3 | J:144707 Chiu SY, Asai N, Costantini F, Hsu W, SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310 |
| 1 | J:281616 Chizhikov VV, Iskusnykh IY, Steshina EY, Fattakhov N, Lindgren AG, Shetty AS, Roy A, Tole S, Millen KJ, Early dorsomedial tissue interactions regulate gyrification of distal neocortex. Nat Commun. 2019 Nov 15;10(1):5192 |
| 1 | J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502 |
| 1 | J:101353 Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG, Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005 Oct;25(20):8874-86 |
| 4 | J:332969 Comerford SA, Hinnant EA, Chen Y, Hammer RE, Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent. PLoS Genet. 2023 Jan;19(1):e1010595 |
| 1 | J:40384 Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH, Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91 |
| 5 | J:306061 Damen M, Wirtz L, Soroka E, Khatif H, Kukat C, Simons BD, Bazzi H, High proliferation and delamination during skin epidermal stratification. Nat Commun. 2021 May 28;12(1):3227 |
| 2 | J:317403 De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, Haigh JJ, Marine JC, Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo. Mol Cell Biol. 2010 Nov;30(22):5394-405 |
| 1 | J:57767 Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, Elson D, Arbeit J, Kipreos ET, Johnson RS, Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999 Oct;23(2):245-8 |
| 1 | J:206142 Delgado-Esteban M, Garcia-Higuera I, Maestre C, Moreno S, Almeida A, APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat Commun. 2013;4:2879 |
| 1 | J:297431 Dewhurst MR, Ow JR, Zafer G, van Hul NKM, Wollmann H, Bisteau X, Brough D, Choi H, Kaldis P, Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020 Nov;16(11):e1009084 |
| 2 | J:77297 Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 2000 Oct;28(1):115-27 |
| 2 | J:221164 Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM, Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93 |
| 1 | J:131874 Di-Poi N, Zakany J, Duboule D, Distinct Roles and Regulations for Hoxd Genes in Metanephric Kidney Development. PLoS Genet. 2007 Dec 21;3(12):e232 |
| 1* | J:158898 Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Bottger T, Harvey RP, Tucker PW, Engel FB, Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One. 2010;5(3):e9748 |
| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 1 | J:129010 Dirlam A, Spike BT, Macleod KF, Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol. 2007 Dec;27(24):8713-28 |
| 1 | J:169134 Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X, Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Development. 2011 Mar;138(5):971-81 |
| 1 | J:233087 Dong D, Yu J, Wu Y, Fu N, Villela NA, Yang P, Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem Biophys Res Commun. 2015 Nov 13;467(2):407-12 |
| 2 | J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104 |
| 1 | J:181779 Driskell I, Oda H, Blanco S, Nascimento E, Humphreys P, Frye M, The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J. 2012 Feb 1;31(3):616-29 |
| 2* | J:54066 Dupe V, Ghyselinck NB, Thomazy V, Nagy L, Davies PJA, Chambon P, Mark M, Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev Biol. 1999 Apr 1;208(1):30-43 |
| 4 | J:206141 Eguren M, Porlan E, Manchado E, Garcia-Higuera I, Canamero M, Farinas I, Malumbres M, The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun. 2013;4:2880 |
| 5 | J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027 |
| 1 | J:239152 Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ, DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. J Neurosci. 2017 Jan 25;37(4):893-905 |
| 2* | J:158790 Eun B, Cho B, Moon Y, Kim SY, Kim K, Kim H, Sun W, Induction of neuronal apoptosis by expression of Hes6 via p53-dependent pathway. Brain Res. 2010 Feb 8;1313:1-8 |
| 1 | J:267941 Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC, Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017 Aug 2;7(1):7129 |
| 2 | J:332795 Falcon KT, Watt KEN, Dash S, Zhao R, Sakai D, Moore EL, Fitriasari S, Childers M, Sardiu ME, Swanson S, Tsuchiya D, Unruh J, Bugarinovic G, Li L, Shiang R, Achilleos A, Dixon J, Dixon MJ, Trainor PA, Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development. Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2116974119 |
| 2* | J:211289 Fantauzzo KA, Soriano P, PI3K-mediated PDGFRalpha signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev. 2014 May 1;28(9):1005-17 |
| 1 | J:190019 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC, The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J. 2012 Oct 17;31(20):4045-56 |
| 1* | J:85726 Fernandez EL, Gustafson AL, Andersson M, Hellman B, Dencker L, Cadmium-induced changes in apoptotic gene expression levels and DNA damage in mouse embryos are blocked by zinc. Toxicol Sci. 2003 Nov;76(1):162-70 |
| 1 | J:305200 Fernandez V, Martinez-Martinez MA, Prieto-Colomina A, Cardenas A, Soler R, Dori M, Tomasello U, Nomura Y, Lopez-Atalaya JP, Calegari F, Borrell V, Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium. EMBO J. 2020 Nov 2;39(21):e105479 |
| 2 | J:173575 Fernandez-Miranda G, Trakala M, Martin J, Escobar B, Gonzalez A, Ghyselinck NB, Ortega S, Canamero M, de Castro IP, Malumbres M, Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development. 2011 Jul;138(13):2661-72 |
| 2 | J:201646 Forsberg K, Wuttke A, Quadrato G, Chumakov PM, Wizenmann A, Di Giovanni S, The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci. 2013 Sep 4;33(36):14318-30 |
| 1 | J:258502 Fouchecourt S, Livera G, Messiaen S, Fumel B, Parent AS, Marine JC, Monget P, Apoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility. Cell Death Differ. 2016 Mar;23(3):521-30 |
| 3* | J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998; |
| 1* | J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408 |
| 1 | J:149918 Fuchs S, Herzog D, Sumara G, Buchmann-Moller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L, Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell. 2009 Mar 6;4(3):236-47 |
| 3 | J:316577 Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, Del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barila D, Maina F, Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. J Hepatol. 2012 Dec;57(6):1292-8 |
| 2 | J:282259 Gal H, Lysenko M, Stroganov S, Vadai E, Youssef SA, Tzadikevitch-Geffen K, Rotkopf R, Biron-Shental T, de Bruin A, Neeman M, Krizhanovsky V, Molecular pathways of senescence regulate placental structure and function. EMBO J. 2019 Sep 16;38(18):e100849 |
| 1 | J:216295 Garnatz AS, Gao Z, Broman M, Martens S, Earley JU, Svensson EC, FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 1;395(1):50-61 |
| 1 | J:253771 Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Moroy T, Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells. Sci Rep. 2016 Jun 7;6:27379 |
| 2 | J:202989 George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F, Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18698-703 |
| 4 | J:193959 Georgia S, Kanji M, Bhushan A, DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15;27(4):372-7 |
| 1 | J:286645 Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J, Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny. Hum Mol Genet. 2020 Mar 27;29(5):766-784 |
| 1 | J:108789 Gladdy RA, Nutter LM, Kunath T, Danska JS, Guidos CJ, p53-Independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol Cancer Res. 2006 May;4(5):311-8 |
| 4 | J:309499 Goh AM, Xue Y, Leushacke M, Li L, Wong JS, Chiam PC, Rahmat SA, Mann MB, Mann KM, Barker N, Lozano G, Terzian T, Lane DP, Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 2015 Jul 20;6(20):17968-80 |
| 2 | J:310617 Gonzalez-Martinez J, Cwetsch AW, Martinez-Alonso D, Lopez-Sainz LR, Almagro J, Melati A, Gomez J, Perez-Martinez M, Megias D, Boskovic J, Gilabert-Juan J, Grana-Castro O, Pierani A, Behrens A, Ortega S, Malumbres M, Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias. JCI Insight. 2021 Aug 23;6(16) |
| 1 | J:213699 Granier CJ, Wang W, Tsang T, Steward R, Sabaawy HE, Bhaumik M, Rabson AB, Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Biol Open. 2014;3(9):821-31 |
| 3* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
| 1 | J:104114 Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G, Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol. 2006 Jan;26(1):192-8 |
| 1 | J:115359 Grotewold L, Ruther U, The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death. EMBO J. 2002 Mar 1;21(5):966-75 |
| 3* | J:308830 Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR, p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet. 2021 Aug;53(8):1207-1220 |
| 2* | J:293342 Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, Sun Z, Zhang H, Wang J, Gao X, Wang J, Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice. Mol Reprod Dev. 2015 Jun;82(6):475-88 |
| 1 | J:189718 Gu Z, Liu Y, Zhang Y, Jin S, Chen Q, Goltzman D, Karaplis A, Miao D, Absence of PTHrP nuclear localization and carboxyl terminus sequences leads to abnormal brain development and function. PLoS One. 2012;7(7):e41542 |
| 2* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
| 1 | J:117093 Gui H, Li S, Matise MP, A cell-autonomous requirement for Cip/Kip cyclin-kinase inhibitors in regulating neuronal cell cycle exit but not differentiation in the developing spinal cord. Dev Biol. 2007 Jan 1;301(1):14-26 |
| 7* | J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85 |
| 2* | J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595 |
| 1 | J:292120 Guo Y, Sui JY, Kim K, Zhang Z, Qu XA, Nam YJ, Willette RN, Barnett JV, Knollmann BC, Force T, Lal H, Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling. Circulation. 2019 Nov 26;140(22):1820-1833 |
| 2* | J:33880 Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW, The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23 |
| 4* | J:201153 Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ, The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1;27(17):1868-85 |
| 1 | J:271634 Hamard PJ, Santiago GE, Liu F, Karl DL, Martinez C, Man N, Mookhtiar AK, Duffort S, Greenblatt S, Verdun RE, Nimer SD, PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes. Cell Rep. 2018 Sep 4;24(10):2643-2657 |
| 3 | J:316639 He MY, Wang G, Han SS, Jin Y, Li H, Wu X, Ma ZL, Cheng X, Tang X, Yang X, Liu GS, Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta. Open Biol. 2016 Jul;6(7) |
| 2 | J:170248 Hernandez-Acosta NC, Cabrera-Socorro A, Morlans MP, Delgado FJ, Suarez-Sola ML, Sottocornola R, Lu X, Gonzalez-Gomez M, Meyer G, Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood. Brain Res. 2011 Feb 4;1372:29-40 |
| 1 | J:279070 Hernandez-Martinez R, Ramkumar N, Anderson KV, p120-catenin regulates WNT signaling and EMT in the mouse embryo. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16872-16881 |
| 8* | J:173795 Hilliard S, Aboudehen K, Yao X, El-Dahr SS, Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching. Dev Biol. 2011 May 15;353(2):354-66 |
| 2* | J:207609 Hilliard SA, Yao X, El-Dahr SS, Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14 |
| 3 | J:264903 Hoang TV, Horowitz ER, Chaffee BR, Qi P, Flake RE, Bruney DG, Rasor BJ, Rosalez SE, Wagner BD, Robinson ML, Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity. Epigenetics. 2017 Jan 2;12(1):27-40 |
| 6* | J:31948 Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF, Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting issue-specific and cell cycle-regulated expressions. J Biol Chem. 1996 Mar 15;271(11):6050-61 |
| 2 | J:218049 Houlihan SL, Feng Y, The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. Elife. 2014;3:e03297 |
| 7* | J:257563 Huang K, Wang Y, Zhang T, He M, Sun G, Wen J, Yan H, Cai H, Yong C, Xia G, Wang C, JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. Biol Open. 2018 Jan 17;7(1):bio029470 |
| 1 | J:174359 Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM, The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12001-6 |
| 1 | J:131838 Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, Zhang P, Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 2008 Jan;6(1):e15 |
| 1 | J:308554 Humpton TJ, Nomura K, Weber J, Magnussen HM, Hock AK, Nixon C, Dhayade S, Stevenson D, Huang DT, Strathdee D, Blyth K, Vousden KH, Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021 Jan 1;35(1-2):117-132 |
| 4 | J:219422 Insolera R, Bazzi H, Shao W, Anderson KV, Shi SH, Cortical neurogenesis in the absence of centrioles. Nat Neurosci. 2014 Nov;17(11):1528-35 |
| 1* | J:181189 Ishimura A, Minehata K, Terashima M, Kondoh G, Hara T, Suzuki T, Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression. Development. 2012 Feb;139(4):749-59 |
| 1* | J:268858 Ishimura A, Terashima M, Tange S, Suzuki T, Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. Cell Tissue Res. 2016 Mar;363(3):723-33 |
| 1* | J:225909 Jang CW, Shibata Y, Starmer J, Yee D, Magnuson T, Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 2015 Jul 1;29(13):1377-92 |
| 1 | J:195792 Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M, Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. PLoS One. 2013;8(1):e54806 |
| 1 | J:199139 Jiang B, Zhao W, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C, Gong Y, Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 2012;7(5):e37070 |
| 2 | J:220466 Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W, Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015 Apr 2;520(7545):57-62 |
| 2* | J:133682 Jones NC, Lynn ML, Gaudenz K, Sakai D, Aoto K, Rey JP, Glynn EF, Ellington L, Du C, Dixon J, Dixon MJ, Trainor PA, Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med. 2008 Feb;14(2):125-33 |
| 2* | J:29811 Jones SN, Roe AE, Donehower LA, Bradley A, Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995 Nov 9;378(6553):206-8 |
| 4 | J:266277 Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Mendelsohn C, Vezina CM, In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8394-8399 |
| 1* | J:273083 Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Vezina CM, Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds. Dev Biol. 2019 Mar 15;447(2):157-169 |
| 8* | J:50202 Jurisicova A, Latham KE, Casper RF, Casper RF, Varmuza SL, Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol Reprod Dev. 1998 Nov;51(3):243-53 |
| 1 | J:152000 Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM, Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27;460(7259):1154-8 |
| 2 | J:95006 Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, Sapozhnikov AM, Whitsett JA, Costa RH, Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L521-30 |
| 2 | J:167331 Kanu N, Penicud K, Hristova M, Wong B, Irvine E, Plattner F, Raivich G, Behrens A, The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. J Biol Chem. 2010 Dec 3;285(49):38534-42 |
| 1 | J:193195 Katoh K, Yamazaki R, Onishi A, Sanuki R, Furukawa T, G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells. J Neurosci. 2012 Dec 5;32(49):17658-70 |
| 1 | J:212924 Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ, Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21 |
| 2* | J:217589 Kawakami E, Tokunaga A, Ozawa M, Sakamoto R, Yoshida N, The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. Mech Dev. 2015 Feb;135:31-42 |
| 3 | J:331939 Keil JM, Doyle DZ, Qalieh A, Lam MM, Funk OH, Qalieh Y, Shi L, Mohan N, Sorel A, Kwan KY, Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80. Nat Commun. 2020 Jul 31;11(1):3839 |
| 1 | J:130256 Keramaris E, Ruzhynsky VA, Callaghan SM, Wong E, Davis RJ, Flavell R, Slack RS, Park DS, Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice. J Biol Chem. 2008 Jan 4;283(1):405-15 |
| 1 | J:337812 Kim EJ, Kim HY, Li L, Tang Q, Kim KH, Ohshima H, Jung HS, Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis. J Dent Res. 2023 Jul;102(7):825-834 |
| 2 | J:313928 Kim EJ, Lee JE, Yoon S, Lee DJ, Mai HN, Ida-Yonemochi H, Choi J, Jung HS, Hypoxia-Responsive Oxygen Nanobubbles for Tissues-Targeted Delivery in Developing Tooth Germs. Front Cell Dev Biol. 2021;9:626224 |
| 3* | J:28733 Kim KK, Soonpaa MH, Daud AI, Koh GY, Kim JS, Field LJ, Tumor suppressor gene expression during normal and pathologic myocardial growth. J Biol Chem. 1994 Sep 9;269(36):22607-13 |
| 1 | J:263685 Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y, BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340 |
| 1* | J:149153 Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Bruning JC, PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Mol Cell Biol. 2009 Jun;29(11):3173-85 |
| 1* | J:283328 Klimovich B, Stiewe T, Timofeev O, Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle. 2020 Jan;19(1):109-123 |
| 1 | J:252381 Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T, The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. Stem Cells. 2017 Jun;35(6):1614-1623 |
| 3 | J:63921 Komarova EA, Christov K, Faerman AI, Gudkov AV, Different impact of p53 and p21 on the radiation response of mouse tissues. Oncogene. 2000 Aug 3;19(33):3791-8 |
| 4 | J:303990 Kon N, Churchill M, Li H, Mukherjee S, Manfredi JJ, Gu W, Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function. Cancer Res. 2021 Feb 15;81(4):935-944 |
| 1* | J:168184 Kon N, Kobayashi Y, Li M, Brooks CL, Ludwig T, Gu W, Inactivation of HAUSP in vivo modulates p53 function. Oncogene. 2010 Mar 4;29(9):1270-9 |
| 2* | J:314680 Kon N, Ou Y, Wang SJ, Li H, Rustgi AK, Gu W, mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression. Genes Dev. 2021 Jan 1;35(1-2):59-64 |
| 4 | J:276962 Kon N, Wang D, Gu W, Loss of SET reveals both the p53-dependent and the p53-independent functions in vivo. Cell Death Dis. 2019 Mar 11;10(3):237 |
| 8 | J:203102 Kon N, Zhong J, Kobayashi Y, Li M, Szabolcs M, Ludwig T, Canoll PD, Gu W, Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ. 2011 Aug;18(8):1366-75 |
| 1* | J:182446 Kon N, Zhong J, Qiang L, Accili D, Gu W, Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012 Feb 10;287(7):5102-11 |
| 1 | J:226425 Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmuller U, Palis J, Zheng Y, Kalfa TA, Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood. 2015 Sep 17;126(12):1473-82 |
| 1* | J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9 |
| 1 | J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26 |
| 1 | J:213268 Kumar P P, Emechebe U, Smith R, Franklin S, Moore B, Yandell M, Lessnick SL, Moon AM, Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex. Elife. 2014 May 29;:e02805 |
| 1 | J:234310 Kuo TL, Weng CC, Kuo KK, Chen CY, Wu DC, Hung WC, Cheng KH, APC haploinsufficiency coupled with p53 loss sufficiently induces mucinous cystic neoplasms and invasive pancreatic carcinoma in mice. Oncogene. 2016 Apr 28;35(17):2223-34 |
| 1 | J:335074 Kuzelova A, Dupacova N, Antosova B, Sunny SS, Kozmik Z Jr, Paces J, Skoultchi AI, Stopka T, Kozmik Z, Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance. Cells. 2023 Mar 28;12(7) |
| 1 | J:254235 Lanctot AA, Guo Y, Le Y, Edens BM, Nowakowski RS, Feng Y, Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017 Aug 1;20(5):1148-1160 |
| 1 | J:345633 Langner E, Cheng T, Kefaloyianni E, Gluck C, Wang B, Mahjoub MR, Cep120 is essential for kidney stromal progenitor cell growth and differentiation. EMBO Rep. 2024 Jan;25(1):428-454 |
| 3 | J:275301 Laos M, Sulg M, Herranen A, Anttonen T, Pirvola U, Indispensable role of Mdm2/p53 interaction during the embryonic and postnatal inner ear development. Sci Rep. 2017 Feb 9;7:42216 |
| 2 | J:272393 Lavado A, Park JY, Pare J, Finkelstein D, Pan H, Xu B, Fan Y, Kumar RP, Neale G, Kwak YD, McKinnon PJ, Johnson RL, Cao X, The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number. Dev Cell. 2018 Dec 3;47(5):576-591.e8 |
| 2 | J:168590 LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE, Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell. 2010 Dec 14;19(6):807-18 |
| 1 | J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487 |
| 1* | J:250142 Lee JY, Lee LJ, Fan CC, Chang HC, Shih HA, Min MY, Chang MS, Important roles of Vilse in dendritic architecture and synaptic plasticity. Sci Rep. 2017 Apr 3;7:45646 |
| 1* | J:69636 Lee KK, Leung AK, Tang MK, Cai DQ, Schneider C, Brancolini C, Chow PH, Functions of the growth arrest specific 1 gene in the development of the mouse embryo. Dev Biol. 2001 Jun 1;234(1):188-203 |
| 1* | J:65540 Lee Y, Barnes DE, Lindahl T, McKinnon PJ, Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev. 2000 Oct 15;14(20):2576-80 |
| 3* | J:71180 Lee Y, Chong MJ, McKinnon PJ, Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci. 2001 Sep 1;21(17):6687-93 |
| 1 | J:191367 Lee Y, Katyal S, Downing SM, Zhao J, Russell HR, McKinnon PJ, Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci. 2012 Jun;15(6):819-26 |
| 1 | J:152528 Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ, The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci. 2009 Aug;12(8):973-80 |
| 1 | J:181920 Lee Y, Shull ER, Frappart PO, Katyal S, Enriquez-Rios V, Zhao J, Russell HR, Brown EJ, McKinnon PJ, ATR maintains select progenitors during nervous system development. EMBO J. 2012 Mar 7;31(5):1177-89 |
| 5* | J:49215 Leveillard T, Gorry P, Niederreither K, Wasylyk B, MDM2 expression during mouse embryogenesis and the requirement of p53. Mech Dev. 1998 Jun;74(1-2):189-93 |
| 4 | J:329967 Li H, Li C, Zhai W, Zhang X, Li L, Wu B, Yu B, Zhang P, Li J, Cui CP, Zhang L, Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Cell Rep. 2022 Oct 4;41(1):111435 |
| 1 | J:320355 Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J, Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Oncogene. 2016 Mar 17;35(11):1468-74 |
| 2 | J:284759 Li Q, Cui S, Ma Q, Liu Y, Yu H, Geng G, Agborbesong E, Ren C, Wei K, Zhang Y, Yang J, Bai X, Cai G, Xie Y, Li X, Chen X, Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. JCI Insight. 2019 Sep 19;4(18) |
| 3* | J:316150 Li R, Yang YG, Gao Y, Wang ZQ, Tong WM, A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res. 2012 May;22(5):859-72 |
| 1 | J:36945 Lichnovsky V, Kamarad V, Kolar Z, Vojtesek B, Expression of p53 protein in tissues and organs of human and mouse embryo. Acta Univ Palacki Olomuc Fac Med. 1994;138:25-7 |
| 2 | J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079 |
| 1* | J:180459 Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D, Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008 Jan 18;29(1):9-22 |
| 1 | J:165360 Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, Schlaepfer DD, Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem. 2010 Jul 9;285(28):21526-36 |
| 1 | J:292113 Lin YN, Lee YS, Li SK, Tang TK, Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly. J Cell Sci. 2020 Jun 24;133(12):jcs243592 |
| 2 | J:270064 Little JN, Dwyer ND, p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects. Hum Mol Genet. 2019 Feb 1;28(3):434-447 |
| 2 | J:304629 Little JN, McNeely KC, Michel N, Bott CJ, Lettieri KS, Hecht MR, Martin SA, Dwyer ND, Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex. J Neurosci. 2021 Apr 14;41(15):3344-3365 |
| 3 | J:145221 Liu G, Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G, The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol. 2007 Dec;213(4):360-8 |
| 3 | J:316568 Liu H, Jia D, Li A, Chau J, He D, Ruan X, Liu F, Li J, He L, Li B, p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev. 2013 Mar 15;22(6):913-27 |
| 3 | J:344312 Liu H, Zhou R, Li S, Dong J, Fang Y, Luo Y, Su H, Lai B, Liang L, Zhang D, Zhang Y, Shyy JY, Zhou B, Yuan Z, Wang Y, Epigenetic repression of Cend1 by lysine-specific demethylase 1 is essential for murine heart development. iScience. 2024 Jan 19;27(1):108722 |
| 1 | J:93217 Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA, Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells. Reproduction. 2004 11;128(5):643-654 |
| 1 | J:258716 Liu X, Hayano S, Pan H, Inagaki M, Ninomiya-Tsuji J, Sun H, Mishina Y, Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death. Genesis. 2018 Mar;56(3):e23093 |
| 3 | J:309253 Lu L, Harutyunyan K, Jin W, Wu J, Yang T, Chen Y, Joeng KS, Bae Y, Tao J, Dawson BC, Jiang MM, Lee B, Wang LL, RECQL4 Regulates p53 Function In Vivo During Skeletogenesis. J Bone Miner Res. 2015 Jun;30(6):1077-89 |
| 1 | J:85761 Lykke-Andersen K, Schaefer L, Menon S, Deng XW, Miller JB, Wei N, Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003 Oct;23(19):6790-7 |
| 3* | J:281340 Ma JJ, Ju X, Xu RJ, Wang WH, Luo ZP, Liu CM, Yang L, Li B, Chen JQ, Meng B, Yang HL, Zhou FQ, Saijilafu, Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc. J Neurosci. 2019 Nov 13;39(46):9107-9118 |
| 1 | J:245570 Ma X, Adelstein RS, A point mutation in Myh10 causes major defects in heart development and body wall closure. Circ Cardiovasc Genet. 2014 Jun;7(3):257-65 |
| 5 | J:37677 MacCallum DE, Hupp TR, Midgley CA, Stuart D, Campbell SJ, Harper A, Walsh FS, Wright EG, Balmain A, Lane DP, Hall PA, The p53 response to ionising radiation in adult and developing murine tissues. Oncogene. 1996 Dec 19;13(12):2575-87 |
| 1* | J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59 |
| 2* | J:85738 MacLean HE, Kim JI, Glimcher MJ, Wang J, Kronenberg HM, Glimcher LH, Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol. 2003 Oct 1;262(1):51-63 |
| 3 | J:37025 Macleod KF, Hu Y, Jacks T, Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system. EMBO J. 1996 Nov 15;15(22):6178-88 |
| 1 | J:143668 Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC, Distinct roles of Mdm2 and Mdm4 in red cell production. Blood. 2007 Mar 15;109(6):2630-3 |
| 3* | J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86 |
| 4 | J:154434 Mangale SS, Modi DN, Reddy KV, Identification of genes regulated by an interaction between alphavbeta3 integrin and vitronectin in murine decidua. Reprod Fertil Dev. 2008;20(2):311-9 |
| 4* | J:235650 Mao H, McMahon JJ, Tsai YH, Wang Z, Silver DL, Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. PLoS Genet. 2016 Sep;12(9):e1006282 |
| 1 | J:255932 Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J, Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma. Nat Commun. 2017 Nov 28;8(1):1819 |
| 1 | J:224364 Marjanovic M, Sanchez-Huertas C, Terre B, Gomez R, Scheel JF, Pacheco S, Knobel PA, Martinez-Marchal A, Aivio S, Palenzuela L, Wolfrum U, McKinnon PJ, Suja JA, Roig I, Costanzo V, Luders J, Stracker TH, CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination. Nat Commun. 2015;6:7676 |
| 4 | J:210514 Martinez P, Ferrara-Romeo I, Flores JM, Blasco MA, Essential role for the TRF2 telomere protein in adult skin homeostasis. Aging Cell. 2014 Aug;13(4):656-68 |
| 2 | J:185038 Martinez P, Flores JM, Blasco MA, 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. J Cell Biol. 2012 Apr 16;197(2):283-300 |
| 1 | J:261834 Maskell LJ, Qamar K, Babakr AA, Hawkins TA, Heads RJ, Budhram-Mahadeo VS, Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart. Cell Death Dis. 2017 Jun 8;8(6):e2861 |
| 2 | J:299031 Matos-Rodrigues GE, Grigaravicius P, Lopez BS, Hofmann TG, Frappart PO, Martins RAP, ATRIP protects progenitor cells against DNA damage in vivo. Cell Death Dis. 2020 Oct 28;11(10):923 |
| 1* | J:297493 Matos-Rodrigues GE, Tan PB, Rocha-Martins M, Charlier CF, Gomes AL, Cabral-Miranda F, Grigaravicius P, Hofmann TG, Frappart PO, Martins RAP, Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome. Dis Model Mech. 2020 Oct 30;13(10):dmm045807 |
| 1 | J:338931 Matsui Y, Djekidel MN, Lindsay K, Samir P, Connolly N, Wu G, Yang X, Fan Y, Xu B, Peng JC, SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development. Nat Commun. 2023 Aug 8;14(1):4754 |
| 7* | J:60700 Matsui Y, Nagano R, Obinata M, Apoptosis of fetal testicular cells is regulated by both p53-dependent and independent mechanisms. Mol Reprod Dev. 2000 Apr;55(4):399-405 |
| 1 | J:175212 Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF, Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 2010 Sep;17(9):1409-19 |
| 6 | J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32 |
| 1 | J:90021 Mesaeli N, Phillipson C, Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells. Mol Biol Cell. 2004 Apr;15(4):1862-70 |
| 2 | J:257406 Metwalli KA, Do MA, Nguyen K, Mallick S, Kin K, Farokhnia N, Jun G, Fakhouri WD, Interferon Regulatory Factor 6 Is Necessary for Salivary Glands and Pancreas Development. J Dent Res. 2018 Feb;97(2):226-236 |
| 1* | J:299155 Miao X, Sun T, Golan M, Mager J, Cui W, Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Mol Reprod Dev. 2020 Nov;87(11):1152-1158 |
| 4 | J:178271 Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, Zwolinska A, Depaepe V, Hochepied T, Skarnes WC, Marine JC, Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. J Clin Invest. 2011 Apr 1;121(4):1329-43 |
| 1 | J:249971 Milstone ZJ, Lawson G, Trivedi CM, Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis. Dev Dyn. 2017 Dec;246(12):1015-1026 |
| 1 | J:267928 Min S, Kim K, Kim SG, Cho H, Lee Y, Chromatin-remodeling factor, RSF1, controls p53-mediated transcription in apoptosis upon DNA strand breaks. Cell Death Dis. 2018 Oct 22;9(11):1079 |
| 1* | J:119126 Miyata K, Yasukawa T, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, Tamamori-Adachi M, Ohnishi Y, Ohtsuki Y, Nakabeppu Y, Kitajima S, Onishi S, Aso T, Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. Cell Death Differ. 2007 Apr;14(4):716-26 |
| 1 | J:215128 Moon AM, Stauffer AM, Schwindinger WF, Sheridan K, Firment A, Robishaw JD, Disruption of G-protein gamma5 subtype causes embryonic lethality in mice. PLoS One. 2014;9(3):e90970 |
| 1 | J:198392 Morishita H, Eguchi S, Kimura H, Sasaki J, Sakamaki Y, Robinson ML, Sasaki T, Mizushima N, Deletion of autophagy-related 5 (Atg5) and Pik3c3 genes in the lens causes cataract independent of programmed organelle degradation. J Biol Chem. 2013 Apr 19;288(16):11436-47 |
| 2 | J:205283 Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M, Programmed cell senescence during mammalian embryonic development. Cell. 2013 Nov 21;155(5):1104-18 |
| 1 | J:151542 Murga M, Bunting S, Montana MF, Soria R, Mulero F, Canamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O, A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009 Aug;41(8):891-8 |
| 1 | J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584 |
| 3 | J:306151 Nguyen DH, Soygur B, Peng SP, Malki S, Hu G, Laird DJ, Apoptosis in the fetal testis eliminates developmentally defective germ cell clones. Nat Cell Biol. 2020 Dec;22(12):1423-1435 |
| 2 | J:255059 Nguyen DTT, Richter D, Michel G, Mitschka S, Kolanus W, Cuevas E, Wulczyn FG, The ubiquitin ligase LIN41/TRIM71 targets p53 to antagonize cell death and differentiation pathways during stem cell differentiation. Cell Death Differ. 2017 Jun;24(6):1063-1078 |
| 1 | J:329236 Nguyen KT, Mun SH, Yang J, Lee J, Seok OH, Kim E, Kim D, An SY, Seo DY, Suh JY, Lee Y, Hwang CS, The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis. Nat Cell Biol. 2022 Aug;24(8):1239-1251 |
| 2 | J:296081 Nguyen PM, Dagley LF, Preaudet A, Lam N, Giam M, Fung KY, Aizel K, van Duijneveldt G, Tan CW, Hirokawa Y, Yip HYK, Love CG, Poh AR, Cruz A, Burstroem C, Feltham R, Abdirahman SM, Meiselbach K, Low RRJ, Palmieri M, Ernst M, Webb AI, Burgess T, Sieber OM, Bouillet P, Putoczki TL, Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020 Feb;27(2):742-757 |
| 1 | J:309998 Nie X, Ricupero CL, Jiao K, Yang P, Mao JJ, mTOR deletion in neural crest cells disrupts cardiac outflow tract remodeling and causes a spectrum of cardiac defects through the mTORC1 pathway. Dev Biol. 2021 Sep;477:241-250 |
| 3 | J:263684 Nie X, Zheng J, Ricupero CL, He L, Jiao K, Mao JJ, mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491 |
| 2 | J:106364 Niimi N, Sugo N, Aratani Y, Koyama H, Genetic interaction between DNA polymerase beta and DNA-PKcs in embryogenesis and neurogenesis. Cell Death Differ. 2005 Feb;12(2):184-91 |
| 3 | J:97328 Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T, Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation. J Clin Invest. 2005 Apr 1;115(4):910-918 |
| 2 | J:53313 Nomura T, Khan MM, Kaul SC, Dong HD, Wadhwa R, Colmenares C, Kohno I, Ishii S, Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 1999 Feb 15;13(4):412-23 |
| 1 | J:253982 Norlin S, Parekh V, Edlund H, The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development. 2018 Jan 3;145(1):dev154468 |
| 1* | J:182585 Oh S, Janknecht R, Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012 Mar 30;420(1):61-5 |
| 1 | J:111068 Orii KE, Lee Y, Kondo N, McKinnon PJ, Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10017-22 |
| 1 | J:90276 Ota MS, Loebel DA, O'Rourke MP, Wong N, Tsoi B, Tam PP, Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28 |
| 1 | J:117590 Panic L, Tamarut S, Sticker-Jantscheff M, Barkic M, Solter D, Uzelac M, Grabusic K, Volarevic S, Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol. 2006 Dec;26(23):8880-91 |
| 1 | J:207293 Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM, Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1240-8 |
| 2 | J:166796 Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC, Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906 |
| 1 | J:240059 Park KC, Lee M, Jeon Y, Jeon R, Baek SH, Lee H, Kim KI, Skin-Specific Deletion of Mis18alpha Impedes Proliferation and Stratification of Epidermal Keratinocytes. J Invest Dermatol. 2017 Feb;137(2):414-421 |
| 1* | J:37752 Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ, p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells [see comments]. Science. 1995 Feb 17;267(5200):1024-7 |
| 1 | J:142505 Parlato R, Kreiner G, Erdmann G, Rieker C, Stotz S, Savenkova E, Berger S, Grummt I, Schutz G, Activation of an endogenous suicide response after perturbation of rRNA synthesis leads to neurodegeneration in mice. J Neurosci. 2008 Nov 26;28(48):12759-64 |
| 2* | J:75359 Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF, JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet. 2002 Feb;30(2):158-66 |
| 1 | J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115 |
| 1 | J:218949 Perucho L, Artero-Castro A, Guerrero S, Ramon y Cajal S, LLeonart ME, Wang ZQ, RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 2014;9(6):e99956 |
| 1* | J:161188 Pewzner-Jung Y, Brenner O, Braun S, Laviad EL, Ben-Dor S, Feldmesser E, Horn-Saban S, Amann-Zalcenstein D, Raanan C, Berkutzki T, Erez-Roman R, Ben-David O, Levy M, Holzman D, Park H, Nyska A, Merrill AH Jr, Futerman AH, A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem. 2010 Apr 2;285(14):10911-23 |
| 1 | J:223048 Pirouz M, Pilarski S, Kessel M, A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013 Aug;9(8):e1003712 |
| 2* | J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96 |
| 1 | J:149563 Pulvers JN, Huttner WB, Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors. Development. 2009 Jun;136(11):1859-68 |
| 2 | J:259872 Quereda V, Porlan E, Canamero M, Dubus P, Malumbres M, An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress. Cell Death Differ. 2016 Mar;23(3):430-41 |
| 5* | J:221155 Quintens R, Verreet T, Janssen A, Neefs M, Leysen L, Michaux A, Verslegers M, Samari N, Pani G, Verheyde J, Baatout S, Benotmane MA, Identification of novel radiation-induced p53-dependent transcripts extensively regulated during mouse brain development. Biol Open. 2015;4(3):331-44 |
| 2 | J:327434 Ramirez M, Badayeva Y, Yeung J, Wu J, Abdalla-Wyse A, Yang E, Trost B, Scherer SW, Goldowitz D, Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions. Elife. 2022 Aug 9;11:e74207 |
| 1* | J:161528 Rantakari P, Nikkila J, Jokela H, Ola R, Pylkas K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R, Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9 |
| 1 | J:61550 Rauch F, Prud'homme J, Arabian A, Dedhar S, St-Arnaud R, Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res. 2000 Apr 10;256(1):105-11 |
| 4 | J:171272 Rinon A, Molchadsky A, Nathan E, Yovel G, Rotter V, Sarig R, Tzahor E, p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. Development. 2011 May;138(9):1827-38 |
| 1 | J:123174 Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A, The notch pathway positively regulates programmed cell death during erythroid differentiation. Leukemia. 2007 Jul;21(7):1496-503 |
| 1 | J:204946 Rodrigues PM, Grigaravicius P, Remus M, Cavalheiro GR, Gomes AL, Martins MR, Frappart L, Reuss D, McKinnon PJ, von Deimling A, Martins RA, Frappart PO, Nbn and atm cooperate in a tissue and developmental stage-specific manner to prevent double strand breaks and apoptosis in developing brain and eye. PLoS One. 2013;8(7):e69209 |
| 1* | J:204457 Ross AP, Mansilla MA, Choe Y, Helminski S, Sturm R, Maute RL, May SR, Hozyasz KK, Wojcicki P, Mostowska A, Davidson B, Adamopoulos IE, Pleasure SJ, Murray JC, Zarbalis KS, A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS One. 2013;8(7):e69333 |
| 2 | J:67553 Ruland J, Sirard C, Elia A, MacPherson D, Wakeham A, Li L, de la Pompa JL, Cohen SN, Mak TW, p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1859-64 |
| 9 | J:166316 Saifudeen Z, Dipp S, Stefkova J, Yao X, Lookabaugh S, El-Dahr SS, p53 regulates metanephric development. J Am Soc Nephrol. 2009 Nov;20(11):2328-37 |
| 1 | J:192892 Saifudeen Z, Liu J, Dipp S, Yao X, Li Y, McLaughlin N, Aboudehen K, El-Dahr SS, A p53-Pax2 pathway in kidney development: implications for nephrogenesis. PLoS One. 2012;7(9):e44869 |
| 1 | J:228258 Sanchez-Macedo N, Feng J, Faubert B, Chang N, Elia A, Rushing EJ, Tsuchihara K, Bungard D, Berger SL, Jones RG, Mak TW, Zaugg K, Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model. Cell Death Differ. 2013 Apr;20(4):659-68 |
| 1 | J:326958 Sapir T, Kshirsagar A, Gorelik A, Olender T, Porat Z, Scheffer IE, Goldstein DB, Devinsky O, Reiner O, Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex. Nat Commun. 2022 Jul 21;13(1):4209 |
| 1 | J:162790 Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S, PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol. 2010 Aug;30(15):3864-74 |
| 6* | J:2003 Schmid P, Lorenz A, Hameister H, Montenarh M, Expression of p53 during mouse embryogenesis. Development. 1991 Nov;113(3):857-65 |
| 1 | J:291483 Sheehan CJ, McMahon JJ, Serdar LD, Silver DL, Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. Development. 2020 Jan 13;147(1):dev182295 |
| 2 | J:278483 Shi L, Qalieh A, Lam MM, Keil JM, Kwan KY, Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nat Commun. 2019 Jun 13;10(1):2588 |
| 2* | J:163898 Shim M, Foley J, Anna C, Mishina Y, Eling T, Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton. J Biol Chem. 2010 May 21;285(21):16206-17 |
| 1 | J:196596 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA, Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15;377(2):333-44 |
| 4* | J:36847 Soonpaa MH, Kim KK, Pajak L, Franklin M, Field LJ, Cardiomyocyte DNA synthesis and binucleation during murine development. Am J Physiol. 1996 Nov;271(5 Pt 2):H2183-9 |
| 1 | J:192592 Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C, BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51 |
| 1 | J:343800 Souali-Crespo S, Condrea D, Vernet N, Feret B, Klopfenstein M, Grandgirard E, Alunni V, Cerciat M, Jung M, Mayere C, Nef S, Mark M, Chalmel F, Ghyselinck NB, Loss of NR5A1 in mouse Sertoli cells after sex determination changes cellular identity and induces cell death by anoikis. Development. 2023 Dec 15;150(24) |
| 1* | J:247327 Spiller CM, Wilhelm D, Jans DA, Bowles J, Koopman P, Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS One. 2017;12(1):e0170576 |
| 1* | J:343201 Srinivasan S, He X, Mirza S, Mager J, Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346 |
| 1* | J:244087 Stopp S, Grundl M, Fackler M, Malkmus J, Leone M, Naumann R, Frantz S, Wolf E, von Eyss B, Engel FB, Gaubatz S, Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development. Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8029-8034 |
| 1 | J:205284 Storer M, Mas A, Robert-Moreno A, Pecoraro M, Ortells MC, Di Giacomo V, Yosef R, Pilpel N, Krizhanovsky V, Sharpe J, Keyes WM, Senescence is a developmental mechanism that contributes to embryonic growth and patterning. Cell. 2013 Nov 21;155(5):1119-30 |
| 1 | J:316135 Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY, The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia. iScience. 2021 Nov 19;24(11):103368 |
| 1 | J:118190 Sugo N, Niimi N, Aratani Y, Masutani M, Suzuki H, Koyama H, Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice. Biochem Biophys Res Commun. 2007 Mar 16;354(3):656-61 |
| 2 | J:94157 Sugo N, Niimi N, Aratani Y, Takiguchi-Hayashi K, Koyama H, p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol. 2004 Nov;24(21):9470-7 |
| 4 | J:292836 Sui P, Li R, Zhang Y, Tan C, Garg A, Verheyden JM, Sun X, E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size. Development. 2019 Dec 16;146(24):dev179820 |
| 1 | J:107145 Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ, Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev. 2004 May 1;18(9):1035-46 |
| 2 | J:212275 Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X, Pygo2 regulates beta-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10215-20 |
| 1 | J:40595 Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW, Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52 |
| 1 | J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95 |
| 1 | J:238904 Suzuki D, Sahu R, Leu NA, Senoo M, The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. 2015 Jan 15;142(2):282-90 |
| 3 | J:127939 Suzuki K, Haraguchi R, Ogata T, Barbieri O, Alegria O, Vieux-Rochas M, Nakagata N, Ito M, Mills AA, Kurita T, Levi G, Yamada G, Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet. 2008 Jan;16(1):36-44 |
| 2* | J:272586 Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4):dev168146 |
| 1 | J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358 |
| 2 | J:129049 Takebayashi S, Tamura T, Matsuoka C, Okano M, Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions. Mol Cell Biol. 2007 Dec;27(23):8243-58 |
| 3 | J:81445 Takeuchi A, Mishina Y, Miyaishi O, Kojima E, Hasegawa T, Isobe K, Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat Genet. 2003 Feb;33(2):172-6 |
| 1 | J:316473 Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C, Heart neurons use clock genes to control myocyte proliferation. Sci Adv. 2021 Dec 3;7(49):eabh4181 |
| 1 | J:315979 Tane S, Kubota M, Okayama H, Ikenishi A, Yoshitome S, Iwamoto N, Satoh Y, Kusakabe A, Ogawa S, Kanai A, Molkentin JD, Nakamura K, Ohbayashi T, Takeuchi T, Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes. J Biol Chem. 2014 Jun 27;289(26):18033-44 |
| 1 | J:156253 Tateossian H, Hardisty-Hughes RE, Morse S, Romero MR, Hilton H, Dean C, Brown SD, Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant. Pathogenetics. 2009;2(1):5 |
| 2 | J:226978 Tateossian H, Morse S, Simon MM, Dean CH, Brown SD, Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42 |
| 3 | J:240517 Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W, HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016 Oct;22(10):1180-1186 |
| 1* | J:259302 Teratake Y, Kuga C, Hasegawa Y, Sato Y, Kitahashi M, Fujimura L, Watanabe-Takano H, Sakamoto A, Arima M, Tokuhisa T, Hatano M, Transcriptional repression of p27 is essential for murine embryonic development. Sci Rep. 2016 May 19;6:26244 |
| 3 | J:123661 Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G, Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol. 2007 Aug;27(15):5479-85 |
| 5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
| 1 | J:166561 Tian L, Peng G, Parant JM, Leventaki V, Drakos E, Zhang Q, Parker-Thornburg J, Shackleford TJ, Dai H, Lin SY, Lozano G, Rassidakis GZ, Claret FX, Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18;29(46):6125-37 |
| 2 | J:308686 Tiu GC, Kerr CH, Forester CM, Krishnarao PS, Rosenblatt HD, Raj N, Lantz TC, Zhulyn O, Bowen ME, Shokat L, Attardi LD, Ruggero D, Barna M, A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. Dev Cell. 2021 Jul 26;56(14):2089-2102.e11 |
| 1 | J:93979 Tomoda K, Yoneda-Kato N, Fukumoto A, Yamanaka S, Kato JY, Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004 Oct 8;279(41):43013-8 |
| 2 | J:268904 Tripathy R, Leca I, van Dijk T, Weiss J, van Bon BW, Sergaki MC, Gstrein T, Breuss M, Tian G, Bahi-Buisson N, Paciorkowski AR, Pagnamenta AT, Wenninger-Weinzierl A, Martinez-Reza MF, Landler L, Lise S, Taylor JC, Terrone G, Vitiello G, Del Giudice E, Brunetti-Pierri N, D'Amico A, Reymond A, Voisin N, Bernstein JA, Farrelly E, Kini U, Leonard TA, Valence S, Burglen L, Armstrong L, Hiatt SM, Cooper GM, Aldinger KA, Dobyns WB, Mirzaa G, Pierson TM, Baas F, Chelly J, Cowan NJ, Keays DA, Mutations in MAST1 Cause Mega-Corpus-Callosum Syndrome with Cerebellar Hypoplasia and Cortical Malformations. Neuron. 2018 Dec 19;100(6):1354-1368.e5 |
| 3 | J:208719 Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH, TCTP is essential for beta-cell proliferation and mass expansion during development and beta-cell adaptation in response to insulin resistance. Endocrinology. 2014 Feb;155(2):392-404 |
| 1 | J:225175 Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D, Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117 |
| 2 | J:138125 Umekawa T, Sugiyama T, Kihira T, Murabayashi N, Zhang L, Nagao K, Kamimoto Y, Ma N, Yodoi J, Sagawa N, Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism. Endocrinology. 2008 Aug;149(8):3980-8 |
| 1 | J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82 |
| 1 | J:261301 Van den Ackerveken P, Mounier A, Huyghe A, Sacheli R, Vanlerberghe PB, Volvert ML, Delacroix L, Nguyen L, Malgrange B, The miR-183/ItgA3 axis is a key regulator of prosensory area during early inner ear development. Cell Death Differ. 2017 Dec;24(12):2054-2065 |
| 1 | J:217080 Van Nostrand JL, Brady CA, Jung H, Fuentes DR, Kozak MM, Johnson TM, Lin CY, Lin CJ, Swiderski DL, Vogel H, Bernstein JA, Attie-Bitach T, Chang CP, Wysocka J, Martin DM, Attardi LD, Inappropriate p53 activation during development induces features of CHARGE syndrome. Nature. 2014 Oct 9;514(7521):228-32 |
| 2 | J:310649 Viais R, Farina-Mosquera M, Villamor-Paya M, Watanabe S, Palenzuela L, Lacasa C, Luders J, Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. Elife. 2021 Aug 24;10:e67989 |
| 6* | J:213978 Vuong L, Brobst DE, Saadi A, Ivanovic I, Al-Ubaidi MR, Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012 Jul;53(8):4821-31 |
| 2 | J:83651 Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R, Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol. 2003 Jun;4(6):533-9 |
| 1 | J:238814 Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W, Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 06;538(7623):118-122 |
| 1 | J:274227 Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ, Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 May 1;79(9):2208-2219 |
| 1 | J:165054 Wang WL, Li Q, Xu J, Cvekl A, Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68 |
| 1 | J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14 |
| 2 | J:195156 Watkins-Chow DE, Cooke J, Pidsley R, Edwards A, Slotkin R, Leeds KE, Mullen R, Baxter LL, Campbell TG, Salzer MC, Biondini L, Gibney G, Phan Dinh Tuy F, Chelly J, Morris HD, Riegler J, Lythgoe MF, Arkell RM, Loreni F, Flint J, Pavan WJ, Keays DA, Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes. PLoS Genet. 2013 Jan;9(1):e1003094 |
| 1 | J:206929 Watson LA, Wang X, Elbert A, Kernohan KD, Galjart N, Berube NG, Dual Effect of CTCF Loss on Neuroprogenitor Differentiation and Survival. J Neurosci. 2014 Feb 19;34(8):2860-70 |
| 3* | J:261042 Welcker D, Jain M, Khurshid S, Jokic M, Hohne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Buttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Hopker K, AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518 |
| 1 | J:278909 Weng SY, Yang CY, Li CC, Sun TP, Tung SY, Yen JJ, Tsai TF, Chen CM, Chen SH, Hsiao M, Huang PH, Yang-Yen HF, Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. J Hepatol. 2011 Apr;54(4):685-94 |
| 1 | J:149874 Wetzel MK, Naska S, Laliberte CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR, p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. Neuron. 2008 Sep 11;59(5):708-21 |
| 1* | J:311932 White AK, Baumgartner M, Lee MF, Drake KD, Aquino GS, Kanadia RN, Trp53 ablation fails to prevent microcephaly in mouse pallium with impaired minor intron splicing. Development. 2021 Oct 15;148(20):dev199591 |
| 2 | J:174241 Wiley LA, Rajagopal R, Dattilo LK, Beebe DC, The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Dis Model Mech. 2011 Jul-Aug;4(4):484-95 |
| 2 | J:309386 Win PW, Oakie A, Li J, Wang R, Beta-cell beta1 integrin deficiency affects in utero development of islet growth and vascularization. Cell Tissue Res. 2020 Jul;381(1):163-175 |
| 2 | J:40102 Wlodarczyk BC, Craig JC, Bennett GD, Calvin JA, Finnell RH, Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology. 1996 Dec;54(6):284-97 |
| 1 | J:151770 Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M, Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Diabetologia. 2009 Oct;52(10):2130-41 |
| 3 | J:320790 Wu Y, Zhou X, Huang X, Xia Q, Chen Z, Zhang X, Yang D, Geng YJ, Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence. J Cell Mol Med. 2016 Apr;20(4):644-54 |
| 3 | J:302304 Xiao C, Grzonka M, Meyer-Gerards C, Mack M, Figge R, Bazzi H, Gradual centriole maturation associates with the mitotic surveillance pathway in mouse development. EMBO Rep. 2021 Feb 3;22(2):e51127 |
| 2 | J:317033 Xie C, Abrams SR, Herranz-Perez V, Garcia-Verdugo JM, Reiter JF, Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity. Dev Cell. 2021 Dec 20;56(24):3334-3348.e6 |
| 2 | J:107178 Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G, Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3226-31 |
| 4 | J:223276 Xiong X, Zhao Y, Tang F, Wei D, Thomas D, Wang X, Liu Y, Zheng P, Sun Y, Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Elife. 2014;3:e02236 |
| 1 | J:314615 Xu C, Shen WB, Reece EA, Hasuwa H, Harman C, Kaushal S, Yang P, Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin. Sci Adv. 2021 Jun;7(27) |
| 1 | J:172224 Xu J, Wang M, Gao X, Hu B, Du Y, Zhou J, Tian X, Huang X, Separase phosphosite mutation leads to genome instability and primordial germ cell depletion during oogenesis. PLoS One. 2011;6(4):e18763 |
| 2* | J:239876 Xu Q, Wang F, Xiang Y, Zhang X, Zhao ZA, Gao Z, Liu W, Lu X, Liu Y, Yu XJ, Wang H, Huang J, Yi Z, Gao S, Li L, Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 2015 Nov 15;142(22):3943-53 |
| 1 | J:339060 Xu W, Yang Y, Yu Y, Wen C, Zhao S, Cao L, Zhao S, Qin Y, Chen ZJ, FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells. BMC Biol. 2023 Aug 15;21(1):174 |
| 1* | J:70271 Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX, Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71 |
| 5 | J:241249 Xue Y, Raharja A, Sim W, Wong ES, Rahmat SA, Lane DP, The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage. Oncogene. 2017 Apr 06;36(14):2002-2013 |
| 1 | J:306240 Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y, Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol. 2021;12:649492 |
| 1* | J:135988 Yamanaka Y, Heike T, Kumada T, Shibata M, Takaoka Y, Kitano A, Shiraishi K, Kato T, Nagato M, Okawa K, Furushima K, Nakao K, Nakamura Y, Taketo MM, Aizawa S, Nakahata T, Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev. 2008 May-Jun;125(5-6):441-50 |
| 4 | J:310840 Yang GN, Ahangar P, Strudwick XL, Kopecki Z, Cowin AJ, Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells. Int J Mol Sci. 2021 Jul 30;22(15) |
| 2 | J:90392 Yang X, Klein R, Tian X, Cheng HT, Kopan R, Shen J, Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94 |
| 1 | J:327430 Yang Y, Xu W, Gao F, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y, Chen ZJ, Zhao S, Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2203208119 |
| 1 | J:339368 Yao F, Huang S, Liu J, Tan C, Xu M, Wang D, Huang M, Zhu Y, Huang X, He S, Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Cell Death Dis. 2023 Aug 23;14(8):543 |
| 2 | J:318371 Ye A, He H, Kim J, PEG3 binds to H19-ICR as a transcriptional repressor. Epigenetics. 2016 Dec;11(12):889-900 |
| 1 | J:111701 Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM, Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84 |
| 3* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
| 1* | J:46940 Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT, Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11 |
| 1 | J:63729 Zeng Q, Kwan A, Oakley B, Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J Comp Neurol. 2000 Sep 4;424(4):640-50 |
| 1* | J:229467 Zhang KK, Xiang M, Zhou L, Liu J, Curry N, Heine Suner D, Garcia-Pavia P, Zhang X, Wang Q, Xie L, Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016 Mar 15;25(6):1140-51 |
| 1* | J:259290 Zhang M, Zhang Y, Xu E, Mohibi S, de Anda DM, Jiang Y, Zhang J, Chen X, Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell Death Differ. 2018 Jun;25(6):1118-1130 |
| 3 | J:240406 Zhang Y, Zeng SX, Hao Q, Lu H, Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner. Dev Biol. 2017 Mar 01;423(1):34-45 |
| 4* | J:217191 Zhang Y, Zhang X, Lu H, Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens dysmorphogenesis. Dev Biol. 2014 Dec 1;396(1):19-30 |
| 1 | J:282261 Zhao J, Tian Y, Zhang H, Qu L, Chen Y, Liu Q, Luo Y, Wu X, p53 Mutant p53(N236S) Induces Neural Tube Defects in Female Embryos. Int J Biol Sci. 2019;15(9):2006-2015 |
| 2 | J:324298 Zhou J, Liu G, Zhang X, Wu C, Ma M, Wu J, Hou L, Yin B, Qiang B, Shu P, Peng X, Comparison of the Spatiotemporal Expression Patterns of Three Cre Lines, Emx1IRES-Cre, D6-Cre and hGFAP-Cre, Commonly Used in Neocortical Development Research. Cereb Cortex. 2022 Apr 5;32(8):1668-1681 |
| 1 | J:310132 Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L, Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol. 2015 Aug;85:1-12 |
| 1 | J:310644 Zhu Q, Chen L, Li Y, Huang M, Shao J, Li S, Cheng J, Yang H, Wu Y, Zhang J, Feng J, Fan M, Wu H, Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells. Cell Rep. 2021 Aug 31;36(9):109639 |
| 2 | J:275567 Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke M, Cantu C, Atak ZK, Zamboni N, Basler K, Sommer L, Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools