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Gene Expression Literature Summary
Symbol
Name
ID
Sry
sex determining region of Chr Y
MGI:98660

73 matching records from 73 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E4 E7.5 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15.5 E16.5 E17.5 E18.5 E19.5 E A
In situ protein (section) 1 3 14 2 6 3 1 2
In situ RNA (section) 3 7 1 1
In situ protein (whole mount) 2
In situ RNA (whole mount) 1 2 1 6 6 13 4 3 1 1
Northern blot 1 1 1
Western blot 2 1 2 1
RT-PCR 1 1 3 1 2 1 15 12 42 13 25 5 18 4 7 8 3 5 2 1 2 7
cDNA clones 1
RNase protection 1 2 1 1 1 2 4
Primer Extension 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Sry  sex determining region of Chr Y   (Synonyms: Tdf, Tdy)
Results  Reference
4J:127090 Albrecht KH, Young M, Washburn LL, Eicher EM, Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles. Genetics. 2003 May;164(1):277-88
1J:130928 Bagheri-Fam S, Sim H, Bernard P, Jayakody I, Taketo MM, Scherer G, Harley VR, Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol. 2008 Feb 1;314(1):71-83
3J:104330 Barrionuevo F, Bagheri-Fam S, Klattig J, Kist R, Taketo MM, Englert C, Scherer G, Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice. Biol Reprod. 2006 Jan;74(1):195-201
4J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
5J:98922 Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development. 2005 Jul;132(13):3045-54
7*J:93500 Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM, Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns. 2004 Nov;5(1):141-9
2J:125196 Bouma GJ, Washburn LL, Albrecht KH, Eicher EM, Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14994-9
2J:64333 Bowles J, Bullejos M, Koopman P, A subtractive gene expression screen suggests a role for vanin-1 in testis development in mice. Genesis. 2000 Jul;27(3):124-35
1*J:150705 Bowles J, Feng CW, Knight D, Smith CA, Roeszler KN, Bagheri-Fam S, Harley VR, Sinclair AH, Koopman P, Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: Implications for retinoid balance in gonad development. Dev Dyn. 2009 Jul 17;238(8):2073-2080
1J:16581 Boyer TR, Erickson RP, Detection of circular and linear transcripts of Sry in pre-implantation mouse embryos: differences in requirement for reverse transcriptase. Biochem Biophys Res Commun. 1994 Jan 28;198(2):492-6
5J:149785 Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D, The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod. 2009 Jun;80(6):1178-88
2J:151715 Bradford ST, Wilhelm D, Bandiera R, Vidal V, Schedl A, Koopman P, A cell-autonomous role for WT1 in regulating Sry in vivo. Hum Mol Genet. 2009 Sep 15;18(18):3429-38
1*J:137460 Bradford ST, Wilhelm D, Koopman P, Comparative analysis of anti-mouse SRY antibodies. Sex Dev. 2007;1(5):305-10
4J:150743 Buaas FW, Val P, Swain A, The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet. 2009 Aug 15;18(16):2989-3001
7J:69779 Bullejos M, Koopman P, Spatially dynamic expression of Sry in mouse genital ridges. Dev Dyn. 2001 Jun;221(2):201-5
2J:96340 Bullejos M, Koopman P, Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal. Dev Biol. 2005 Feb 15;278(2):473-81
4*J:23597 Cao QP, Gaudette MF, Robinson DH, Crain WR, Expression of the mouse testis-determining gene Sry in male preimplantation embryos. Mol Reprod Dev. 1995 Feb;40(2):196-204
1*J:15425 Capel B, Rasberry C, Dyson J, Bishop CE, Simpson E, Vivian N, Lovell-Badge R, Rastan S, Cattanach BM, Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993 Nov;5(3):301-7
2*J:32422 Carlisle C, Winking H, Weichenhan D, Nagamine CM, Absence of correlation between Sry polymorphisms and XY sex reversal caused by the M. m. domesticus Y chromosome. Genomics. 1996 Apr 1;33(1):32-45
1J:89368 Chaboissier MC, Kobayashi A, Vidal VI, Lutzkendorf S, van de Kant HJ, Wegner M, de Rooij DG, Behringer RR, Schedl A, Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development. 2004 May;131(9):1891-901
3J:189064 Chassot AA, Bradford ST, Auguste A, Gregoire EP, Pailhoux E, de Rooij DG, Schedl A, Chaboissier MC, WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad. Development. 2012 Dec;139(23):4461-72
1*J:31475 Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow PN, Lovell-Badge R, A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996 Feb;122(2):509-20
3J:183829 Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH, Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
1J:107426 Dinapoli L, Batchvarov J, Capel B, FGF9 promotes survival of germ cells in the fetal testis. Development. 2006 Apr;133(8):1519-27
5J:22243 Dolci S, Geremia R, Albanesi C, Rossi P, Expression of the Xist gene in urogenital ridges of midgestation male embryos. Biochem Biophys Res Commun. 1994 Nov 30;205(1):334-40
7*J:44565 Dolci S, Grimaldi P, Geremia R, Pesce M, Rossi P, Identification of a promoter region generating Sry circular transcripts both in germ cells from male adult mice and in male mouse embryonal gonads. Biol Reprod. 1997 Nov;57(5):1128-35
1J:127542 Elliott AM, de Miguel MP, Rebel VI, Donovan PJ, Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival. Dev Biol. 2007 Nov 15;311(2):347-58
4J:204550 Fujimoto Y, Tanaka SS, Yamaguchi YL, Kobayashi H, Kuroki S, Tachibana M, Shinomura M, Kanai Y, Morohashi K, Kawakami K, Nishinakamura R, Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013 Aug 26;26(4):416-30
9J:191095 Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C, GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
2*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
6*J:26101 Hacker A, Capel B, Goodfellow P, Lovell-Badge R, Expression of Sry, the mouse sex determining gene. Development. 1995 Jun;121(6):1603-14
5J:71149 Hammes A, Guo JK, Lutsch G, Leheste JR, Landrock D, Ziegler U, Gubler MC, Schedl A, Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell. 2001 Aug 10;106(3):319-29
5J:65566 Hellani A, Ji J, Mauduit C, Deschildre C, Tabone E, Benahmed M, Developmental and hormonal regulation of the expression of oligodendrocyte-specific protein/claudin 11 in mouse testis. Endocrinology. 2000 Aug;141(8):3012-9
2J:106304 Jeays-Ward K, Dandonneau M, Swain A, Wnt4 is required for proper male as well as female sexual development. Dev Biol. 2004 Dec 15;276(2):431-40
6*J:27741 Jeske YW, Bowles J, Greenfield A, Koopman P, Expression of a linear Sry transcript in the mouse genital ridge. Nat Genet. 1995 Aug;10(4):480-2
9*J:33399 Jeske YW, Mishina Y, Cohen DR, Behringer RR, Koopman P, Analysis of the role of Amh and Fra1 in the Sry regulatory pathway. Mol Reprod Dev. 1996 Jun;44(2):153-8
3J:199917 Johnen H, Gonzalez-Silva L, Carramolino L, Flores JM, Torres M, Salvador JM, Gadd45g is essential for primary sex determination, male fertility and testis development. PLoS One. 2013;8(3):e58751
2*J:166891 Kashimada K, Koopman P, Sry: the master switch in mammalian sex determination. Development. 2010 Dec;137(23):3921-30
2J:181719 Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K, Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology. 2012 Feb;153(2):913-24
12J:96334 Kidokoro T, Matoba S, Hiramatsu R, Fujisawa M, Kanai-Azuma M, Taya C, Kurohmaru M, Kawakami H, Hayashi Y, Kanai Y, Yonekawa H, Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev Biol. 2005 Feb 15;278(2):511-25
1*J:137462 Klattig J, Sierig R, Kruspe D, Makki MS, Englert C, WT1-mediated gene regulation in early urogenital ridge development. Sex Dev. 2007;1(4):238-54
17*J:10838 Koopman P, Munsterberg A, Capel B, Vivian N, Lovell-Badge R, Expression of a candidate sex-determining gene during mouse testis differentiation. Nature. 1990 Nov 29;348(6300):450-2
1J:194924 Lavery R, Chassot AA, Pauper E, Gregoire EP, Klopfenstein M, de Rooij DG, Mark M, Schedl A, Ghyselinck NB, Chaboissier MC, Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals. PLoS Genet. 2012;8(12):e1003170
8*J:21125 Lee CH, Taketo T, Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad. Dev Biol. 1994 Oct;165(2):442-52
3*J:69946 Lee CH, Taketo T, Low levels of Sry transcripts cannot be the sole cause of B6-Y(TIR) sex reversal. Genesis. 2001 May;30(1):7-11
3*J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1J:183814 Ludbrook LM, Bernard P, Bagheri-Fam S, Ryan J, Sekido R, Wilhelm D, Lovell-Badge R, Harley VR, Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9). Endocrinology. 2012 Apr;153(4):1948-58
6*J:74052 Mayer A, Mosler G, Just W, Pilgrim C, Reisert I, Developmental profile of Sry transcripts in mouse brain. Neurogenetics. 2000 Sep;3(1):25-30
4J:117362 Mazaud Guittot S, Tetu A, Legault E, Pilon N, Silversides DW, Viger RS, The proximal Gata4 promoter directs reporter gene expression to sertoli cells during mouse gonadal development. Biol Reprod. 2007 Jan;76(1):85-95
1J:154029 Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B, Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes Dev. 2009 Nov 1;23(21):2521-36
3J:199294 Munger SC, Natarajan A, Looger LL, Ohler U, Capel B, Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of Mammalian sex determination. PLoS Genet. 2013 Jul;9(7):e1003630
1*J:47046 Nagamine CM, Capehart J, Carlisle C, Chang D, Ovotestes in B6-XXSxr sex-reversed mice. Dev Biol. 1998 Apr 1;196(1):24-32
1*J:36829 Nagamine CM, Carlisle C, The dominant white spotting oncogene allele Kit(W-42J) exacerbates XY(DOM) sex reversal. Development. 1996 Nov;122(11):3597-605
8*J:58863 Nagamine CM, Morohashi K, Carlisle C, Chang DK, Sex reversal caused by Mus musculus domesticus Y chromosomes linked to variant expression of the testis-determining gene Sry. Dev Biol. 1999 Dec 1;216(1):182-94
3J:86618 Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF, Testis determination requires insulin receptor family function in mice. Nature. 2003 Nov 20;426(6964):291-5
3*J:90693 Nishino K, Hattori N, Tanaka S, Shiota K, DNA methylation-mediated control of Sry gene expression in mouse gonadal development. J Biol Chem. 2004 May 21;279(21):22306-13
4J:92839 Nordqvist K, Tohonen V, An mRNA differential display strategy for cloning genes expressed during mouse gonad development. Int J Dev Biol. 1997 Aug;41(4):627-38
2J:186462 Notini AJ, McClive PJ, Meachem SJ, van den Bergen JA, Western PS, Gustin SE, Harley VR, Koopman P, Sinclair AH, Redd1 is a novel marker of testis development but is not required for normal male reproduction. Sex Dev. 2012;6(5):223-30
1J:164348 Oh HJ, Li Y, Lau YF, Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod. 2005 Feb;72(2):407-15
7J:172637 Park S, Zeidan K, Shin JS, Taketo T, SRY upregulation of SOX9 is inefficient and delayed, allowing ovarian differentiation, in the B6.Y(TIR) gonad. Differentiation. 2011 Jul;82(1):18-27
1*J:186533 Pennekamp P, Feldner S, Seesing FJ, Psathaki OE, Scholer HR, Wieacker P, Dworniczak B, Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice. Sex Dev. 2011;5(4):197-204
10J:67267 Perera EM, Martin H, Seeherunvong T, Kos L, Hughes IA, Hawkins JR, Berkovitz GD, Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. Endocrinology. 2001 Jan;142(1):455-63
5J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
1J:156651 Sarraj MA, Escalona RM, Umbers A, Chua HK, Small C, Griswold M, Loveland K, Findlay JK, Stenvers KL, Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice. Biol Reprod. 2010 Jan;82(1):153-62
1J:174891 Sim H, Argentaro A, Czech DP, Bagheri-Fam S, Sinclair AH, Koopman P, Boizet-Bonhoure B, Poulat F, Harley VR, Inhibition of SRY-calmodulin complex formation induces ectopic expression of ovarian cell markers in developing XY gonads. Endocrinology. 2011 Jul;152(7):2883-93
10*J:98391 Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF, Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Dev Dyn. 2005 Jun;233(2):612-22
1J:78688 Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH, Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002 Oct;129(19):4627-34
2J:57530 Toyooka Y, Tanaka SS, Hirota O, Tanaka S, Takagi N, Yamanouchi K, Tojo H, Tachi C, Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY. Int J Dev Biol. 1998 Nov;42(8):1143-51
1J:172351 Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, Wells S, Cheeseman M, Xia Y, Ostrer H, Greenfield A, Minor Abnormalities of Testis Development in Mice Lacking the Gene Encoding the MAPK Signalling Component, MAP3K1. PLoS One. 2011;6(5):e19572
9J:191096 Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A, Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012 Nov 13;23(5):1020-31
3J:121150 Wilhelm D, Hiramatsu R, Mizusaki H, Widjaja L, Combes AN, Kanai Y, Koopman P, SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem. 2007 Apr;282(14):10553-60
13J:103443 Wilhelm D, Martinson F, Bradford S, Wilson MJ, Combes AN, Beverdam A, Bowles J, Mizusaki H, Koopman P, Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol. 2005 Nov 1;287(1):111-24
3J:149243 Wilhelm D, Washburn LL, Truong V, Fellous M, Eicher EM, Koopman P, Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev. 2009 May-Jun;126(5-6):324-36

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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory