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Gene Expression Literature Summary
Symbol
Name
ID
Hnf1a
HNF1 homeobox A
MGI:98504

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4.5 E6.5 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13.5 E14 E14.5 E15.5 E16 E16.5 E17 E17.5 E18.5 E A
In situ protein (section) 2 2 1 4 3 1 4 1 2 1 2 3 7
In situ RNA (section) 1 1 1 1 1 1 2 1 1 3 1 1 1 1 3
In situ RNA (whole mount) 1 1 1 1
Northern blot 1 2
Western blot 1 3
RT-PCR 2 2 1 1 1 1 3 2 3 2 3 1 9 6 6 6 3 2 3 1 10
cDNA clones 1 1 1 1
RNase protection 1 1 1 1 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Hnf1a  HNF1 homeobox A   (Synonyms: hepatocyte nuclear factor 1, Hnf-1, HNF1, HNF1[a], Hnf1alpha, HNF1-alpha, LFB1, Tcf1)
Results  Reference
2J:61931 Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K, BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
4*J:31831 Blumenfeld M, Maury M, Chouard T, Yaniv M, Condamine H, Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development. 1991 Oct;113(2):589-99
10J:122635 Bosse T, Fialkovich JJ, Piaseckyj CM, Beuling E, Broekman H, Grand RJ, Montgomery RK, Krasinski SD, Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol. 2007 May;292(5):G1302-14
1J:106993 Briancon N, Weiss MC, In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J. 2006 Mar 22;25(6):1253-62
12J:31593 Cereghini S, Ott MO, Power S, Maury M, Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development. 1992 Nov;116(3):783-97
2*J:75933 Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP, The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development. 2002 Apr;129(8):1819-28
4*J:32278 De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, Cortese R, LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J. 1991 Jun;10(6):1435-43
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*J:47784 Dragatsis I, Efstratiadis A, Zeitlin A, Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues. Development. 1998 Apr;125(8):1529-39
1J:64984 Duncan SA, Transcriptional regulation of liver development. Dev Dyn. 2000 Oct;219(2):131-42
1J:55508 Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, Zenz R, Wagner EF, Zatloukal K, Functions of c-Jun in liver and heart development. J Cell Biol. 1999 May 31;145(5):1049-61
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
7*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1J:142415 Hoffman BG, Zavaglia B, Beach M, Helgason CD, Expression of Groucho/TLE proteins during pancreas development. BMC Dev Biol. 2008;8:81
1J:130203 Ijpenberg A, Perez-Pomares JM, Guadix JA, Carmona R, Portillo-Sanchez V, Macias D, Hohenstein P, Miles CM, Hastie ND, Munoz-Chapuli R, Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Dev Biol. 2007 Dec 1;312(1):157-70
5*J:89458 Jochheim A, Hillemann T, Kania G, Scharf J, Attaran M, Manns MP, Wobus AM, Ott M, Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int J Dev Biol. 2004 Feb;48(1):23-9
3J:192058 Jonckheere N, Vincent A, Franquet-Ansart H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, Van Seuningen I, GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Biochim Biophys Acta. 2012 Aug;1819(8):869-76
2J:53312 Kaestner KH, Katz J, Liu Y, Drucker DJ, Schutz G, Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev. 1999 Feb 15;13(4):495-504
1*J:94267 Kamiya A, Inoue Y, Kodama T, Gonzalez FJ, Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 2004 Dec 3;578(1-2):63-8
2*J:54660 Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T, Miyajima A, Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 1999 Apr 15;18(8):2127-36
1J:142721 Kanazawa T, Konno A, Hashimoto Y, Kon Y, Expression of Hepatocyte Nuclear Factor 4alpha in Developing Mice. Anat Histol Embryol. 2008 Sep 17;
3J:158123 Kanazawa T, Konno A, Hashimoto Y, Kon Y, Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney. Dev Dyn. 2010 Apr;239(4):1145-54
3J:65105 Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M, Noguchi T, Homeobox gene hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61
10J:111670 Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I, Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006 Aug 15;20(16):2293-305
3J:87162 Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J, Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. Hum Mol Genet. 2003 Dec 15;12(24):3307-14
1J:194050 Massa F, Garbay S, Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E, Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
1J:153980 Matsushita T, Chan YY, Kawanami A, Balmes G, Landreth GE, Murakami S, Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol. 2009 Nov;29(21):5843-57
3J:46477 Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B, Gearhart J, Identification of elf1, a beta-spectrin, in early mouse liver development. Int J Dev Biol. 1998 Mar;42(2):221-4
4J:12868 Miura N, Iwai K, Miyamoto I, Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos. Eur J Cell Biol. 1993 Apr;60(2):376-82
11J:79272 Nammo T, Yamagata K, Hamaoka R, Zhu Q, Akiyama TE, Gonzalez FJ, Miyagawa J, Matsuzawa Y, Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas. Diabetologia. 2002 Aug;45(8):1142-53
4*J:130176 Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I, Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas. Gene Expr Patterns. 2008 Jan;8(2):96-106
2J:83133 Nemer G, Nemer M, Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol. 2003 Feb 1;254(1):131-48
1J:152582 Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA, The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009 Jul;119(7):1888-98
6*J:1977 Ott MO, Rey-Campos J, Cereghini S, Yaniv M, vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech Dev. 1991 Dec;36(1-2):47-58
6*J:122569 Puri S, Hebrok M, Dynamics of embryonic pancreas development using real-time imaging. Dev Biol. 2007 Jun 1;306(1):82-93
4J:14806 Serfas MS, Tyner AL, HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. Am J Physiol. 1993 Sep;265(3 Pt 1):G506-13
1J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1J:144999 Su H, Trombly MI, Chen J, Wang X, Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
1J:63039 Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH, Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83
1J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
2J:93592 Tam PP, Khoo PL, Wong N, Tsang TE, Behringer RR, Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function. Dev Biol. 2004 Oct 1;274(1):171-87
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2J:138818 Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I, Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell. 2008 Aug 22;31(4):531-43
1*J:117226 Wei K, Che N, Chen F, Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression. Dev Dyn. 2007 Feb;236(2):416-25
4J:168513 Xu H, He JH, Xiao ZD, Zhang QQ, Chen YQ, Zhou H, Qu LH, Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development. Hepatology. 2010 Oct;52(4):1431-42

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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory