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Gene Expression Literature Summary
Symbol
Name
ID
Sox3
SRY (sex determining region Y)-box 3
MGI:98365

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12.5 E13.5 E14.5 E15 E15.5 E16.5 E18.5 E A
In situ protein (section) 1 1 6 1 4 6 3 2 1 2 2 4 6
In situ RNA (section) 2 1 2 2 1 5 3 1 3 2 2 1 1 1 2
In situ protein (whole mount) 1 1 1
In situ RNA (whole mount) 1 1 2 1 2 2 1 2 1 1
In situ reporter (knock in) 1 1 1 2 1 1
Northern blot 1 1 1
RT-PCR 1 1 1 1 1 1 1 1 1 1 1 1 4 1 1 2 1 1 5
cDNA clones 1
RNase protection 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Sox3  SRY (sex determining region Y)-box 3   (Synonyms: Sox-3)
Results  Reference
2J:181010 Acloque H, Ocana OH, Matheu A, Rizzoti K, Wise C, Lovell-Badge R, Nieto MA, Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell. 2011 Sep 13;21(3):546-58
1J:128347 Ahituv N, Zhu Y, Visel A, Holt A, Afzal V, Pennacchio LA, Rubin EM, Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007 Sep;5(9):e234
1J:198458 Ahlfeld J, Favaro R, Pagella P, Kretzschmar HA, Nicolis S, Schuller U, Sox2 requirement in sonic hedgehog-associated medulloblastoma. Cancer Res. 2013 Jun 15;73(12):3796-807
4J:101530 Bowl MR, Nesbit MA, Harding B, Levy E, Jefferson A, Volpi E, Rizzoti K, Lovell-Badge R, Schlessinger D, Whyte MP, Thakker RV, An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. J Clin Invest. 2005 Oct;115(10):2822-31
12*J:31475 Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow PN, Lovell-Badge R, A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development. 1996 Feb;122(2):509-20
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3J:204443 Egan CM, Nyman U, Skotte J, Streubel G, Turner S, O'Connell DJ, Rraklli V, Dolan MJ, Chadderton N, Hansen K, Farrar GJ, Helin K, Holmberg J, Bracken AP, CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and polycomb gene repression. Dev Cell. 2013 Aug 12;26(3):223-36
1J:99610 Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V, Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
1J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
1J:194843 Ferri A, Favaro R, Beccari L, Bertolini J, Mercurio S, Nieto-Lopez F, Verzeroli C, La Regina F, De Pietri Tonelli D, Ottolenghi S, Bovolenta P, Nicolis SK, Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh. Development. 2013 Mar;140(6):1250-61
1J:155627 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Gill H, Raoof S, De Gasperi R, Elder G, Kessaris N, Richardson WD, Malas S, SOX1 links the function of neural patterning and Notch signalling in the ventral spinal cord during the neuron-glial fate switch. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1114-20
1J:175526 Gomez-Lopez S, Wiskow O, Favaro R, Nicolis SK, Price DJ, Pollard SM, Smith A, Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. Glia. 2011 Nov;59(11):1588-99
7*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
5J:206315 Hoffmann SA, Hos D, Kuspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S, Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014 Jan;141(1):39-50
2J:123251 Holm PC, Mader MT, Haubst N, Wizenmann A, Sigvardsson M, Gotz M, Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. Mol Cell Neurosci. 2007 Jan;34(1):99-119
3J:195300 Hughes J, Piltz S, Rogers N, McAninch D, Rowley L, Thomas P, Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism. PLoS Genet. 2013 Mar;9(3):e1003290
1J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
2J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
1J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
1J:137186 Kurimoto K, Yabuta Y, Ohinata Y, Shigeta M, Yamanaka K, Saitou M, Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice. Genes Dev. 2008 Jun 15;22(12):1617-35
2J:185560 Lee B, Rizzoti K, Kwon DS, Kim SY, Oh S, Epstein DJ, Son Y, Yoon J, Baek K, Jeong Y, Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer. Dev Biol. 2012 Jun 15;366(2):393-403
6J:184232 Lee K, Tan J, Morris MB, Rizzoti K, Hughes J, Cheah PS, Felquer F, Liu X, Piltz S, Lovell-Badge R, Thomas PQ, Congenital hydrocephalus and abnormal subcommissural organ development in Sox3 transgenic mice. PLoS One. 2012;7(1):e29041
3*J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1J:156172 Marklund U, Hansson EM, Sundstrom E, de Angelis MH, Przemeck GK, Lendahl U, Muhr J, Ericson J, Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45
1J:138323 Miyagi S, Masui S, Niwa H, Saito T, Shimazaki T, Okano H, Nishimoto M, Muramatsu M, Iwama A, Okuda A, Consequence of the loss of Sox2 in the developing brain of the mouse. FEBS Lett. 2008 Aug 6;582(18):2811-5
1*J:180596 Ohyama K, Yasuda K, Onga K, Kakizuka A, Mori N, Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: Implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Gene Expr Patterns. 2012 Jan;12(1-2):36-45
1J:162001 Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ, NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. J Neurosci. 2010 Jul 7;30(27):9127-39
2*J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96
3J:99393 Raverot G, Weiss J, Park SY, Hurley L, Jameson JL, Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev Biol. 2005 Jul 1;283(1):215-25
7J:88507 Rizzoti K, Brunelli S, Carmignac D, Thomas PQ, Robinson IC, Lovell-Badge R, SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat Genet. 2004 Mar;36(3):247-55
6J:128002 Rizzoti K, Lovell-Badge R, SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis. Development. 2007 Oct;134(19):3437-48
8J:199191 Rogers N, Cheah PS, Szarek E, Banerjee K, Schwartz J, Thomas P, Expression of the murine transcription factor SOX3 during embryonic and adult neurogenesis. Gene Expr Patterns. 2013 Oct;13(7):240-8
3J:123685 Saarimaki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J, Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J Neurosci. 2007 Aug 8;27(32):8581-92
1J:148018 Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K, Shiroishi T, A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
1J:142649 Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP, Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism. Dis Model Mech. 2008 Nov;1(4-5):241-54
1J:124679 Schreiner S, Cossais F, Fischer K, Scholz S, Bosl MR, Holtmann B, Sendtner M, Wegner M, Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007 Sep;134(18):3271-81
3J:175105 Shen JH, Ingraham HA, Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002 Mar;16(3):529-40
2J:116148 Stolt CC, Schlierf A, Lommes P, Hillgartner S, Werner T, Kosian T, Sock E, Kessaris N, Richardson WD, Lefebvre V, Wegner M, SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006 Nov;11(5):697-709
1*J:98585 Stolt CC, Schmitt S, Lommes P, Sock E, Wegner M, Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord. Dev Biol. 2005 May 15;281(2):309-17
2J:171839 Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P, Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest. 2011 Jan 4;121(1):328-41
2J:145841 Tanaka S, Kamachi Y, Tanouchi A, Hamada H, Jing N, Kondoh H, Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells. Mol Cell Biol. 2004 Oct;24(20):8834-46
1*J:143535 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J, Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol. 2009 Jan 1;325(1):238-48
1J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1J:82084 Van de Putte T, Maruhashi M, Francis A, Nelles L, Kondoh H, Huylebroeck D, Higashi Y, Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet. 2003 Feb;72(2):465-70
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
9*J:57065 Wood HB, Episkopou V, Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Mech Dev. 1999 Aug;86(1-2):197-201
2J:120909 Xu C, Fan CM, Allocation of paraventricular and supraoptic neurons requires Sim1 function: a role for a Sim1 downstream gene PlexinC1. Mol Endocrinol. 2007 May;21(5):1234-45
1J:182725 Zhao L, Zevallos SE, Rizzoti K, Jeong Y, Lovell-Badge R, Epstein DJ, Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia. Dev Cell. 2012 Mar 13;22(3):585-96
1J:157264 Zhao Y, Mailloux CM, Hermesz E, Palkovits M, Westphal H, A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol. 2010 Jan 15;337(2):313-23

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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory