Gene Expression Literature Summary

• Symbol: Polr2a
• Name: polymerase (RNA) II (DNA directed) polypeptide A
• ID: MGI:98086

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E17	E18	E18.5	E	P
Immunohistochemistry (section)	1	1		1		3		1	1				1	1		1		3
In situ RNA (section)				1		2		1	1	2	4	1	1			2		5
Immunohistochemistry (whole mount)	2																	1
In situ RNA (whole mount)			1	1	1	1
Western blot							1		1	2							1	1
RT-PCR				1				1		2		1	1		1			4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Polr2a  polymerase (RNA) II (DNA directed) polypeptide A   (Synonyms: 220kDa, Rpo2-1)
Results	Reference
1	J:269736 Ancelin K, Syx L, Borensztein M, Ranisavljevic N, Vassilev I, Briseno-Roa L, Liu T, Metzger E, Servant N, Barillot E, Chen CJ, Schule R, Heard E, Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation. Elife. 2016 Feb 2;5:e08851
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:308799 Billings SE, Myers NM, Quiruz L, Cheng AG, Opposing effects of Wnt/beta-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea. Development. 2021 Jun 1;148(11):dev199091
2*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2	J:171293 Campbell GR, Baudhuin A, Vranizan K, Ngai J, Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
1	J:302526 Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X, EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):31
2	J:310811 Chen Y, Damayanti NP, Irudayaraj J, Dunn K, Zhou FC, Diversity of two forms of DNA methylation in the brain. Front Genet. 2014;5:46
1	J:274882 Del-Pozo J, MacIntyre N, Azar A, Glover J, Milne E, Cheeseman M, Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model. Dis Model Mech. 2019 Mar 21;12(3):dmm038315
1	J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
1*	J:182924 Galatioto J, Mascareno E, Siddiqui MA, CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration. J Cell Sci. 2010 Nov 1;123(Pt 21):3789-95
2	J:284494 Hancock ML, Meyer RC, Mistry M, Khetani RS, Wagschal A, Shin T, Ho Sui SJ, Naar AM, Flanagan JG, Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression. Cell. 2019 Apr 18;177(3):722-736.e22
1	J:245009 Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almodovar C, Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 06;8:14583
3	J:304154 Honjo K, Won WJ, King RG, Ianov L, Crossman DK, Easlick JL, Shakhmatov MA, Khass M, Vale AM, Stephan RP, Li R, Davis RS, Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection. Front Immunol. 2020;11:82
5	J:190424 Kraemer N, Neubert G, Issa L, Ninnemann O, Seiler AE, Kaindl AM, Reference genes in the developing murine brain and in differentiating embryonic stem cells. Neurol Res. 2012 Sep;34(7):664-8
1*	J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
2	J:280465 Lewis WR, Bales KL, Revell DZ, Croyle MJ, Engle SE, Song CJ, Malarkey EB, Uytingco CR, Shan D, Antonellis PJ, Nagy TR, Kesterson RA, Mrug MM, Martens JR, Berbari NF, Gross AK, Yoder BK, Mks6 mutations reveal tissue- and cell type-specific roles for the cilia transition zone. FASEB J. 2019 Jan;33(1):1440-1455
1*	J:270646 Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A, Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem. 2018 Aug 24;293(34):13176-13190
2*	J:141643 Montano MM, Doughman YQ, Deng H, Chaplin L, Yang J, Wang N, Zhou Q, Ward NL, Watanabe M, Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
2	J:297063 Najarro EH, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG, Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. Development. 2020 Oct 5;147(19):dev191981
1	J:338266 Nie X, Xu Q, Xu C, Chen F, Wang Q, Qin D, Wang R, Gao Z, Lu X, Yang X, Wu Y, Gu C, Xie W, Li L, Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation. Nat Commun. 2023 Jul 17;14(1):4275
1*	J:291583 Novakova M, Hampl M, Vrabel D, Prochazka J, Petrezselyova S, Prochazkova M, Sedlacek R, Kavkova M, Zikmund T, Kaiser J, Juan HC, Fann MJ, Buchtova M, Kohoutek J, Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13. Front Cell Dev Biol. 2019;7:155
3	J:245924 Pauerstein PT, Tellez K, Willmarth KB, Park KM, Hsueh B, Efsun Arda H, Gu X, Aghajanian H, Deisseroth K, Epstein JA, Kim SK, A radial axis defined by semaphorin-to-neuropilin signaling controls pancreatic islet morphogenesis. Development. 2017 Oct 15;144(20):3744-3754
1	J:286590 Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH, Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 Mar 9;52(5):647-658.e6
1	J:154764 Schoeftner S, Blanco R, de Silanes IL, Munoz P, Gomez-Lopez G, Flores JM, Blasco MA, Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19393-8
1	J:122743 Seki Y, Yamaji M, Yabuta Y, Sano M, Shigeta M, Matsui Y, Saga Y, Tachibana M, Shinkai Y, Saitou M, Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. Development. 2007 Jul;134(14):2627-38
2*	J:337000 Simmers MD, Jima DD, Tsuji Y, Cowley M, LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response. Front Cell Dev Biol. 2023;11:1151108
1	J:172308 Stefan M, Simmons RA, Bertera S, Trucco M, Esni F, Drain P, Nicholls RD, Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011 May;300(5):E909-22
1*	J:311142 Sun H, Wang T, Atkinson PJ, Billings SE, Dong W, Cheng AG, Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing. Front Cell Dev Biol. 2021;9:690955
1*	J:105770 Tierling S, Dalbert S, Schoppenhorst S, Tsai CE, Oliger S, Ferguson-Smith AC, Paulsen M, Walter J, High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12. Genomics. 2006 Feb;87(2):225-35
1	J:169365 Turner JM, Mahadevaiah SK, Benavente R, Offenberg HH, Heyting C, Burgoyne PS, Analysis of male meiotic 'sex body' proteins during XY female meiosis provides new insights into their functions. Chromosoma. 2000 Sep;109(6):426-32
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:339060 Xu W, Yang Y, Yu Y, Wen C, Zhao S, Cao L, Zhao S, Qin Y, Chen ZJ, FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells. BMC Biol. 2023 Aug 15;21(1):174
1	J:327430 Yang Y, Xu W, Gao F, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y, Chen ZJ, Zhao S, Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2203208119
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:255262 Yu C, Fan X, Sha QQ, Wang HH, Li BT, Dai XX, Shen L, Liu J, Wang L, Liu K, Tang F, Fan HY, CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes. Cell Rep. 2017 Aug 1;20(5):1161-1172
1*	J:138573 Yurttas P, Vitale AM, Fitzhenry RJ, Cohen-Gould L, Wu W, Gossen JA, Coonrod SA, Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development. 2008 Aug;135(15):2627-36
1	J:333722 Zhao S, Huang C, Yang Y, Xu W, Yu Y, Wen C, Cao L, Gao F, Qin Y, Chen ZJ, Guo T, Zhao S, DNA repair protein FANCD2 has both ubiquitination-dependent and ubiquitination-independent functions during germ cell development. J Biol Chem. 2023 Jan 13;299(3):102905
3	J:172282 Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ, Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One. 2011;6(4):e18795