Gene Expression Literature Summary

• Symbol: Plat
• Name: plasminogen activator, tissue
• ID: MGI:97610

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2.5	E4	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	P
Immunohistochemistry (section)								1	1	2			1		2	1		2	1						4
In situ RNA (section)					1	1				1	1	1	1	1	2	1	1	1	3	2	1	1	1	1	6
In situ RNA (whole mount)						1	1	1
In situ reporter (knock in)																									1
Northern blot	1	1	1	1				1	1	1	1		1		1	1		1	2	1		1		1	4
Western blot															1										2
RT-PCR	2	1			1	2		6	2	2	2		4		3	1		1		1					4
cDNA clones						1		1																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Plat  plasminogen activator, tissue   (Synonyms: D8Ertd2e, MGC:18508, tPA, t-PA)
Results	Reference
2	J:206954 Achuta VS, Rezov V, Uutela M, Louhivuori V, Louhivuori L, Castren ML, Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice. J Neurosci. 2014 Jan 29;34(5):1916-23
1	J:297574 Bres EE, Safina D, Muller J, Bedner P, Yang H, Helluy X, Shchyglo O, Jansen S, Mark MD, Esser A, Steinhauser C, Herlitze S, Pietrzik CU, Sirko S, Manahan-Vaughan D, Faissner A, Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures. Glia. 2020 Dec;68(12):2517-2549
1*	J:177885 Brunskill EW, Georgas K, Rumballe B, Little MH, Potter SS, Defining the molecular character of the developing and adult kidney podocyte. PLoS One. 2011;6(9):e24640
4*	J:157446 Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR, Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19;18(1):25-38
1	J:161416 Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG, Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol. 2010 Jun 15;342(2):169-79
6*	J:99963 Collinge JE, Simirskii VN, Duncan MK, Expression of tissue plasminogen activator during eye development. Exp Eye Res. 2005 Jul;81(1):90-6
1	J:39631 Domashenko AD, Latham KE, Hatton KS, Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development. Mol Reprod Dev. 1997 May;47(1):57-65
3*	J:86843 Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI, Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Dev Biol. 2003 Dec 15;264(2):309-22
1	J:139945 El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M, SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. Development. 2008 Sep;135(17):2981-91
1	J:93392 Fredriksson L, Li H, Fieber C, Li X, Eriksson U, Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 2004 Sep 29;23(19):3793-802
6*	J:29590 Friedman GC, Seeds NW, Tissue plasminogen activator mRNA expression in granule neurons coincides with their migration in the developing cerebellum. J Comp Neurol. 1995 Oct 2;360(4):658-70
3*	J:324293 Gindi N, Grossman H, Bar-Joseph H, Miller I, Nemerovsky L, Hadas R, Nevo N, Galiani D, Dekel N, Shalgi R, Fyn and argonaute 2 participate in maternal-mRNA degradation during mouse oocyte maturation. Cell Cycle. 2022 Apr;21(8):792-804
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:250152 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z, Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12;5:12982
1	J:39694 Jensen PJ, Lavker RM, Modulation of the plasminogen activator cascade during enhanced epidermal proliferation in vivo. Cell Growth Differ. 1996 Dec;7(12):1793-804
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
22*	J:24334 Lefebvre O, Regnier C, Chenard MP, Wendling C, Chambon P, Basset P, Rio MC, Developmental expression of mouse stromelysin-3 mRNA. Development. 1995 Apr;121(4):947-55
1	J:45195 Melnick M, Chen H, Buckley S, Warburton D, Jaskoll T, Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis. Dev Dyn. 1998 Jan;211(1):11-25
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
5	J:88700 Odet F, Guyot R, Leduque P, Le Magueresse-Battistoni B, Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development. Endocrinology. 2004 Mar;145(3):1481-9
1	J:61177 Oh SP, Seki T, Goss KA, Imamura T, Yi Y, Donahoe PK, Li L, Miyazono K, ten Dijke P, Kim S, Li E, Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2626-31
9*	J:74089 Ong K, Horsfall W, Conway EM, Schuh AC, Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
5	J:27182 Rambhatla L, Patel B, Dhanasekaran N, Latham KE, Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach. Mol Reprod Dev. 1995 Jul;41(3):314-24
2	J:190524 Shalom-Barak T, Zhang X, Chu T, Timothy Schaiff W, Reddy JK, Xu J, Sadovsky Y, Barak Y, Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
1*	J:262744 Shetty R, Joshi D, Jain M, Vasudevan M, Paul JC, Bhat G, Banerjee P, Abe T, Kiyonari H, VijayRaghavan K, Inamdar MS, Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632
1	J:152846 Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH, Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development. 2009 Aug;136(15):2653-63
6	J:36056 Thewke DP, Seeds NW, Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system. J Neurosci. 1996 Nov 1;16(21):6933-44
2	J:53445 Thewke DP, Seeds NW, The expression of mRNAs for hepatocyte growth factor/scatter factor, its receptor c-met, and one of its activators tissue-type plasminogen activator show a systematic relationship in the developing and adult cerebral cortex and hippocampus. Brain Res. 1999 Mar 13;821(2):356-67
2*	J:17586 Timme TL, Truong LD, Merz VW, Krebs T, Kadmon D, Flanders KC, Park SH, Thompson TC, Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis. Endocrinology. 1994 Mar;134(3):1039-45
1*	J:83730 Wang G, Zhang J, Moskophidis D, Mivechi NF, Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003 May;36(1):48-61
9	J:258463 Wang Y, Terrell AM, Riggio BA, Anand D, Lachke SA, Duncan MK, beta1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3896-3922