Gene Expression Literature Summary

• Symbol: Pcsk5
• Name: proprotein convertase subtilisin/kexin type 5
• ID: MGI:97515

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E3	E3.5	E4	E4.5	E5	E5.5	E6	E6.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E14.5	E15.5	E16.5	E18.5	E19	E19.5	P
Immunohistochemistry (section)							1		1		1									1						1
In situ RNA (section)								1		1		2	3		2	4	2	2	1	1	2	1	1	1	1	5
In situ RNA (whole mount)												1	1	1	2	1	3
In situ reporter (knock in)																			1							1
Northern blot			1			1		1		1		1	1		1	1	1	1								1
Western blot											1															1
RT-PCR	1	1		1	1	1																				3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pcsk5  proprotein convertase subtilisin/kexin type 5   (Synonyms: b2b1549Clo, b2b585Clo, PC5/6A, PC5A, PC6, SPC6)
Results	Reference
1*	J:165396 Chitramuthu BP, Baranowski DC, Cadieux B, Rousselet E, Seidah NG, Bennett HP, Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development. Dev Dyn. 2010 Nov;239(11):2933-46
7*	J:34068 Constam DB, Calfon M, Robertson EJ, SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996 Jul;134(1):181-91
8*	J:104195 Essalmani R, Hamelin J, Marcinkiewicz J, Chamberland A, Mbikay M, Chretien M, Seidah NG, Prat A, Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse. Mol Cell Biol. 2006 Jan;26(1):354-61
6	J:134264 Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A, In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5750-5
1	J:256979 Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD, Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone. Bone. 2018 Feb;107:45-55
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
3	J:165252 Mesnard D, Constam DB, Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. J Cell Biol. 2010 Oct 4;191(1):129-39
6	J:137433 Nie G, Li Y, Wang M, Liu YX, Findlay JK, Salamonsen LA, Inhibiting uterine PC6 blocks embryo implantation: an obligatory role for a proprotein convertase in fertility. Biol Reprod. 2005 Apr;72(4):1029-36
1	J:174826 Rousselet E, Marcinkiewicz J, Kriz J, Zhou A, Hatten ME, Prat A, Seidah NG, PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. J Lipid Res. 2011 Jul;52(7):1383-91
1	J:140467 Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, Chretien M, Calvo F, Seidah NG, Khatib AM, Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7. Gut. 2008 Nov;57(11):1573-82
1	J:142110 Shifley ET, Cole SE, Lunatic fringe protein processing by proprotein convertases may contribute to the short protein half-life in the segmentation clock. Biochim Biophys Acta. 2008 Dec;1783(12):2384-90
6*	J:104961 St Germain C, Croissandeau G, Mayne J, Baltz JM, Chretien M, Mbikay M, Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development. Mol Reprod Dev. 2005 Dec;72(4):483-93
2*	J:241568 Szumska D, Cioroch M, Keeling A, Prat A, Seidah NG, Bhattacharya S, Pcsk5 is required in the early cranio-cardiac mesoderm for heart development. BMC Dev Biol. 2017 Apr 26;17(1):6
1	J:136243 Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S, VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 2008 Jun 1;22(11):1465-77
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
1	J:116943 Thomas JT, Prakash D, Weih K, Moos M Jr, CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces. J Biol Chem. 2006 Sep 8;281(36):26725-33
1*	J:175584 Tsuda T, Iwai N, Deguchi E, Kimura O, Ono S, Furukawa T, Sasaki Y, Fumino S, Kubota Y, PCSK5 and GDF11 Expression in the Hindgut Region of Mouse Embryos with Anorectal Malformations. Eur J Pediatr Surg. 2011 Aug;21(4):238-41
17	J:79640 Wong BS, Liu S, Schultz GA, Rancourt DE, Subtilisin proprotein convertase-6 expression in the mouse uterus during implantation and artificially induced decidualization. Mol Reprod Dev. 2002 Apr;61(4):453-9