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Gene Expression Literature Summary
Symbol
Name
ID
Otx2
orthodenticle homolog 2
MGI:97451

413 matching records from 413 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E A
In situ protein (section) 1 2 2 9 2 5 4 2 8 2 17 4 12 4 21 2 8 1 16 2 6 3 7 2 4 2 4 1 6 16
In situ RNA (section) 1 4 18 4 15 8 7 3 18 9 46 1 16 4 44 1 9 3 18 3 10 3 4 1 4 2 7 4 15
In situ protein (whole mount) 1 1 1 1 2 1 1
In situ RNA (whole mount) 2 2 2 18 15 59 40 72 20 65 2 25 1 10 5 1 2 11
In situ reporter (knock in) 1 1 1 2 5 1 5 3 3 1 3 1 3 1 1 1 2
Northern blot 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
Western blot 4 1 4 1 1 1 1 1
RT-PCR 2 2 1 1 2 2 7 2 7 3 6 3 3 1 5 1 3 7 3 1 4 2 3 1 1 1 2 9
cDNA clones 1 2 1 1 2
RNase protection 1 1 5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Otx2  orthodenticle homolog 2   (Synonyms: E130306E05Rik)
Results  Reference
1J:142510 Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV, Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9
8*J:89361 Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A, OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501
3*J:52989 Acampora D, Avantaggiato V, Tuorto F, Barone P, Perera M, Choo D, Wu D, Corte G, Simeone A, Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development. 1999 Apr;126(7):1417-26
3J:47899 Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A, Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development. 1998 May;125(9):1691-702
11*J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104
4J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50
7*J:72726 Acampora D, Boyl PP, Signore M, Martinez-Barbera JP, Ilengo C, Puelles E, Annino A, Reichert H, Corte G, Simeone A, OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development. 2001 Dec;128(23):4801-13
16J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
7J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55
13*J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
2J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809
4J:53300 Acampora D, Simeone A, The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis. Trends Neurosci. 1999 Mar;22(3):116-22
2J:185533 Achim K, Peltopuro P, Lahti L, Li J, Salminen M, Partanen J, Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development. 2012 Jul;139(13):2360-70
1J:69637 Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M, The wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev Biol. 2001 Jun 1;234(1):244-60
2*J:98077 Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, McInnes RR, Auricchio A, Banfi S, Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet. 2005 Apr 1;14(7):913-23
2J:127541 Andersson O, Bertolino P, Ibanez CF, Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
1J:90898 Andrae J, Afink G, Zhang XQ, Wurst W, Nister M, Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia. Mol Cell Neurosci. 2004 Jun;26(2):308-21
13*J:20959 Ang SL, Conlon RA, Jin O, Rossant J, Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development. 1994 Oct;120(10):2979-89
2J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
3J:134435 Anselme I, Laclef C, Lanaud M, Ruther U, Schneider-Maunoury S, Defects in brain patterning and head morphogenesis in the mouse mutant Fused toes. Dev Biol. 2007 Apr 1;304(1):208-20
2J:131055 Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ, Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
1J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47
2*J:32929 Avantaggiato V, Acampora D, Tuorto F, Simeone A, Retinoic acid induces stage-specific repatterning of the rostral central nervous system. Dev Biol. 1996 May 1;175(2):347-57
5*J:49909 Ba-Charvet KT, von Boxberg Y, Guazzi S, Boncinelli E, Godement P, A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain. Development. 1998 Nov;125(21):4273-82
7J:63629 Baas D, Bumsted KM, Martinez JA, Vaccarino FM, Wikler KC, Barnstable CJ, The subcellular localization of OTX2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res Mol Brain Res. 2000 May 31;78(1-2):26-37
2J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76
8*J:29060 Bally-Cuif L, Cholley B, Wassef M, Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech Dev. 1995 Sep;53(1):23-34
1J:130205 Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP, Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007 Dec 1;312(1):312-20
2J:181601 Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA, Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn. 2012 Apr;241(4):814-29
5J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
2J:131764 Basson MA, Echevarria D, Petersen Ahn C, Sudarov A, Joyner AL, Mason IJ, Martinez S, Martin GR, Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. Development. 2008 Mar;135(5):889-98
4J:83532 Baumer N, Marquardt T, Stoykova A, Spieler D, Treichel D, Ashery-Padan R, Gruss P, Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development. 2003 Jul;130(13):2903-15
3J:81247 Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB, Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002 Dec;4(12):981-5
2*J:49955 Belaoussoff M, Farrington SM, Baron MH, Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
1*J:71879 Bernier G, Vukovich W, Neidhardt L, Herrmann BG, Gruss P, Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development. 2001 Oct;128(20):3987-94
12J:188155 Bharti K, Gasper M, Ou J, Brucato M, Clore-Gronenborn K, Pickel J, Arnheiter H, A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet. 2012 Jul;8(7):e1002757
1J:175338 Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V, Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9
1J:198636 Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J, Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 2013 Jul;140(14):2961-71
2J:173623 Biechele S, Cox BJ, Rossant J, Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol. 2011 Jul 15;355(2):275-85
1J:122457 Binato R, Pizzatti L, Abdelhay E, Otx2 is a putative candidate to activate mice Msx1 gene from distal enhancer. Biochem Biophys Res Commun. 2007 Jun 29;358(2):655-60
4*J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
2J:137136 Blaess S, Stephen D, Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103
3J:118802 Blak AA, Naserke T, Saarimaki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W, Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev Biol. 2007 Mar 1;303(1):231-43
1J:185651 Bluske KK, Vue TY, Kawakami Y, Taketo MM, Yoshikawa K, Johnson JE, Nakagawa Y, beta-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus. Development. 2012 Aug;139(15):2692-702
1J:111395 Boehmelt G, Wakeham A, Elia A, Sasaki T, Plyte S, Potter J, Yang Y, Tsang E, Ruland J, Iscove NN, Dennis JW, Mak TW, Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. EMBO J. 2000 Oct 2;19(19):5092-104
1J:121232 Bok J, Dolson DK, Hill P, Ruther U, Epstein DJ, Wu DK, Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development. 2007 May;134(9):1713-22
1J:28206 Boncinelli E, Patterns of gene expression and the subdivision of the forebrain. Hum Reprod. 1995;10(Abstract Book 2):1 (Abstr)
10*J:71034 Boyl PP, Signore M, Acampora D, Martinez-Barbera JP, Ilengo C, Annino A, Corte G, Simeone A, Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR. Development. 2001 Aug;128(15):2989-3000
2J:70006 Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ, Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001 Jun 21;411(6840):965-9
3J:155785 Brinkmeier ML, Davis SW, Carninci P, MacDonald JW, Kawai J, Ghosh D, Hayashizaki Y, Lyons RH, Camper SA, Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics. 2009 May;93(5):449-60
2J:57538 Broccoli V, Boncinelli E, Wurst W, The caudal limit of Otx2 expression positions the isthmic organizer. Nature. 1999 Sep 9;401(6749):164-8
1*J:76815 Broccoli V, Colombo E, Cossu G, Dmbx1 is a paired-box containing gene specifically expressed in the caudal most brain structures. Mech Dev. 2002 Jun;114(1-2):219
1J:88192 Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W, Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. J Neurosci. 2003 May 15;23(10):4199-207
2J:176481 Brown A, Machan JT, Hayes L, Zervas M, Molecular organization and timing of Wnt1 expression define cohorts of midbrain dopamine neuron progenitors in vivo. J Comp Neurol. 2011 Oct 15;519(15):2978-3000
1J:180898 Brown AS, Epstein DJ, Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development. 2011 Sep;138(18):3967-76
1J:175804 Brzezinski JA 4th, Kim EJ, Johnson JE, Reh TA, Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011 Aug;138(16):3519-31
4J:156665 Brzezinski JA 4th, Lamba DA, Reh TA, Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb;137(4):619-29
2J:121357 Bu P, Evrard YA, Lozano G, Dent SY, Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May;27(9):3405-16
1*J:89168 Bulfone A, Caccioppoli C, Pardini C, Faedo A, Martinez S, Banfi S, Pcp4l1, a novel gene encoding a Pcp4-like polypeptide, is expressed in specific domains of the developing brain. Gene Expr Patterns. 2004 May;4(3):297-301
3J:60735 Bumsted KM, Barnstable CJ, Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest Ophthalmol Vis Sci. 2000 Mar;41(3):903-8
1J:92326 Burton Q, Cole LK, Mulheisen M, Chang W, Wu DK, The role of Pax2 in mouse inner ear development. Dev Biol. 2004 Aug 1;272(1):161-75
1J:159104 Cai Z, Feng GS, Zhang X, Temporal requirement of the protein TyrosinePhosphatase Shp2 in establishing the neuronal fatein early retinal development. J Neurosci. 2010 Mar 17;30(11):4110-9
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2J:155225 Castelo-Branco G, Andersson ER, Minina E, Sousa KM, Ribeiro D, Kokubu C, Imai K, Prakash N, Wurst W, Arenas E, Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Dev Dyn. 2009 Sep 30;239(1):211-221
1*J:142648 Castranio T, Mishina Y, Bmp2 is required for cephalic neural tube closure in the mouse. Dev Dyn. 2008 Dec 18;238(1):110-122
1J:112232 Chazaud C, Rossant J, Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development. 2006 Sep;133(17):3379-87
1J:104371 Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW, The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006 Jan;133(2):319-29
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2J:161813 Chilov D, Sinjushina N, Saarimaki-Vire J, Taketo MM, Partanen J, beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. PLoS One. 2010;5(6):e10881
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1J:173332 Chung S, Moon JI, Leung A, Aldrich D, Lukianov S, Kitayama Y, Park S, Li Y, Bolshakov VY, Lamonerie T, Kim KS, ES cell-derived renewable and functional midbrain dopaminergic progenitors. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9703-8
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1J:156733 Deng M, Pan L, Xie X, Gan L, Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear. Dev Biol. 2010 Feb 1;338(1):38-49
6J:206591 Di Giovannantonio LG, Di Salvio M, Omodei D, Prakash N, Wurst W, Pierani A, Acampora D, Simeone A, Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 2014 Jan;141(2):377-88
3J:166896 Di Salvio M, Di Giovannantonio LG, Acampora D, Prosperi R, Omodei D, Prakash N, Wurst W, Simeone A, Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP. Nat Neurosci. 2010 Dec;13(12):1481-8
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1J:190919 Ellisor D, Rieser C, Voelcker B, Machan JT, Zervas M, Genetic dissection of midbrain dopamine neuron development in vivo. Dev Biol. 2012 Dec 15;372(2):249-62
2J:198627 Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H, Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013 Aug;140(15):3128-38
3J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
1J:172287 Esteve P, Sandonis A, Cardozo M, Malapeira J, Ibanez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P, SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. Nat Neurosci. 2011 May;14(5):562-9
2J:176438 Esteve P, Sandonis A, Ibanez C, Shimono A, Guerrero I, Bovolenta P, Secreted frizzled-related proteins are required for Wnt/{beta}-catenin signalling activation in the vertebrate optic cup. Development. 2011 Oct;138(19):4179-84
1J:104125 Evans AL, Gage PJ, Expression of the homeobox gene Pitx2 in neural crest is required for optic stalk and ocular anterior segment development. Hum Mol Genet. 2005 Nov 15;14(22):3347-59
1J:149800 Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Gotz M, Sommer L, Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell. 2008 May 8;2(5):472-83
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