Gene Expression Literature Summary

• Symbol: Oprm1
• Name: opioid receptor, mu 1
• ID: MGI:97441

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)																							2					4				13
In situ RNA (section)								1		1		1		1		2		2		3		2	3	2		1		3		1		9
Immunohistochemistry (whole mount)	2	1	1	2	1	2
In situ RNA (whole mount)																							1
In situ reporter (knock in)																																2
Western blot																												1				2
RT-PCR	1	1	1	1	1	1	1		1		1		1		1		1		1		1				1		1		1		1	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Oprm1  opioid receptor, mu 1   (Synonyms: MOP-R, MOP receptor, mor, MOR-1, muOR, Oprm)
Results	Reference
1	J:131380 Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD, Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008 Jan 16;28(3):622-32
4*	J:288326 Bailly J, Del Rossi N, Runtz L, Li JJ, Park D, Scherrer G, Tanti A, Birling MC, Darcq E, Kieffer BL, Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus. eNeuro. 2020 May/Jun;7(3):ENEURO.0433-19.2020
1	J:106971 Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q, Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 Feb 2;49(3):365-77
14*	J:213203 Chen Y, Kong S, Tang X, Fu Y, Wang B, Zhang S, Wang H, Preimplantation mouse embryo is a target for opioid ligand-receptor signaling. Biol Reprod. 2014 Jul;91(1):4
1	J:157097 Cocas LA, Miyoshi G, Carney RS, Sousa VH, Hirata T, Jones KR, Fishell G, Huntsman MM, Corbin JG, Emx1-lineage progenitors differentially contribute to neural diversity in the striatum and amygdala. J Neurosci. 2009 Dec 16;29(50):15933-46
1	J:201994 Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K, The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4026-35
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:185665 Guo Z, Zhao C, Huang M, Huang T, Fan M, Xie Z, Chen Y, Zhao X, Xia G, Geng J, Cheng L, Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
1*	J:203842 He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B, Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29;154(5):1085-99
1	J:262500 Hirata H, Umemori J, Yoshioka H, Koide T, Watanabe K, Shimoda Y, Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages. J Neurosci Res. 2016 Jan;94(1):74-89
3	J:41135 Kalyuzhny AE, Hensleigh HC, Arvidsson U, Elde R, Immunocytochemical localization of mu-opioid receptors in follicular cells and preimplantation mouse embryos. Anat Embryol (Berl). 1997 May;195(5):451-5
13*	J:79813 Ko JL, Chen HC, Loh HH, Differential promoter usage of mouse mu-opioid receptor gene during development. Brain Res Mol Brain Res. 2002 Aug 15;104(2):184-93
1	J:256526 Kuerbitz J, Arnett M, Ehrman S, Williams MT, Vorhees CV, Fisher SE, Garratt AN, Muglia LJ, Waclaw RR, Campbell K, Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes. J Neurosci. 2018 Jan 31;38(5):1160-1177
5	J:80266 Le Moine C, Fauchey V, Jaber M, Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development. Neuroscience. 2002;112(1):131-9
2	J:134641 Liao WL, Tsai HC, Wang HF, Chang J, Lu KM, Wu HL, Lee YC, Tsai TF, Takahashi H, Wagner M, Ghyselinck NB, Chambon P, Liu FC, Modular patterning of structure and function of the striatum by retinoid receptor signaling. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6765-70
2*	J:314358 Liu S, Kim DI, Oh TG, Pao GM, Kim JH, Palmiter RD, Banghart MR, Lee KF, Evans RM, Han S, Neural basis of opioid-induced respiratory depression and its rescue. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2022134118
1	J:206284 Lu KM, Evans SM, Hirano S, Liu FC, Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
1	J:155518 Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF, Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21900-5
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
1	J:126070 Richards AB, Scheel TA, Wang K, Henkemeyer M, Kromer LF, EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. Eur J Neurosci. 2007 May;25(9):2619-28
1	J:226849 Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Meneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME, Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Hum Mol Genet. 2015 Dec 20;24(25):7159-70
1	J:142535 Sargeant TJ, Day DJ, Miller JH, Steel RW, Acute in utero morphine exposure slows G2/M phase transition in radial glial and basal progenitor cells in the dorsal telencephalon of the E15.5 embryonic mouse. Eur J Neurosci. 2008 Sep;28(6):1060-7
4	J:127248 Sargeant TJ, Day DJ, Mrkusich EM, Foo DF, Miller JH, Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain. Brain Res. 2007 Oct 17;1175:28-38
1	J:290119 Soleilhavoup C, Travaglio M, Patrick K, Garcao P, Boobalan E, Adolfs Y, Spriggs RV, Moles-Garcia E, Dhiraj D, Oosterveen T, Ferri SL, Abel T, Brodkin ES, Pasterkamp RJ, Brooks BP, Panman L, Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:72724 Toresson H, Campbell K, A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice. Development. 2001 Dec;128(23):4769-80
1	J:343077 Tran H, Sawatari A, Leamey CA, Ten-m3 plays a role in the formation of thalamostriatal projections. Dev Neurobiol. 2023 Oct-Nov;83(7-8):255-267
1	J:160511 Waclaw RR, Ehrman LA, Pierani A, Campbell K, Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse. J Neurosci. 2010 May 19;30(20):6944-53
1	J:83567 Yun K, Garel S, Fischman S, Rubenstein JL, Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia. J Comp Neurol. 2003 Jun 23;461(2):151-65
2	J:66590 Yun K, Potter S, Rubenstein JL, Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001 Jan;128(2):193-205
10*	J:47101 Zhu Y, Hsu MS, Pintar JE, Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse. J Neurosci. 1998 Apr 1;18(7):2538-49
1*	J:50180 Zhu Y, Pintar JE, Expression of opioid receptors and ligands in pregnant mouse uterus and placenta. Biol Reprod. 1998 Oct;59(4):925-32