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Gene Expression Literature Summary
Symbol
Name
ID
Nos3
nitric oxide synthase 3, endothelial cell
MGI:97362

42 matching records from 42 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2 E2.5 E3 E3.5 E4 E7.5 E8 E8.5 E9 E9.5 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19.5 E20 E A
In situ protein (section) 1 2 1 3 1 3 1 3 2 1 1 2 2 1 1 2 2 1 3 2 1 6
In situ RNA (section) 1 1 2 1 3 1 1 1 1 1 1 3
In situ protein (whole mount) 1 1 1 1 1 1 1
In situ RNA (whole mount) 1 1 1 1 1 1 1 1 1
Western blot 2 1 2 1 1 1 4
RT-PCR 3 2 2 1 2 2 2 3 1 1 1 2 1 2 7
cDNA clones 1 1
RNase protection 1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Nos3  nitric oxide synthase 3, endothelial cell   (Synonyms: 2310065A03Rik, ecNOS, eNOS, Nos-3)
Results  Reference
1J:137057 Araya R, Kudo M, Kawano M, Ishii K, Hashikawa T, Iwasato T, Itohara S, Terasaki T, Oohira A, Mishina Y, Yamada M, BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 2008 Jul;38(3):417-30
5J:42234 Arnhold S, Andressen C, Bloch W, Mai JK, Addicks K, NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons. Neurosci Lett. 1997 Jul 4;229(3):165-8
6J:96845 Arnhold S, When M, Labbe D, Andressen C, Addicks K, Transient expression of NOS-II during development of the murine enteric nervous system. J Mol Histol. 2004 Nov;35(8-9):741-8
5J:53873 Baylis SA, Strijbos PJ, Sandra A, Russell RJ, Rijhsinghani A, Charles IG, Weiner CP, Temporal expression of inducible nitric oxide synthase in mouse and human placenta. Mol Hum Reprod. 1999 Mar;5(3):277-86
10J:63329 Bloch W, Fleischmann BK, Lorke DE, Andressen C, Hops B, Hescheler J, Addicks K, Nitric oxide synthase expression and role during cardiomyogenesis. Cardiovasc Res. 1999 Aug 15;43(3):675-84
1J:206313 Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA, The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13:40
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
4J:59951 Gagioti S, Scavone C, Bevilacqua E, Participation of the mouse implanting trophoblast in nitric oxide production during pregnancy. Biol Reprod. 2000 Feb;62(2):260-8
1J:192166 Gentile C, Muise-Helmericks RC, Drake CJ, VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation. Dev Biol. 2013 Jan 1;373(1):163-75
1J:34801 Gnanapandithen K, Chen Z, Kau CL, Gorczynski RM, Marsden PA, Cloning and characterization of murine endothelial constitutive nitric oxide synthase. Biochim Biophys Acta. 1996 Aug 14;1308(2):103-6
1J:183603 Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A, Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011 Apr 1;108(7):813-23
7J:98913 Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ, Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?. Circ Res. 2004 Apr 30;94(8):1115-23
1J:83701 Hemberger M, Nozaki T, Masutani M, Cross JC, Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Dev Dyn. 2003 Jun;227(2):185-91
2J:53273 Ji GJ, Fleischmann BK, Bloch W, Feelisch M, Andressen C, Addicks K, Hescheler J, Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition. FASEB J. 1999 Feb;13(2):313-24
1J:190719 Joza S, Wang J, Fox E, Hillman V, Ackerley C, Post M, Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
6J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
1J:152416 Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki-Migishima R, Umeki Y, Hohjoh H, Yanagawa Y, Shinba T, Itoh M, Nakamura K, Goto Y, Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet. 2009 Oct 1;18(19):3708-24
2J:175663 Laforest B, Andelfinger G, Nemer M, Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011 Jul 1;121(7):2876-87
2J:127228 Lee JS, Yu Q, Shin JT, Sebzda E, Bertozzi C, Chen M, Mericko P, Stadtfeld M, Zhou D, Cheng L, Graf T, MacRae CA, Lepore JJ, Lo CW, Kahn ML, Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell. 2006 Dec;11(6):845-57
2J:137621 Lin IC, Smartt JM Jr, Nah HD, Ischiropoulos H, Kirschner RE, Nitric oxide stimulates proliferation and differentiation of fetal calvarial osteoblasts and dural cells. Plast Reconstr Surg. 2008 May;121(5):1554-66; discussion 1567-9
1J:204675 Mandal S, Stanco A, Buys ES, Enikolopov G, Rubenstein JL, Soluble guanylate cyclase generation of cGMP regulates migration of MGE neurons. J Neurosci. 2013 Oct 23;33(43):16897-914
1*J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
2J:101254 Miller AA, Hislop AA, Vallance PJ, Haworth SG, Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L299-306
1J:167548 Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M, An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19356-61
6J:109243 Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E, Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy. Development. 2004 May;131(10):2485-96
2J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
8J:74206 Nishikimi A, Matsukawa T, Hoshino K, Ikeda S, Kira Y, Sato EF, Inoue M, Yamada M, Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice. Reproduction. 2001 Dec;122(6):957-63
6*J:95790 Richard C, Gao J, LaFleur B, Christman BW, Anderson J, Brown N, Reese J, Patency of the preterm fetal ductus arteriosus is regulated by endothelial nitric oxide synthase and is independent of vasa vasorum in the mouse. Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R652-60
4J:181330 Sabine A, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hagerling R, Pollmann C, Bebber D, Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Makinen T, Kiefer F, Kwak BR, Petrova TV, Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation. Dev Cell. 2012 Feb 14;22(2):430-45
1J:33809 Sanchez MP, Silos-Santiago I, Frisen J, He B, Lira SA, Barbacid M, Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):70-3
1J:198319 Sayin VI, Nilton A, Ibrahim MX, Agren P, Larsson E, Petit MM, Hulten LM, Stahlman M, Johansson BR, Bergo MO, Lindahl P, Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment. PLoS One. 2013;8(2):e55720
1*J:135081 Schmidt H, Stonkute A, Juttner R, Schaffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG, The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007 Oct 22;179(2):331-40
3J:124878 Sierro F, Biben C, Martinez-Munoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, Harvey RP, Martinez-A C, Mackay CR, Mackay F, Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
1J:186473 Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y, Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
1J:148113 Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y, Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. Diabetologia. 2009 May;52(5):962-71
15*J:151374 Teichert AM, Scott JA, Robb GB, Zhou YQ, Zhu SN, Lem M, Keightley A, Steer BM, Schuh AC, Adamson SL, Cybulsky MI, Marsden PA, Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system. Circ Res. 2008 Jul 3;103(1):24-33
1J:187204 Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V, Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1J:85181 Yang ZZ, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings BA, Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem. 2003 Aug 22;278(34):32124-31
1J:63408 Yip JW, Yip YP, Nakajima K, Capriotti C, Reelin controls position of autonomic neurons in the spinal cord. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8612-6
6J:57952 Young HM, Ciampoli D, Hsuan J, Canty AJ, Expression of Ret-, p75(NTR)-, Phox2a-, Phox2b-, and tyrosine hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut. Dev Dyn. 1999 Oct;216(2):137-52
1J:201159 Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT, Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400

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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory