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Gene Expression Literature Summary
Symbol
Name
ID
Met
met proto-oncogene
MGI:96969

81 matching records from 81 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E2.5 E3.5 E4.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E A
In situ protein (section) 1 2 3 4 2 1 4 2 1 1 1 2 1 2 10
In situ RNA (section) 1 1 1 1 1 7 4 9 8 1 2 5 2 3 2 5 1 2 2 1 1 5 2 2 10
In situ RNA (whole mount) 1 2 1 3 1 3 6 4 14 5 7 2 6 1 2 1 3 1 1
In situ reporter (knock in) 1 1
Northern blot 1 1 1 1 3
Western blot 1 1 2 1 2 1 2 6
RT-PCR 1 1 1 1 1 1 1 3 5 2 5 2 4 1 6 1 2 1 4 1 3 1 8
cDNA clones 1 1 1
RNase protection 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Met  met proto-oncogene   (Synonyms: c-Met, HGF receptor, Par4)
Results  Reference
9J:74504 Amano O, Yamane A, Shimada M, Koshimizu U, Nakamura T, Iseki S, Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos. Dev Dyn. 2002 Mar;223(2):169-79
9J:32851 Andermarcher E, Surani MA, Gherardi E, Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis. Dev Genet. 1996;18(3):254-66
3J:187740 Anderson C, Williams VC, Moyon B, Daubas P, Tajbakhsh S, Buckingham ME, Shiroishi T, Hughes SM, Borycki AG, Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity. Genes Dev. 2012 Sep 15;26(18):2103-17
1J:112275 Bajard L, Relaix F, Lagha M, Rocancourt D, Daubas P, Buckingham ME, A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb. Genes Dev. 2006 Sep 1;20(17):2450-64
3J:28570 Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C, Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments]. Nature. 1995 Aug 31;376(6543):768-71
5J:116003 Boon EM, Pouwels W, Redeker S, Joosten SP, Hamann J, van der Neut R, Pals ST, Activation of Wnt signaling in the intestinal mucosa of Apc +/min mice does not cause overexpression of the receptor tyrosine kinase Met. Cancer Sci. 2006 Aug;97(8):710-5
1J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
5*J:120667 Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG, The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. J Immunol. 2003 Aug 1;171(3):1297-303
4J:174459 Boyle MP, Bernard A, Thompson CL, Ng L, Boe A, Mortrud M, Hawrylycz MJ, Jones AR, Hevner RF, Lein ES, Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
1*J:56466 Brohmann H, Jagla K, Birchmeier C, The role of Lbx1 in migration of muscle precursor cells. Development. 2000 Jan;127(2):437-45
3*J:60988 Caton A, Hacker A, Naeem A, Livet J, Maina F, Bladt F, Klein R, Birchmeier C, Guthrie S, The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons. Development. 2000 Apr;127(8):1751-66
1J:186298 Chen D, Wang W, Guo W, Yu Q, Burnstock G, He C, Xiang Z, Zheng H, Expression of P2Y(6) receptors in the developing mouse skeletal muscle and after injury and repair. J Anat. 2011 Jun;218(6):643-51
1*J:38385 Conway SJ, Henderson DJ, Copp AJ, Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development. 1997 Jan;124(2):505-14
1J:72379 Cornelison DD, Filla MS, Stanley HM, Rapraeger AC, Olwin BB, Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Dev Biol. 2001 Nov 1;239(1):79-94
4*J:32016 Daston G, Lamar E, Olivier M, Goulding M, Pax-3 is necessary for migration but not differentiation of limb muscle precursors in the mouse. Development. 1996 Mar;122(3):1017-27
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3J:37462 Ebens A, Brose K, Leonardo ED, Hanson MG Jr, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M, Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron. 1996 Dec;17(6):1157-72
1J:32900 Epstein JA, Shapiro DN, Cheng J, Lam PY, Maas RL, Pax3 modulates expression of the c-Met receptor during limb muscle development. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4213-8
1J:115962 Finckenstein FG, Davicioni E, Osborn KG, Cavenee WK, Arden KC, Anderson MJ, Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube. Transgenic Res. 2006 Oct;15(5):595-614
1J:42845 Garry DJ, Yang Q, Bassel-Duby R, Williams RS, Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. Dev Biol. 1997 Aug 15;188(2):280-94
7J:164668 Gascon E, Gaillard S, Malapert P, Liu Y, Rodat-Despoix L, Samokhvalov IM, Delmas P, Helmbacher F, Maina F, Moqrich A, Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010 Sep 15;30(37):12414-23
1*J:86049 Gavalas A, Ruhrberg C, Livet J, Henderson CE, Krumlauf R, Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes. Development. 2003 Dec;130(23):5663-79
1J:81465 Giacobini P, Giampietro C, Fioretto M, Maggi R, Cariboni A, Perroteau I, Fasolo A, Hepatocyte growth factor/scatter factor facilitates migration of GN-11 immortalized LHRH neurons. Endocrinology. 2002 Sep;143(9):3306-15
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
2J:56498 Gross MK, Moran-Rivard L, Velasquez T, Nakatsu MN, Jagla K, Goulding M, Lbx1 is required for muscle precursor migration along a lateral pathway into the limb. Development. 2000 Jan;127(2):413-24
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:177323 Hara M, Yuasa S, Shimoji K, Onizuka T, Hayashiji N, Ohno Y, Arai T, Hattori F, Kaneda R, Kimura K, Makino S, Sano M, Fukuda K, G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation. J Exp Med. 2011 Apr 11;208(4):715-27
1J:176192 Hayashi S, Rocancourt D, Buckingham M, Relaix F, Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
3*J:85300 Helmbacher F, Dessaud E, Arber S, deLapeyriere O, Henderson CE, Klein R, Maina F, Met signaling is required for recruitment of motor neurons to PEA3-positive motor pools. Neuron. 2003 Aug 28;39(5):767-77
1*J:54638 Henderson DJ, Conway SJ, Copp AJ, Rib truncations and fusions in the Sp2H mouse reveal a role for Pax3 in specification of the ventro-lateral and posterior parts of the somite. Dev Biol. 1999 May 1;209(1):143-58
1J:147972 Hutcheson DA, Zhao J, Merrell A, Haldar M, Kardon G, Embryonic and fetal limb myogenic cells are derived from developmentally distinct progenitors and have different requirements for beta-catenin. Genes Dev. 2009 Apr 15;23(8):997-1013
3J:81793 Ieraci A, Forni PE, Ponzetto C, Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15200-5
11*J:85916 Ikari T, Hiraki A, Seki K, Sugiura T, Matsumoto K, Shirasuna K, Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn. 2003 Oct;228(2):173-84
7J:172491 Judson MC, Bergman MY, Campbell DB, Eagleson KL, Levitt P, Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain. J Comp Neurol. 2009 Apr 10;513(5):511-31
4J:101061 Kajiya K, Hirakawa S, Ma B, Drinnenberg I, Detmar M, Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005 Aug 17;24(16):2885-95
2J:95006 Kalinichenko VV, Gusarova GA, Kim IM, Shin B, Yoder HM, Clark J, Sapozhnikov AM, Whitsett JA, Costa RH, Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L521-30
1J:93443 Keller C, Hansen MS, Coffin CM, Capecchi MR, Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004 Dec 1;18(21):2608-13
1J:156014 Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, Buckingham ME, Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009 Dec;17(6):892-9
8J:174591 Lamballe F, Genestine M, Caruso N, Arce V, Richelme S, Helmbacher F, Maina F, Pool-specific regulation of motor neuron survival by neurotrophic support. J Neurosci. 2011 Aug 3;31(31):11144-58
1J:86619 Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG, Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
2J:155594 Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, MacNeil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F, Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet. 2009 Dec;41(12):1295-302
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
4J:36244 Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R, Ponzetto C, Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development. Cell. 1996 Nov 1;87(3):531-42
5*J:107734 Maina F, Hilton MC, Andres R, Wyatt S, Klein R, Davies AM, Multiple roles for hepatocyte growth factor in sympathetic neuron development. Neuron. 1998 May;20(5):835-46
1J:56172 Mankoo BS, Collins NS, Ashby P, Grigorieva E, Pevny LH, Candia A , Wright CV , Rigby PW , Pachnis V, Mox2 is a component of the genetic hierarchy controlling limb muscle development. Nature. 1999 Jul 1;400(6739):69-73
2*J:48130 Mennerich D, Schafer K, Braun T, Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb. Mech Dev. 1998 May;73(2):147-58
3*J:86667 Mic FA, Duester G, Patterning of forelimb bud myogenic precursor cells requires retinoic acid signaling initiated by Raldh2. Dev Biol. 2003 Dec 1;264(1):191-201
7J:61424 Patel Y, Kim H, Rappolee DA, A role for hepatocyte growth factor during early postimplantation growth of the placental lineage in mice. Biol Reprod. 2000 Apr;62(4):904-12
1J:168399 Perala N, Jakobson M, Ola R, Fazzari P, Penachioni JY, Nymark M, Tanninen T, Immonen T, Tamagnone L, Sariola H, Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2011 Feb;81(2):81-91
4J:106496 Ponzetto C, Pante G, Prunotto' C, Ieraci A, Maina F, Met signaling mutants as tools for developmental studies. Int J Dev Biol. 2000;44(6):645-53
8J:69135 Powell EM, Mars WM, Levitt P, Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon. Neuron. 2001 Apr;30(1):79-89
1J:165260 Qin S, Taglienti M, Nauli SM, Contrino L, Takakura A, Zhou J, Kreidberg JA, Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct 1;120(10):3617-28
8J:34854 Rappolee DA, Iyer A, Patel Y, Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis. Circ Res. 1996 Jun;78(6):1028-36
2J:90568 Relaix F, Rocancourt D, Mansouri A, Buckingham M, Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev. 2004 May 1;18(9):1088-105
11*J:116681 Ricci G, Catizone A, Galdieri M, Expression and functional role of hepatocyte growth factor and its receptor (c-met) during fetal mouse testis development. J Endocrinol. 2006 Dec;191(3):559-70
6*J:58905 Ricci G, Catizone A, Innocenzi A, Galdieri M, Hepatocyte growth factor (HGF) receptor expression and role of HGF during embryonic mouse testis development. Dev Biol. 1999 Dec 1;216(1):340-7
2J:194027 Ricci G, Guglielmo MC, Caruso M, Ferranti F, Canipari R, Galdieri M, Catizone A, Hepatocyte growth factor is a mouse fetal leydig cell terminal differentiation factor. Biol Reprod. 2012;87(6):146
1J:201042 Saito Y, Kojima T, Takahashi N, The septum transversum mesenchyme induces gall bladder development. Biol Open. 2013;2:779-788
4*J:18486 Santos OF, Barros EJ, Yang XM, Matsumoto K, Nakamura T, Park M, Nigam SK, Involvement of hepatocyte growth factor in kidney development. Dev Biol. 1994 Jun;163(2):525-9
1J:125303 Schaeper U, Vogel R, Chmielowiec J, Huelsken J, Rosario M, Birchmeier W, Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15376-81
2J:57891 Schafer K, Braun T, Early specification of limb muscle precursor cells by the homeobox gene Lbx1h. Nat Genet. 1999 Oct;23(2):213-6
2J:122940 Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL, FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron. 2006 Jun 15;50(6):841-53
1J:27414 Sommers CL, Huang K, Shores EW, Grinberg A, Charlick DA, Kozak CA, Love PE, Murine txk: a protein tyrosine kinase gene regulated by T cell activation. Oncogene. 1995 Jul 20;11(2):245-51
7J:14770 Sonnenberg E, Meyer D, Weidner KM, Birchmeier C, Scatter factor/hepatocyte growth factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development. J Cell Biol. 1993 Oct;123(1):223-35
1J:63128 Sosa-Pineda B, Wigle JT, Oliver G, Hepatocyte migration during liver development requires Prox1. Nat Genet. 2000 Jul;25(3):254-5
1J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
1J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
2J:201612 Takeda S, Liu H, Sasagawa S, Dong Y, Trainor PA, Cheng EH, Hsieh JJ, HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013 Jul 1;123(7):3154-65
7J:36056 Thewke DP, Seeds NW, Expression of hepatocyte growth factor/scatter factor, its receptor, c-met, and tissue-type plasminogen activator during development of the murine olfactory system. J Neurosci. 1996 Nov 1;16(21):6933-44
5J:53445 Thewke DP, Seeds NW, The expression of mRNAs for hepatocyte growth factor/scatter factor, its receptor c-met, and one of its activators tissue-type plasminogen activator show a systematic relationship in the developing and adult cerebral cortex and hippocampus. Brain Res. 1999 Mar 13;821(2):356-67
1J:197015 Thompson PJ, Norton KA, Niri FH, Dawe CE, McDermid HE, CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis. J Mol Biol. 2012 Feb 3;415(5):793-806
5J:60178 Uchiyama K, Ishikawa A, Hanaoka K, Expression of lbx1 involved in the hypaxial musculature formation of the mouse embryo. J Exp Zool. 2000 Feb 15;286(3):270-9
3J:91730 Verma-Kurvari S, Parada LF, Identification of tyrosine kinases expressed in the male mouse gubernaculum during development. Dev Dyn. 2004 Aug;230(4):660-5
1J:178355 Wang J, Kumar RM, Biggs VJ, Lee H, Chen Y, Kagey MH, Young RA, Abate-Shen C, The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development. Dev Cell. 2011 Sep 13;21(3):575-88
10J:22270 Woolf AS, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine LG, Jat PS, Noble MD, Gherardi E, Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J Cell Biol. 1995 Jan;128(1-2):171-84
8J:199203 Wu HH, Levitt P, Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem. Dev Neurosci. 2013;35(1):1-16
1J:124125 Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH, Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007 Aug 1;308(1):44-53
11*J:34184 Yang XM, Vogan K, Gros P, Park M, Expression of the met receptor tyrosine kinase in muscle progenitor cells in somites and limbs is absent in Splotch mice. Development. 1996 Jul;122(7):2163-71
1*J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
2J:132613 Zhou HM, Wang J, Rogers R, Conway SJ, Lineage-specific responses to reduced embryonic Pax3 expression levels. Dev Biol. 2008 Mar 15;315(2):369-82

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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory