Gene Expression Literature Summary

• Symbol: Lmnb1
• Name: lamin B1
• ID: MGI:96795

59 matching records from 59 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E2.5	E3	E3.5	E7.5	E8.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E	P
Immunohistochemistry (section)						2	1	1	1			2	2		1		2		3		3		4	1		1	9
In situ RNA (section)									1		1			1	1			1				1					1
Immunohistochemistry (whole mount)	2	1	2	2																							3
In situ RNA (whole mount)									3			2	1
In situ reporter (knock in)																	1								1	1	1
Western blot		1		1				1	2	1		3	3						2	1	1	1	7	1		2	13
RT-PCR					1				1				1			1		1	1				2	1		1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lmnb1  lamin B1
Results	Reference
1	J:326354 Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella LV, Pouchin P, Cohen-Tannoudji M, David L, Chazaud C, NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
1	J:196086 Appler JM, Lu CC, Druckenbrod NR, Yu WM, Koundakjian EJ, Goodrich LV, Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20;33(8):3679-91
1	J:220857 Bartoletti-Stella A, Gasparini L, Giacomini C, Corrado P, Terlizzi R, Giorgio E, Magini P, Seri M, Baruzzi A, Parchi P, Brusco A, Cortelli P, Capellari S, Messenger RNA processing is altered in autosomal dominant leukodystrophy. Hum Mol Genet. 2015 May 15;24(10):2746-56
3	J:180603 Bertrand AT, Renou L, Papadopoulos A, Beuvin M, Lacene E, Massart C, Ottolenghi C, Decostre V, Maron S, Schlossarek S, Cattin ME, Carrier L, Malissen M, Arimura T, Bonne G, DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death. Hum Mol Genet. 2012 Mar 1;21(5):1037-48
5*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1*	J:83658 Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM, Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25;300(5619):633-6
1	J:303700 Cajigas I, Chakraborty A, Lynam M, Swyter KR, Bastidas M, Collens L, Luo H, Ay F, Kohtz JD, Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological control in developing forebrain. Development. 2021 Mar 15;148(6):dev197202
1	J:239652 Cajigas I, Leib DE, Cochrane J, Luo H, Swyter KR, Chen S, Clark BS, Thompson J, Yates JR 3rd, Kingston RE, Kohtz JD, Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development. 2015 Aug 01;142(15):2641-52
1	J:82346 Ceni C, Pochon N, Brun V, Muller-Steffner H, Andrieux A, Grunwald D, Schuber F, De Waard M, Lund F, Villaz M, Moutin MJ, CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain. Biochem J. 2003 Feb 15;370(Pt 1):175-83
4	J:144707 Chiu SY, Asai N, Costantini F, Hsu W, SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310
1	J:325357 Chomiak AA, Guo Y, Kopsidas CA, McDaniel DP, Lowe CC, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y, Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 Jun 17;25(6):104354
1	J:158610 Coffinier C, Chang SY, Nobumori C, Tu Y, Farber EA, Toth JI, Fong LG, Young SG, Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5076-81
7	J:264980 Coffinier C, Jung HJ, Nobumori C, Chang S, Tu Y, Barnes RH 2nd, Yoshinaga Y, de Jong PJ, Vergnes L, Reue K, Fong LG, Young SG, Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell. 2011 Dec;22(23):4683-93
1	J:319637 Cole JD, Sarabia Del Castillo J, Gut G, Gonzalez-Bohorquez D, Pelkmans L, Jessberger S, Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging. Elife. 2022 Jan 28;11:e68000
4*	J:194083 De Castro SC, Malhas A, Leung KY, Gustavsson P, Vaux DJ, Copp AJ, Greene ND, Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice. PLoS Genet. 2012;8(11):e1003059
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:190019 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC, The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. EMBO J. 2012 Oct 17;31(20):4045-56
1*	J:130649 Fossat N, Le Greneur C, Beby F, Vincent S, Godement P, Chatelain G, Lamonerie T, A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. BMC Dev Biol. 2007;7:122
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3	J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86
1	J:245014 Giacomini C, Mahajani S, Ruffilli R, Marotta R, Gasparini L, Lamin B1 protein is required for dendrite development in primary mouse cortical neurons. Mol Biol Cell. 2016 Jan 01;27(1):35-47
1	J:329965 Gogolou A, Souilhol C, Granata I, Wymeersch FJ, Manipur I, Wind M, Frith TJR, Guarini M, Bertero A, Bock C, Halbritter F, Takasato M, Guarracino MR, Tsakiridis A, Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. Elife. 2022 Sep 26;11:e74263
1*	J:107596 Goodchild RE, Kim CE, Dauer WT, Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron. 2005 Dec 22;48(6):923-32
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595
1	J:336184 Hayashi S, Oe S, Koike T, Seki-Omura R, Nakano Y, Hirahara Y, Tanaka S, Ito T, Yasukochi Y, Higasa K, Kitada M, OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse. J Neurochem. 2023 May;165(3):303-317
2	J:283078 Hickmott JW, Gunawardane U, Jensen K, Korecki AJ, Simpson EM, Epistasis between Pax6(Sey) and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials. Gene Ther. 2018 Dec;25(8):524-537
1	J:117378 Hosoya-Ohmura S, Mochizuki N, Suzuki M, Ohneda O, Ohneda K, Yamamoto M, GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo. J Biol Chem. 2006 Oct 27;281(43):32820-30
7	J:289360 Houliston E, Guilly MN, Courvalin JC, Maro B, Expression of nuclear lamins during mouse preimplantation development. Development. 1988 Feb;102(2):271-8
2	J:224310 Ishihara T, Ban-Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, Aoki H, Katada S, Nakada K, Nomura M, Mizushima N, Mihara K, Ishihara N, Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015 Jan;35(1):211-23
9	J:197315 Jung HJ, Nobumori C, Goulbourne CN, Tu Y, Lee JM, Tatar A, Wu D, Yoshinaga Y, de Jong PJ, Coffinier C, Fong LG, Young SG, Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
1	J:298091 Kao CS, van Bruggen R, Kim JR, Chen XXL, Chan C, Lee J, Cho WI, Zhao M, Arndt C, Maksimovic K, Khan M, Tan Q, Wilson MD, Park J, Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020 Oct 20;11(1):5304
1	J:160544 Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT, A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9861-6
1	J:178993 Kim Y, Sharov AA, McDole K, Cheng M, Hao H, Fan CM, Gaiano N, Ko MS, Zheng Y, Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011 Dec 23;334(6063):1706-10
1*	J:322393 Kimura R, U Inoue Y, Kikkawa T, Tatehana M, Morimoto Y, Inada H, Oki S, Inoue T, Osumi N, Detection of REST expression in the testis using epitope-tag knock-in mice generated by genome editing. Dev Dyn. 2022 Mar;251(3):525-535
1	J:309479 Lee JM, Jung HJ, Fong LG, Young SG, Do lamin B1 and lamin B2 have redundant functions?. Nucleus. 2014 Jul-Aug;5(4):287-92
4	J:220914 Lee JM, Tu Y, Tatar A, Wu D, Nobumori C, Jung HJ, Yoshinaga Y, Coffinier C, de Jong PJ, Fong LG, Young SG, Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. Mol Biol Cell. 2014 May;25(10):1666-75
1*	J:270646 Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A, Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem. 2018 Aug 24;293(34):13176-13190
1	J:306622 MacPherson MJ, Erickson SL, Kopp D, Wen P, Aghanoori MR, Kedia S, Burns KML, Vitobello A, Tran Mau-Them F, Thomas Q, Gold NB, Brucker W, Amlie-Wolf L, Gripp KW, Bodamer O, Faivre L, Muona M, Menzies L, Baptista J, Guegan K, Male A, Wei XC, He G, Long Q, Innes AM, Yang G, Nucleocytoplasmic transport of the RNA-binding protein CELF2 regulates neural stem cell fates. Cell Rep. 2021 Jun 8;35(10):109226
1	J:345312 Mak S, Hammes A, Canonical and Non-Canonical Localization of Tight Junction Proteins during Early Murine Cranial Development. Int J Mol Sci. 2024 Jan 24;25(3)
2	J:314902 Noguchi A, Ito K, Uosaki Y, Ideta-Otsuka M, Igarashi K, Nakashima H, Kakizaki T, Kaneda R, Uosaki H, Yanagawa Y, Nakashima K, Arakawa H, Takizawa T, Decreased Lamin B1 Levels Affect Gene Positioning and Expression in Postmitotic Neurons. Neurosci Res. 2021 May 28;
1	J:301537 Park KC, Park JH, Baek SH, Kim KI, Pontin-deficiency causes senescence in fibroblast cells and epidermal keratinocytes but induces apoptosis in cancer cells. Biochim Biophys Acta Mol Cell Res. 2020 Sep;1867(9):118740
1	J:335234 Parveen N, Wang JK, Bhattacharya S, Cuala J, Singh Rajkumar M, Butler AE, Wu X, Shih HP, Georgia SK, Dhawan S, DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic beta-cell Heterogeneity. Diabetes. 2023 Jan 6;72(5):575-89
1*	J:302139 Ramirez-Martinez A, Zhang Y, Chen K, Kim J, Cenik BK, McAnally JR, Cai C, Shelton JM, Huang J, Brennan A, Evers BM, Mammen PPA, Xu L, Bassel-Duby R, Liu N, Olson EN, The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization. Nat Commun. 2021 Jan 29;12(1):690
2	J:252201 Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA, Mardaryev A, p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct;137(10):2157-2167
2	J:339839 Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM, Stroud MJ, Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovasc Res. 2023 Sep 5;119(11):2074-2088
1	J:270627 Sakakibara I, Wurmser M, Dos Santos M, Santolini M, Ducommun S, Davaze R, Guernec A, Sakamoto K, Maire P, Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Skelet Muscle. 2016;6(1):30
2	J:221285 Singh I, Mehta A, Contreras A, Boettger T, Carraro G, Wheeler M, Cabrera-Fuentes HA, Bellusci S, Seeger W, Braun T, Barreto G, Hmga2 is required for canonical WNT signaling during lung development. BMC Biol. 2014;12:21
1	J:336153 Skory RM, Moverley AA, Ardestani G, Alvarez Y, Domingo-Muelas A, Pomp O, Hernandez B, Tetlak P, Bissiere S, Stern CD, Sakkas D, Plachta N, The nuclear lamina couples mechanical forces to cell fate in the preimplantation embryo via actin organization. Nat Commun. 2023 May 29;14(1):3101
2*	J:242348 Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC, Meioc maintains an extended meiotic prophase I in mice. PLoS Genet. 2017 Apr;13(4):e1006704
4*	J:324295 Spruce T, Plass M, Gohr A, Ray D, Martinez de Lagran M, Rot G, Novoa A, Burguera D, Permanyer J, Miret M, Zheng H, Swanson MS, Morris Q, Mallo M, Dierssen M, Hughes TR, Pernaute B, Irimia M, The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians. PLoS Biol. 2022 Apr;20(4):e3001615
3	J:246890 Stroud MJ, Feng W, Zhang J, Veevers J, Fang X, Gerace L, Chen J, Nesprin 1alpha2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol. 2017 Jul 03;216(7):1915-1924
1	J:322322 Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R, Fujimura S, Tani N, Takeda N, Araki K, Ishiguro KI, FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience. 2022 Apr 15;25(4):104008
1*	J:221495 Tapia O, Fong LG, Huber MD, Young SG, Gerace L, Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
1	J:143917 Tsika RW, Schramm C, Simmer G, Fitzsimons DP, Moss RL, Ji J, Overexpression of TEAD-1 in Transgenic Mouse Striated Muscles Produces a Slower Skeletal Muscle Contractile Phenotype. J Biol Chem. 2008 Dec 26;283(52):36154-67
2*	J:91473 Vergnes L, Peterfy M, Bergo MO, Young SG, Reue K, Lamin B1 is required for mouse development and nuclear integrity. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10428-33
1	J:310855 Yiu JHC, Cheung SWM, Cai J, Chan KS, Chen J, Cheong LY, Chau HT, Xu A, Li RHW, Woo CW, TLR5 Supports Development of Placental Labyrinthine Zone in Mice. Front Cell Dev Biol. 2021;9:711253
1	J:346053 Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanovic N, Devkota R, Henn M, Bohlooly-Y M, Hernandez-Hernandez A, Alsheimer M, Boren J, Pilon M, Shibuya H, Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315
1	J:155113 Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M, SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87