Gene Expression Literature Summary

• Symbol: Lamp2
• Name: lysosomal-associated membrane protein 2
• ID: MGI:96748

52 matching records from 52 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E4	E5	E5.5	E6	E6.5	E7.5	E9	E9.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)		1			3	3	2			2	1		2		2	2	1	4			19
In situ RNA (section)			1							1				1	1						1
Immunohistochemistry (whole mount)				1		1													1
In situ RNA (whole mount)									1
Western blot	1																	1		1	6
RT-PCR								1	2			1		3							5
cDNA clones									1												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lamp2  lysosomal-associated membrane protein 2   (Synonyms: CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3)
Results	Reference
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
1	J:134891 Alkemade FE, Gittenberger-de Groot AC, Schiel AE, VanMunsteren JC, Hogers B, van Vliet LS, Poelmann RE, Havekes LM, Willems van Dijk K, DeRuiter MC, Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life. Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2228-35
2*	J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
2	J:185338 Boucherat O, Chakir J, Jeannotte L, The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol Open. 2012;q:677-691
1	J:67398 Chan JC, Ganopolsky JG, Cornelissen I, Suckow MA, Sandoval-Cooper MJ, Brown EC, Noria F, Gailani D, Rosen ED, Ploplis VA, Castellino FJ, The characterization of mice with a targeted combined deficiency of protein c and factor XI. Am J Pathol. 2001 Feb;158(2):469-79
1	J:304329 Chen D, He F, Lu T, Huang J, Li M, Cai D, Huang C, Chen D, Xiong F, VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis. Genesis. 2021 Mar 7;:e23415
1	J:32190 Dardik A, Smith RM, Schultz RM, Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst. Dev Biol. 1992 Dec;154(2):396-409
3	J:207468 Desai TJ, Brownfield DG, Krasnow MA, Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014 Mar 13;507(7491):190-4
1	J:226026 Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C, Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42
2	J:275030 Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N, Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice. PLoS Genet. 2019 May;15(5):e1008084
1*	J:105164 Fernandez-Valdivia R, Zhang Y, Pai S, Metzker ML, Schumacher A, l7Rn6 Encodes a Novel Protein Required for Clara Cell Function in Mouse Lung Development. Genetics. 2006 Jan;172(1):389-99
1	J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
1	J:192856 George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE, Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol. 2012 Dec;32(24):5116-28
1	J:289005 Gerner-Mauro KN, Akiyama H, Chen J, Redundant and additive functions of the four Lef/Tcf transcription factors in lung epithelial progenitors. Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12182-12191
1*	J:323825 Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB, He DZ, Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Sci Adv. 2022 Apr 8;8(14):eabk0942
3	J:239805 Grigaravicius P, Kaminska E, Hubner CA, McKinnon PJ, von Deimling A, Frappart PO, Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain. Cell Death Differ. 2016 Mar;23(3):454-68
1	J:215459 Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T, Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90
1	J:221347 Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS, Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia - a novel mouse model providing insights into geleophysic dysplasia. Dis Model Mech. 2015 May 1;8(5):487-99
2	J:303495 Iwaki A, Moriwaki K, Sobajima T, Taniguchi M, Yoshimura SI, Kunii M, Kanda S, Kamada Y, Miyoshi E, Harada A, Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. FASEB J. 2020 Jul;34(7):9450-9465
1*	J:153715 Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ, Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56
2	J:187732 Kawamura N, Sun-Wada GH, Aoyama M, Harada A, Takasuga S, Sasaki T, Wada Y, Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012 Sep 18;3:1071
2*	J:295945 Kawamura N, Takaoka K, Hamada H, Hadjantonakis AK, Sun-Wada GH, Wada Y, Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism. Cell Rep. 2020 Jun 9;31(10):107733
1	J:197476 Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Holscher C, Muller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M, Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013 Mar;16(3):273-80
1	J:302544 Kimura T, Saito H, Kawasaki M, Takeichi M, CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains. Development. 2021 Feb 5;148(3):dev195073
2	J:222854 Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T, Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35
1	J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011 Mar;240(3):577-88
1	J:317416 Liu J, Qi Y, Chao J, Sathuvalli P, Y Lee L, Li S, CREG1 promotes lysosomal biogenesis and function. Autophagy. 2021 Dec;17(12):4249-4265
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:334501 Maglica M, Kelam N, Haque E, Perutina I, Racetin A, Filipovic N, Katsuyama Y, Vukojevic K, Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1(-/-)(yotari) Mice. Biomolecules. 2023 Feb 21;13(3)
1	J:91786 Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL, Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem. 2004 Jul 30;279(31):32869-81
1	J:237617 Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, Jimenez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S, Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739
1	J:79288 Murata Y, Sun-Wada GH, Yoshimizu T, Yamamoto A, Wada Y, Futai M, Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons. J Biol Chem. 2002 Sep 27;277(39):36296-303
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1	J:116773 Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev. 2006 Dec 15;20(24):3382-94
1	J:138557 Pallerla SR, Lawrence R, Lewejohann L, Pan Y, Fischer T, Schlomann U, Zhang X, Esko JD, Grobe K, Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem. 2008 Jun 13;283(24):16885-94
1	J:286691 Perea-Gomez A, Cases O, Lelievre V, Pulina MV, Collignon J, Hadjantonakis AK, Kozyraki R, Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse. Sci Rep. 2019 Jul 15;9(1):10168
1	J:291414 Perez-Estrada JR, Hernandez-Garcia D, Leyva-Castro F, Ramos-Leon J, Cuevas-Benitez O, Diaz-Munoz M, Castro-Obregon S, Ramirez-Solis R, Garcia C, Covarrubias L, Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging. Free Radic Biol Med. 2019 May 1;135:102-115
1	J:216097 Reibring CG, El Shahawy M, Hallberg K, Kannius-Janson M, Nilsson J, Parkkila S, Sly WS, Waheed A, Linde A, Gritli-Linde A, Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One. 2014;9(5):e96007
2	J:199892 Rhee S, Guerrero-Zayas MI, Wallingford MC, Ortiz-Pineda P, Mager J, Tremblay KD, Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS One. 2013;8(3):e58828
3*	J:256230 Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J, Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643
1*	J:85207 Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I, Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9
1*	J:275903 Shiura H, Abe K, Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH. Sci Rep. 2019 Mar 6;9(1):3637
1*	J:312380 Sun-Wada GH, Tabata H, Wada Y, Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm. Sci Rep. 2021 Sep 29;11(1):19355
1	J:327396 Sun-Wada GH, Wada Y, The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos. Sci Rep. 2022 Aug 10;12(1):13590
3	J:225806 Tang FL, Erion JR, Tian Y, Liu W, Yin DM, Ye J, Tang B, Mei L, Xiong WC, VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for alpha-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. J Neurosci. 2015 Jul 22;35(29):10613-28
1	J:334814 Tang YC, Ponsin K, Graham-Paquin AL, Luthold C, Homsy K, Schindler M, Tran V, Cote JF, Bordeleau F, Khadra A, Bouchard M, Coordination of non-professional efferocytosis and actomyosin contractility during epithelial tissue morphogenesis. Cell Rep. 2023 Mar 28;42(3):112202
1	J:240239 Weis VG, Knowles BC, Choi E, Goldstein AE, Williams JA, Manning EH, Roland JT, Lapierre LA, Goldenring JR, Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016 Feb 01;2(2):131-157
1	J:315742 Yazaki Y, Hara Y, Tamaki H, Fukaya M, Sakagami H, Endosomal localization of FIP3/Arfophilin-1 and its involvement in dendritic formation of mouse hippocampal neurons. Brain Res. 2014 Apr 4;1557:55-65
1	J:215917 Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N, TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014 Sep 1;33(17):1882-95
2	J:317803 Zeng L, Zhou J, Zhang Y, Wang X, Wang M, Su P, Differential Expression Profiles and Potential Intergenerational Functions of tRNA-Derived Small RNAs in Mice After Cadmium Exposure. Front Cell Dev Biol. 2021;9:791784
1*	J:117102 Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E, Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81
1	J:344234 Zou W, Lv Y, Zhang S, Li L, Sun L, Jiao J, Lysosomal dynamics regulate mammalian cortical neurogenesis. Dev Cell. 2024 Jan 8;59(1):64-78.e5