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Gene Expression Literature Summary
Symbol
Name
ID
Il6
interleukin 6
MGI:96559

34 matching records from 34 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E3.5 E4 E7.5 E10 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E20 E A
In situ protein (section) 1 1 1 1 1 1 1 2
In situ RNA (section) 1 1 1 1 1 1 1 1
In situ protein (whole mount) 1 1 1
Northern blot 1 1 1 1 1 2
Western blot 1
RT-PCR 1 1 1 1 1 1 1 1 2 1 1 2 1 3 1 3 4 1 3 1 6 1 3 3 13
RNase protection 2 2 2 4 2 1 3
Nuclease S1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Il6  interleukin 6   (Synonyms: Il-6)
Results  Reference
2*J:162893 Baston-Buest DM, Schanz A, Buest S, Fischer JC, Kruessel JS, Hess AP, The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S in mice. Reproduction. 2010 Apr;139(4):741-8
1J:185338 Boucherat O, Chakir J, Jeannotte L, The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways. Biol Open. 2012;q:677-691
6*J:17727 Burns TM, Clough JA, Klein RM, Wood GW, Berman NE, Developmental regulation of cytokine expression in the mouse brain. Growth Factors. 1993;9(4):253-8
3*J:19249 Chang Y, Albright S, Lee F, Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development. J Neuroimmunol. 1994 Jun;52(1):9-17
1J:171873 Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R, Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation. J Clin Invest. 2010 Dec 1;120(12):4353-65
7J:21326 Deman J, Humblet C, Martin MT, Boniver J, Defresne MP, Analysis by in situ hybridization of cytokine mRNA expression in the murine developing thymus. Int Immunol. 1994 Oct;6(10):1613-9
7J:35158 Deman J, Van Meurs M, Claassen E, Humblet C, Boniver J, Defresne MP, In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus. Immunology. 1996 Sep;89(1):152-7
1J:141953 Derradji H, Bekaert S, De Meyer T, Jacquet P, Abou-El-Ardat K, Ghardi M, Arlette M, Baatout S, Ionizing radiation-induced gene modulations, cytokine content changes and telomere shortening in mouse fetuses exhibiting forelimb defects. Dev Biol. 2008 Aug 7;322(2):302-313
1J:82631 Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, Saito Y, Takemori T, Kimura M, Sato H, Taniguchi M, Nishikawa S, Nakayama T, Koseki H, Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev Biol. 2003 Mar 15;255(2):278-89
1J:205533 Gallagher D, Norman AA, Woodard CL, Yang G, Gauthier-Fisher A, Fujitani M, Vessey JP, Cancino GI, Sachewsky N, Woltjen K, Fatt MP, Morshead CM, Kaplan DR, Miller FD, Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway. Cell Stem Cell. 2013 Nov 7;13(5):564-76
6J:31226 Gerwin N, Jia GQ, Kulbacki R, Gutierrez-Ramos JC, Interleukin gene expression in mouse preimplantation development. Dev Immunol. 1995;4(3):169-79
3*J:142881 Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ, Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol. 2009 Jan 1;182(1):636-46
3J:186161 Hu B, Castillo E, Harewood L, Ostano P, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GF, Dotto GP, Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20
1J:69420 Jaskoll T, Melnick M, Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 Nov 1;256(3):252-68
2J:137419 Kajino-Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, Jobin C, Ninomiya-Tsuji J, Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol. 2008 Jul 15;181(2):1143-52
1J:130907 Kevill KA, Bhandari V, Kettunen M, Leng L, Fan J, Mizue Y, Dzuira JD, Reyes-Mugica M, McDonald CL, Baugh JA, O'Connor CL, Aghai ZH, Donnelly SC, Bazzy-Asaad A, Bucala RJ, A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. J Immunol. 2008 Jan 1;180(1):601-8
7*J:17723 Kohchi C, Noguchi K, Tanabe Y, Mizuno D, Soma G, Constitutive expression of TNF-alpha and -beta genes in mouse embryo: roles of cytokines as regulator and effector on development. Int J Biochem. 1994 Jan;26(1):111-9
1J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1J:177567 Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W, Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
2J:32604 Liang L, Kover K, Dey SK, Andrews GK, Regulation of interleukin-6 and interleukin-1 beta gene expression in the mouse deciduum. J Reprod Immunol. 1996 Feb;30(1):29-52
1J:187360 McKean DM, Niswander L, Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
5J:67809 Melnick M, Chen H, Zhou Y, Jaskoll T, Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec. 2001 Mar 1;262(3):318-30
6J:68367 Melnick M, Chen H, Zhou YM, Jaskoll T, Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001;168(4):233-45
6J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
1J:144402 Miralles F, Hebrard S, Lamotte L, Durel B, Gilgenkrantz H, Li Z, Daegelen D, Tuil D, Joshi RL, Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis. Lab Invest. 2006 Oct;86(10):1020-36
7*J:44503 Montgomery RA, Dallman MJ, Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny. Cytokine. 1997 Oct;9(10):717-26
7*J:55762 Montgomery RA, Dallman MJ, Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol. 1991 Jul 15;147(2):554-60
2J:194606 Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A, Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice. Endocrinology. 2013 Feb;154(2):597-602
2J:135431 Salminen A, Paananen R, Vuolteenaho R, Metsola J, Ojaniemi M, Autio-Harmainen H, Hallman M, Maternal endotoxin-induced preterm birth in mice: fetal responses in toll-like receptors, collectins, and cytokines. Pediatr Res. 2008 Mar;63(3):280-6
3J:180111 Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M, Surfactant protein A modulates the lipopolysaccharide-induced inflammatory response related to preterm birth. Cytokine. 2011 Nov;56(2):442-9
2J:174962 Sugiyama D, Kulkeaw K, Mizuochi C, Horio Y, Okayama S, Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production. Biochem Biophys Res Commun. 2011 Jul 1;410(2):301-6
1J:193689 Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T, Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31
1J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
3J:168909 Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY, Dragon (repulsive guidance molecule B) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 1;186(3):1369-76

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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory