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Gene Expression Literature Summary
Symbol
Name
ID
Hspg2
perlecan (heparan sulfate proteoglycan 2)
MGI:96257

103 matching records from 103 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E2.5 E3.5 E4 E4.5 E5 E5.5 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E P
Immunohistochemistry (section) 1 1 1 1 3 2 4 3 5 2 8 4 7 8 5 6 4 12 4 6 1 10 3 6 9 2 9 2 30
In situ RNA (section) 1 1 1 1 1 1 1 1 2 1 2 2 1 1 2 1 1 1 1
Immunohistochemistry (whole mount) 1
In situ RNA (whole mount) 1 1
Northern blot 1 1 1 1 1 1
Western blot 1 1
RT-PCR 1 1 2 1 1 1 3 1 4 4 3 3 1 1 1 1 9
cDNA clones 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Hspg2  perlecan (heparan sulfate proteoglycan 2)   (Synonyms: Pcn, per, perlecan, Plc)
Results  Reference
1J:245045 Aghajanian H, Cho YK, Rizer NW, Wang Q, Li L, Degenhardt K, Jain R, Pdgfralpha functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017 Sep 01;10(9):1101-1108
1J:110553 Allen JM, Bateman JF, Hansen U, Wilson R, Bruckner P, Owens RT, Sasaki T, Timpl R, Fitzgerald J, WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan. J Biol Chem. 2006 Mar 17;281(11):7341-9
1J:139369 Allen JM, Brachvogel B, Farlie PG, Fitzgerald J, Bateman JF, The extracellular matrix protein WARP is a novel component of a distinct subset of basement membranes. Matrix Biol. 2008 May;27(4):295-305
1J:102740 Alpy F, Jivkov I, Sorokin L, Klein A, Arnold C, Huss Y, Kedinger M, Simon-Assmann P, Lefebvre O, Generation of a conditionally null allele of the laminin alpha1 gene. Genesis. 2005 Oct;43(2):59-70
1J:153597 Anderson C, Thorsteinsdottir S, Borycki AG, Sonic hedgehog-dependent synthesis of laminin alpha1 controls basement membrane assembly in the myotome. Development. 2009 Oct;136(20):3495-504
1J:74542 Arikawa-Hirasawa E, Rossi SG, Rotundo RL, Yamada Y, Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice. Nat Neurosci. 2002 Feb;5(2):119-23
1J:67299 Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, Yamada Y, Perlecan is essential for cartilage and cephalic development. Nat Genet. 1999 Nov;23(3):354-8
1J:100029 Bader BL, Smyth N, Nedbal S, Miosge N, Baranowsky A, Mokkapati S, Murshed M, Nischt R, Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice. Mol Cell Biol. 2005 Aug;25(15):6846-56
1J:108443 Bajanca F, Luz M, Raymond K, Martins GG, Sonnenberg A, Tajbakhsh S, Buckingham M, Thorsteinsdottir S, Integrin {alpha}6{beta}1-laminin interactions regulate early myotome formation in the mouse embryo. Development. 2006 May;133(9):1635-44
1J:218940 Barnette DN, VandeKopple M, Wu Y, Willoughby DA, Lincoln J, RNA-seq analysis to identify novel roles of scleraxis during embryonic mouse heart valve remodeling. PLoS One. 2014;9(7):e101425
2J:159868 Benezech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamano JH, Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010 Apr 15;184(8):4521-30
4J:117635 Bose K, Nischt R, Page A, Bader BL, Paulsson M, Smyth N, Loss of nidogen-1 and -2 results in syndactyly and changes in limb development. J Biol Chem. 2006 Dec 22;281(51):39620-9
1J:78596 Brandau O, Aszodi A, Hunziker EB, Neame PJ, Vestweber D, Fassler R, Chondromodulin I is dispensable during enchondral ossification and eye development. Mol Cell Biol. 2002 Sep;22(18):6627-35
2J:175154 Brown AJ, Alicknavitch M, D'Souza SS, Daikoku T, Kirn-Safran CB, Marchetti D, Carson DD, Farach-Carson MC, Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation. Bone. 2008 Oct;43(4):689-99
1J:202949 Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J, Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18042-51
1J:248927 Clements R, Turk R, Campbell KP, Wright KM, Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017 Aug 30;37(35):8559-8574
1J:80720 Costell M, Carmona R, Gustafsson E, Gonzalez-Iriarte M, Fassler R, Munoz-Chapuli R, Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice. Circ Res. 2002 Jul 26;91(2):158-64
2J:58700 Costell M, Gustafsson E, Aszodi A, Morgelin M, Bloch W, Hunziker E, Addicks K, Timpl R, Fassler R, Perlecan maintains the integrity of cartilage and some basement membranes. J Cell Biol. 1999 Nov 29;147(5):1109-22
8J:262042 Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D'Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Harvey RP, Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation. Nature. 2018 May;557(7705):439-445
1*J:116164 Dequeant ML, Glynn E, Gaudenz K, Wahl M, Chen J, Mushegian A, Pourquie O, A complex oscillating network of signaling genes underlies the mouse segmentation clock. Science. 2006 Dec 8;314(5805):1595-8
1J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
1J:230611 Dierker T, Bachvarova V, Krause Y, Li JP, Kjellen L, Seidler DG, Vortkamp A, Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biol. 2016 Jan;49:82-92
1J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
2J:237202 Fantauzzo KA, Soriano P, PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev. 2016 Nov 01;30(21):2443-2458
1*J:79225 Flugel-Koch C, Ohlmann A, Piatigorsky J, Tamm ER, Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn. 2002 Oct;225(2):111-25
1*J:83696 Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, Murphy M, Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn. 2003 Jun;227(2):170-84
3*J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
10J:55507 French MM, Smith SE, Akanbi K, Sanford T, Hecht J, Farach-Carson MC, Carson DD, Expression of the heparan sulfate proteoglycan, perlecan, during mouse embryogenesis and perlecan chondrogenic activity in vitro. J Cell Biol. 1999 May 31;145(5):1103-15
13J:227060 Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S, An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59(3):2553
1J:167570 Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H, Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52
1J:139508 Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP, Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 1;22(15):2111-24
1J:95798 Garl PJ, Wenzlau JM, Walker HA, Whitelock JM, Costell M, Weiser-Evans MC, Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN. Circ Res. 2004 Feb 6;94(2):175-83
2*J:98797 Gersdorff N, Muller M, Otto S, Poschadel R, Hubner S, Miosge N, Basement membrane composition in the early mouse embryo day 7. Dev Dyn. 2005 May 13;233(3):1140-1148
1J:47014 Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH, Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998 Apr 1;17(7):1860-70
1J:195888 Gustafsson E, Almonte-Becerril M, Bloch W, Costell M, Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro. PLoS One. 2013;8(1):e53715
1J:73993 Hall M, Gofflot F, Iseki S, Morriss-Kay GM, Effects of the curly tail genotype on neuroepithelial integrity and cell proliferation during late stages of primary neurulation. J Anat. 2001 Dec;199(Pt 6):645-55
16*J:43266 Handler M, Yurchenco PD, Iozzo RV, Developmental expression of perlecan during murine embryogenesis. Dev Dyn. 1997 Oct;210(2):130-45
1J:216157 Harunaga JS, Doyle AD, Yamada KM, Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility. Dev Biol. 2014 Oct 15;394(2):197-205
2J:227320 Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL, Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol. 2015 Jun 8;209(5):739-57
1J:179356 Hu H, Li J, Gagen CS, Gray NW, Zhang Z, Qi Y, Zhang P, Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol. 2011 May 1;519(7):1320-37
7*J:203017 Ida-Yonemochi H, Harada H, Ohshima H, Saku T, Reciprocal expressions between alpha-dystroglycan and integrin beta1, perlecan receptors, in the murine enamel organ development. Gene Expr Patterns. 2013 Dec;13(8):293-302
3J:166656 Ida-Yonemochi H, Nakajima M, Saku T, Heparanase, heparan sulfate and perlecan distribution along with the vascular penetration during stellate reticulum retraction in the mouse enamel organ. Arch Oral Biol. 2010 Oct;55(10):778-87
9J:98778 Ida-Yonemochi H, Ohshiro K, Swelam W, Metwaly H, Saku T, Perlecan, a Basement Membrane-type Heparan Sulfate Proteoglycan, in the Enamel Organ: Its Intraepithelial Localization in the Stellate Reticulum. J Histochem Cytochem. 2005 Jun;53(6):763-72
1J:134970 Inoue T, Ogawa M, Mikoshiba K, Aruga J, Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008 Apr 30;28(18):4712-25
1J:188305 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y, Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 May;31(4):234-45
6*J:36833 Joseph SJ, Ford MD, Barth C, Portbury S, Bartlett PF, Nurcombe V , Greferath U, A proteoglycan that activates fibroblast growth factors during early neuronal development is a perlecan variant. Development. 1996 Nov;122(11):3443-52
2J:68197 Julian J, Das SK, Dey SK, Baraniak D, Ta VT, Carson DD, Expression of heparin/heparan sulfate interacting protein/ribosomal protein l29 during the estrous cycle and early pregnancy in the mouse. Biol Reprod. 2001 Apr;64(4):1165-75
2J:119297 Kikkawa Y, Miner JH, Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function. Dev Biol. 2006 Aug 1;296(1):265-77
1J:82909 Kikkawa Y, Virtanen I, Miner JH, Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane. J Cell Biol. 2003 Apr 14;161(1):187-96
1J:99700 Kiyozumi D, Osada A, Sugimoto N, Weber CN, Ono Y, Imai T, Okada A, Sekiguchi K, Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp Cell Res. 2005 May 15;306(1):9-23
2J:111788 Kiyozumi D, Sugimoto N, Sekiguchi K, Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11981-6
1J:185210 Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K, Basement membrane assembly of the integrin alpha8beta1 ligand nephronectin requires Fraser syndrome-associated proteins. J Cell Biol. 2012 May 28;197(5):677-89
2J:71581 Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, Chu ML, Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
1J:51970 Kubota Y, Morita T, Kusakabe M, Sakakura T, Ito K, Spatial and temporal changes in chondroitin sulfate distribution in the sclerotome play an essential role in the formation of migration patterns of mouse neural crest cells. Dev Dyn. 1999 Jan;214(1):55-65
2J:129899 Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. J Comp Neurol. 2007 Dec 20;505(6):630-43
1J:196758 Li YN, Pinzon-Duarte G, Dattilo M, Claudepierre T, Koch M, Brunken WJ, The expression and function of netrin-4 in murine ocular tissues. Exp Eye Res. 2012 Mar;96(1):24-35
1J:184380 Li YN, Radner S, French MM, Pinzon-Duarte G, Daly GH, Burgeson RE, Koch M, Brunken WJ, The gamma3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies. Matrix Biol. 2012 Mar;31(2):120-34
1*J:90754 Liu Y, Stein E, Oliver T, Li Y, Brunken WJ, Koch M, Tessier-Lavigne M, Hogan BL, Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol. 2004 May 25;14(10):897-905
1J:178786 Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE, Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell. 2011 Oct 18;21(4):758-69
1*J:139122 Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K, Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12849-54
2J:199683 McKee KK, Yang DH, Patel R, Chen ZL, Strickland S, Takagi J, Sekiguchi K, Yurchenco PD, Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
4J:154365 Mikedis MM, Downs KM, Collagen type IV and Perlecan exhibit dynamic localization in the Allantoic Core Domain, a putative stem cell niche in the murine allantois. Dev Dyn. 2009 Nov 4;238(12):3193-3204
1J:81999 Miosge N, Simniok T, Sprysch P, Herken R, The collagen type XVIII endostatin domain is co-localized with perlecan in basement membranes in vivo. J Histochem Cytochem. 2003 Mar;51(3):285-96
1J:141609 Mokkapati S, Baranowsky A, Mirancea N, Smyth N, Breitkreutz D, Nischt R, Basement membranes in skin are differently affected by lack of nidogen 1 and 2. J Invest Dermatol. 2008 Sep;128(9):2259-67
1*J:65873 Monkley SJ, Zhou XH, Kinston SJ, Giblett SM, Hemmings L, Brown JE, Pritchard CA, Critchley DR, Fassler R, Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
1J:171515 Muller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E, The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis. Development. 2011 Apr;138(7):1297-308
1J:168140 Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y, DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 1;25(3):263-74
8*J:69095 Olguin H, Brandan E, Expression and localization of proteoglycans during limb myogenic activation. Dev Dyn. 2001 May;221(1):106-15
1J:106013 Ormestad M, Astorga J, Landgren H, Wang T, Johansson BR, Miura N, Carlsson P, Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Development. 2006 Mar;133(5):833-43
5*J:128839 Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP, Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007 Dec;134(23):4177-86
1J:190758 Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S, Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 2012 Jul 9;198(1):103-14
2J:93434 Rautavuoma K, Takaluoma K, Sormunen R, Myllyharju J, Kivirikko KI, Soininen R, Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14120-5
1J:213067 Riccomagno MM, Sun LO, Brady CM, Alexandropoulos K, Seo S, Kurokawa M, Kolodkin AL, Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Neuron. 2014 Feb 19;81(4):779-86
1J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
2J:181275 Romano RA, Smalley K, Magraw C, Serna VA, Kurita T, Raghavan S, Sinha S, DeltaNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development. 2012 Feb;139(4):772-82
1*J:36890 Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S, Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
3J:91312 San Martin S, Soto-Suazo M, Zorn TM, Perlecan and Syndecan-4 in Uterine Tissues during the Early Pregnancy in Mice. Am J Reprod Immunol. 2004 Jul;52(1):53-9
2J:161883 Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK, Perlecan is critical for heart stability. Cardiovasc Res. 2008 Dec 1;80(3):435-44
1J:96100 Scheele S, Falk M, Franzen A, Ellin F, Ferletta M, Lonaio P, Andersson B, Timpl R, Forsberg E, Ekblom P, Laminin alpha1 globular domains 4-5 induce fetal development but are not vital for embryonic basement membrane assembly. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1502-6
4*J:137171 Shay EL, Greer CA, Treloar HB, Dynamic expression patterns of ECM molecules in the developing mouse olfactory pathway. Dev Dyn. 2008 Jul;237(7):1837-50
1J:214897 Shi Y, Tu Y, De Maria A, Mecham RP, Bassnett S, Development, composition, and structural arrangements of the ciliary zonule of the mouse. Invest Ophthalmol Vis Sci. 2013 Apr;54(4):2504-15
1J:127022 Shibata S, Dias RA, Hashimoto-Uoshima M, Abe T, Yanagishita M, Immunohistochemical localization of syndecan-1 in the dental follicle of postnatal mouse teeth. J Periodontol. 2007 Jul;78(7):1322-8
1J:176064 Shimokawa K, Kimura-Yoshida C, Nagai N, Mukai K, Matsubara K, Watanabe H, Matsuda Y, Mochida K, Matsuo I, Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo. Dev Cell. 2011 Aug 16;21(2):257-72
1J:239493 Sigoillot SM, Bourgeois F, Karmouch J, Molgo J, Dobbertin A, Chevalier C, Houlgatte R, Leger J, Legay C, Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency. FASEB J. 2016 Jun;30(6):2382-99
2J:239547 Sivakamasundari V, Kraus P, Sun W, Hu X, Lim SL, Prabhakar S, Lufkin T, A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development. Biol Open. 2017 Feb 15;6(2):187-199
7*J:39797 Smith SE, French MM, Julian J, Paria BC, Dey SK, Carson DD, Expression of heparan sulfate proteoglycan (perlecan) in the mouse blastocyst is regulated during normal and delayed implantation. Dev Biol. 1997 Apr 1;184(1):38-47
1J:163656 Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafe L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR, Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21;362(3):206-16
1J:81766 Smits P, Lefebvre V, Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003 Mar;130(6):1135-48
4J:80734 Soto-Suazo M, San Martin S, Ferro ES, Zorn TM, Differential expression of glycosaminoglycans and proteoglycans in the migratory pathway of the primordial germ cells of the mouse. Histochem Cell Biol. 2002 Jul;118(1):69-78
2J:132583 Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP, Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell. 2008 Feb;14(2):298-311
2J:167396 Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K, Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
4J:138609 Takatoh J, Kudoh H, Kondo S, Hanaoka K, Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vomeronasal nerve defasciculation in mouse olfactory system. Exp Neurol. 2008 Sep;213(1):36-47
1*J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
2J:240973 Tao C, Zhang X, Retinal Proteoglycans Act as Cellular Receptors for Basement Membrane Assembly to Control Astrocyte Migration and Angiogenesis. Cell Rep. 2016 Nov 08;17(7):1832-1844
1J:152558 Vallejo-Illarramendi A, Zang K, Reichardt LF, Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development. J Clin Invest. 2009 Aug;119(8):2218-30
2J:143362 Walker JL, Menko AS, Khalil S, Rebustini I, Hoffman MP, Kreidberg JA, Kukuruzinska MA, Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 2008 Nov;237(11):3128-41
2J:76368 Willem M, Miosge N, Halfter W, Smyth N, Jannetti I, Burghart E, Timpl R, Mayer U, Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. Development. 2002 Jun;129(11):2711-22
1J:194150 Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD, Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012 Dec 6;76(5):931-44
2J:177837 Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainen T, Vainio S, Tryggvason K, Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn. 2011 Dec;240(12):2646-56
2J:236386 Xu X, Li Z, Leng Y, Neu CP, Calve S, Knockdown of the pericellular matrix molecule perlecan lowers in situ cell and matrix stiffness in developing cartilage. Dev Biol. 2016 Oct 15;418(2):242-7
5J:140258 Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S, Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008 Aug 22;283(34):23139-49
3J:178649 Yang DH, McKee KK, Chen ZL, Mernaugh G, Strickland S, Zent R, Yurchenco PD, Renal collecting system growth and function depend upon embryonic gamma1 laminin expression. Development. 2011 Oct;138(20):4535-44
1J:125640 Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM, Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct;39(10):1225-34

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last database update
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