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Gene Expression Literature Summary
Symbol
Name
ID
Hba-a1
hemoglobin alpha, adult chain 1
MGI:96015

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E5.5 E6.5 E7.5 E8.5 E9.5 E10.5 E11 E11.5 E12.5 E13.5 E14.5 E15.5 E16.5 E17.5 E18.5 E A
In situ protein (section) 1 1
In situ RNA (section) 1 2 2 1 2 2 2
In situ RNA (whole mount) 1 1 1 1
Northern blot 1
Western blot 1 1 1 1
RT-PCR 1 1 1 2 5 4 1 2 3 2 5 1 1 1 2 2 4
RNase protection 1 1
Nuclease S1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Hba-a1  hemoglobin alpha, adult chain 1   (Synonyms: alpha 1 globin, Hba1)
Results  Reference
2J:117669 Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A, Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation. FASEB J. 2003 Aug;17(11):1496-8
2J:142972 Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS, UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008 Nov 7;283(45):30461-70
2*J:100942 Fu XH, Liu DP, Tang XB, Liu G, Lv X, Li YJ, Liang CC, A conserved, extended chromatin opening within alpha-globin locus during development. Exp Cell Res. 2005 Sep 10;309(1):174-84
1*J:36249 Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH, Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12355-8
1J:204573 Funnell AP, Mak KS, Twine NA, Pelka GJ, Norton LJ, Radziewic T, Power M, Wilkins MR, Bell-Anderson KS, Fraser ST, Perkins AC, Tam PP, Pearson RC, Crossley M, Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Mol Cell Biol. 2013 Aug;33(15):2976-87
1J:130852 Griffin CT, Brennan J, Magnuson T, The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development. 2008 Feb;135(3):493-500
7*J:29665 Hendrey J, Lin D, Dziadek M, Developmental analysis of the Hba(th-J) mouse mutation: effects on mouse peri-implantation development and identification of two candidate genes. Dev Biol. 1995 Nov;172(1):253-63
1*J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1J:182447 Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, Chui DH, Cardoso WV, Ai X, Lu J, Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012 Feb 17;287(8):5979-87
1*J:35594 Kieran MW, Perkins AC, Orkin SH, Zon LI, Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9126-31
2J:153993 Liang SY, Moghimi B, Crusselle-Davis VJ, Lin IJ, Rosenberg MH, Li X, Strouboulis J, Huang S, Bungert J, Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor. Mol Cell Biol. 2009 Nov;29(21):5900-10
1*J:31156 Lin CS, Lim SK, D'Agati V, Costantini F, Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
5J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
5J:181018 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Cheah PS, Smyth GK, Tan SS, Hahn CN, Thomas T, Thomas PQ, Scott HS, Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis. Cereb Cortex. 2011 Mar;21(3):683-97
2*J:86682 Loyd MR, Okamoto Y, Randall MS, Ney PA, Role of AP1/NFE2 binding sites in endogenous alpha-globin gene transcription. Blood. 2003 Dec 1;102(12):4223-8
2J:162666 Miccio A, Blobel GA, Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Mol Cell Biol. 2010 Jul;30(14):3460-70
1J:35077 Ohsugi M, Hwang SY, Butz S, Knowles BB, Solter D, Kemler R, Expression and cell membrane localization of catenins during mouse preimplantation development. Dev Dyn. 1996 Aug;206(4):391-402
1*J:146219 Postel EH, Wohlman I, Zou X, Juan T, Sun N, D'Agostin D, Cuellar M, Choi T, Notterman DA, La Perle KM, Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn. 2009 Mar;238(3):775-87
12J:146606 Pritchard C , Mecham B , Dumpit R , Coleman I , Bhattacharjee M , Chen Q , Sikes RA , Nelson PS, Conserved gene expression programs integrate mammalian prostate development and tumorigenesis. Cancer Res. 2009 Mar 1;69(5):1739-47
2J:67993 Ramamurthy L, Barbour V, Tuckfield A, Clouston DR, Topham D, Cunningham JM, Jane SM, Targeted disruption of the CP2 gene, a member of the NTF family of transcription factors. J Biol Chem. 2001 Mar 16;276(11):7836-42
1J:63425 Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M, Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 2000 Jul 21;102(2):221-31
1J:91136 Tasheva ES, Ke A, Deng Y, Jun C, Takemoto LJ, Koester A, Conrad GW, Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004 Jun 17;10:403-16
2*J:97640 Tominaga K, Kirtane B, Jackson JG, Ikeno Y, Ikeda T, Hawks C, Smith JR, Matzuk MM, Pereira-Smith OM, MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol. 2005 Apr;25(8):2924-37
9J:52217 Trimborn T, Gribnau J, Grosveld F, Fraser P, Mechanisms of developmental control of transcription in the murine alpha-and beta-globin loci. Genes Dev. 1999 Jan 1;13(1):112-24
1J:127131 Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R, Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis. Genes Cells. 2007 May;12(5):581-92
1J:56429 Vannucchi AM, Linari S, Lin CS, Koury MJ, Bondurant MC, Migliaccio AR, Increased expression of the distal, but not of the proximal, Gata1 transcripts during differentiation of primary erythroid cells. J Cell Physiol. 1999 Sep;180(3):390-401
1J:46127 Visvader JE, Fujiwara Y, Orkin SH, Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 1998 Feb 15;12(4):473-9

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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory