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Gene Expression Literature Summary
Symbol
Name
ID
Lrp2
low density lipoprotein receptor-related protein 2
MGI:95794

32 matching records from 32 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2.5 E3 E3.5 E4 E4.5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10.5 E11.5 E12.5 E13.5 E14.5 E15.5 E16.5 E17 E17.5 E18.5 E20 E A
In situ protein (section) 2 1 1 3 3 4 2 4 3 2 2 3 1 2 1 1 1 1 2 6
In situ RNA (section) 1 1 1
In situ protein (whole mount) 1 1 1 1 1 1 1 1
In situ RNA (whole mount) 1 1 1 1
In situ reporter (knock in) 1 1
Western blot 1 1
RT-PCR 1 1 1 1 1 1 2 2 1 3 1 3 2 2 3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Lrp2  low density lipoprotein receptor-related protein 2   (Synonyms: b2b1625.2Clo, D230004K18Rik, Gp330, Megalin)
Results  Reference
1J:98256 Assemat E, Vinot S, Gofflot F, Linsel-Nitschke P, Illien F, Chatelet F, Verroust P, Louvet-Vallee S, Rinninger F, Kozyraki R, Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryo. Biol Reprod. 2005 May;72(5):1079-86
2J:203560 Burk RF, Olson GE, Hill KE, Winfrey VP, Motley AK, Kurokawa S, Maternal-fetal transfer of selenium in the mouse. FASEB J. 2013 Aug;27(8):3249-56
3J:199615 Cases O, Perea-Gomez A, Aguiar DP, Nykjaer A, Amsellem S, Chandellier J, Umbhauer M, Cereghini S, Madsen M, Collignon J, Verroust P, Riou JF, Creuzet SE, Kozyraki R, Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem. 2013 Jun 7;288(23):16655-70
10J:181474 Christ A, Christa A, Kur E, Lioubinski O, Bachmann S, Willnow TE, Hammes A, LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
7J:88400 Drake CJ, Fleming PA, Larue AC, Barth JL, Chintalapudi MR, Argraves WS, Differential distribution of cubilin and megalin expression in the mouse embryo. Anat Rec A Discov Mol Cell Evol Biol. 2004 Mar;277(1):163-70
2J:168197 Dubreuil V, Marzesco AM, Corbeil D, Huttner WB, Wilsch-Brauninger M, Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J Cell Biol. 2007 Feb 12;176(4):483-95
7J:130836 Gerbe F, Cox B, Rossant J, Chazaud C, Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol. 2008 Jan 15;313(2):594-602
4*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:194051 Heliot C, Desgrange A, Buisson I, Prunskaite-Hyyrylainen R, Shan J, Vainio S, Umbhauer M, Cereghini S, HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
1*J:150394 Jouret F, Auzanneau C, Debaix H, Wada GH, Pretto C, Marbaix E, Karet FE, Courtoy PJ, Devuyst O, Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005 Nov;16(11):3235-46
1J:123312 Kurumada S, Onishi A, Imai H, Ishii K, Kobayashi T, Sato SB, Stage-specific association of apolipoprotein A-I and E in developing mouse retina. Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1815-23
5*J:199961 Lai SC, Nakayama Y, Sequeira JM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Bottiglieri T, Quadros EV, The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. FASEB J. 2013 Jun;27(6):2468-75
2J:74182 Legallicier B, Trugnan G, Murphy G, Lelongt B, Ronco P, Expression of the type IV collagenase system during mouse kidney development and tubule segmentation. J Am Soc Nephrol. 2001 Nov;12(11):2358-69
1J:59629 Lehtonen S, Riento K, Olkkonen VM, Lehtonen E, Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Kidney Int. 1999 Sep;56(3):815-26
4J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2010 Nov 8;
1*J:103780 Maurer ME, Cooper JA, Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein. J Cell Sci. 2005 Nov 15;118(Pt 22):5345-55
1*J:168293 Nada S, Hondo A, Kasai A, Koike M, Saito K, Uchiyama Y, Okada M, The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J. 2009 Mar 4;28(5):477-89
6J:183783 Ortega MC, Cases O, Merchan P, Kozyraki R, Clemente D, de Castro F, Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development. Glia. 2012 May;60(6):851-66
2J:104891 Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R, Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006 Jan;133(1):151-61
7J:151683 Parreira KS, Debaix H, Cnops Y, Geffers L, Devuyst O, Expression patterns of the aquaporin gene family during renal development: influence of genetic variability. Pflugers Arch. 2009 Aug;458(4):745-59
2J:199892 Rhee S, Guerrero-Zayas MI, Wallingford MC, Ortiz-Pineda P, Mager J, Tremblay KD, Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS One. 2013;8(3):e58828
1J:180919 Schulz LC, Roberts RM, Dynamic changes in leptin distribution in the progression from ovum to blastocyst of the pre-implantation mouse embryo. Reproduction. 2011 Jun;141(6):767-77
1J:119685 Smith BT, Mussell JC, Fleming PA, Barth JL, Spyropoulos DD, Cooley MA, Drake CJ, Argraves WS, Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006;6:30
2J:95319 Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE, LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005 Jan;132(2):405-14
1J:98337 Strope S, Rivi R, Metzger T, Manova K, Lacy E, Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules. Development. 2004 Oct;131(19):4787-95
7J:104562 Wicher G, Larsson M, Rask L, Aldskogius H, Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord. J Comp Neurol. 2005 Nov 14;492(2):123-31
2J:34835 Willnow TE, Hilpert J, Armstrong SA, Rohlmann A, Hammer RE, Burns DK, Herz J, Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8460-4
1J:121266 Yang DH, Cai KQ, Roland IH, Smith ER, Xu XX, Disabled-2 is an epithelial surface positioning gene. J Biol Chem. 2007 Apr 27;282(17):13114-22
1*J:79862 Yang DH, Smith ER, Roland IH, Sheng Z, He J, Martin WD, Hamilton TC, Lambeth JD, Xu XX, Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002 Nov 1;251(1):27-44
1J:93296 Yu H, Wessels A, Chen J, Phelps AL, Oatis J, Tint GS, Patel SB, Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome. BMC Dev Biol. 2004 Mar 2;4(1):1
1*J:117102 Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E, Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81

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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory