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Gene Expression Literature Summary
Symbol
Name
ID
Flna
filamin, alpha
MGI:95556

15 matching records from 15 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E9.5 E10.5 E11.5 E12.5 E13.5 E14 E14.5 E15.5 E16 E16.5 E17 E17.5 E A
In situ protein (section) 1 1 3 3 1 1 1 3 2 3
In situ RNA (section) 1 2 2 2 1 2 1
Western blot 2 1 2 1 3
RT-PCR 1 1 1
cDNA clones 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Flna  filamin, alpha   (Synonyms: ABP-280, actin-binding protein 280, Dilp2, F730004A14Rik, filamin-1, Fln1, GENA 379)
Results  Reference
3*J:59239 Chiang W, Greaser ML, Lyons GE, Filamin isogene expression during mouse myogenesis. Dev Dyn. 2000 Jan;217(1):99-108
1*J:132026 Farrington-Rock C, Kirilova V, Dillard-Telm L, Borowsky AD, Chalk S, Rock MJ, Cohn DH, Krakow D, Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Hum Mol Genet. 2008 Mar 1;17(5):631-41
3J:118252 Feng Y, Chen MH, Moskowitz IP, Mendonza AM, Vidali L, Nakamura F, Kwiatkowski DJ, Walsh CA, Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
2J:112274 Hart AW, Morgan JE, Schneider J, West K, McKie L, Bhattacharya S, Jackson IJ, Cross SH, Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet. 2006 Aug 15;15(16):2457-67
1J:185200 Lian G, Lu J, Hu J, Zhang J, Cross SH, Ferland RJ, Sheen VL, Filamin A Regulates Neural Progenitor Proliferation and Cortical Size through Wee1-Dependent Cdk1 Phosphorylation. J Neurosci. 2012 May 30;32(22):7672-84
2J:51716 Liu G, Thomas L, Warren RA, Enns CA, Cunningham CC, Hartwig JH, Thomas G, Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997 Dec 29;139(7):1719-33
1J:125095 Lu J, Lian G, Lenkinski R, De Grand A, Vaid RR, Bryce T, Stasenko M, Boskey A, Walsh C, Sheen V, Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet. 2007 Jul 15;16(14):1661-75
6J:161210 Norris RA, Moreno-Rodriguez R, Wessels A, Merot J, Bruneval P, Chester AH, Yacoub MH, Hagege A, Slaugenhaupt SA, Aikawa E, Schott JJ, Lardeux A, Harris BS, Williams LK, Richards A, Levine RA, Markwald RR, Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis. Dev Dyn. 2010 Jul;239(7):2118-27
4J:117267 Sarkisian MR, Bartley CM, Chi H, Nakamura F, Hashimoto-Torii K, Torii M, Flavell RA, Rakic P, MEKK4 signaling regulates filamin expression and neuronal migration. Neuron. 2006 Dec 7;52(5):789-801
5J:202654 Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA, Developmental basis for filamin-A-associated myxomatous mitral valve disease. Cardiovasc Res. 2012 Oct 1;96(1):109-19
9J:79977 Sheen VL, Feng Y, Graham D, Takafuta T, Shapiro SS, Walsh CA, Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002 Nov 1;11(23):2845-54
1J:129038 Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C, Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007 Nov;27(22):7935-46
1J:185565 Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB, Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012 Jun 15;366(2):111-24
3J:187673 Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V, Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
2J:120066 Zhou X, Tian F, Sandzen J, Cao R, Flaberg E, Szekely L, Cao Y, Ohlsson C, Bergo MO, Boren J, Akyurek LM, Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3919-24

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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory