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Gene Expression Literature Summary
Symbol
Name
ID
Fgfr4
fibroblast growth factor receptor 4
MGI:95525

71 matching records from 71 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E3.5 E5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E A
In situ protein (section) 1 1 1 1 2 1 2 1 1 1 1 2
In situ RNA (section) 1 1 1 1 1 1 2 1 3 3 2 6 4 13 1 4 2 7 1 1 4 4
In situ protein (whole mount) 1
In situ RNA (whole mount) 2 2 1 2 5 1 2 1 1 2
Northern blot 1 1 1 2 1 1 2 1 2 1 2 2 1 1 1 3
Western blot 1 2
RT-PCR 1 1 1 1 1 3 4 4 8 2 2 4 2 2 1 2 1 2 1 1 1 12
cDNA clones 2 1 1 1 1 1 1
RNase protection 1 1 1 1 1 1 1 1 1 1 1 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Fgfr4  fibroblast growth factor receptor 4   (Synonyms: Fgfr-4)
Results  Reference
3*J:203801 Amann R, Trueb B, Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. Int J Mol Med. 2013 Nov;32(5):983-8
3*J:67307 Bachler M, Neubuser A, Expression of members of the Fgf family and their receptors during midfacial development. Mech Dev. 2001 Feb;100(2):313-6
1J:98791 Blak AA, Naserke T, Weisenhorn DM, Prakash N, Partanen J, Wurst W, Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Dev Dyn. 2005 Apr 13;233(3):1023-1030
2J:160580 Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL, FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008;3:17
1J:164280 Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P, FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell. 2010 Sep 14;19(3):440-9
3J:149242 Cameron TL, Belluoccio D, Farlie PG, Brachvogel B, Bateman JF, Global comparative transcriptome analysis of cartilage formation in vivo. BMC Dev Biol. 2009;9:20
1J:185530 Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z, MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis. Dev Cell. 2012 Jun 12;22(6):1176-90
1J:91010 Chi L, Zhang S, Lin Y, Prunskaite-Hyyrylainen R, Vuolteenaho R, Itaranta P, Vainio S, Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Development. 2004 Jul;131(14):3345-56
4J:84134 Cool SM, Sayer RE, van Heumen WR, Pickles JO, Nurcombe V, Temporal and spatial expression of fibroblast growth factor receptor 4 isoforms in murine tissues. Histochem J. 2002 Jun-Jul;34(6-7):291-7
1J:99606 Coumoul X, Shukla V, Li C, Wang RH, Deng CX, Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference. Nucleic Acids Res. 2005;33(11):e102
1*J:12606 deLapeyriere O, Ollendorff V, Planche J, Ott MO, Pizette S, Coulier F, Birnbaum D, Expression of the Fgf6 gene is restricted to developing skeletal muscle in the mouse embryo. Development. 1993 Jun;118(2):601-11
1J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
7*J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*J:81601 Ford-Perriss M, Guimond SE, Greferath U, Kita M, Grobe K, Habuchi H, Kimata K, Esko JD, Murphy M, Turnbull JE, Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling. Glycobiology. 2002 Nov;12(11):721-7
2J:170649 Garcia CM, Huang J, Madakashira BP, Liu Y, Rajagopal R, Dattilo L, Robinson ML, Beebe DC, The function of FGF signaling in the lens placode. Dev Biol. 2011 Mar 1;351(1):176-85
2*J:3319 Gilardi-Hebenstreit P, Nieto MA, Frain M, Mattei MG, Chestier A, Wilkinson DG, Charnay P, An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
1J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57
2J:98519 Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller MJ, Hamard G, Maire P, Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005 May;132(9):2235-49
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. http://www.gudmap.org. 2004;
1J:204192 Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F, A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci. 2013 Nov 6;33(45):17656-66
6J:184019 Han D, Zhao H, Parada C, Hacia JG, Bringas P Jr, Chai Y, A TGFbeta-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May;139(9):1640-50
1J:93900 Hasegawa H, Ashigaki S, Takamatsu M, Suzuki-Migishima R, Ohbayashi N, Itoh N, Takada S, Tanabe Y, Laminar patterning in the developing neocortex by temporally coordinated fibroblast growth factor signaling. J Neurosci. 2004 Oct 6;24(40):8711-9
2J:137155 Hayashi T, Ray CA, Bermingham-McDonogh O, Fgf20 is required for sensory epithelial specification in the developing cochlea. J Neurosci. 2008 Jun 4;28(23):5991-9
6*J:156926 Hayashi T, Ray CA, Younkins C, Bermingham-McDonogh O, Expression patterns of FGF receptors in the developing mammalian cochlea. Dev Dyn. 2010 Feb 3;239(3):1019-1026
5*J:79832 Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M, Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development. 2002 Dec;129(24):5767-78
1J:55594 Iseki S, Wilkie AO, Morriss-Kay GM, Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999 Dec;126(24):5611-20
1J:115924 Iwabuchi T, Goetinck PF, Syndecan-4 dependent FGF stimulation of mouse vibrissae growth. Mech Dev. 2006 Nov;123(11):831-41
3J:74539 Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M, Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs. 2002;170(2-3):83-98
1J:127233 Kaneko KJ, Kohn MJ, Liu C, DePamphilis ML, Transcription factor TEAD2 is involved in neural tube closure. Genesis. 2007 Sep;45(9):577-87
1J:155751 Kang W, Wong LC, Shi SH, Hebert JM, The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J Neurosci. 2009 Nov 18;29(46):14571-80
2J:48564 Kettunen P, Karavanova I, Thesleff I, Responsiveness of developing dental tissues to fibroblast growth factors: expression of splicing alternatives of FGFR1, -2, -3, and of FGFR4; and stimulation of cell proliferation by FGF-2, -4, -8, and -9. Dev Genet. 1998;22(4):374-85
1J:178935 Kitagaki J, Ueda Y, Chi X, Sharma N, Elder CM, Truffer E, Costantini F, Lewandoski M, Perantoni AO, FGF8 is essential for formation of the ductal system in the male reproductive tract. Development. 2011 Dec;138(24):5369-78
24J:2028 Korhonen J, Partanen J, Alitalo K, Expression of FGFR-4 mRNA in developing mouse tissues. Int J Dev Biol. 1992 Jun;36(2):323-9
4J:88398 Kumabe S, Immunohistochemical study of genesis of the mouse oral vestibule. Okajimas Folia Anat Jpn. 2003 Oct;80(4):93-102
2*J:132070 Kwiatkowski BA, Kirillova I, Richard RE, Israeli D, Yablonka-Reuveni Z, FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation. J Cell Physiol. 2008 Jan 9;215(3):803-817
8J:137423 Lagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME, Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008 Jul 1;22(13):1828-37
1J:117073 Li C, Scott DA, Hatch E, Tian X, Mansour SL, Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development. 2007 Jan;134(1):167-76
1*J:171624 Machold R, Klein C, Fishell G, Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):349-59
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2J:192712 Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O, Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
2*J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
1J:134393 Nyeng P, Norgaard GA, Kobberup S, Jensen J, FGF10 signaling controls stomach morphogenesis. Dev Biol. 2007 Mar 1;303(1):295-310
2J:45221 Ozawa K, Seo M, Imamura T, A quantitative method for evaluation of FGF family and FGF receptor family gene expression by RT-PCR. Brain Res Brain Res Protoc. 1997 Aug;1(3):211-6
6*J:35179 Ozawa K, Uruno T, Miyakawa K, Seo M, Imamura T, Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development. Brain Res Mol Brain Res. 1996 Sep 5;41(1-2):279-88
1J:173447 Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD, FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size. PLoS Genet. 2011 Jun;7(6):e1002098
6*J:74134 Pickles JO, The expression of fibroblast growth factors and their receptors in the embryonic and neonatal mouse inner ear. Hear Res. 2001 May;155(1-2):54-62
2*J:160766 Porntaveetus T, Oommen S, Sharpe PT, Ohazama A, Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. Gene Expr Patterns. 2010 Jun;10(4-5):193-8
3*J:38854 Qian X, Davis AA, Goderie SK, Temple S, FGF2 concentration regulates the generation of neurons and glia from multipotent cortical stem cells. Neuron. 1997 Jan;18(1):81-93
7J:50179 Rappolee DA, Patel Y, Jacobson K, Expression of fibroblast growth factor receptors in peri-implantation mouse embryos. Mol Reprod Dev. 1998 Nov;51(3):254-64
2J:176344 Ratzka A, Baron O, Grothe C, FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system. PLoS One. 2011;6(8):e23564
4J:82654 Reid S, Ferretti P, Differential expression of fibroblast growth factor receptors in the developing murine choroid plexus. Brain Res Dev Brain Res. 2003 Mar 14;141(1-2):15-24
3J:61430 Rice DP, Aberg T, Chan Y, Tang Z, Kettunen PJ, Pakarinen L, Maxson RE, Thesleff I, Integration of FGF and TWIST in calvarial bone and suture development. Development. 2000 May;127(9):1845-55
1J:22208 Ruiz JC, Conlon FL, Robertson EJ, Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
1J:94932 Satoh Y, Haraguchi R, Wright TJ, Mansour SL, Partanen J, Hajihosseini MK, Eswarakumar VP, Lonai P, Yamada G, Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors. Anat Embryol (Berl). 2004 Sep;208(6):479-86
1J:92065 Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B, Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627-36
1*J:94299 Serls AE, Doherty S, Parvatiyar P, Wells JM, Deutsch GH, Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development. 2005 Jan;132(1):35-47
1J:187729 Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M, A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development. 2012 Sep;139(18):3363-72
2J:122940 Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL, FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron. 2006 Jun 15;50(6):841-53
1J:161120 Shukla V, Coumoul X, Deng CX, RNAi-based conditional gene knockdown in mice using a U6 promoter driven vector. Int J Biol Sci. 2007;3(2):91-9
15J:11593 Stark KL, McMahon JA, McMahon AP, FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development. 1991 Oct;113(2):641-51
1*J:168653 Sylvestersen KB, Herrera PL, Serup P, Rescan C, Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):105-11
1J:104381 Takeuchi Y, Molyneaux K, Runyan C, Schaible K, Wylie C, The roles of FGF signaling in germ cell migration in the mouse. Development. 2005 Dec;132(24):5399-409
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1*J:65741 Thomas T, Voss AK, Petrou P, Gruss P, The murine gene, traube, is essential for the growth of preimplantation embryos. Dev Biol. 2000 Nov 15;227(2):324-42
1J:199245 Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K, Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab. 2013 Jun 4;17(6):916-28
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
4*J:71776 Wiedemann M, Trueb B, The mouse Fgfrl1 gene coding for a novel FGF receptor-like protein(1). Biochim Biophys Acta. 2001 Sep 21;1520(3):247-50
6*J:85919 Wright TJ, Hatch EP, Karabagli H, Karabagli P, Schoenwolf GC, Mansour SL, Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development. Dev Dyn. 2003 Oct;228(2):267-72
6J:150712 Yaguchi Y, Yu T, Ahmed MU, Berry M, Mason I, Basson MA, Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development. Dev Dyn. 2009 Jun 19;238(8):2058-2072
1*J:101025 Yaylaoglu MB, Titmus A, Visel A, Alvarez-Bolado G, Thaller C, Eichele G, Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn. 2005 Oct;234(2):371-86

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory